- Proteins
- The mouse embryonal carcinoma lines PCC4-F and F9 have played important roles in the isolation and characterization of the two ubiquitous basement membrane proteins, laminin and entactin. (biomedsearch.com)
- Membrane glycoproteins are membrane proteins which play important roles in cell recognition. (wikipedia.org)
- Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes, and whose exact biological function is not yet clear. (wikipedia.org)
- This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. (mybiosource.com)
- Membrane glycoprotein E3 gp19K inhibits the insertion of class I MHC proteins in the host-cell membrane, thereby preventing T-cell lymphocytes from recognizing that the host cell has been infected by a virus. (wikipedia.org)
- Multiple techniques have been described by the term eastern blotting, most use proteins blotted from SDS-PAGE gel on to a PVDF or nitrocellulose membrane. (wikipedia.org)
- The method involved blotting of phospholipids on PVDF or nitrocellulose membrane prior to transfer of proteins onto the same nitrocellulose membrane by conventional Western blotting and probing with conformation specific antibodies. (wikipedia.org)
- 2002) Eastern blot has also been used to describe an immunoblot performed on proteins blotted to a PVDF membrane from a PAGE gel run with opposite polarity. (wikipedia.org)
- 2005) Eastern blot has been used to describe a blot of proteins on PVDF membrane where the probe is an aptamer rather than an antibody. (wikipedia.org)
- as a technique which probes proteins blotted to PVDF membrane with lectins, cholera toxin and chemical stains to detect glycosylated, lipoylated or phosphorylated proteins. (wikipedia.org)
- LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. (wikipedia.org)
- poly-N-acetyllactosamine groups which are involved in interactions with selectin and other glycan-binding proteins LAMP1 and LAMP2 glycoproteins comprise 50% of all lysosomal membrane proteins, and are thought to be responsible in part for maintaining lysosomal integrity, pH and catabolism. (wikipedia.org)
- platelet membrane glycoproteins
- Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. (wikipedia.org)
- When the blood vessel wall is damaged, platelet membrane glycoproteins interact with the extracellular matrix. (wikipedia.org)
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- lysosomal membrane glycoprotein
- Also known as Lysosome-associated membrane glycoprotein 1 (LAMP-1) (Lysosome-associated membrane protein 1) (120 kDa lysosomal membrane glycoprotein) (CD107 antigen-like family member A) (LGP-120) (Lysosomal membrane glycoprotein A) (LGP-A) (P2B) (CD antigen CD107a). (mybiosource.com)
- Structure of human lysosomal membrane glycoprotein 1. (wikipedia.org)
- carbohydrate ligands
- This glycoprotein provides selectins with carbohydrate ligands. (wikipedia.org)
- It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. (wikipedia.org)
- integral membrane
- Below are the list of possible Antigenic integral membrane glycoprotein products. (mybiosource.com)
- Also known as Antigenic integral membrane glycoprotein (Antigen Sm25). (mybiosource.com)
- Sodium/bile acid cotransporters are integral membrane glycoproteins. (wikipedia.org)
- LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes. (wikipedia.org)
- The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. (wikipedia.org)
- LYVE1 is a type I integral membrane glycoprotein. (wikipedia.org)
- surface glycoproteins
- Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. (wikipedia.org)
- protein
- Also known as Membrane glycoprotein spo14 (SEC12-like protein) (Sporulation-specific protein 14). (mybiosource.com)
- Also known as Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (CD antigen CD208). (mybiosource.com)
- Also known as Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5). (mybiosource.com)
- Membrane protein E3 RID-alpha and membrane protein E3 RID-beta performs a variety of molecular functions that contribute to inhibiting apoptosis. (wikipedia.org)
- The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. (wikipedia.org)
- The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP). (wikipedia.org)
- The oxidized protein is then treated with a complex mixture, generating a new conjugate on the membrane. (wikipedia.org)
- It was found that PSMA was the same as the membrane protein in the small intestine responsible for removal of gamma-linked glutamates from polygammaglutamate folate. (wikipedia.org)
- The FOLH1 gene has multiple potential start sites and splice forms, giving rise to differences in membrane protein structure, localization, and carboxypeptidase activity based on the parent tissue. (wikipedia.org)
- Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene. (wikipedia.org)
- Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene. (wikipedia.org)
- It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. (wikipedia.org)
- Lysosome-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene. (wikipedia.org)
- The protein encoded by this gene is a member of a family of membrane glycoproteins. (wikipedia.org)
- Online Mendelian Inheritance in Man (OMIM) Lysosome-associated membrane protein 2 -309060 Konecki DS, Foetisch K, Zimmer KP, Schlotter M, Lichter-Konecki U (October 1995). (wikipedia.org)
- Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. (wikipedia.org)
- Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. (wikipedia.org)
- The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. (wikipedia.org)
- Cell surface glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. (wikipedia.org)
- Characterization
- One of these, M1536-B3, synthesizes and deposits copious quantities of extracellular matrix glycoproteins, which led to the initial discovery and characterization of laminin and entactin. (biomedsearch.com)
- Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. (wikipedia.org)
- vesicle membrane
- Also, transection of one or both branches of the axon decreases the amount of 3H-fucose incorporated during a short period into a putative vesicle membrane glycoprotein but not into other glycoproteins. (jneurosci.org)
- neuronal
- PLP is highly related to GPM6A, a neuronal membrane glycoprotein. (wikipedia.org)
- antigen
- Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. (wikipedia.org)
- transmembrane glycoprotein
- This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. (wikipedia.org)
- gene encodes
- This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. (wikipedia.org)
- This gene encodes a receptor for the OX-2 membrane glycoprotein. (wikipedia.org)
- inhibition
- Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. (diabetesjournals.org)
- Inhibition of intracellular migration of membrane glycoproteins in rat intestinal columnar cells and hepatocytes as visualized by light and electron-microscope radioautography after 3H-fucose injection. (biomedsearch.com)
- receptor
- Plasma cell membrane glycoprotein-1 (PC-1) inhibits insulin receptor (IR) tyrosine kinase activity and subsequent cellular signaling. (diabetesjournals.org)
- These results suggest that this immunologically related glycoprotein IIb/IIIa is a receptor for platelet binding to the tumor cell surface, an event which precedes overt platelet aggregation and is dependent upon an intact tumor cell microfilament and intermediate filament network. (rti.org)
- cDNA
- The differentiated cells synthesize basement membrane components and provided the probes for the cDNA cloning of entactin and the three chains of laminin. (biomedsearch.com)
- Membrane glycoprotein PC-1, an inhibitor of insulin signaling, produces insulin resistance when overexpressed in cells transfected with PC-1 cDNA. (diabetesjournals.org)
- lysosome-associated membrane
- It is one of the lysosome-associated membrane glycoproteins. (wikipedia.org)
- intracellular
- Influence of colchicine and vinblastine on the intracellular migration of secretory and membrane glycoproteins: III. (biomedsearch.com)
- 1984), light-microscope radioautographic studies showed that colchicine or vinblastine inhibited intracellular migration of glycoproteins out of the Golgi region in a variety of cell types. (biomedsearch.com)
- Microtubules may, therefore, be necessary for intracellular transport of membrane glycoproteins, although the possibility of a direct action of these drugs on Golgi or plasma membranes must also be considered. (biomedsearch.com)
- tumor
- In addition, tumor cell platelet interactions require the lateral mobility of specific receptors (i.e., clustering) on the tumor cell plasma membrane. (rti.org)
- Furthermore, treatment of tumor cells with specific antibodies to the platelet glycoprotein IIb/IIIa complex inhibits tumor cell-platelet interaction at the macroscopic level (i.e., aggregation) and at the ultrastructural level (i.e., platelet adhesion to the tumor cell surface). (rti.org)
- This suggests that the three glycoproteins are involved in tumor development, specifically in the processes of angiogenesis and tissue remodeling. (wikipedia.org)
- plasma membranes
- They are rarely found on the plasma membranes of normal cells, and are found more on highly metastatic tumors than on poorly metastatic ones. (wikipedia.org)
- immunoglobulin superfamily
- Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. (wikipedia.org)
- IIIa
- In consequence, this complex activates GPIIb / IIIa membrane glycoproteins allowing them to bind fibrinogen. (wikipedia.org)
- The IIb / IIIa complex is a major platelet membrane component. (wikipedia.org)
- Fibrinogen sites recognized by glycoprotein IIb / IIIa complex: dodecapeptide located in the C-terminal of the fibrinogen γ chain (the most important) RGD sequence of the α chain → the Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. (wikipedia.org)
- A membrane glycoprotein immunologically related to the platelet glycoprotein IIb/IIIa complex was identified on Walker 256 carcinosarcoma cells using specific polyclonal and monoclonal antibodies and Northern blot analysis using complementary DNA probes for IIb and IIIa. (rti.org)
- LAMP1
- LAMP1 and LAMP2 make up about 50% of lysosomal membrane glycoproteins. (wikipedia.org)
- In a study of glial tumors, the cell membranes of glial and endothelial cells were found to contain LAMP1 and LAMP2, while YKL-40 (a different glycoprotein) was found in the cytoplasm. (wikipedia.org)
- The expression of LAMP1 and LAMP2 glycoproteins are linked, as deficiencies in LAMP1 gene will lead to increased expression of LAMP2 glycoproteins. (wikipedia.org)
- Although the LAMP1 glycoproteins primarily reside across lysosomal membranes, in certain cases they can be expressed across the plasma membrane of the cell. (wikipedia.org)
- Expression of LAMP1 at the cell surface can occur due to lysosomal fusion with the cell membrane. (wikipedia.org)
- polypeptide
- The 35 k polypeptide is the major glycoprotein in the mouse lens membrane and shows increased incorporation of the tritium label with progression of the cataract. (arvojournals.org)
- Other changes observed in glycoproteins of the Philly mouse lens during cataract development were a loss of the 103 k and 71 k polypeptides and a corresponding increase in the 66 k polypeptide. (arvojournals.org)
- adhesion
- Adhesion-inhibiting polyclonal antibodies were first used by Gerisch (1977) to identify glycoproteins responsible for Dictyostelium aggregation. (springer.com)
- Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV as well, function as receptors engaged in platelet adhesion to collagen. (wikipedia.org)
- isolation
- The isolation of integral surface membrane molecules participating in adhesive phenomena is an important but elusive goal of developmental and cell biology. (springer.com)
- host immune response
- CR1 beta membrane glycoprotein modulates the host immune response. (wikipedia.org)
- antibodies
- The membrane is then probed with antibodies for epitopes of interest. (wikipedia.org)
- cytoplasm
- Residing primarily across lysosomal membranes, these glycoproteins consist of a large, highly glycosylated end with N-linked carbon chains on the luminal side of the membrane, and a short C-terminal tail exposed to the cytoplasm. (wikipedia.org)
- elisa
- MBS2883482 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thy-1 membrane glycoprotein (THY1) ELISA Kit target analytes in biological samples. (mybiosource.com)
- novel
- One of these was a novel gene encoding a membrane glycoprotein containing a leucine-rich repeat (LRR), a C2-type Ig-like domain, and a fibronectin (FN) type III domain, and the transcript of which was specifically expressed in the retina. (jneurosci.org)
- Golgi
- This suggests that labeled glycoproteins destined for the apical plasma membrane were inhibited from leaving the Golgi region, while migration to the lateral plasma membrane was not impaired. (biomedsearch.com)
- This indicates that the drugs inhibited migration of membrane glycoproteins from the Golgi region to the various portions of the plasma membrane. (biomedsearch.com)
- antibody
- The method is described more fully in the article on Far-eastern blotting, but is based on antibody or lectin staining of lipids transferred to PVDF membranes. (wikipedia.org)
- maturation
- The evidence suggests that it is inserted into or absorbed on to the plasma membrane, and since its appearance on spermatozoa correlates with the acquisition of fertilizing capacity it should serve as a good marker for assessing maturation in vitro. (mysciencework.com)
- hepatocytes
- In the present work, the effects of these drugs on migration of membrane glycoproteins have been examined at the ultrastructural level in duodenal villous columnar cells and hepatocytes. (biomedsearch.com)
- In hepatocytes, labeling of the sinusoidal plasma membrane was reduced by 83% after colchicine and by 85% after vinblastine treatment. (biomedsearch.com)
- galactose oxidase
- The membrane glycoproteins were labeled by treatment with galactose oxidase and tritiated borohydride. (arvojournals.org)
- The major glycoprotein on the plasma membrane of testicular spermatozoa labelled with the galactose oxidase/NaB3H4 technique has mol.wt. (mysciencework.com)
- epididymis
- Labelling of membrane glycoproteins on rat spermatozoa collected from different regions of the epididymis. (mysciencework.com)
- As spermatozoa pass through the epididymis, labelling of this glycoprotein disappears and is replaced by labelling of a 32 000-mol.wt. (mysciencework.com)
- human
- Cell membrane expression of LAMP-1 observed in the following cancer types: Human fibrosarcoma, Colon adenocarcinoma, Melanoma, Pancreatic adenocarcinoma, and Astrocytoma. (wikipedia.org)
- resides
- GCPII is a zinc metalloenzyme that resides in membranes. (wikipedia.org)
- subunits
- These subunits form Ca2+ - dependent complex on the surface of platelet membrane in a 1:1 ratio. (wikipedia.org)