Mesenchymal stem cells transplant stem cells. Medical search. Frequent questions

Mesenchymal stem cells (MSCs) are non-haematopoietic stromal cells that reside mainly in the bone marrow compartment, but also in fat and other tissues. (medscape.com)
Background: We have previously shown bone marrow-derived mesenchymal stem cells (MSCs) may shift immune responses toward anti-inflammatory pathways and stabilize the course of obstructive chronic lung allograft syndrome (o-CLAD) after lung transplantation. (elsevierpure.com)
Conclusion: Intravenous infusions of bone marrow-derived MSCs are well tolerated in lung transplant recipients with moderate-to-severe CLAD. (elsevierpure.com)
Intramyocardial transplantation of mesenchymal stem cells (MSCs) has emerged as a leading contender in the pursuit of clinical intervention and therapy. (springer.com)
MSCs are capable of secreting a large array of soluble factors, which have had demonstrated effects on pathogenic cardiac remolding, fibrosis, immune activation, and cardiac stem cell proliferation within the damaged heart. (springer.com)
MSCs are also capable of differentiation into cardiomyocytes, endothelial cells, and vascular smooth muscle cells, although the relative contribution of trilineage differentiation and paracrine effectors on cardiac repair remains the subject of active investigation. (springer.com)
Thus, the effectiveness of this treatment strategy is limited unless MSCs are directly transplanted into the spinal cord lesion. (frontiersin.org)
AIM: To improve the colonization price of transplanted mesenchymal stem cells (MSCs) within the liver and effect of MSC transplantation for acute liver failure (ALF). (biodiversityhotspot.org)
INTRODUCTION In recent years mesenchymal stem cells (MSCs) have shown paracrine and immunoregulatory effects to repair damaged tissues[1 2 A large number of studies based on stem cell transplantation has achieved impressive results and has provided new ideas for treatment of various diseases. (biodiversityhotspot.org)
Retrospective studies have revealed that low colonization of transplanted MSCs in the liver was the main reason restricting the efficacy of MSC transplantation[6]. (biodiversityhotspot.org)
Mesenchymal stromal cells (MSCs) are currently being investigated for use in a wide variety of clinical applications. (wjgnet.com)
Mesenchymal stem cells (MSCs), cultured ex vivo, recently were shown to be able to migrate into sites of brain injuries when transplanted systemically or locally, suggesting that MSCs possess migratory capacity. (nih.gov)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. (biomedcentral.com)
Human tube MSCs can be easily isolated, expanded in vitro , present a mesenchymal profile and are able to differentiate into muscle, fat, cartilage and bone in vitro . (biomedcentral.com)
The aim of this study is to evaluate the safety and feasibility of using mesenchymal stem cells (MSCs) to replace rituximab in ABO-i LT. (researchsquare.com)
With the properties of immunomodulation and regeneration, mesenchymal stem cells (MSCs) are emerging as a promising approach for many diseases, including acute-on-chronic hepatic failure, rheumatoid arthritis and inflammatory bowel disease. (researchsquare.com)
Injection of progenitor cells, especially mesenchymal stem cells (MSCs) is found to be an effective and better solution for repairing degenerative cartilage compared to implantation of differentiated cells such as articular cartilage. (medgadget.com)
Previous research on the efficacy of stem cell therapy for heart repair has shown possible benefit from mesenchymal stem cells (MSCs) -- cells found in bone marrow that create connective tissue, bone and cartilage. (sciencedaily.com)
As a cell-based therapy, MSCs have a number of unique advantages: they can be taken from genetically distinct donors, are easy to prepare, and have a tendency to collect within injured areas. (sciencedaily.com)
10, 2019 The use of primary mesenchymal stem cells (MSCs) is fraught with ageing-related shortfalls such as limited expansion and early senescence. (sciencedaily.com)
It can act as a carrier and deliver mesenchymal stem cells (MSCs) to the site. (medtronic.com)
Exosomes harvested from mesenchymal stem cells (MSCs-Exo), as a treatment for diseases, has better safety and convenience compared with stem cell therapy, and will certainly play a huge role in the future clinical treatment of diseases. (fightaging.org)
Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. (biomedcentral.com)
Different cell types such as bone marrow MSCs (BMSCs), periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSC) are key stem cells used in stem cell-based periodontal regeneration [ 19 ]. (biomedcentral.com)
In addition, it has been reported that in vivo monitoring of transplanted MSCs in an acute myocardial infarction tracked only 4.4% of MSCs in the transplanted site after 1 week, which indicated the poor survival rate of transplanted MSCs. (biomedcentral.com)
Studies in my laboratory have focused on advancing a thorough, systematic understanding of the basic biology of canine MSCs to inform the design of future stem cell clinical trials in the dog and their use for translational studies. (upenn.edu)
The first is to engraft mesenchymal stem cells (MSCs) onto a graft or a biosynthetic matrix to provide a viable osteoinductive scaffold material for segmental defect repair. (ispub.com)
It detailed their early clinical trial successes in using Mesenchymal Stem Cells (MSCs) to stop kidney transplant rejection and to repair acute kidney injury (among many other medical wonders). (globaldialysis.com)
Then, following the finding of MSCs capacity to suppress the immune system, they also began clinical studies to evaluate their safety and effectiveness for treating transplant rejection. (globaldialysis.com)
A typical kidney transplant rejection treatment protocol consists of a series of small infusions (about 40mls) of MSCs into a vein, typically over a 4 week period: the rejection fades away. (globaldialysis.com)
Dr. Mezey is interested in the biology of bone marrow stromal cells (MSCs). (nih.gov)
In addition, they are studying how MSCs might regulate red cell production in the bone marrow of patients with anemia. (nih.gov)
Dr. Mezey's group collaborates with clinicians to find out the best ways to use the unique properties of these cells in patients, and to prime MSCs for targeted use. (nih.gov)
At NIDCR, Dr. Mezey established the Adult Stem Cell Section to study the biology of bone marrow derived stem cells (MSCs). (nih.gov)
Recent studies suggested that microvesicles (MVs) released from mesenchymal stem cells (MSCs) exert therapeutic effects in various degenerative diseases. (biomedcentral.com)
The co-administration of glial cell line-derived neurotrophic factor (GDNF) and mesenchymal stem cells (MSCs) in hydrogels (HGs) has emerged as a powerful strategy to enhance the efficient integration of transplanted cells in Parkinson's disease (PD). (unav.edu)
Mesenchymal stem cells (MSCs) are a promising cell source for the treatment of ischemic stroke. (molcells.org)
AFS cells and bone marrow-derived mesenchymal stem cells (MSCs) were resuspended in fibrin-collagen gel and "printed" over the wound site. (indexindex.com)
However, tracking of fluorescently labeled AFS cells and MSCs revealed that the cells remained transiently and did not permanently integrate in the tissue. (indexindex.com)
Accordingly, we performed proteomic analysis, which showed that AFS cells secreted a number of growth factors at concentrations higher than those of MSCs. (indexindex.com)
The cell types addressed include both those commonly in current use for patient treatment, such as whole blood and hematopoietic stem cells and also examples of new cell-based medicines including tissue progenitor cells (MSCs), (The use of the term Mesenchymal Stem Cell (MSC) has been hotly debated in the literature as it actually applies to several different cell types. (ossiumhealth.com)
2 (2007) observed that cell adhesion and proliferation, as well as the osteogenic differentiation of mouse mesenchymal stem cells (MSCs) to Ti discs were significantly similar to those on the plastic surface of the culture, indicating Ti as an excellent material for repairing hard tissue in the field of bone tissue engineering. (bvsalud.org)
The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has recently been explored in various pathological conditions of the central nervous system (CNS). (nih.gov)
Intracerebral transplantation of BM-MSCs into the brain of an induced AD model reduced their Aβ levels when compared to sham-transplanted animals. (nih.gov)

A series of studies has confirmed the accelerative effect of stromal cell-derived factor (SDF)-1α in homing and survival of stem cells[7-11]. (biodiversityhotspot.org)
SDF-1α is a chemoattractant protein of the CXC family produced by bone marrow stromal cells. (biodiversityhotspot.org)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432099/all/Mesenchymal_stromal_cells_as_treatment_or_prophylaxis_for_acute_or_chronic_graft‐versus‐host_disease_in_haematopoietic_stem_cell_transplant__HSCT__recipients_with_a_haematological_condition. (unboundmedicine.com)
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? (wjgnet.com)
rMSCs transplanted into the lateral ventricles of the rat brain migrated to the avulsed hypoglossal nucleus, where the expression of chemokines, stromal-cell-derived factor 1 (SDF-1), and fractalkine was observed to be increased. (nih.gov)
Her research work primarily included evaluation of the effects of mesenchymal stromal cells on the immune cell repertoire of kidney transplant patients. (nih.gov)
B cells: a new player in mesenchymal stromal cell-mediated immune modulation in renal transplant patients. (nih.gov)
Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
Mesenchymal stem cells are heterogenous adult multipotent stromal cells that can be isolated from various sources including: bone marrow, peripheral blood, umbilical cord blood, dental pulp, and adipose tissue. (intechopen.com)
Under his direction the Section has collaborated with Institute Investigators to develop and implement methods to produce clinical Natural Killer cell, dendritic cell, bone marrow stromal cell, Chimeric antigen receptor (CAR) T cell and viral specific T cell products. (nih.gov)
Bone Marrow Derived Mesenchyme Stromal Cells Harness Purinergenic Signaling to Tolerize Human Th1 Cells In Vivo. (nih.gov)
Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses. (nih.gov)
Impaired function of bone marrow stromal cells in systemic mastocytosis. (nih.gov)

Mesenchymal stem cells (MSC) are currently the most clinically applicable stem cell for transplantation. (nih.gov)
In summary, we propose that knockdown of Rac1 gene could significantly boost cell survival and promote the recovery of neurological functions after BMMSCs transplantation in TBI mice. (aging-us.com)
In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of administration, the safety and the clinical efficacy of mesenchymal stem cell (MSC) transplantation in patients with active and progressive multiple sclerosis. (medscape.com)
Menasche P (2003) Myoblast-based cell transplantation. (springer.com)
Mesenchymal stem cell (MSC) transplantation has been shown to represent a potential treatment for traumatic spinal cord injury (SCI). (frontiersin.org)
However many researchers have also found the phenomenon of poor efficacy of cell transplantation. (biodiversityhotspot.org)
Although 1-year survival after organ transplantation has improved markedly over the last 15 years, the prevalence of morbidities such as systemic hypertension, diabetes mellitus, renal insufficiency, and malignancy remain high in transplant recipients as compared with the general population. (nih.gov)
Transplantation of these cells has shown that they can differentiate and be integrated into the neural tissue. (nature.com)
Neural stem cells taken from the embryonic spinal cord are an appealing source of cells for transplantation because they are involved in spinal cord progeny. (nature.com)
Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation. (stembook.org)
Epithelial cell therapies have been at an impasse because of inefficient methods of transplantation to solid organs. (nih.gov)
Patch grafting strategies were established enabling transplantation of ≥107th organoids/patch of porcine GFP+ biliary tree stem/progenitors into livers of wild type hosts. (nih.gov)
Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation. (nih.gov)
Sciences (ITS) from Ahmedabad, Indian for utilization of stem cells in treatment of patients having undergone kidney transplantation. (cellmedicine.com)
The subject matter discussed is the use of stem cells to circumvent the need for immune suppression during transplantation. (cellmedicine.com)
A recent publication: Effect of co-transplantation of mesenchymal stem cells and hematopoietic stem cells as compared to hematopoietic stem cell transplantation alone in renal transplantation to achieve donor hypo-responsiveness. (cellmedicine.com)
They have certain immunomodulatory, immunosuppressive, and antimicrobial properties that enable them to have several therapeutic and clinical applications including: treatment of autoimmune disorders, role in hematopoietic stem cell transplantation and regenerative medicine, as well as treatment of various infections and their associated complications such as septic shock and acute respiratory distress syndrome. (intechopen.com)
Stem cell transplantation, taking healthy cells and injecting them into the patient, has been shown to functionally restore an ovary's ability to produce fertile eggs in in vivo models. (umn.edu)
Such regimens in Gvhd are tailored to conditioning and transplant type and used for hematopoietic stem cell transplantation (HSCT). (coherentmarketinsights.com)
Despite the readily available graft sources for allogeneic hematopoietic cell transplantation (alloHCT), a significant unmet need remains in the timely provision of suitable unrelated donor grafts. (ossiumhealth.com)
Hematopoietic Stem and Progenitor Cells (HSPC) from cadaveric donors (CDs) have been used historically almost exclusively in the context of tolerance induction in combined bone marrow (BM) and solid organ transplantation. (ossiumhealth.com)
With advances in medicine including gene therapy, the number of conditions that can be treated with stem cell transplantation continues to grow. (nih.gov)
Conventional clinical management for absent T-cell function consists of immune reconstitution using stem cell or bone marrow transplantation. (medscape.com)
Additionally, the project is committed to addressing issues of inequality and discrimination in the lung transplant process, focusing on improving access to transplantation for marginalized groups and simplifying the complex referral processes. (lu.se)
Overall, " The bridge - lungs for life " seeks to revolutionize lung transplantation in Scandinavia by combining centralized EVLP facilities, innovative therapies, and efforts to promote equality in access to transplant services. (lu.se)
to tissue, following cell labeling and transplantation. (nih.gov)
In this study we used a well developed model for liver determine whether the observed contrast could have been due cell transplantation to demonstrate that single-cell detec- to dead cells or free particles, and the results confirmed that tion in vivo can be achieved with MRI. (nih.gov)

The first 53 received autologous (derived from the patient's own bone marrorw) stem cell transplants plus standard doses of CNIs. (rxwiki.com)
Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants. (rxwiki.com)
Traditional bone-repair treatments can be divided into two groups: the bone transport (Ilizarov technology) and the graft transplant (autologous or allogeneic bone grafts). (ispub.com)
To investigate the efficacy and feasibility of percutaneous intramyocardial injection of bone marrow mesenchymal stem cells (MSC) and autologous bone marrow-derived mononuclear cells (BMMNC) on cardiac functional improvement in porcine myocardial infarcted hearts. (thno.org)
To date, most stem cell therapies for auto-immune diseases have been transplants of the patient's own (autologous) stem cells. (parentsguidecordblood.org)
Today's adult patients are undergoing autologous transplants with stem cells harvested from their bone marrow or peripheral blood, but today's children could use their own cord blood for autologous transplants if they develop an autoimmune disease later in life. (parentsguidecordblood.org)
At Northwestern University in Chicago, a group led by Dr. Richard Burt has given autologous stem cell transplants as experimental treatment for about 23 different autoimmune diseases. (parentsguidecordblood.org)
In 2015 Dr. Burt's group published a retrospective study of outcomes for 151 MS patients who had received autologous stem cell transplants and were followed for two to four years post-transplant. (parentsguidecordblood.org)
The MS Society of the UK has prepared a tutorial (see the accompanying graphic) for patients who are considering autologous stem cell transplants. (parentsguidecordblood.org)
During autologous transplant, the patient is free from such complications. (coherentmarketinsights.com)

To study how Allogro® can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. (ispub.com)
To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, like transcriptional factors (RUNX2), bone related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (CD105) were examined by means of real time Reverse Transcription-Polymerase Chain Reaction (real time RT-PCR). (ispub.com)
Microenvironment signals play a critical role in directing the differentiation of stem cells. (biomedcentral.com)
Sertoli cells (SCs) provide a unique microenvironment that is essential for germ cell differentiation. (biomedcentral.com)
The aim of this study was to investigate the effect of SCs on the differentiation of HUMSCs towards male germ cells using a co-culture system that mimicked the in vivo male germ cell microenvironment. (biomedcentral.com)
The HUMSC-SC co-culture system mimics a native microenvironment for germ cell colonization without any in vitro artificial manipulation and can be used to explore the mechanisms controlling the differentiation of male germ cells from HUMSCs. (biomedcentral.com)
However, the progression through the meiotic process is still a challenge in the in vitro differentiation of male germ cells from stem cells. (biomedcentral.com)
Stem cells obtained from amniotic fluid show high proliferative capacity in culture and multilineage differentiation potential. (indexindex.com)
The term "adhesion" to the biomaterial refers to the most important phase, since the quality of it will influence morphology and the capacity of cell proliferation and differentiation 3 . (bvsalud.org)

Although MSC homing has been described, this process does not appear to be highly efficacious because only a few cells reach the target tissue and remain there after systemic administration. (wjgnet.com)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
These progenitor cells which constitute a reservoir found within the connective tissue of most organs are involved in the maintenance and repair of tissues throughout the postnatal life of an individual. (biomedcentral.com)
There has been no systematic, comparative study on the roles of these two groups of placental cells and the whole placental tissue in the placental angiogenesis. (biomedcentral.com)
In this study, primary cytotrophoblasts (CTBs) from early pregnancy and primary human placenta-derived mesenchymal stem cells (hPDMSCs) from different stages of pregnancy were selected as the cell research objects, and full-term placental tissue was selected as the tissue research object to detect the effects of their conditioned medium (CM) on human umbilical vein endothelial cell (HUVEC) angiogenesis. (biomedcentral.com)
We successfully isolated primary hPDMSCs and CTBs, collected CM from these placental cells and sub-cultured placental tissue, and then evaluated the effects of the CM on a series of angiogenic processes in HUVECs in vitro. (biomedcentral.com)
Furthermore, we measured the levels of angiogenic factors in the CM of placental cells or tissue by an angiogenesis antibody array. (biomedcentral.com)
The results showed that not only placental cells but also sub-cultured placental tissue, to some extent, promoted HUVEC angiogenesis in vitro by promoting proliferation, adhesion, migration, invasion, and tube formation. (biomedcentral.com)
Placental cell-derived CM collected at 24 h or 48 h had the best effect, and sub-cultured placental tissue-derived CM collected at 7 days had the best effect among all the different time points. (biomedcentral.com)
The semiquantitative angiogenesis antibody array showed that 18 of the 43 angiogenic factors had obvious spots in placental cell-derived CM or sub-cultured placental tissue-derived CM, and the levels of 5 factors (including CXCL-5, GRO, IL-6, IL-8, and MCP-1) were the highest in sub-cultured placental tissue-derived CM. (biomedcentral.com)
CM obtained from placental cells (primary CTBs or hPDMSCs) or sub-cultured placental tissue contained proangiogenic factors and promoted HUVEC angiogenesis in vitro. (biomedcentral.com)
This FOA invites applications from groups of two (2) or more institutions to participate in a clinical studies program to improve the long-term outcome of transplant recipients (thoracic organ, abdominal organ and vascular composite tissue). (nih.gov)
A solid human embryonic spinal cord tissue transplanted into the cavity of an adult injured spinal cord has been shown to yield beneficial morphological effects in both acute and chronic SCI. (nature.com)
While there are many challenges, they seem much easier to overcome than cell and tissue therapies. (fightaging.org)
The organ's clearance of hyaluronans enabled restoration of tissue-specific paracrine and systemic signaling, resulting in return of normal hepatic histology, with donor parenchymal cells uniformly integrated amidst host cells and that had differentiated to mature hepatocytes and cholangiocytes. (nih.gov)
This suggests the role of stem cell-released signaling molecules and factors on tissue regeneration. (biomedcentral.com)
Ongoing studies seek to define mechanisms by which Col3 regulates cell activities and fate and apply this knowledge to the development of novel biomaterials for tissue engineering strategies. (upenn.edu)
Apoptosis is a morphologically and biochemically distinctive form of cell death, critical in the maintenance of tissue homeostasis. (researchgate.net)
Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
Last month a senior researcher from the Cell and Tissue Therapies WA at the Royal Perth Hospital (CTTWA) presented a paper to the Renal Society of Australia's annual conference that has profound implications for us BigDers. (globaldialysis.com)
Mesenchymal ("Mezen-kye mel") Stem Cells are adult stem cells that can give rise to many types of tissue, such as bone, cartilage and fat. (globaldialysis.com)
Recently, cell-based therapy has emerged as a novel potential approach for regenerating heart tissue. (thno.org)
It is important to understand that although the use of allogeneic mesenchymal stem cell injections for damaged brain tissue and nerve cells has shown some of the highest efficacy for treating this condition, patients undergoing this treatment should not create the false expectation of a guaranteed cure. (stemcellmexico.org)
Some specific applications in- Primary mouse hepatocytes were labeled with both su- clude stem cell tracking to damaged myocardium (1), early perparamagnetic and fluorescent agents, and transplanted detection of tissue rejection (2), early detection of cancer into the spleens of recipient mice. (nih.gov)

In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Stem cell-based therapies are moving closer to clinical application. (nature.com)
Once harvested from stem cells in culture, exosomes are much easier to store and use in therapy than is the case for the cells themselves, while still appearing to deliver similar benefits in the context of first generation stem cell therapies. (fightaging.org)
I am quite optimistic about organelle transplants, which is one level up from the exosome therapies. (fightaging.org)
The goals of the Volk laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients. (upenn.edu)
Together with collaborators, our laboratory has shown regenerative medical strategies (cell-based therapies, electrical stimulation and biomaterials) improve quality of cutaneous wound healing, and determined mechanisms by which they promote optimal repair, using small and large animal models as well as in human subjects. (upenn.edu)
Our laboratory has a long-standing interest in adult cell-based therapies, with a goal to develop and then optimize novel treatments to improve healing of companion animals. (upenn.edu)
Our current clinical trial in client-owned dogs with elbow dysplasia will compare efficacy of post-operative cell-based therapies (bone marrow vs adipose-derived) in improving clinical outcomes. (upenn.edu)
Stroncek DF , Fellowes V, Pham C, Khuu H, Fowler DH, Wood LV, Sabatino M. Counter-flow elutriation of clinical peripheral blood mononuclear cell concentrates for the production of dendritic and T cell therapies. (nih.gov)
The current research and development programs in Gvhd are equipped with novel therapies such as Adienne Pharma's Begedina and mesenchymal stem cell therapies. (coherentmarketinsights.com)
The project recognizes the limitations of EVLP in treating all damaged lungs and therefore aims to develop new therapies, particularly based on mesenchymal stem cells (MSC). (lu.se)

Although the use of rituximab greatly reduces the morbidity of antibody-mediated rejection (AMR), severe adverse effects, such as infection and biliary complications still seriously threatening the survival of the transplant recipients. (researchsquare.com)
The goals of this research will be to target immune-mediated causes of morbidity and mortality in transplant recipients and evaluate interventions to address them. (nih.gov)
The National Institute of Allergy and Infectious Diseases (NIAID) invites new or renewal applications from groups of two (2) or more institutions to participate in a clinical studies program to improve the long-term outcome of recipients of thoracic or abdominal organ transplants or vascularized composite allografts (VCA). (nih.gov)
The goals of this research will be to further our understanding of and ultimately reduce immune-mediated morbidity and mortality in thoracic and abdominal organ and VCA transplant recipients. (nih.gov)
RxWiki News) Kidney transplants save lives, but only if recipients' bodies accept the new organ. (rxwiki.com)

Tumor-Associated Macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. (stembook.org)

The third strategy uses targeted delivery of therapeutic genes (using viral and non-viral vectors) that either transduce host cells in vivo or stably transduce cells in vitro for subsequent implantation in vivo. (ispub.com)
The burgeoning preclinical and clinical experience with human adult adipose-derived cells appears to be promising but interpretation of the current literature with in vitro studies, translational research and FDA-registered investigations emphasizes the need for standardized methods to advance basic science knowledge and beneficial safe clinical outcomes. (scirp.org)
Our previous study has demonstrated that human umbilical cord Wharton's jelly-derived mesenchymal stem cells (HUMSCs) could differentiate towards male germ cells in vitro , but HUMSC-derived germ-like cells expressed only few germ cell markers. (biomedcentral.com)
Thus, in vitro culture systems of human germ cells may open the way to a novel approach to reproductive engineering and eventually novel clinical applications to treat male infertility. (biomedcentral.com)
In recent years, the research on derivation of male germ cells from stem cells has opened new perspectives for investigating germ cell development in vitro . (biomedcentral.com)
The addition of exogenous factors to the culture media such as bone morphogenetic proteins, testosterone and retinoic acid, which play basic roles in germ cell development in vivo , seems to help expand the germ cell population and push them to the meiotic process in vitro , but it is not enough to direct them through that process properly [ 6 ]. (biomedcentral.com)
The SC-germ cell co-culture system has been used to examine the effects of hormones and growth factors on spermatogonial survival and proliferation in vitro [ 10 ]. (biomedcentral.com)
In parallel, we showed that AFS cell-conditioned media induced endothelial cell migration in vitro. (indexindex.com)
For example, patients with partial DGS rarely lack T-cell function as measured by in vitro T-cell proliferation to nonspecific mitogens. (medscape.com)
We continuously exposed the human prostate epithelial stem/progenitor cell line WPE-stem to an environmentally relevant level of arsenic (5 μM) in vitro and determined the acquired cancer phenotype. (nih.gov)
1.63 m in diameter) were used as the date, single cells have been imaged in vitro in culture superparamagnetic label. (nih.gov)
This method was recently extended to that these particles are efficiently endocytosed by a wide visualizing single cells and single particles in in vitro variety of cell types, with labeling capacity as high as embryo samples by MRI (7). (nih.gov)

A Double-Blind, Randomized, Placebo Controlled Clinical Trial of Allogeneic Mesenchymal Stem Cells for the Treatment of Patients With Acute Myocardial Infarction" American College of Cardiology's Innovation in Intervention: i2 Summit in New Orleans, La. (sciencedaily.com)
The generation of neuronal phenotypes in the adult brain, 1-6 months post-bone marrow transplant, shows a remarkable plasticity of adult tissues with potential clinical applications, even after lethal irradiation. (nature.com)
Since the specialty of Plastic Surgery with its position statement on stem cells and fat grafting is committed to advancing evidence-base preclinical and clinical studies in compliance with FDA-regulations, an updated review of cell biology provides insights to achieve these goals. (scirp.org)
Although more success has been achieved in preclinical trials on the use of mesenchymal stem cells in animal models than in human clinical trials, particularly in septic shock and Chagas disease, more progress has been made in both disorders after the recent use of specific sources and certain doses of mesenchymal stem cells. (intechopen.com)
The clinical application of mesenchymal stem cells in the treatment of several diseases still faces real challenges that need to be resolved. (intechopen.com)
Two years ago the Centre began clinical trials on lung and kidney transplant rejection, and on repairing donor kidneys that have been damaged during removal, between transplants, or when blood supply returns to the kidney when first transplanted. (globaldialysis.com)
Among various cell types, bone marrow-derived mononuclear cells (BMMNC) have been most widely applied in clinical trials and basic research [ 2 - 7 ]. (thno.org)
The transfection of embryonic stem cell lines with marked or fluorescent proteins allows for characterization of the differentiated germ cells, but the use of transfected lines disqualifies the male germ cells obtained for their application in clinical procedures [ 6 ]. (biomedcentral.com)
Some very exciting results have been reported within the past year from clinical trials of stem cell transplants for Multiple Sclerosis (MS) . Very briefly, in MS the patient's immune system attacks myelin, the fatty protective sheath around nerve fibers in the brain and spinal cord, causing inflammation and creating lesions that are visible in magnetic resonance images (MRI). (parentsguidecordblood.org)
When a physician described the outcomes as "miraculous", a clinical trial of stem cell transplants for MS at the Royal Hallamshire Hospital in Sheffield UK received huge media coverage. (parentsguidecordblood.org)
Human clinical trials will likely be the next step to test the safety and efficacy of this approach to stem cell donation. (nih.gov)

In Dr. Chefetz's paper, "Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell", treatment of POI through stem cell transplant is discussed. (umn.edu)

Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
The stem cell concentrate was cryopreserved and reinfused through arteriography into the donor patient. (nature.com)
Donor-derived cells expressing neuronal proteins (neuronal phenotypes) were developed in the CNS after intravascular delivery of genetically marked adult mouse bone marrow into lethally irradiated normal adult hosts, resulting in a population of donor-derived cells in the brain with distinct characteristics from the bone marrow. (nature.com)
Grafts containing donor mature hepatocytes, partnered with endothelia, and in the same graft biomaterials as for stem/progenitor organoids, did not engraft. (nih.gov)
During his four years as medical director of the NMDP, the program coordinated their first unrelated donor transplant and subsequently increased the number of marrow donations by unrelated individuals. (nih.gov)
This type of therapy could be accessible to many patients if it is proven effective, since there is no need to search for a matching stem cell donor. (parentsguidecordblood.org)
Following a high dose of chemotherapy, the bone marrow is received by patient the donor through infusion, which helps with resumption of blood cells production. (coherentmarketinsights.com)
Also, prior to the transplant, cells of the donor and recipient are closely screened and matched so as to avoid Gvhd by ensuring the closest possible match. (coherentmarketinsights.com)
Deceased organ donor-derived bone marrow (BM) can be preemptively screened, cryogenically banked for on-demand use, and made available in adequate cell doses for HCT. (ossiumhealth.com)
This suggests that there might be ways to make transplants even more successful by optimizing gene activity within donor stem cells. (nih.gov)
But many people in need of a transplant today struggle to find a well-matched donor. (nih.gov)
If you are interested in volunteering as a stem cell donor, check out the National Marrow Donor Program . (nih.gov)

Mastergraft™ bone graft products are osteoconductive, resorbable scaffolds that extend autograft and facilitate the delivery - and maintain the viability - of the patient's own cells. (medtronic.com)
This may happen after a bone marrow transplant where the donor's bone marrow attacks the patient's organs and tissues, in serious cases with horrendous consequences. (globaldialysis.com)
Our stem cell treatment for Parkinson's Disease (PD) consists of depositing allogeneic mesenchymal stem cells directly into the patient's body to help repair or replace the dopamine-producing nerve cells, as well as any other neurological damages sustained during the disease, our treatment can reduce the inflammation and can limit the overall proper functioning of the patient's brain. (stemcellmexico.org)
This has led researchers to wonder if stem cell transplants could also reset the immune system so that it would not attack the patient's own body in autoimmune diseases, such as Multiple Sclerosis, Lupus, and Rheumatoid Arthritis. (parentsguidecordblood.org)
Study co-authors Jonathan Hoggatt (r) and Bin-Kuan Chou (l) look through a microscope at a patient's mobilized stem cells. (nih.gov)

To compare the efficacy and safety of umbilical cord blood mononuclear cells (CBMNC) and azathioprine (AZA) in the treatment of patients with steroid-dependent or -resistant ulcerative colitis. (oncotarget.com)
An alternative hematopoietic progenitor cell (HPC) graft source obtained from the vertebral bodies (VBs) of deceased organ donors could alleviate many of the obstacles associated with using grafts from healthy living donors or umbilical cord blood (UCB). (ossiumhealth.com)

Corticosterone mediates the inhibitory effect of restraint stress on the migration of mesenchymal stem cell to carbon tetrachloride-induced fibrotic liver by down-regulating CXCR4/7 expression. (stembook.org)

Montserrat N, Jopling C, Izpisua Belmonte JC (2010) Understanding the molecular basis for cardiomyocyte cell cycle regulation: new insights in cardiac regeneration after injury? (springer.com)
Beltrami AP, Barlucchi L, Torella D et al (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. (springer.com)
Our study demonstrated that administration of bone mesenchymal stem cell-derived extracellular vesicles (BMSC-EV) reduced brain cell death, enhanced neuronal survival and regeneration, and improved motor function compared with the administration of BMSC-EV free culture media (EV-free CM). Besides, the BSCB was attenuated and pericyte coverage was significantly decreased in vivo . (frontiersin.org)
They have the capacity to undergo dynamic endocrine-induced changes during the menstrual cycle, including cell growth and regeneration, in order to provide the unique environment required for the maintenance of male and female gamete viability, fertilization, and early embryo development as well as transport to the uterus [ 24 ]. (biomedcentral.com)
The growing adoption of minimally invasive surgical procedures is projected to drive the growth of the stem cell cartilage regeneration market. (medgadget.com)
The global stem cell cartilage regeneration market is estimated to be valued at US$ 298.3 million in 2019 and is expected to exhibit a CAGR of 9.1% over the forecast period (2020-2027). (medgadget.com)
On the basis of region, the global stem cell cartilage regeneration market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. (medgadget.com)
North America is projected to be the most lucrative region for the growth of the stem cell cartilage regeneration market over the forecast period, owing to the high presence of key players in the region. (medgadget.com)
Key players such as Vericel Corporation, Osiris Therapeutics, among others are focusing on various growth strategies such as gaining product approvals for launching innovative stem cell-based cartilage regeneration products and technologies in the market. (medgadget.com)
Furthermore, increasing geriatric population, who are more prone to degenerative disorders such as osteoarthritis among the U.S. population, is further projected to propel growth of the stem cell cartilage regeneration market in the region. (medgadget.com)
Asia Pacific stem cell cartilage regeneration market revenue is projected to witness significant growth over the forecast period. (medgadget.com)
In India, stem cell-based cartilage regeneration procedures are conducted by various hospitals and clinics. (medgadget.com)
4 Although it has been recognized for decades that CNS is resistant to regeneration, recent studies have shown that these cells can also potentially recover and multiply. (nature.com)
Stem cell-based periodontal regeneration is currently at the center of attention [ 18 ]. (biomedcentral.com)
It is expected that the stem cells transplanted by this method will survive better and contribute more to the recovery and regeneration of damaged hearts compared to those transplanted by the current methods. (qmul.ac.uk)
Because of the lack of significant immunogenicity and the ability of the amniotic fluid-derived stem (AFS) cells to modulate the inflammatory response, we investigated whether they could augment wound healing in a mouse model of skin regeneration. (indexindex.com)
Cell Engineering and Regeneration , (June 2022). (ossiumhealth.com)

To evaluate the effect of autogenous undifferentiated stem cell infusion for the treatment of patients with chronic spinal cord injury (SCI) on somatosensory evoked potentials (SSEPs). (nature.com)
The patients were followed up for 2.5 years and submitted to SSEP studies to evaluate the improvement in SSEPs after undifferentiated cell infusion. (nature.com)

Now, scientists are working on ways to prevent kidney transplant rejection. (rxwiki.com)
These cell transplants may lower the rate of rejection, reduce the risk of infection, and improve kidney function. (rxwiki.com)
Antibody-based induction therapy plus calcineurin inhibitors (CNIs) such as Astella (tacrolimus) is commonly used to prevent kidney transplant rejection. (rxwiki.com)
They found that patients who received stem cell transplants had lower kidney rejection rates than those who received the traditional antibody therapy. (rxwiki.com)
In comparison, only four (7.5 percent) patients in the first stem cell group had a rejection. (rxwiki.com)
Similarly, only four (7.7 percent) of the 52 patients in the second stem cell group had a rejection. (rxwiki.com)
The work discussed in the article uses the ability of stem cells to 'immune modulate' and therefore inhibit rejection. (cellmedicine.com)
When a patient undergoes kidney transplant, he/she might face difficulties, including complete rejection. (cellmedicine.com)
Recent research has shown that a specific type of stem cell - mesenchymal stem cells - collected from healthy donors, can be transplanted into patients without causing immune rejection. (qmul.ac.uk)
The light of rejection-free, healthy kidney transplants has entered the tunnel, and should arrive at our end in just three to five years. (globaldialysis.com)

1] R apid mobilization reveals a highly engraftable hematopoietic stem cell . (nih.gov)

Since this type of cell therapy likely achieves the majority of its beneficial effects via the signaling produced by transplanted cells in the short period of time before they die, academia and industry is ever more focused on reproducing that signaling without the need for cells. (fightaging.org)

By establishing a centralized ex vivo lung perfusion (EVLP) facility the project intends to rehabilitate damaged lungs and significantly increase transplant efficiency. (lu.se)
to macrophages (2), and some initial reports have described labeled hepatocyte phantoms in combination with histological in vivo labeling of peripheral T cells (16) and neural stem evaluation confirmed the presence of dispersed single hepato- cells (17). (nih.gov)

This trial makes an important contribution in the field of stem cell-based treatments for heart disease by providing safety and efficacy data for a unique and promising type of stem cell to treat cardiac damage," said Joshua Hare, M.D., of the University of Miami and lead author of the study. (sciencedaily.com)

The possibility of using stem cells for regenerative medicine has opened a new field of investigation. (biomedcentral.com)
8 Embryonic stem cells (ESCs) are promising as a potentially regenerative therapy for neurological conditions such as Parkinson's disease and SCI. (nature.com)

Additionally, two RNA-seq hub genes ( VEGFA and MMP-2 ) were identified to play critical roles in shRac1-mediated cell survival. (aging-us.com)
The Wnt family are a class of glycoproteins that are widely involved in neural development, axonal guidance, cell proliferation and neural cell survival ( 5 , 6 ). (spandidos-publications.com)

Vodyanik MA, Yu J, Zhang X et al (2010) A mesoderm-derived precursor for mesenchymal stem and endothelial cells. (springer.com)
It is well known that placental villi consist of different cell types: (1) trophoblasts (syncytiotrophoblasts and cytotrophoblasts), (2) mesenchymal cells (mesenchymal stem cells, fibroblasts, mesenchymal-derived macrophages-Hoffbauer cells), and (3) fetal vascular cells (vascular smooth muscle cells, vascular pericytes, and endothelial cells) [ 4 ]. (biomedcentral.com)

In addition, it is clear that there are substantial health disparities in transplant outcomes. (nih.gov)
Stem cell transplants can improve outcomes for kidney transplant patients. (rxwiki.com)

Bone marrow mesenchymal stem cells (BMMSCs)-based therapy has emerged as a promising novel therapy for Traumatic Brain Injury (TBI). (aging-us.com)

In certain people with cancer or other serious diseases, transplants of healthy adult stem cells can be lifesaving. (nih.gov)
It was similar to the gene activity seen in stem cells found during earlier development, not in adult bone marrow. (nih.gov)

Prevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia: A reference laboratory experience. (medscape.com)
Over the six month follow-up period, the stem cell-treated patients had lower rates of side effects such as cardiac arrhythmias, and had significant improvements in heart, lung and global function. (sciencedaily.com)
The trial patients underwent peripheral blood stem cell mobilization and collection. (nature.com)
Another 52 patients received stem cell transplants plus a lower dose of CNIs. (rxwiki.com)
Kidney function recovered faster among patients in both of the stem cell groups, compared to those in the antibody therapy group. (rxwiki.com)
Patients in both stem cell groups had a much lower risk of infection than those in the antibody therapy group. (rxwiki.com)
These findings suggest that stem cells may reduce the need for immunosuppressive therapy in kidney transplant patients. (rxwiki.com)
Several case reports have suggested that bone marrow transplant may be of some benefit for patients with particularly severe HPP. (medscape.com)
Recent advances in stem cell therapy are likely to be translated to new therapeutic options bringing new hope to patients with POI. (umn.edu)
Stem cell therapy in patients with acute myocardial infarction (AMI) has shown mixed results [ 1 ], and the wide diversity of technical procedures used in each study has made comparison difficult. (thno.org)
Our patient satisfaction level for Parkinson's Disease (PD) patients after their stem cell treatment is high. (stemcellmexico.org)
All of our stem cell treatments are reviewed and administered by subject manner specialist in the area who have been trained in both US and Mexico, not just general medicine doctors or physicians, to ensure the highest level of precision, understanding of the condition and quality of treatment for our patients. (stemcellmexico.org)
We are 100% clear and honest with our patients, not everyone is a candidate for our stem cell treatments, we turn-down many patients where our specialist deems not a good fit for the treatment, to avoid false promises or expectations when the risks outweigh the benefits. (stemcellmexico.org)
For decades, physicians have relied on stem cell transplants to reset the immune system of patients who have hematologic cancers, such as leukemia and lymphoma. (parentsguidecordblood.org)
Another advantage of patients using their own stem cells is that the transplant requires less severe chemotherapy conditioning, which decreases the risk of complications such as life-threatening infections. (parentsguidecordblood.org)
During any transplant of stem cell and bone marrow some complications arises that may be mild or severe, those are the graft versus host disease (Gvhd) they occur especially in immune-compromised patients. (coherentmarketinsights.com)
The increased risk for reactive airway disease and thyroiditis in patients with DGS and the high incidence of autoimmune hemolytic anemia in patients with WAS are examples of defective T-cell/B-cell interactions that result in self-reactivity. (medscape.com)

The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. (biomedcentral.com)

Cells can then migrate isms would have an enormous impact in all fields in- out of the spleen to the liver, where they engraft. (nih.gov)
The important est in using MRI to track cells after they are labeled with fact is that they migrate and engraft as single cells (20). (nih.gov)

Exosomes are membrane-bound packages of signal molecules secreted by cells, and one of the primary means by which stem cells affect the behavior of surrounding cells. (fightaging.org)

Indeed, mice given the cells after receiving hefty doses of radiation rebounded faster to the needed levels of healthy blood cells. (nih.gov)

Hatzistergos KE, Blum A, Ince T et al (2011) What is the oncologic risk of stem cell treatment for heart disease? (springer.com)
1. Decitabine treatment Induces a Viral Mimicry Response in Cervical cancer Cells and Further Sensitizes Cells to Chemotherapy. (nih.gov)
The growing epidemic of osteoarthritis among the global population is projected to increase the adoption of efficient and promising treatment such as stem cell therapy over the forecast period. (medgadget.com)
The use of mesenchymal stem cells for the treatment of HPP has demonstrated some promise , but long-term effectiveness remains unknown. (medscape.com)
Nevertheless, the utilization of this type of stem cells has shown remarkable progress in the treatment of few infections such as tuberculosis. (intechopen.com)
National charity Heart Research UK has awarded nearly £112,000 to the team from the William Harvey Research Institute at Queen Mary, to study a novel method to deliver stem cells for the treatment of heart failure. (qmul.ac.uk)
Stem cell therapy is a promising new approach for the treatment of heart failure, but further understanding and refinement of the protocol is essential for this approach to be widely used in the hospital. (qmul.ac.uk)
AUSTIN, Minn - March 31, 2021 - Dr. Ilana Chefetz, head of the Cancer Stem Cells & Necroptosis lab at The Hormel Institute, has recently published two scientific papers on possible new treatments for primary ovarian insufficiency - a condition affecting some women who undergo chemotherapy treatment. (umn.edu)
Dr. Chefetz's other recent paper, "AMPKa-like proteins as LKB 1 downstream targets in cell physiology and cancer", looks at another possible POI treatment. (umn.edu)
A Comparative Study of Three Different Types of Stem Cells for Treatment of Rat Spinal Cord Injury. (cas.cz)
Benefits from stem cell treatment for Parkinson's Disease (PD) can vary from patient to patient depending on many factors including current health condition, medical history, level of damage and other factors. (stemcellmexico.org)
Stem Cell Mexico is a team of board-certified specialist led by our chief medical director Cesar Amescua, an experienced and recognized stem cell treatment specialist, anesthesiologist and pain medicine expert with over 30 years of practicing experience. (stemcellmexico.org)
We pride ourselves in being the safest and most honest stem cell treatment clinic in Mexico. (stemcellmexico.org)
What is the cost of the stem cell treatment for Parkinson's Disease (PD)? (stemcellmexico.org)
During cancer treatment, the radioactive agents or the chemicals affects the healthy cells along with the cancer cells. (coherentmarketinsights.com)
Reconstruction of body cells affected during cancer treatment can be fixed using stem cell and bone marrow transplant. (coherentmarketinsights.com)
Taken together, our results indicate that bioprinting AFS cells could be an effective treatment for large-scale wounds and burns. (indexindex.com)
Studies in animals showed that GROβ treatment encouraged blood-forming stem cells to be relased into the bloodstream much as G-CSF does [2]. (nih.gov)
As reported recently in the journal Cell , the treatment didn't appear to cause any adverse effects. (nih.gov)
Unfortunately, while stem cells did move into the circulation with the treatment, they were not in sufficient numbers for donation. (nih.gov)
Stem cells collected following the GROβ/AMD3100 treatment, when infused into mice, showed greater transplant success compared to those collected in the standard way. (nih.gov)
Using recently developed methods to look at the specific pattern of genes activated after the combination treatment, the researchers found that these blood-forming stem cells had a unique pattern of gene expression. (nih.gov)

The following book chapter will be an updated review on the role of mesenchymal stem cells in various infections and their complications. (intechopen.com)

Our results showed that silencing these proteins significantly reduced oxidative stress and cell death/apoptosis, and promoted implanted BMMSCs proliferation after TBI. (aging-us.com)
R&D strategies in Gvhd are characterized by an increasing trend towards maintaining appropriate prophylactic regimens and inhibiting proliferation and activation of T-cell. (coherentmarketinsights.com)

Intracerebral injection of rhSDF-1alpha has also been shown to stimulate the homing of transplanted rMSCs to the site of injection in the brain. (nih.gov)
Such improvements are now on the horizon.NIH-funded researchers recently found that, at least in mice, a single injection of two complementary treatments can generate enough stem cells in 15 minutes [1]. (nih.gov)

These observations suggest that the increased wound closure rates and angiogenesis may be due to delivery of secreted trophic factors, rather than direct cell-cell interactions. (indexindex.com)

Despite the enduring controversy surrounding the use of embryonic stem cells for disease research, scientists continue to evaluate the therapeutic potential of other types of stem cells. (sciencedaily.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
They become the various cells throughout our bodies during early development, and help maintain and repair certain tissues during growth and adulthood. (globaldialysis.com)

Erratum to: Ascorbic acid improves pluripotency of human parthenogenetic embryonic stem cells through modifying imprinted gene expression in the Dlk1-Dio3 region. (stembook.org)

In the inflammed parenchyma of mdx mice (a genetic model of muscular dystrophy), TUS upregulated PD-L1 and IDO, which in turn, reduced cytoxic T-cell effects in the muscle. (nih.gov)
Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice. (stembook.org)
Knockout and transgenic mice have been developed for specific T-cell disorders and are recognized to have helped predict human genetic disorders. (medscape.com)
Bone marrow (harvested from 4- to 6-week-old C57BL/6 mice) cell-suspension cultures grown in stem cell medium for 2 weeks were used for all experiments. (nih.gov)

Mastergraft synthetic bone graft can be hydrated with cell-rich bone marrow aspirate (BMA). (medtronic.com)
Their first trial, in 2007, was as the last resort for a young bone marrow transplant patient who was suffering the final (and usually fatal) stage of Graft vs Host Disease (GVHD). (globaldialysis.com)
Graft versus host disease occurs when particular type of white blood cells are not compatible with the existing cell type and thus, leads to an attack by the transplanted cells on the recipient body. (coherentmarketinsights.com)

Placental vascular development is complex and delicate and involves many types of placental cells, such as trophoblasts, and mesenchymal stem cells. (biomedcentral.com)
Therefore, proper development of the placental vasculature depends on the autocrine and paracrine signals of vascular cells and other types of placental cells [ 9 ]. (biomedcentral.com)

Neural cell apoptosis serves a key role in spinal cord injury (SCI), which is a threat to human health. (spandidos-publications.com)
Neural cell apoptosis has a key role in secondary injury, which directly affects the recovery of white matter and neurological function ( 1 ) during spinal cord injury (SCI). (spandidos-publications.com)
These drugs target the structure and function of the spinal cord microcirculation and are essential for maintaining the normal function of spinal neurons, axons, and glial cells. (bvsalud.org)

Dr. Kaundal completed her Ph.D. in Life Sciences (Stem Cells and Immunology) in Dec 2018 from Panjab University, Chandigarh, India. (nih.gov)

The stem cells would comprise mesenchymal cells generated from the donors' fat, and haematopoetic stem cells taken from donors' bone marrow and blood. (cellmedicine.com)
Under Dr. Stroncek's direction, the Transfusion Service Laboratory began genotyping RBC antigens and discovered that the low pH and high osmolarity of citrate anticoagulant in blood components caused RBCs from donors with sickle cell trait to occlude leukocyte reduction filters. (nih.gov)
This research project will test the safety and ability of the cell-sheet technique in delivering mesenchymal stem cells, from healthy donors, to the heart. (qmul.ac.uk)
For example, stem-cell donors most often undergo five days of injections to build up enough of those vital cells in the blood for donation. (nih.gov)
Today, most stem cell donors avoid the OR. (nih.gov)
By making stem cell donation easier for donors, the hope is that advances like this one will help to maintain a steady supply of those life-giving cells. (nih.gov)

Stem cells in our bodies have the amazing ability to self-renew (make exact copies of themselves) as well transform, or differentiate, into other cell types with specialized functions, such as blood cells, muscle cells, and so on. (globaldialysis.com)
Many studies have shown that stem cells differentiate into mature cells based on the signals from the microenvironment [ 7 ]. (biomedcentral.com)

Flow cytometry was used to confirm integrity of Bone-Marrow derived Mesenchymal Stem Cell cultures by analyzing the expression levels of CD29, CD34, CD45, CD71, CD90, and CD117. (nih.gov)

This process depends on a specific environment provided by the somatic cells of the testis and requires endocrine and auto/paracrine regulation, as well as direct cell-cell interactions [ 8 ]. (biomedcentral.com)

However, the mechanisms underlying the migration of these cells remain unclear. (nih.gov)
A secondary aim was to establish the effect of SMC migration on the above response parameters to S1P using the HSV scratch assay, where a ∼2 mm line of cells was scraped away from the surface of a glass cover slip and the remaining cells incubated for 24 h. (researchgate.net)
This suggested a functional change in the cell following migration that may have been attributable to TRPC5, for example, channel up-regulation. (researchgate.net)
some go to the lungs, ing, and monitoring cell migration. (nih.gov)

Anatomy48

Organisms14

Diseases28

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment65

Psychiatry and Psychology1

Phenomena and Processes47

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture6

Information Science3

Named Groups2

Health Care10

MSCs48

Stromal13

Transplantation27

Autologous10

Differentiation9

Tissue24

Therapies11

Recipients5

Epithelial-mesenchyma1

Vitro12

Clinical11

Potential of mesenchymal1

Donor12

Patient's5

Umbilical2

Carbon tetrachloride-induced1

Regeneration17

Infusion2

Rejection10

Hematopoietic1

Beneficial Effects1

Vivo2

Efficacy1

Regenerative2

Survival2

Endothelial2

Outcomes2

Therapy has emerged as a promi1

Adult2

Patients17

Multipotent1

Engraft2

Exosomes1

Doses1

Treatment22

Complications1

Proliferation2

Injection2

Angiogenesis1

Therapeutic potential1

Tissues2

Embryonic stem1

Mice4

Graft3

Vascular2

Spinal cord3

Life Sciences1

Donors6

Differentiate2

Bone marrow-derived1

Paracrine1

Migration4