• Men with this condition may exhibit azoospermia (no sperm production), oligozoospermia (small number of sperm production), or they may produce abnormally shaped sperm (teratozoospermia). (wikipedia.org)
  • Offspring of men with severe oligozoospermia or azoospermia have a significantly increased risk of developing cystic fibrosis. (genosalut.com)
  • In severe oligozoospermia or azoospermia, low ejaculate volume, low ejaculate pH and little or no fructose in seminal plasma suggest an obstruction of the seminal pathways at the level of the prostate gland, when vasal aplasia and ejaculatory disorders are excluded. (unboundmedicine.com)
  • Pre-operatively, sperm analysis demonstrated typical low-volume ejaculates with azoospermia in 12 and severe oligozoospermia in four cases. (unboundmedicine.com)
  • Sperm may be underdeveloped, abnormally shaped, carrying damaged genetic material, or unable to move properly. (ssmr.org)
  • An affected man's body may produce no mature sperm cells (azoospermia), fewer than the usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly. (medlineplus.gov)
  • Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
  • Males with this syndrome carry an extra X chromosome (XXY), meaning they have 47 chromosomes compared to the normal 46 in each cell. (wikipedia.org)
  • Where a normal healthy male will have both an X and a Y chromosome, affected males have genetic deletions in the Y chromosome. (wikipedia.org)
  • if a male is fathered by a man who also exhibited Y chromosome deletions then this trait will be passed down. (wikipedia.org)
  • Abnormalities in chromosomal numbers and structure as well as deletions on the important Y chromosome present in normal males can also impact fertility. (ssmr.org)
  • Y chromosome infertility is a condition that affects the production of sperm and causes male infertility, which means it is difficult or impossible for affected men to father children. (medlineplus.gov)
  • Men with Y chromosome infertility do not have any other signs or symptoms related to the condition. (medlineplus.gov)
  • Some men with Y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. (medlineplus.gov)
  • Y chromosome infertility occurs in approximately 1 in 2,000 to 1 in 3,000 males of all ethnic groups. (medlineplus.gov)
  • called X and Y. Females have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY). (medlineplus.gov)
  • Many genes on the Y chromosome are involved in male sex determination and development. (medlineplus.gov)
  • As a result, either few sperm develop or sperm do not develop at all, leading to Y chromosome infertility. (medlineplus.gov)
  • Most cases of this condition result from new (de novo) deletions on the Y chromosome that occur during formation of sperm cells in an affected individual's father who is not himself infertile. (medlineplus.gov)
  • When men with Y chromosome infertility do father children, either naturally or with the aid of assisted reproductive technologies, they pass the genetic changes on the Y chromosome to all their sons. (medlineplus.gov)
  • Recently, several recurrent X-chromosome microdeletions (located in subtelomeric region of the long arm) were reported to be associated with male infertility in Spanish and Italian males. (ubbcluj.ro)
  • Males with Klinefelter's syndrome have an extra X chromosome, which causes abnormal development of the testicles. (ubbcluj.ro)
  • The Y chromosome contains the genetic material with the codes that determine the male gender, and related masculine characteristics and development. (ubbcluj.ro)
  • Background Genetic causes of male infertility are hypothesized to involve multiple types of mutations, from single gene defects to complex chromosome rearrangements. (ubbcluj.ro)
  • Missing regions on the Y chromosome (microdeletions) occur in 6% of men with low sperm counts and 15% of men with no sperm counts. (wellinghomeopathy.com)
  • This mosaicism, due to the presence of the ring Y chromosome and depending upon on the presence or absence of the SRY gene can result in a wide spectrum of manifestations ranging from females with a Turner syndrome-like phenotype to phenotypic males. (juniperpublishers.com)
  • Chromosomal anomalies and genetic mutations account for nearly 10-15% of all male infertility cases. (wikipedia.org)
  • Identification of novel homozygous missense and deletion mutations manifesting oligospermia infertility in Kashmiri population. (cdc.gov)
  • Mutations that occur during the reproduction process, when the DNA of both parents is replicated, can lead to infertility in males later in life. (ubbcluj.ro)
  • Alternatively, normal sperm may be produced in abnormally low numbers (oligospermia) or seemingly not at all (azoospermia). (ssmr.org)
  • Loss of this genetic material likely prevents the production of one or more proteins needed for normal sperm cell development. (medlineplus.gov)
  • Mumps Malaria Testicular cancer Defects in USP26 in some cases Acrosomal defects affecting egg penetration Idiopathic oligospermia - unexplained sperm deficiencies account for 30% of male infertility. (wikipedia.org)
  • In one study, researchers investigated the effect of supplementation with L-arginine in healthy males, males with diabetes, and males with idiopathic asthenozoospermia. (baby4you.co.nz)
  • One study found that the male children of men who used intracytoplasmic sperm injection (ICSI) to conceive were significantly more likely to experience poor semen quality parameters - including lower sperm concentration , sperm count , and motility - compared to male children who were naturally conceived. (givelegacy.com)
  • Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and surgery, orchitis, varicocele, infections, prostatitis, testicular cancer, failure of immunosuppression and unprotected receptive anal or oral sex with men. (wikipedia.org)
  • Testicular torsion, or twisting of the testicle resulting in a strangulation of the blood supply, occurs in men whose tissue surrounding the testicle is not well attached to the scrotum. (ssmr.org)
  • The primary benefits of varicocele repair in azoospermic men with spermatogenic failure are the return of motile sperm in semen and the ability to avoid an invasive surgical procedure for testicular sperm extraction. (metromaleclinic.com)
  • An abnormal postcoital test result is observed in 10% of infertile couples. (medscape.com)
  • An estimated 15% of couples meet this criterion and are considered infertile, with approximately 35% due to female factors alone, 30% due to male factors alone, 20% due to a combination of female and male factors, and 15% unexplained. (medscape.com)
  • Factors relating to male infertility include: Antisperm antibodies (ASA) have been considered as infertility cause in around 10-30% of infertile couples. (wikipedia.org)
  • Male factor causes approximately 30% to 50% of infertile couples. (heraldopenaccess.us)
  • It is one of several difficulties couples may have delivering sperm to the vagina during intercourse. (ssmr.org)
  • One-third of the causes of infertility in heterosexual couples can be attributed to male problems, one-third to female problems, and one-third to a mix of factors or undetermined causes. (iyurved.com)
  • Author summary Male sterility affects one in seven couples, and around half of these are the result of male factor disorders. (ubbcluj.ro)
  • Detection of certain genetic causes of male infertility allows couples to be informed about the potential to transmit genetic abnormalities that may affect the health of offspring. (ubbcluj.ro)
  • Despite this, many genetic causes of male infertility remain unknown, even though it is recognised that rates of genetic abnormalities are likely to be increased among men requiring ART. (ubbcluj.ro)
  • Sperm abnormalities include: 1 To conceive a child, a male's sperm must combine with a female's egg. (ubbcluj.ro)
  • In addition, 2% of men with low counts and 15-20% of men with no sperm counts will harbor chromosomal abnormalities detected by cytogenetic analysis (karyotype). (wellinghomeopathy.com)
  • Infertility in men can result from deficiencies in sperm formation, concentration, or transportation. (medscape.com)
  • Infertile men may have deficiencies in sperm formation, concentration (eg, oligospermia [too few sperm], azoospermia [no sperm in the ejaculate]), or transportation. (medscape.com)
  • Repair of varicoceles have positively shown to improve sperm concentration and motility and improve pregnancy rates. (metromaleclinic.com)
  • Studies indicate that treatment with quercetin for 14 days results in a significant increase in sperm motility, viability and concentration. (baby4you.co.nz)
  • Oligospermia is a male fertility issue defined as a low sperm concentration in the ejaculate. (wellinghomeopathy.com)
  • Low sperm concentration or "sperm count" is the number of sperm in a prescribed volume of ejaculate. (wellinghomeopathy.com)
  • Triggered by a man's immunologic response to his own sperm, the production of antisperm antibodies results from injury, surgery or infection of the reproductive tract. (ssmr.org)
  • They impair sperm development by preventing proper drainage of blood from the testicles back into the abdomen. (ssmr.org)
  • It is a disorder where the veins in the scrotum that surround the testicles enlarge and impair sperm quality. (iyurved.com)
  • Resulting in males having smaller testes, reducing the amount of testosterone and sperm production. (wikipedia.org)
  • Usually, affected men show no symptoms, although they may have smaller testes. (wikipedia.org)
  • The herb is thought to create an increase in the body's blood flow, which increases the production of sperm and helps keep the testes healthy. (ctrlr.org)
  • On presentation, he had a normal male phenotype, short stature, palpable testes and delayed sexual development. (juniperpublishers.com)
  • Young males who aren't yet producing mature sperm. (upmc.com)
  • Male infertility refers to a sexually mature male's inability to impregnate a fertile female. (wikipedia.org)
  • But we have no solid evidence for what is the threshold, if any, for the sperm count to exceed in order to allow the male to be fertile [4,5,7]. (infertile.com)
  • In cases of sole male-factor infertility, the female partner is fertile, and has properly functioning ovaries, fallopian tubes, and uterus. (givelegacy.com)
  • Female-factor infertility would be the opposite - a case in which the male partner was fertile, but the female partner had a condition that affected their ability to conceive or carry a pregnancy. (givelegacy.com)
  • Because vitamin C works wonders for sperm health, it is essential to boost sperm production, make them more fertile, and keep them healthy. (iyurved.com)
  • Reference ranges for sperm counts are defined in fertile (not infertile) men. (wellinghomeopathy.com)
  • Male infertility is commonly due to deficiencies in the semen, and semen quality is used as a surrogate measure of male fecundity. (wikipedia.org)
  • Any portion of the male reproductive tract, such as the vas deferens, the epididymis, or the ejaculatory duct inside the prostate can be obstructed, preventing normal transport of sperm from the testicles to the urethra, where it leaves the body during ejaculation. (ssmr.org)
  • We know that sperm counts can range from zero to 500,000,000 or more per ml [4-7]. (infertile.com)
  • Genetics, environmental factors, lifestyle decisions, low sperm counts, and other factors can all contribute to causes of infertility in males. (iyurved.com)
  • Male Infertility Causes - More than 90% of male infertility cases are due to low sperm counts, poor sperm quality, or both. (ubbcluj.ro)
  • In 2% of men, low sperm counts may be due to hormonal imbalance from prolactinoma. (wellinghomeopathy.com)
  • It is also important to remember that sperm counts are a relatively sensitive measure of overall health. (wellinghomeopathy.com)
  • The consistent use of hot tubs or baths, recreational drugs such as alcohol, cocaine, marijuana or tobacco, and fevers from flu's or other infections can all lower sperm counts in otherwise healthy men. (wellinghomeopathy.com)
  • Chronic stress from sleep disorders, travelling, or from work or emotional issues can also lower sperm counts. (wellinghomeopathy.com)
  • A number of conditions could contribute to male-factor infertility, including low sperm count or poor sperm motility . (givelegacy.com)
  • When levels of these hormones are severely low, poor sperm development can result. (ssmr.org)
  • While many cases of male-factor infertility can be treated with simple lifestyle interventions, in some cases, the cause is deeper - your genes. (givelegacy.com)
  • DAZ (Deleted in Azoospermia) family genes are important fertility factors in many animals including humans. (ijbs.com)
  • Varicoceles are dilated scrotal veins that are present in about 15 percent of all men but are more common in infertile men - about 40 percent. (ssmr.org)
  • Varicoceles are the most common correctable and treatable cause of male infertility. (ssmr.org)
  • hence, the term is used as a synonym of recurrent Definition and causes of infertility Santiago Brugo-Olmedo1, Claudio Chillik, Susana Kopelman CEGYR, Center for Gynecology and Reproduction Studies, Viamonte 1438, Capital Federal (1055), Argentina Infertility in Men and Women Mary Goodman March 15, 2006 Infertility in Males Although men with Cystic Fibrosis still may have a great sex life, the majority of them are infertile. (ubbcluj.ro)
  • Some hormones produced by the pituitary gland are responsible for stimulating the testicles to make sperm. (ssmr.org)
  • Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population. (cdc.gov)
  • Male-factor infertility and genetics: Is male infertility inherited? (givelegacy.com)
  • In general, the impact of genetics on male fertility is not fully understood. (givelegacy.com)
  • Genetics may contribute to anywhere from 15-60% of male-factor infertility. (givelegacy.com)
  • So while other male fertility factors like age , diet, lifestyle , and hormones may be common, genetics is sometimes a factor or even the sole cause of male-factor infertility. (givelegacy.com)
  • One sign that male-factor infertility may involve genetics: There is some evidence that men who are infertile are more likely to have sons who are infertile, as well. (givelegacy.com)
  • Genetics play a central role in fertility, particularly since sperm carry half of the DNA mix to the partner's egg. (ssmr.org)
  • Artificial Insemination (AI) - The introduction of sperm directly into a female's reproductive tract for fertilization of the egg. (nordicalagos.org)
  • These cases occur in men with no history of the disorder in their family. (medlineplus.gov)
  • In this case, even though the egg-sperm binding does occur, the resulting embryo is unable to implant or cannot develop till the end of the pregnancy, that is, delivery. (invitra.com)
  • In some cases, however, an underlying problem such as an inherited hormonal imbalance or a condition that blocks the passage of sperm may cause signs and symptoms. (wellinghomeopathy.com)
  • At Genosalut we analyse the genetic causes of male infertility and female infertility. (genosalut.com)
  • Patients with mosaic 45, X/46,X(r)Y karyotype, present with phenotypes ranging from females with Turner-like phenotypes, phenotypic males and females with mixed gonadal dysgenesis, to almost phenotypic normal males [ 4 , 5 ]. (juniperpublishers.com)
  • Experts estimate about one-third of infertility cases are male-factor infertility, one-third are female-factor infertility, and the final third involve factors related to both partners, or are unexplained. (givelegacy.com)
  • The results of the study showed that sperm density and motility significantly improved with CoQ10 treatment. (baby4you.co.nz)
  • The initial evaluation of the male patient should be rapid, noninvasive, and cost-effective, as nearly 70% of conditions that cause infertility in men can be diagnosed with history, physical examination, and hormonal and semen analysis alone. (medscape.com)
  • It affects approximately 7% of all men. (wikipedia.org)
  • One of the most commonly known causes of infertility is Klinefelter syndrome, which affects one in 500-1000 newborn males. (wikipedia.org)
  • Quercetin is a potent antioxidant that has been shown to have beneficial affects on several sperm parameters. (baby4you.co.nz)