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  • tumor
  • In addition, tumor cell platelet interactions require the lateral mobility of specific receptors (i.e., clustering) on the tumor cell plasma membrane. (rti.org)
  • Furthermore, treatment of tumor cells with specific antibodies to the platelet glycoprotein IIb/IIIa complex inhibits tumor cell-platelet interaction at the macroscopic level (i.e., aggregation) and at the ultrastructural level (i.e., platelet adhesion to the tumor cell surface). (rti.org)
  • This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
  • IIIa
  • In consequence, this complex activates GPIIb / IIIa membrane glycoproteins allowing them to bind fibrinogen. (wikipedia.org)
  • The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
  • Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
  • A membrane glycoprotein immunologically related to the platelet glycoprotein IIb/IIIa complex was identified on Walker 256 carcinosarcoma cells using specific polyclonal and monoclonal antibodies and Northern blot analysis using complementary DNA probes for IIb and IIIa. (rti.org)
  • polypeptide
  • Other changes observed in glycoproteins of the Philly mouse lens during cataract development were a loss of the 103 k and 71 k polypeptides and a corresponding increase in the 66 k polypeptide. (arvojournals.org)
  • elisa
  • MBS2883482 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thy-1 membrane glycoprotein (THY1) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • novel
  • One of these was a novel gene encoding a membrane glycoprotein containing a leucine-rich repeat (LRR), a C2-type Ig-like domain, and a fibronectin (FN) type III domain, and the transcript of which was specifically expressed in the retina. (jneurosci.org)
  • antibody
  • The method is described more fully in the article on Far-eastern blotting, but is based on antibody or lectin staining of lipids transferred to PVDF membranes. (wikipedia.org)
  • human
  • Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
  • progression
  • During the progression of this disease the synovial membrane becomes a place where constant inflammatory processes take place, which can eventually lead to cartilage damage and joint destruction and deformation. (wikipedia.org)
  • cancer
  • Parallel studies are investigating their interaction with secondary targets such as calcineurin and calmodulin which may be responsible for unwanted side effects and the multidrug resistance drug transporter, P-glycoprotein, where interaction may enhance potential for cancer chemotherapy. (uky.edu)
  • muscle
  • Ca 2+ sparks are the elementary units of Ca 2+ signaling in the striated muscle fibers that appear as highly localized Ca 2+ release events mediated by ryanodine receptor (RyR) Ca 2+ release channels on the sarcoplasmic reticulum (SR) membrane. (jove.com)
  • channels
  • Hodgkin and Huxley's original model only employed two voltage-sensitive currents (Voltage sensitive ion channels are glycoprotein molecules which extend through the lipid bilayer, allowing ions to traverse under certain conditions through the axolemma), the fast-acting sodium and the inward-rectifying potassium. (wikipedia.org)
  • found
  • Although "H. salinarum" is unable to catabolize glucose, the transcription factor TrmB has been proven to regulate the gluconeogenic production of sugars found on the S-layer glycoprotein. (wikipedia.org)