Proteins
- The mouse embryonal carcinoma lines PCC4-F and F9 have played important roles in the isolation and characterization of the two ubiquitous basement membrane proteins, laminin and entactin. (biomedsearch.com)
- Membrane glycoproteins are membrane proteins which play important roles in cell recognition. (wikipedia.org)
- Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. (wikipedia.org)
- This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. (mybiosource.com)
- Membrane glycoprotein E3 gp19K inhibits the insertion of class I MHC proteins in the host-cell membrane, thereby preventing T-cell lymphocytes from recognizing that the host cell has been infected by a virus. (wikipedia.org)
- Multiple techniques have been described by the term eastern blotting, most use proteins blotted from SDS-PAGE gel on to a PVDF or nitrocellulose membrane. (wikipedia.org)
- The method involved blotting of phospholipids on PVDF or nitrocellulose membrane prior to transfer of proteins onto the same nitrocellulose membrane by conventional Western blotting and probing with conformation specific antibodies. (wikipedia.org)
- 2002) Eastern blot has also been used to describe an immunoblot performed on proteins blotted to a PVDF membrane from a PAGE gel run with opposite polarity. (wikipedia.org)
- 2005) Eastern blot has been used to describe a blot of proteins on PVDF membrane where the probe is an aptamer rather than an antibody. (wikipedia.org)
- as a technique which probes proteins blotted to PVDF membrane with lectins, cholera toxin and chemical stains to detect glycosylated, lipoylated or phosphorylated proteins. (wikipedia.org)
- LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. (wikipedia.org)
- poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
Protein
- Also known as Membrane glycoprotein spo14 (SEC12-like protein) (Sporulation-specific protein 14). (mybiosource.com)
- Also known as Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (CD107 antigen-like family member A) (LGP-120) (Lysosomal membrane glycoprotein A) (LGP-A) (P2B) (CD antigen CD107a). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (CD antigen CD208). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5). (mybiosource.com)
- Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to inhibiting apoptosis. (wikipedia.org)
- The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. (wikipedia.org)
- The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP). (wikipedia.org)
- The oxidized protein is then treated with a complex mixture, generating a new conjugate on the membrane. (wikipedia.org)
- It was found that PSMA was the same as the membrane protein in the small intestine responsible for removal of gamma-linked glutamates from polygammaglutamate folate. (wikipedia.org)
- The FOLH1 gene has multiple potential start sites and splice forms, giving rise to differences in membrane protein structure, localization, and carboxypeptidase activity based on the parent tissue. (wikipedia.org)
- Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. (wikipedia.org)
- LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes. (wikipedia.org)
- Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. (wikipedia.org)
- It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. (wikipedia.org)
- The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. (wikipedia.org)
- Lysosome-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene. (wikipedia.org)
- The protein encoded by this gene is a member of a family of membrane glycoproteins. (wikipedia.org)
- Online Mendelian Inheritance in Man (OMIM) Lysosome-associated membrane protein 2 -309060 Konecki DS, Foetisch K, Zimmer KP, Schlotter M, Lichter-Konecki U (October 1995). (wikipedia.org)
- As an integral membrane protein, LPP3 contains six hydrophobic transmembrane domains and a hydrophilic catalytic site composed of three conserved domains. (wikipedia.org)
- This protein is a membrane glycoprotein localized at the cell plasma membrane. (wikipedia.org)
- Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
- Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. (wikipedia.org)
- The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
- Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. (wikipedia.org)
Neuronal
- PLP is highly related to GPM6A, a neuronal membrane glycoprotein. (wikipedia.org)
lysosomal membrane glycoprotein
- Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
carbohydrate ligands
- This glycoprotein provides selectins with carbohydrate ligands. (wikipedia.org)
- It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
extracellular
- One of these, M1536-B3, synthesizes and deposits copious quantities of extracellular matrix glycoproteins, which led to the initial discovery and characterization of laminin and entactin. (biomedsearch.com)
- When the blood vessel wall is damaged, platelet membrane glycoproteins interact with the extracellular matrix. (wikipedia.org)
- LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid (LPA) and short-chain phosphatidic acid. (wikipedia.org)
- The catalytic site typically faces the extracellular matrix when located on the cell membrane and faces the lumen when located in intracellular membranes. (wikipedia.org)
surface glycoproteins
- Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. (wikipedia.org)
- Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. (wikipedia.org)
Characterization
- Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. (wikipedia.org)
Major Glycoprotein
- The 35 k polypeptide is the major glycoprotein in the mouse lens membrane and shows increased incorporation of the tritium label with progression of the cataract. (arvojournals.org)
vesicle membrane
- Also, transection of one or both branches of the axon decreases the amount of 3H-fucose incorporated during a short period into a putative vesicle membrane glycoprotein but not into other glycoproteins. (jneurosci.org)
antigen
- Also known as Antigenic integral membrane glycoprotein (Antigen Sm25). (mybiosource.com)
- Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. (wikipedia.org)
transmembrane glycoprotein
- This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)
gene encodes
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. (wikipedia.org)
- This gene encodes a receptor for the OX-2 membrane glycoprotein. (wikipedia.org)
inhibition
- Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. (diabetesjournals.org)
- Inhibition of intracellular migration of membrane glycoproteins in rat intestinal columnar cells and hepatocytes as visualized by light and electron-microscope radioautography after 3H-fucose injection. (biomedsearch.com)
receptor
- Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyrosine kinase activity and subsequent cellular signaling. (diabetesjournals.org)
- These results suggest that this immunologically related glycoprotein IIb/IIIa is a receptor for platelet binding to the tumor cell surface, an event which precedes overt platelet aggregation and is dependent upon an intact tumor cell microfilament and intermediate filament network. (rti.org)
cDNA
- The differentiated cells synthesize basement membrane components and provided the probes for the cDNA cloning of entactin and the three chains of laminin. (biomedsearch.com)
- Membrane glycoprotein PC-1, an inhibitor of insulin signaling, produces insulin resistance when overexpressed in cells transfected with PC-1 cDNA. (diabetesjournals.org)
lysosome-associated membrane
- Below are the list of possible Lysosome-associated membrane glycoprotein products. (mybiosource.com)
- It is one of the lysosome-associated membrane glycoproteins. (wikipedia.org)
tumor
- In addition, tumor cell platelet interactions require the lateral mobility of specific receptors (i.e., clustering) on the tumor cell plasma membrane. (rti.org)
- Furthermore, treatment of tumor cells with specific antibodies to the platelet glycoprotein IIb/IIIa complex inhibits tumor cell-platelet interaction at the macroscopic level (i.e., aggregation) and at the ultrastructural level (i.e., platelet adhesion to the tumor cell surface). (rti.org)
- This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
plasma membranes
- Microtubules may, therefore, be necessary for intracellular transport of membrane glycoproteins, although the possibility of a direct action of these drugs on Golgi or plasma membranes must also be considered. (biomedsearch.com)
- They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
immunoglobulin superfamily
- Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. (wikipedia.org)
IIIa
- In consequence, this complex activates GPIIb / IIIa membrane glycoproteins allowing them to bind fibrinogen. (wikipedia.org)
- The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
- Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
- A membrane glycoprotein immunologically related to the platelet glycoprotein IIb/IIIa complex was identified on Walker 256 carcinosarcoma cells using specific polyclonal and monoclonal antibodies and Northern blot analysis using complementary DNA probes for IIb and IIIa. (rti.org)
LAMP1
- LAMP1 and LAMP2 make up about 50% of lysosomal membrane glycoproteins. (wikipedia.org)
- In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
- The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. (wikipedia.org)
- Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. (wikipedia.org)
- Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
polypeptide
- Other changes observed in glycoproteins of the Philly mouse lens during cataract development were a loss of the 103 k and 71 k polypeptides and a corresponding increase in the 66 k polypeptide. (arvojournals.org)
adhesion
- Adhesion-inhibiting polyclonal antibodies were first used by Gerisch (1977) to identify glycoproteins responsible for Dictyostelium aggregation. (springer.com)
- Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV as well, function as receptors engaged in platelet adhesion to collagen. (wikipedia.org)
isolation
- The isolation of integral surface membrane molecules participating in adhesive phenomena is an important but elusive goal of developmental and cell biology. (springer.com)
host immune response
- CR1 beta membrane glycoprotein modulates the host immune response. (wikipedia.org)
antibodies
- The membrane is then probed with antibodies for epitopes of interest. (wikipedia.org)
cytoplasm
- Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail exposed to the cytoplasm. (wikipedia.org)
elisa
- MBS2883482 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thy-1 membrane glycoprotein (THY1) ELISA Kit target analytes in biological samples. (mybiosource.com)
novel
- One of these was a novel gene encoding a membrane glycoprotein containing a leucine-rich repeat (LRR), a C2-type Ig-like domain, and a fibronectin (FN) type III domain, and the transcript of which was specifically expressed in the retina. (jneurosci.org)
Golgi
- 1984), light-microscope radioautographic studies showed that colchicine or vinblastine inhibited intracellular migration of glycoproteins out of the Golgi region in a variety of cell types. (biomedsearch.com)
- This suggests that labeled glycoproteins destined for the apical plasma membrane were inhibited from leaving the Golgi region, while migration to the lateral plasma membrane was not impaired. (biomedsearch.com)
- This indicates that the drugs inhibited migration of membrane glycoproteins from the Golgi region to the various portions of the plasma membrane. (biomedsearch.com)
antibody
- The method is described more fully in the article on Far-eastern blotting, but is based on antibody or lectin staining of lipids transferred to PVDF membranes. (wikipedia.org)
hepatocytes
- In the present work, the effects of these drugs on migration of membrane glycoproteins have been examined at the ultrastructural level in duodenal villous columnar cells and hepatocytes. (biomedsearch.com)
- In hepatocytes, labeling of the sinusoidal plasma membrane was reduced by 83% after colchicine and by 85% after vinblastine treatment. (biomedsearch.com)
human
- Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
platelet
- These subunits form Ca2+ - dependent complex on the surface of platelet membrane in a 1:1 ratio. (wikipedia.org)
galactose
- The membrane glycoproteins were labeled by treatment with galactose oxidase and tritiated borohydride. (arvojournals.org)
type
- LYVE1 is a type I integral membrane glycoprotein. (wikipedia.org)
- It is a type 2 activity PAP, which localizes to the plasma membrane, and is one of four known LPP isoforms. (wikipedia.org)
resides
- GCPII is a zinc metalloenzyme that resides in membranes. (wikipedia.org)
proteins
- The mathematical models formulated in computational neuroscience are useful since they capture the essential features of the biological system at multiple spatial-temporal scales, from membrane currents, proteins, and chemical coupling to network oscillations , columnar and topographic architecture, and learning and memory. (wikipedia.org)
- Hybrid orbitrap-quadrupole mass spectrometry and ELISAs showed hpECM to be rich in collagens, basement membrane proteins, and regenerative growth factors (e.g. (sigmaaldrich.com)
- The S-layer is made of a cell-surface glycoprotein, which accounts for approximately 50% of the cell surface proteins. (wikipedia.org)
- These proteins form a lattice in the membrane. (wikipedia.org)
- The dystrophin-glycoprotein complex (DGC) comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. (wikipedia.org)
- Myelin-associated glycoprotein (MAG, Siglec-4) is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NoGo-66 receptor, (NgR). (wikipedia.org)
- It is localized to the Golgi apparatus, specifically in the trans-Golgi region, and acts almost exclusively on secretory and plasma membrane proteins. (wikipedia.org)
- Yeast OST is composed of eight different membrane-spanning proteins in three subcomplexes (one of them is OST4). (wikipedia.org)
- In addition, dolichols can be adducted to proteins as a posttranslational modification, a process in which branched carbohydrate trees are formed on a dolichol moiety and then transferred to an assembly of proteins to form a large glycoprotein in the rough endoplasmic reticulum. (wikipedia.org)
- This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (wikipedia.org)
- The endogenous glucocorticoid hormone cortisol diffuses through the cell membrane into the cytoplasm and binds to the glucocorticoid receptor (GR) resulting in release of the heat shock proteins. (wikipedia.org)
- The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. (wikipedia.org)
- The envelopes are typically derived from portions of the host cell membranes (phospholipids and proteins), but include some viral glycoproteins. (wikipedia.org)
protein
- Matveeva, E.A.;Price, D.A.;Whiteheart, S.W.;Vanaman, T.C.;Gerhardt, G.A.;Slevin, J.T. "Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy. (uky.edu)
- H. salinarum express the membrane protein bacteriorhodopsin which acts as a light-driven proton pump. (wikipedia.org)
- It consists of a short cytosolic region that contains the N-terminus of the protein, a single transmembrane region of about 17 amino acids in length, a small stem region of about 40 amino acids in length, and a larger, catalytic region that is located on the luminal side of the membrane. (wikipedia.org)
- Oligosaccharyltransferase or OST (EC 2.4.1.119) is a membrane protein complex that transfers a 14-sugar oligosaccharide from dolichol to nascent protein. (wikipedia.org)
- It is a type I membrane protein. (wikipedia.org)
residues
- Sulfate residues are abundant on the glycan chains of the glycoprotein, giving it a negative charge. (wikipedia.org)
- Its importance can be further demonstrated by the fact as much as 1% of all secreted and membrane tyrosine residues are found to be sulfated. (wikipedia.org)
- A lipid-linked core-oligosaccharide is assembled at the membrane of the endoplasmic reticulum and transferred to selected asparagine residues of nascent polypeptide chains by the oligosaccharyl transferase complex. (wikipedia.org)
tyrosine
- We have also shown that the plasma membrane calcium pump is regulated by contact mediated tyrosine phosphorylation in both excitable cells and platelets. (uky.edu)
anchor
- Dolichols function as a membrane anchor for the formation of the oligosaccharide Glc3-Man9-GlcNAc2 (where Glc is glucose, Man is mannose, and GlcNAc is N-acetylglucosamine). (wikipedia.org)
- Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. (wikipedia.org)
consists
- The membrane consists of a single lipid monolayer surrounded by an S-layer. (wikipedia.org)
- The inner lining of the joint consists of the synovium (also called the synovial membrane), a thin layer located between the joint capsule and the joint cavity. (wikipedia.org)
progression
- During the progression of this disease the synovial membrane becomes a place where constant inflammatory processes take place, which can eventually lead to cartilage damage and joint destruction and deformation. (wikipedia.org)
cell surface
- MIRL may refer to: Membrane Inhibitor of Reactive Lysis, CD59, a cell surface glycoprotein that inhibits complement-mediated lysis. (wikipedia.org)
plasma
- Poste, G., Nicolson, G.L.: Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells. (springer.com)
- One primary focus is the plasma membrane Ca2+-pumping ATPase (PMCA) in eucaryotes. (uky.edu)
surface
- The brush border on the apical surface of the epithelial cells is covered with glycocalyx, which is composed of oligosaccharides attached to membrane glycoproteins and glycolipids. (wikipedia.org)
- Glycoproteins on the surface of the envelope serve to identify and bind to receptor sites on the host's membrane. (wikipedia.org)
cancer
- Parallel studies are investigating their interaction with secondary targets such as calcineurin and calmodulin which may be responsible for unwanted side effects and the multidrug resistance drug transporter, P-glycoprotein, where interaction may enhance potential for cancer chemotherapy. (uky.edu)
include
- Membrane-bound PRRs include Toll like receptors (TLRs) and C-type lectin receptors (CLRs). (wikipedia.org)
major
- These cells represent the main source of hyaluronic acid and also other glycoproteins, major components of the synovial fluid. (wikipedia.org)
focus
- seedling lectin (MASL) can specifically focus on particular glycoproteins portrayed by individual cells [57, (world-of-links.com)
muscle
- Ca 2+ sparks are the elementary units of Ca 2+ signaling in the striated muscle fibers that appear as highly localized Ca 2+ release events mediated by ryanodine receptor (RyR) Ca 2+ release channels on the sarcoplasmic reticulum (SR) membrane. (jove.com)
channels
- Hodgkin and Huxley's original model only employed two voltage-sensitive currents (Voltage sensitive ion channels are glycoprotein molecules which extend through the lipid bilayer, allowing ions to traverse under certain conditions through the axolemma), the fast-acting sodium and the inward-rectifying potassium. (wikipedia.org)
found
- Although "H. salinarum" is unable to catabolize glucose, the transcription factor TrmB has been proven to regulate the gluconeogenic production of sugars found on the S-layer glycoprotein. (wikipedia.org)
layer
- Prior research have got proven that MASL contacts with PDPN on the membrane layer of most cancers cells . (world-of-links.com)
- Synovial membrane is divided into two compartments - the outer layer (subintima) and the inner layer (intima). (wikipedia.org)
- To securely contain of the contents of the intestinal lumen, the cells of the epithelial layer are joined together by tight junctions thus forming a contiguous and relatively impermeable membrane. (wikipedia.org)