• Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis. (sdrugs.com)
  • The family of Chlamydiaceae comprises 3 pathogens that can infect humans: Chlamydia trachomatis, Chlamydia psittaci, and Chlamydia pneumoniae. (lecturio.com)
  • 90 serotypes of Streptococcus pneumoniae (pneumococci). (msdmanuals.com)
  • Globally, multi-drug resistant (MDR) bacteria were estimated to cause 4.95 (3.62-6.57) million deaths a year, with third-generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae among the leading causes of MDR deaths worldwide [ 1 ]. (biomedcentral.com)
  • Cefepime for Injection and Dextrose Injection is indicated for the treatment of pneumonia (moderate to severe) caused by Streptococcus pneumoniae (including cases associated with concurrent bacteremia), Pseudomonas aeruginosa , Klebsiella pneumoniae , or Enterobacter species. (guidelinecentral.com)
  • Cefepime for Injection and Dextrose Injection is indicated for complicated intra-abdominal infections (used in combination with metronidazole) caused by Escherichia coli , viridans group streptococci, Pseudomonas aeruginosa , Klebsiella pneumoniae , Enterobacter species, or Bacteroides fragilis [ see Clinical Studies (14.2) ]. (guidelinecentral.com)
  • Strep agalactiae is bacitracin resistant, so the colonies remain intact, whereas Strep pyogenes is bacitracin sensitive, so the colonies die off. (osmosis.org)
  • Streptococcus pyogenes is a major human-specific bacterial pathogen that causes a wide array of manifestations ranging from mild localized infections to life-threatening invasive infections. (nih.gov)
  • This activity describes the bacterium Streptococcus pyogenes (S. pyogenes) and reviewed the epidemiology, clinical manifestations of S. pyogenes infections, evaluation, and management of clinical infections caused by S. pyogenes. (nih.gov)
  • Beta-hemolytic streptococci are characterized as group A streptococci ( Streptococcus pyogenes ) and group B streptococci ( Streptococcus agalactiae ). (nih.gov)
  • S. pyogenes is a gram-positive, catalase-negative, oxidase negative, β-hemolytic streptococci. (nih.gov)
  • Most frequently, Streptococcus agalactiae causes neonatal infections like pneumonia , sepsis , meningitis , and septic arthritis . (osmosis.org)
  • In the western world, GBS (in the absence of effective prevention measures) is the major cause of several bacterial infections of the newborn neonatal infection sepsis, pneumonia, and meningitis, which can lead to death or long-term sequelae. (wikipedia.org)
  • Streptococcus agalactiae is a major cause of bacterial pneumonia, sepsis, and meningitis in human neonates. (unipv.it)
  • While the bacteria is usually harmless in healthy adults, it is a major cause of meningitis, pneumonia, and and sepsis in neonates [3] . (kenyon.edu)
  • In clinical practice, combination therapy with a cell wall-active agent and a synergistic aminoglycoside should be considered for treating serious enterococcal infections in critically ill patients and in those with evidence of sepsis , as well as in patients with endocarditis, meningitis, osteomyelitis, or joint infections. (medscape.com)
  • Claim: Estimates suggest there were 320,414 cases of meningitis and neonatal sepsis in 2019. (gambohospital.org)
  • www.meningitis.org/mpt , cases and death tab, IHME data claiming there were an estimated 320,414 cases of meningitis and neonatal sepsis in 2019. (gambohospital.org)
  • Claim: Estimates suggest there were 25,196 deaths due to meningitis and neonatal sepsis in one year. (gambohospital.org)
  • www.meningitis.org/mpt , cases and death tab, IHME data claiming there were an estimated 25,196 deaths due to meningitis and neonatal sepsis in 2019. (gambohospital.org)
  • These bacteria are responsible for more than half of the deaths from meningitis globally and they cause other severe diseases like sepsis and pneumonia. (gambohospital.org)
  • The opportunistic pathogen Streptococcus agalactiae is the major cause of meningitis and sepsis in a newborn's first week, as well as a considerable cause of pneumonia, urinary tract infections, and sepsis in immunocompromised adults. (uea.ac.uk)
  • Group B streptococcus (GBS), or Streptococcus agalactiae, is one of the leading causes of morbidity and mortality among newborns, resulting in sepsis, pneumonia, and meningitis. (centroitalianoreiki.it)
  • Pneumococcus is not a common cause of neonatal infection in high-income countries, but a study of neonatal infections in South Asia identified pneumococcus as a culture-confirmed cause of neonatal sepsis almost as commonly as Streptococcus agalactiae (group B streptococcus) in infants 0-59 days of age [ 2 ]. (biomedcentral.com)
  • En recién nacidos, es la causa más frecuente de sepsis (infección en la sangre) y meningitis (infección del líquido y del recubrimiento que rodea al cerebro). (epnet.com)
  • The BIOFIRE® FILMARRAY® Pneumonia Panel plus enables rapid and accurate automated testing for 27 bacteria and viruses that cause pneumonia and other lower respiratory tract infections (LRTI), as well as for 7 genetic markers of antibiotic resistance. (biomerieux-nordic.com)
  • Now, a particular trait of Streptococcus species is that they are catalase negative, meaning they do not produce an enzyme called catalase. (osmosis.org)
  • Streptococcus agalactiae , also known as group B streptococcus , is a gram-positive, beta-hemolytic, catalase-negative, and bacitracin -resistant bacterium, which can cause several infections in humans. (osmosis.org)
  • Group B Strep (GBS), also known as Streptococcus agalactiae, is a Gram-positive, beta-hemolytic, catalase-negative, facultative anaerobe that is a normal component of the gastrointestinal and genitourinary tracts [1] . (kenyon.edu)
  • Streptococci are gram-positive, catalase-negative, coagulase-negative cocci that occur in pairs or chains. (nih.gov)
  • In adults, S. agalactiae is primarily associated with bacteremia, skin and soft tissue infections (SSTI), and urinary tract infections (UTI) and occasionally with necrotizing fasciitis, arthritis, toxic shock syndrome, endocarditis, or meningitis ( 4 - 6 ). (cdc.gov)
  • Later on, Strep agalactiae was found to also be a human potential pathogen responsible for a number of infections that most commonly affect pregnant women and newborns. (osmosis.org)
  • To prevent Streptococcus agalactiae infections in neonates, intrapartum antibiotic prophylaxis can be administered to vaginally colonized pregnant females. (osmosis.org)
  • Streptococcus agalactiae bacteria, responsible for vaginal and urinary tract infections and newborn infections including meningitis and septicemia. (blogarama.com)
  • BACKGROUND: Streptococcus agalactiae, referred to as Group B Streptococcus (GBS), is a prominent bacterium causing life-threatening neonatal infections. (bvsalud.org)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of ceftriaxone for injection, and other antibacterial drugs, ceftriaxone for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • They are broad-spectrum bacteriostatic antibiotics that are used to treat infections caused by many gram-positive and gram-negative bacteria. (medscape.com)
  • Daptomycin is a natural product that has clinical utility in the treatment of infections caused by aerobic Gram-positive bacteria. (globalrph.com)
  • Discussions with clinicians in multiple states raised concerns about a possible increase in pediatric intracranial infections, particularly those caused by Streptococcus bacteria, during the past year and the possible contributing role of SARS-CoV-2 infection. (medscape.com)
  • Felix d'Herelle first coined the term "bacteriophage" ( 4 ), literally meaning "bacterium eater," and began using phages to treat bacterial infections in human patients ( Fig. 1 ). (asm.org)
  • Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (lookformedical.com)
  • Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. (lookformedical.com)
  • Haemophilus influenzae Type b (Hib) Vaccine Haemophilus influenzae type b conjugate vaccine helps prevent Haemophilus infections but not infections caused by other strains of H. influenzae bacteria. (msdmanuals.com)
  • Consequently, β-lactams are also used to treat a variety of pathologies in humans such as septicemia, urinary tract infections, respiratory infections, meningitis, and peritonitis. (biomedcentral.com)
  • Consequently, the characteristics of the infections may vary from mild upper respiratory tract infections to severe, opportunistic, and even fatal infections with bacteria, viruses, or fungi. (mdpi.com)
  • Several comparisons of S. agalactiae in humans and cattle have been published, and most authors conclude that isolates from these species form largely distinct populations with regard to the core genome and the accessory genome ( 10 - 12 ). (cdc.gov)
  • The plural term group B streptococci (referring to the serotypes) and the singular term group B streptococcus (referring to the single species) are both commonly encountered (even though S. halichoeri and S. pseudoporcinus are also group B Streptococci). (wikipedia.org)
  • The species name agalactiae meaning "of no milk", alludes to this. (wikipedia.org)
  • METHODS: The effect of rose bengal aPDI on various GBS serotypes, Lactobacillus species, human eukaryotic cell lines and microbial vaginal flora composition was evaluated. (bvsalud.org)
  • This indicates exposure risk for humans and domestic animals and highlights that this pathogen can circulate endemically in many wildlife species even in densely populated urban areas. (cdc.gov)
  • Cryptosporidium canis is a zoonotic species causing cryptosporidiosis in humans in addition to its natural hosts dogs and other fur animals. (cdc.gov)
  • A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. (lookformedical.com)
  • The normal flora of the mouth and GI tract consists of more than 400 species of bacteria, as well as fungi (mainly Candida spp. (stemcelldaily.com)
  • About 100 species have been described within the genus Streptococcus . (slu.se)
  • Many species within the genus Enterococcus have earlier been classified as streptococci and, thus, they are closely related. (slu.se)
  • Our case report deals with an unusual case of bacterial meningitis caused by Streptococcus agalactiae in a young male patient who is a known case of HIV infection with no recent source of bacterial infection/colonization and other known risk factors. (ecronicon.net)
  • Reviewed By Experts Human Papillomavirus infection is a common sexually transmitted infection and serves as the primary catalyst for various epithelial lesions and cancers. (blogarama.com)
  • During the course of infection, S. agalactiae adheres to a variety of epithelial cells but the underlying mechanisms are only poorly understood. (unipv.it)
  • The main risk factor for an early-onset GBS infection in a neonate is colonization of a birthing person's genital tract with Group B strep during labor [4] . (kenyon.edu)
  • Meningitis: Swelling (inflammation) of the membranes covering the brain and spinal cord caused by infection. (medlineplus.gov)
  • Immune deficiencies such as HIV infection or complement deficiency, immunosuppression, and active or passive smoking can also raise the risk of different types of meningitis. (gambohospital.org)
  • Although S. agalactiae grows well in vitro by fermentative metabolism, it is shown here that the absence of NDH-2 results in attenuated virulence, as observed by reduced colonization in heart and kidney in a mouse model of systemic infection. (uea.ac.uk)
  • Bacterial meningitis in infants is a serious infection of the meninges and subarachnoid space. (msdmanuals.com)
  • Acute Bacterial Meningitis Acute bacterial meningitis is rapidly progressive bacterial infection of the meninges and subarachnoid space. (msdmanuals.com)
  • Both these bacteria are beta-hemolytic, but Strep agalactiae makes a substance called CAMP factor, which enhances the action of staphylococcal beta-hemolysin. (osmosis.org)
  • The in vitro spectrum of activity of daptomycin encompasses most clinically relevant Gram-positive pathogenic bacteria. (globalrph.com)
  • This article provides an overview of the most important human pathogenic bacteria. (amboss.com)
  • The following table provides an overview of the nomenclature of important human pathogenic bacteria, according to their form and Gram staining properties. (amboss.com)
  • Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. (cdc.gov)
  • It is also recognized as an emerging pathogen in human adults worldwide and as a reemerging mammary pathogen of cattle in northern Europe ( 1 - 3 ). (cdc.gov)
  • Host and pathogen factors contribute to the emergence of S. agalactiae among adults ( 3 ). (cdc.gov)
  • S. agalactiae is the most common human pathogen of streptococci belonging to group B of the Rebecca Lancefield classification of streptococci. (wikipedia.org)
  • S. agalactiae is also a common veterinary pathogen, because it can cause bovine mastitis (inflammation of the udder) in dairy cows. (wikipedia.org)
  • Streptococcus agalactiae (group B Streptococcus ) is a major cause of neonatal infectious disease in humans in many countries and is carried asymptomatically by a large proportion of adults. (cdc.gov)
  • Based on principles of action well known to science, produced using cutting edge technology with pharma quality ingredients, cleverly proportioned and perfectly balanced, CitrusDefence® is the best safeguard against the spread of bacteria, fungi and viruses, using what nature has made easier ally to the human ingenuity. (activelaboratoryinc.com)
  • The therapeutic use of bacteriophages, viruses that infect and kill bacteria, is well suited to be part of the multidimensional strategies to combat antibiotic resistance. (asm.org)
  • These microorganisms include bacteria, fungi, viruses and protozoa that live in harmony with the host under normal conditions, and provide various benefits such as digestion, immunity, metabolism and protection from pathogens. (stemcelldaily.com)
  • The highest burden of disease is seen in a region of sub-Saharan Africa, known as the African Meningitis Belt, especially recognised to be at high risk of epidemics of meningococcal but also pneumococcal meningitis. (gambohospital.org)
  • Second-generation fluoroquinolones, such as gatifloxacin and moxifloxacin, have excellent cerebrospinal fluid (CSF) penetration, and animal models suggest that they are effective in penicillin- and ceftriaxone-resistant pneumococcal meningitis. (medscape.com)
  • 2020). Group B Strep was first recognized as a widespread threat to newborns in the early 1970's. (evidencebasedbirth.com)
  • Deletion of the fbsA gene in various S. agalactiae strains substantially reduced their binding of soluble fibrinogen and their adherence to and invasion of epithelial cells, indicating a role of FbsA in these different processes. (unipv.it)
  • In general, GBS is a harmless commensal bacterium being part of the human microbiota colonizing the gastrointestinal and genitourinary tract of up to 30% of healthy human adults (asymptomatic carriers). (wikipedia.org)
  • IMPORTANCE S. agalactiae is part of the human intestinal microbiota and is present in the vagina of ~30% of healthy women. (uea.ac.uk)
  • The human body is home to a diverse and complex community of microorganisms, collectively known as the normal flora or microbiota. (stemcelldaily.com)
  • Considering the risk factors for S. agalactiae in nonpregnant adults and demographic changes in many countries, the incidence of group B streptococcal disease can be anticipated to increase ( 4 ). (cdc.gov)
  • Strep agalactiae are also called Group B Strep - GBS - in Lancefield classification developed by an American microbiologist Rebecca Lancefield. (osmosis.org)
  • Streptococcus agalactiae (also known as group B streptococcus or GBS) is a gram-positive coccus (round bacterium) with a tendency to form chains (as reflected by the genus name Streptococcus). (wikipedia.org)
  • GBS is characterized by the presence in the cell wall of the antigen group B of Lancefield classification (Lancefield grouping) that can be detected directly in intact bacteria using latex agglutination tests. (wikipedia.org)
  • This artistic recreation, based on scanning electron microscopy (SEM), depicts a three-dimensional (3D), computer-generated image, of a group of Gram-positive, Streptococcus agalactiae (group B Streptococcus) bacteria. (kenyon.edu)
  • In the 1970s, the bacterium group B Streptococcus (GBS) emerged as the leading infectious cause of early neonatal morbidity and mortality in the United States ( 1--4 ). (cdc.gov)
  • Lancefield serological grouping system is used to differentiate group A streptococci (GAS) from other streptococci. (nih.gov)
  • In some countries, pregnant people are tested for Group B Streptococcus (Group B Strep or GBS) bacteria towards the end of pregnancy. (evidencebasedbirth.com)
  • If a pregnant person is a carrier of Group B Strep (sometimes called "colonized with GBS") and not treated with appropriate antibiotics during labor, then there is a 1-2% chance that their baby will develop early GBS disease. (evidencebasedbirth.com)
  • The topic of Group B Strep can be controversial. (evidencebasedbirth.com)
  • In other places around the world (sometimes even within high-resource countries), marginalized groups of people are not provided basic health care options, such as accurate testing for Group B Strep, IV antibiotics, or medical help when they or their infants experience serious illness or complications. (evidencebasedbirth.com)
  • So, what is Group B Strep, and why do health care providers worry about newborn GBS disease? (evidencebasedbirth.com)
  • In this updated version of the Evidence Based Birth® Signature Article, we provide a global perspective on Group B Strep, as well as an explanation of how GBS and antibiotics relate to the microbiome. (evidencebasedbirth.com)
  • What is Group B Strep? (evidencebasedbirth.com)
  • Group B Streptococcus is a type of bacteria that naturally lives in the large intestine and can migrate down to the rectum, vagina, and urinary tract, usually without causing illness. (evidencebasedbirth.com)
  • 2017). However, carrier rates can be as low as 8%, or as high as 35%, depending on the part of the world that you live in and how common Group B Strep is in the bodies of people living there. (evidencebasedbirth.com)
  • During most of your life, if you carry Group B Strep, it is considered physiological, or normal (ACOG 2019). (evidencebasedbirth.com)
  • Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ceftriaxone for Injection or other antibacterial drugs in the future.Diarrhea is common problem caused by antibiotics which usually ends when the antibiotic is discontinued. (drugcentral.org)
  • Intramammary (IMM) ceftiofur treatment is commonly used in dairy farms to prevent mastitis, though its impact on the cattle gut microbiome and selection of antibiotic-resistant bacteria has not been elucidated. (biomedcentral.com)
  • RESULTS: RB-mediated aPDI was evidenced to exert high bactericidal efficacy towards S. agalactiae in vitro (>4 log10 units of viability reduction for planktonic and >2 log10 units for multispecies biofilm culture) and in vivo (ca. 2 log10 units of viability reduction in mice vaginal GBS colonization model) in microbiological and metagenomic analyses. (bvsalud.org)
  • If the bacteria is present in a pregnant person, it can be directly transferred to their baby in a multitude of ways. (kenyon.edu)
  • To help reduce the risk for GBS, pregnant women should get tested for the bacteria at 35 to 37 weeks into their pregnancy. (medlineplus.gov)
  • At the same time, RB-mediated aPDI was evidenced to be not mutagenic and safe for human vaginal cells, as well as capable of maintaining the balance and viability of vaginal microbial flora. (bvsalud.org)
  • Esta bacteria vive en el tracto gastrointestinal y genitourinario y se encuentran en el área vaginal o rectal en el 10% al 35% de todas las mujeres adultas sanas. (epnet.com)
  • Hence, use of third-generation cephalosporins to treat humans and for livestock production may contribute to the emergence of ESBL-producing Enterobacteriaceae. (biomedcentral.com)
  • So, Strep agalactiae refers to the round bacteria that grow in chains and that was previously known to infect cattle, resulting in reduced milk production. (osmosis.org)
  • As other virulent bacteria, GBS harbors an important number of virulence factors (virulence factors are molecules produced by bacteria that boosts their capacity to infect and damage human tissues), the most important being the capsular polysaccharide (rich in sialic acid) and a pore-forming toxin, β-hemolysin. (wikipedia.org)
  • In the 1950s, S. agalactiae was the most common mastitis-causing bacterium among dairy cattle in Europe, severely reducing milk quality and quantity. (cdc.gov)
  • A bacterium which causes mastitis in cattle and occasionally in man. (lookformedical.com)
  • A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals. (lookformedical.com)
  • Claim: But global health modellers estimate that there could be more than 100,000 cases of bacterial and viral meningitis per year in the country. (gambohospital.org)
  • To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. (cdc.gov)
  • Isolates from humans and cattle differed in lactose fermentation, which is encoded on the accessory genome and represents an adaptation to the bovine mammary gland. (cdc.gov)
  • however, a subset (25%) shed higher levels of ceftiofur-resistant bacteria for up to 2 weeks post-treatment. (biomedcentral.com)
  • Tetracyclines inhibit protein synthesis and, therefore, bacterial growth by binding with 30S and possibly 50S ribosomal subunits of susceptible bacteria. (medscape.com)
  • Infectious diseases seriously threaten human health, and various infectious diseases may cause millions of severe cases and even death every year. (blogarama.com)
  • Around 1 in 10 people who get this type of meningitis die and 1 in 5 have severe complications. (gambohospital.org)
  • In summary, we demonstrate the essential role of NDH-2 in respiration and its contribution to S. agalactiae virulence and propose it as a potential drug target. (uea.ac.uk)