Membrane glucose transport proteins facilitative. Medical search. Frequent questions

Both of these effects occur without corresponding changes in the subcellular distribution of the GLUT4 glucose transporter isoform. (psu.edu)
In this report, we have utilized the impermeant, exofacial bis-mannose glucose transporter- specific photolabel, 2-N-4- (1-azi-2,2,2-trifluoroethyl)benzoyl-1, 3-bis (D-mannos-4-yloxy) -2-propylamine (ATB-BMPA), to examine the cell surface accessibility of GLUT4 glucose transporters under these conditions. (psu.edu)
the plasma membrane concentration of GLUT4 as assessed by Western blotting is unchanged. (psu.edu)
Photolabeling the corresponding plasma membranes revealed that these alterations in the ability of the photolabel to bind to GLUT4 are transient as the levels of both photolabel incorporation and plasma membrane glucose transport activity were consistent with the observed GLUT4 concentration. (psu.edu)
These data suggest that insulin-stimulated GLUT4 glucose transporters can exist in two distinct states within the adipocyte plasma membrane, one functional and accessible to extracellular substrate and one non-functional and unable to bind extracellular substrate. (psu.edu)
The Rab-GTPase-activating proteins (GAPs) TBC1D1 and TBC1D4 play important roles in the insulin-stimulated translocation of the glucose transporter GLUT4 from intracellular vesicles to the plasma membrane in muscle cells and adipocytes. (bath.ac.uk)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Glucose Transporter 4 (GLUT4) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (jsce-ip.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Glucose Transporter 4 (GLUT4) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)
The insulin-responsive aminopeptidase (IRAP/VP165/gp160) was identified originally in GLUT4-containing vesicles and shown to translocate in response to insulin, much like the glucose transporter 4 (GLUT4). (johnshopkins.edu)
As assayed by membrane 'sheets', GLUT4 and IRAP showed similar internalization rates that are wortmannin-insensitive and occur with a half- time of roughly 5 min. (johnshopkins.edu)

The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). (lbl.gov)
High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. (lbl.gov)
Consumed fructose enters enterocytes of the intestinal epithelial apical membrane mediated by glucose transporter 5 (GLUT5). (openveterinaryjournal.com)
Fructose is a class of monosaccharides with the highest level of sweetness compared to glucose and sucrose, often used as a sweetener by the food and beverage industry ( Douard and Ferraris, 2008 ). (openveterinaryjournal.com)
Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. (biomedcentral.com)
Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of mTOR. (biomedcentral.com)
These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis, but the details of these interactions remain unclear. (biomedcentral.com)
SLC2A8 is the insulin-regulated facilitative glucose transporter.SLC2A8 binds cytochalasin B in a glucose-inhibitable manner.SLC2A8 seems to be a dual-specific sugar transporter as it is inhibitable by fructose. (novusbio.com)

Hydrodynamic analysis and electron microscopy of GLUT1/lipid/detergent micelles and freeze fracture electron microscopy of GLUT1 proteoliposomes support the hypothesis that the glucose transporter is a multimeric (probably tetrameric) complex of GLUT1 proteins. (umassmed.edu)
GLUT1 does not appear to exchange rapidly between protein/lipid/detergent micelles but is able to self-associate in the plane of the lipid bilayer. (umassmed.edu)
Quantitatively deglycosylated GLUT1 displays aberrant electrophoretic mobility, but each protein band contains full-length GLUT1 and the less mobile species, when treated with additional detergent and reductant, converts to the more mobile species. (umassmed.edu)
The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. (lbl.gov)

The glucose transporters expressed in the renal proximal tubule ensure that less than 0.5 g/day (range 0.03-0.3 g/d) is excreted in the urine of healthy adults. (medscape.com)

Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11) also known as glucose transporter type 10/11 (GLUT-10/11) is a protein that in humans is encoded by the SLC2A11 gene. (wikipedia.org)
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. (genetex.com)
FRG is a rare disorder due mainly to mutations in the sodium-glucose cotransporter 2 gene ( SGLT2 ) that are responsible for the majority of cases. (medscape.com)
Mutations in the sodium-glucose cotransporter 2 gene are responsible for the majority of cases. (medscape.com)
Mice lacking the Hnf-1α gene ( 3 , 4 ) also have a dramatic reduction in insulin secretory response to glucose. (diabetesjournals.org)
We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
The dopamine transporter ( DAT ) also ( sodium-dependent dopamine transporter ) is a membrane-spanning protein coded for in the human by the SLC6A3 gene , (also known as DAT1 ), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol . (cloudfront.net)
The gene that encodes the DAT protein is located on chromosome 5 , consists of 15 coding exons , and is roughly 64 kbp long. (cloudfront.net)
Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism , known as a variable number tandem repeat , in the SLC6A3 gene, which influences the amount of protein expressed. (cloudfront.net)
In Library, lysine-10( H3K9) vision gene has required a green protein-protein for visual studies and lacks visually one of the unknown conditions known with acid( Peters et al. (erik-mill.de)
Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
In most single gene autisms (Rett, Fragile-X, Pitt Hopkins etc) the underlying problem is that a faulty gene does not do its job of producing the expected protein. (epiphanyasd.com)
For example, in Timothy Syndrome the mutation in the gene produces too much of the protein, in this case the L-type calcium channel Cav1.2. (epiphanyasd.com)

Synthetic peptides corresponding to SLC2A8 (solute carrier family 2, facilitated glucose transporter, member 8). (novusbio.com)

Facilitative transport occurs in essentially all cell types and is driven by the concentration gradient across cellular membranes. (medscape.com)
A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process. (nih.gov)

Galactose, glucose uniporter, Gal2. (lbl.gov)
Lactase deficiency (LD) is the failure to express the enzyme that hydrolyses lactose into galactose and glucose in the small intestine. (bmj.com)

Glucose is removed from ASL in proximal airways via facilitative glucose transporters, down a concentration gradient generated by intracellular glucose metabolism. (ersjournals.com)
Once dopamine binds, the protein undergoes a conformational change, which allows both sodium and dopamine to unbind on the intracellular side of the membrane. (cloudfront.net)

May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. (biossusa.com)
It enters the gastrointestinal tract and is absorbed across the brush border of the small intestine into the enterocytes of the apical membrane of the intestinal epithelium, mediated by glucose transporter 5 (GLUT5) or Solute carrier family 2 A5 (SLC2A5). (openveterinaryjournal.com)

For over 50 years, glucose has been recognised to cross the lung epithelial barrier and be transported by lung epithelial cells. (ersjournals.com)
Since the mid-1960s, it has been known that there are energy-dependent, sodium-coupled glucose transporter (SGLT) and energy-independent, facilitative glucose transporter (GLUT) pathways for glucose uptake in the lung [ 1 ], and that glucose can permeate the alveolar epithelial barrier [ 2 ]. (ersjournals.com)
In primary cultures of human bronchial epithelial cells (HBECs) with 16.6±0.4 mM glucose in the basolateral medium, ASL glucose was 2.2±0.5 mM [ 11 ]. (ersjournals.com)
ASL glucose concentrations are the net result of diffusion of glucose from blood and interstitial fluid across the respiratory epithelium into the ASL, and removal of glucose from ASL by epithelial glucose transport processes. (ersjournals.com)
Glucose diffusion is determined by epithelial permeability to glucose, the transepithelial glucose gradient and surface area. (ersjournals.com)
In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. (biomedcentral.com)

10 (8):e0135262 c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction. (genetex.com)
Results are consistent with a central, hydrophilic, translocation pathway comprised of amphipathic, membrane-spanning domains that alter associations upon ligand/substrate binding. (umassmed.edu)
DAT function requires the sequential binding and co-transport of two Na + ions and one Cl − ion with the dopamine substrate. (cloudfront.net)
Glucose is the major substrate for ATP synthesis through glycolysis and oxidative phosphorylation (OXPHOS), whereas intermediary metabolism through the tricarboxylic acid (TCA) cycle utilizes non-glucose-derived monocarboxylates, amino acids, and alpha ketoacids to support mitochondrial ATP and GTP synthesis. (molvis.org)

Glucose removal is determined by cellular glucose uptake and metabolism ( fig. 1 ) [ 4 , 12 - 14 ]. (ersjournals.com)
Although the adult human brain represents only 2% of the total body weight, it consumes up to 20% of the total glucose metabolism under normal resting physiological conditions (e.g. (frontiersin.org)
Confocal studies showed differential cellular and compartmental distribution of isozymes involved in glucose, glutamate, glutamine, lactate, and creatine metabolism. (molvis.org)

The three terminal products of carbohydrate digestion are transported through the enterocyte brush border membrane via facilitative transporter proteins such as the sodium-glucose cotransporter 1 (SGLT1), glucose transporter 2 (GLUT2), and glucose transporter S (GLUTS). (your-doctor.net)
Bile acids act as detergents which increase the solubility oflipid micelles which are taken up by the brush border membrane of the jejunum, where over 90% of fat is absorbed. (your-doctor.net)
Reabsorption of glucose predominantly occurs on the brush border membrane of the convoluted segment of the proximal tubule. (medscape.com)

solute carrier family 2, facilitated glucose transporter member 8. (lbl.gov)

Movement across a biological membrane is more complicated and is a function of lipid solubility of the ion/molecule as well as the presence of channels or transport proteins that can allow the ion/molecule to cross the membrane (see Lipid Bilayer Permeability and Summary of Membrane Transport Processes ). (physiologyweb.com)

In immortalised human airway cells (line H441) with 10 mM glucose in the basolateral medium, apical ASL glucose was 0.24±0.07 mM [ 10 ]. (ersjournals.com)

The concentration gradient may exist across a biological membrane, where the concentration is higher on one side of the membrane compared to the other side. (physiologyweb.com)

A class of nucleotide translocases found abundantly in mitochondria that function as integral components of the inner mitochondrial membrane. (nih.gov)

Insulin-stimulated glucose transport activity in rat adipocytes is inhibited by isoproterenol and enhanced by adenosine. (psu.edu)
This study characterizes the trafficking and kinetics of IRAP in exocytosis, endocytosis, and recycling to the membrane in 3T3-L1 adipocytes. (johnshopkins.edu)
After exposure of 3T3-L1 adipocytes to insulin, IRAP translocated to the plasma membrane as assessed by either cell fractionation, surface biotinylation, or the plasma membrane sheet assay. (johnshopkins.edu)

Organelles from endosperm of etiolated seedlings were isolated and subjected to liquid chromatography-tandem mass spectrometry (LC-MS/MS). Computer-assisted deconvolution algorithms were applied to reliably assign the identified proteins to their correct subcellular localization and to determine the abundance of the different organelles in the heterogeneous protein samples. (bvsalud.org)

Below are the most recent publications written about "Glucose Transport Proteins, Facilitative" by people in Profiles. (ouhsc.edu)
Below are the most recent publications written about "Serotonin Plasma Membrane Transport Proteins" by people in Profiles. (musc.edu)
Below are the most recent publications written about "Amino Acid Transport System y+L" by people in Profiles. (musc.edu)

The arrangement of multiple GLUTs across all somatic tissues signifies the important role of glucose across all organisms. (preprints.org)
Our understanding of the role of glucose transport in the lung and the mechanisms that regulate glucose movement across the human lung epithelium lags far behind that of the gut and kidney. (ersjournals.com)

Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis. (ouhsc.edu)
Drosophila Solute Carrier 5A5 Regulates Systemic Glucose Homeostasis by Mediating Glucose Absorption in the Midgut. (ouhsc.edu)
Understanding of mechanisms underlying lung glucose homeostasis could identify new therapeutic targets for control of ASL glucose and prevention and treatment of lung infection. (ersjournals.com)
The kidneys play an important role in glucose homeostasis. (medscape.com)
It helps to maintain glucose homeostasis by at least two mechanisms. (medscape.com)

Although the pattern of inheritance that best fits FRG is one of co-dominance, increased glucose excretion was not observed in all individuals with similar or identical mutations. (medscape.com)
Heterozygosity for mutations suggest a role of nongenetic factors or other genes involved in renal glucose transport. (medscape.com)

Consequently the affinity of the transporters for glucose along the tubule increases to allow for complete reabsorption of glucose from the urine. (medscape.com)
low-affinity glucose transporter HXT4. (lbl.gov)
Low-affinity glucose transporter LGT1. (lbl.gov)
A leucine-sensitive amino acid transport system with high affinity for basic amino acids( AMINO ACIDS, BASIC). (musc.edu)

In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. (genetex.com)
DAT is an integral membrane protein that removes dopamine from the synaptic cleft and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. (cloudfront.net)

The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters. (ouhsc.edu)
Kinetics of mucopolysaccharide and glycoprotein synthesis by chick embryo chondrocytes: effect of D-glucose concentration in the culture medium. (unclesarm.com)
Glycosaminoglycans are polymers of forms of glucose (glucosamine, glucuronic acid, iduronic acid) suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus. (biomedcentral.com)

An electrogenic transport process is one that leads to the translocation of net charge across the membrane. (physiologyweb.com)
The Na + /K + ATPase is electrogenic because for every ATP molecule hydrolyzed, 3 Na + ions are transported out of the cell and 2 K + ions are transported into the cell (leading to the translocation of one net positive charge out of the cell). (physiologyweb.com)

The GLUT members belong to a family of glucose transporter proteins that facilitate glucose transport across the cell membrane. (preprints.org)
They facilitate passive diffusion of GLUCOSE across the CELL MEMBRANE. (ouhsc.edu)

The ESCRT portion tends typically human for receptor-ligand transport that is fulfilment metabolized unidirectional binds. (erik-mill.de)

A type of secondary active transport across a biological membrane in which a transport protein couples the movement of an ion (usually Na + or H + ) down its electrochemical gradient to the movement of another ion or molecule against a concentration or electrochemical gradient. (physiologyweb.com)
The ion/molecule being transported against a chemical or electrochemical gradient is referred to as the driven ion/molecule. (physiologyweb.com)
In cotransport, the direction of transport is the same for both the driving ion and driven ion/molecule (into the cell or out of the cell). (physiologyweb.com)
This transport process is referred to as active transport because the driven ion/molecule is transported against a concentration or electrochemical gradient. (physiologyweb.com)
Glycolysis is an anaerobic, sequential, enzymatic and catabolic multi-step process that converts a single glucose molecule into two pyruvates in the cytoplasm coupled with the production of two NADH molecules and a net yield of two molecules of ATP. (kdwis.com)
Studies using electrophysiology and radioactive-labeled dopamine have confirmed that the dopamine transporter is similar to other monoamine transporters in that one molecule of neurotransmitter can be transported across the membrane with one or two sodium ions. (cloudfront.net)

An example is the Na + /glucose cotransporter (SGLT), which couples the movement of Na + into the cell down its electrochemical gradient to the movement of glucose into the cell against its concentration gradient. (physiologyweb.com)
The driving force for DAT-mediated dopamine reuptake is the ion concentration gradient generated by the plasma membrane Na + /K + ATPase . (cloudfront.net)

It consists of 14 separate exons spanning approximately 7.7kb of genomic DNA, and encodes the 672 amino acid protein SGLT2. (medscape.com)
Amino Acid Transport System y+L" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
This graph shows the total number of publications written about "Amino Acid Transport System y+L" by people in this website by year, and whether "Amino Acid Transport System y+L" was a major or minor topic of these publications. (musc.edu)
preferentially, post-translational amino-acid JmjC increases are activated provided and conserved to regulate pentose cell polysaccharides with antimicrobial program protein and Clot positions. (erik-mill.de)

This is in contrast to conditions in the gut and kidney, where luminal glucose concentrations regularly exceed plasma glucose concentrations [ 6 , 7 ]. (ersjournals.com)
0.01 mM and plasma glucose 0.19 mM [ 3 ]. (ersjournals.com)
As plasma glucose concentration increases, there is concordant increase in the filtered load of glucose. (medscape.com)

The blastocyst/testis glucose transporter, Glut8 (Doege et al. (lbl.gov)
Western Blot: Glucose Transporter GLUT8 Antibody [NBP1-59812] - Human Fetal Heart, Antibody Dilution: 1.0 ug/ml. (novusbio.com)
Western Blot: Glucose Transporter GLUT8 Antibody [NBP1-59812] - NCI-H226 cell lysate, concentration 0.2-1 ug/ml. (novusbio.com)

Renal glucosuria is the excretion of glucose in the urine in detectable amounts at normal blood glucose concentrations in the absence of any signs of generalized proximal renal tubular dysfunction due to a reduction in the renal tubular reabsorption of glucose. (medscape.com)

Cancer cells are known to proliferate uncontrollably and therefore, have greater demand for energy and a ready supply of the building blocks necessary for the biosynthesis of macromolecules such as nucleotides, proteins and lipids). (kdwis.com)

We show that despite a profound defect in glucose-stimulated insulin secretion, diabetic Hnf-1α −/− mice have a robust glibenclamide-induced insulin secretory response. (diabetesjournals.org)
Clinical studies in humans indicate that β-cell dysfunction in MODY3 patients leads to a defect in glucose-stimulated insulin secretion that is responsible for chronic hyperglycemia ( 2 ). (diabetesjournals.org)
Insulin secretion from islets of Hnf-1α −/− mice is blunted in response to glucose and other glycolytic stimuli but normal in response to non-nutrient secretagogues such as potassium ( 5 ). (diabetesjournals.org)
stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. (unclesarm.com)

Na + /glucose cotransporter and H + /dipeptide cotransporter are examples of cotransporters. (physiologyweb.com)

SLC2A11 belongs to a family of plasma membrane proteins that mediate transport of sugars across the membrane by facilitative diffusion. (wikipedia.org)

Glucose enters at the luminal side of the proximal tubular cells by an active carrier-mediated transport process that requires energy provided by the sodium gradient between the intra- and extracellular compartments generated by sodium-potassium ATPase. (medscape.com)

Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)

A family of monosaccharide transport proteins characterized by 12 membrane spanning helices. (ouhsc.edu)

Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. (genetex.com)
may comprise part of the glucose-sensing mechanism of the beta cell. (biossusa.com)
Glucose enters the cell along with sodium, and sodium exits the cell at the basolateral side of the cell, which is sodium-independent and a facilitative transport requiring no energy. (medscape.com)
Cerebral function requires the cooperative interaction between different cell types, namely neurons, astrocytes, microglia and oligodendrocytes, and depends on high metabolic activity supported by continuous supply of oxygen and glucose from the blood ( Siesjö, 1978 ). (frontiersin.org)
Description: A sandwich ELISA kit for detection of Glucose Transporter 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)
DAT is a symporter that moves dopamine across the cell membrane by coupling the movement to the energetically-favorable movement of sodium ions moving from high to low concentration into the cell. (cloudfront.net)
The proteins of such MAPKs increased and were then repress UniProt differential download Sarkozy, Israël et whereby steps include to the spliced group before any further cell. (erik-mill.de)
In tract, markup at cell H3 lysine-5( H3K4) and detailed( H3K36), forming glucose and potential at these receptors, is released synthesized to partially associated kinases( shown in Martin & Zhang 2005). (erik-mill.de)

Defects in glucose transport have been linked to metabolic disorders, insulin resistance and diabetes. (preprints.org)
Blood flow is indeed directly related to the cerebral metabolic rate of glucose consumption (CMR glc ) ( Sokoloff, 1978 ). (frontiersin.org)

The energy required to drive transport resides in the transmembrane electrochemical gradient of the driving ion. (physiologyweb.com)

Glucose diffuses into ASL via paracellular pathways at a rate determined by paracellular permeability and the transepithelial glucose gradient. (ersjournals.com)

As the rate of glucose entering the nephron rises above 260-350mg/1.73m 2 /min (14.5-19.5mmol/1.73m 2 /min), the excess glucose exceeds the reabsorptive capacity of proximal tubule and is excreted in the urine (i.e. glucosuria). (medscape.com)
Secondary active transport occurs in the intestine and the kidney tubules (predominantly proximal tubule) and is mediated by members of the SGLT transporter family. (medscape.com)

Teaching NeuroImage: Fasting EEG in Glucose Transporter-1 Deficiency Syndrome. (ouhsc.edu)

Cytokine regulation of facilitated glucose transport in human articular chondrocytes. (unclesarm.com)

Wang, X. Avian and Mammalian Facilitative Glucose Transporters. (preprints.org)

Two means of glucose transport are noted: facilitative and secondary active transport. (medscape.com)
It is referred to as secondary active transport because no ATP hydrolysis is involved in this process (as opposed to primary active transport). (physiologyweb.com)
Secondary active transport is also referred to as ion-coupled transport. (physiologyweb.com)

Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses. (unclesarm.com)
β-galactosyl-1,4 glucose) is the main source of carbohydrate in human milk and that of other mammals, except for sea lions and walruses which produce low volume, viscous and fatty lactose-free milk. (bmj.com)

USP6NL, also named RN-tre, is a GTPase-activating protein involved in control of endocytosis and signal transduction. (aacrjournals.org)

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