- lysosome-associated membrane protein
- Also known as Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (CD107 antigen-like family member A) (LGP-120) (Lysosomal membrane glycoprotein A) (LGP-A) (P2B) (CD antigen CD107a). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5). (mybiosource.com)
- Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition. (nih.gov)
- Constitutive expression of a COOH-terminal leucine mutant of lysosome-associated membrane protein-1 causes its exclusive localization in low density intracellular vesicles. (nih.gov)
- Data show thart lysosome-associated membrane protein type 2a (LAMP-2A) forms a coiled coil helix trimer in n-dodecylphosphocholine micelle, and protein substrates interact with its cytosolic tail. (nih.gov)
- Lysosome-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene. (wikipedia.org)
- Online Mendelian Inheritance in Man (OMIM) Lysosome-associated membrane protein 2 -309060 Konecki DS, Foetisch K, Zimmer KP, Schlotter M, Lichter-Konecki U (October 1995). (wikipedia.org)
- protein
- Also known as Membrane glycoprotein spo14 (SEC12-like protein) (Sporulation-specific protein 14). (mybiosource.com)
- Also known as Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (CD antigen CD208). (mybiosource.com)
- The protein encoded by this gene is a member of a family of membrane glycoproteins. (nih.gov)
- Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to inhibiting apoptosis. (wikipedia.org)
- The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. (wikipedia.org)
- The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP). (wikipedia.org)
- The oxidized protein is then treated with a complex mixture, generating a new conjugate on the membrane. (wikipedia.org)
- It was found that PSMA was the same as the membrane protein in the small intestine responsible for removal of gamma-linked glutamates from polygammaglutamate folate. (wikipedia.org)
- The FOLH1 gene has multiple potential start sites and splice forms, giving rise to differences in membrane protein structure, localization, and carboxypeptidase activity based on the parent tissue. (wikipedia.org)
- Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. (wikipedia.org)
- LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes. (wikipedia.org)
- Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. (wikipedia.org)
- It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. (wikipedia.org)
- The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. (wikipedia.org)
- Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins. (wikipedia.org)
- Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
- Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. (wikipedia.org)
- The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
- Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. (wikipedia.org)
- proteins
- Membrane glycoproteins are membrane proteins which play important roles in cell recognition. (wikipedia.org)
- Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. (wikipedia.org)
- This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. (mybiosource.com)
- Membrane glycoprotein E3 gp19K inhibits the insertion of class I MHC proteins in the host-cell membrane, thereby preventing T-cell lymphocytes from recognizing that the host cell has been infected by a virus. (wikipedia.org)
- Multiple techniques have been described by the term eastern blotting, most use proteins blotted from SDS-PAGE gel on to a PVDF or nitrocellulose membrane. (wikipedia.org)
- The method involved blotting of phospholipids on PVDF or nitrocellulose membrane prior to transfer of proteins onto the same nitrocellulose membrane by conventional Western blotting and probing with conformation specific antibodies. (wikipedia.org)
- 2002) Eastern blot has also been used to describe an immunoblot performed on proteins blotted to a PVDF membrane from a PAGE gel run with opposite polarity. (wikipedia.org)
- 2005) Eastern blot has been used to describe a blot of proteins on PVDF membrane where the probe is an aptamer rather than an antibody. (wikipedia.org)
- as a technique which probes proteins blotted to PVDF membrane with lectins, cholera toxin and chemical stains to detect glycosylated, lipoylated or phosphorylated proteins. (wikipedia.org)
- LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. (wikipedia.org)
- poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
- lysosomal membrane glycoprotein
- Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
- carbohydrate ligands
- This glycoprotein provides selectins with carbohydrate ligands. (nih.gov)
- It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
- inhibition
- Inhibition of intracellular migration of membrane glycoproteins in rat intestinal columnar cells and hepatocytes as visualized by light and electron-microscope radioautography after 3H-fucose injection. (biomedsearch.com)
- vesicle membrane
- Also, transection of one or both branches of the axon decreases the amount of 3H-fucose incorporated during a short period into a putative vesicle membrane glycoprotein but not into other glycoproteins. (jneurosci.org)
- neuronal
- PLP is highly related to GPM6A, a neuronal membrane glycoprotein. (wikipedia.org)
- antigen
- Also known as Antigenic integral membrane glycoprotein (Antigen Sm25). (mybiosource.com)
- Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. (wikipedia.org)
- transmembrane glycoprotein
- This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)
- gene encodes
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. (wikipedia.org)
- This gene encodes a receptor for the OX-2 membrane glycoprotein. (wikipedia.org)
- intracellular
- Influence of colchicine and vinblastine on the intracellular migration of secretory and membrane glycoproteins: III. (biomedsearch.com)
- 1984), light-microscope radioautographic studies showed that colchicine or vinblastine inhibited intracellular migration of glycoproteins out of the Golgi region in a variety of cell types. (biomedsearch.com)
- Microtubules may, therefore, be necessary for intracellular transport of membrane glycoproteins, although the possibility of a direct action of these drugs on Golgi or plasma membranes must also be considered. (biomedsearch.com)
- receptor
- The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits. (nih.gov)
- Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. (wikipedia.org)
- LAMP2
- Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane. (nih.gov)
- LAMP1 and LAMP2 make up about 50% of lysosomal membrane glycoproteins. (wikipedia.org)
- In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
- The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. (wikipedia.org)
- immunoglobulin superfamily
- Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. (wikipedia.org)
- LAMP1
- Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike. (nih.gov)
- Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. (wikipedia.org)
- Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
- characterization
- Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. (wikipedia.org)
- plasma
- but there was little change in labeling of the lateral plasma membrane. (biomedsearch.com)
- This suggests that labeled glycoproteins destined for the apical plasma membrane were inhibited from leaving the Golgi region, while migration to the lateral plasma membrane was not impaired. (biomedsearch.com)
- In hepatocytes, labeling of the sinusoidal plasma membrane was reduced by 83% after colchicine and by 85% after vinblastine treatment. (biomedsearch.com)
- Labeling of the lateral plasma membrane also decreased, although not so dramatically. (biomedsearch.com)
- This indicates that the drugs inhibited migration of membrane glycoproteins from the Golgi region to the various portions of the plasma membrane. (biomedsearch.com)
- describe how does an integral membrane glycoprotein travel from ER to the Golgi and from the Golgi to the plasma membrane? (mywordsolution.com)
- Plasma cell membrane glycoprotein PC-1. (wikipedia.org)
- They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
- platelet
- Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. (wikipedia.org)
- When the blood vessel wall is damaged, platelet membrane glycoproteins interact with the extracellular matrix. (wikipedia.org)
- Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV as well, function as receptors engaged in platelet adhesion to collagen. (wikipedia.org)
- The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
- These subunits form Ca2+ - dependent complex on the surface of platelet membrane in a 1:1 ratio. (wikipedia.org)
- elisa
- MBS2883482 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thy-1 membrane glycoprotein (THY1) ELISA Kit target analytes in biological samples. (mybiosource.com)
- antibody
- The 5E8 antibody and the M r 160,000 glycoprotein that it recognizes represent two very useful components with which to test several new antibody-mediated drug delivery systems in the treatment of human lung tumors. (aacrjournals.org)
- The method is described more fully in the article on Far-eastern blotting, but is based on antibody or lectin staining of lipids transferred to PVDF membranes. (wikipedia.org)
- cDNA
- Membrane glycoprotein PC-1, an inhibitor of insulin signaling, produces insulin resistance when overexpressed in cells transfected with PC-1 cDNA. (diabetesjournals.org)
- polypeptide
- The 35 k polypeptide is the major glycoprotein in the mouse lens membrane and shows increased incorporation of the tritium label with progression of the cataract. (arvojournals.org)
- Other changes observed in glycoproteins of the Philly mouse lens during cataract development were a loss of the 103 k and 71 k polypeptides and a corresponding increase in the 66 k polypeptide. (arvojournals.org)
- host immune response
- CR1 beta membrane glycoprotein modulates the host immune response. (wikipedia.org)
- Dictyostelium
- Adhesion-inhibiting polyclonal antibodies were first used by Gerisch (1977) to identify glycoproteins responsible for Dictyostelium aggregation. (springer.com)
- antibodies
- The membrane is then probed with antibodies for epitopes of interest. (wikipedia.org)
- cytoplasm
- Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail exposed to the cytoplasm. (wikipedia.org)
- novel
- One of these was a novel gene encoding a membrane glycoprotein containing a leucine-rich repeat (LRR), a C2-type Ig-like domain, and a fibronectin (FN) type III domain, and the transcript of which was specifically expressed in the retina. (jneurosci.org)
- hepatocytes
- In the present work, the effects of these drugs on migration of membrane glycoproteins have been examined at the ultrastructural level in duodenal villous columnar cells and hepatocytes. (biomedsearch.com)
- isolation
- The isolation of integral surface membrane molecules participating in adhesive phenomena is an important but elusive goal of developmental and cell biology. (springer.com)
- tumor cell
- This major M r 160,000 glycoprotein that was identified on two different human lung tumor cell lines was also found on a human large cell tumor tissue obtained by surgical biopsy. (aacrjournals.org)
- amino
- Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
- human
- Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
- type
- LYVE1 is a type I integral membrane glycoprotein. (wikipedia.org)
- rabbit
- In contrast to the murine lens, the 35 k peptide could not be detected in rabbit lens membranes. (arvojournals.org)
- resides
- GCPII is a zinc metalloenzyme that resides in membranes. (wikipedia.org)
- Describe
- 2011) A recent study used the term eastern blotting to describe detection of glycoproteins with lectins such as concanavalin A There is clearly no single accepted definition of the term. (wikipedia.org)
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