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Bruch MembraneChoroid PlexusChoroidChoroid Plexus NeoplasmsMembranesCell MembraneMembrane LipidsIntracellular MembranesMembrane PotentialsMembranes, ArtificialPapilloma, Choroid PlexusChoroid NeoplasmsErythrocyte MembraneMembrane FluidityCell Membrane PermeabilityBasement MembraneMembrane Transport Proteins
Bruch'sRetinalChoroidalEpitheliumCiliary bodyEyeballEpithelialTissueScleraProteinCerebrospinalEncodesUveaTumor cellsExtracellularBasementCorneaLateralDrusenLayerArisePlasmaAbnormalityAdenocarcinomaIntegralMacularInflammatoryOccurTissuesDiabeticRenalWallsBrainCellAGEsAdministrationLocationAreaImageCommonEyes
Bruch's22
  • To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's membranes and choroid in vivo. (nih.gov)
  • Human Bruch's membrane samples were isolated from the retinal pigment epithelium (RPE) and choroid and subjected to reversed-phase high-performance liquid chromatography to determine pentosidine content. (nih.gov)
  • Immunohistochemical evaluation showed evidence of pentosidine in Bruch's membrane, choroidal extracellular matrix, and vessel walls in the 82-year-old nondiabetic and diabetic globes. (nih.gov)
  • We provide biochemical and immunohistochemical evidence for the formation of pentosidine and CML structures in human Bruch's membrane and choroid with age. (nih.gov)
  • These changes could promote aging of the RPE-Bruch's membrane-choroid complex. (nih.gov)
  • Bruch's membrane": Innermost layer of the choroid. (wikipedia.org)
  • With Bruch's membrane ruptured, these processes penetrated into the choroid. (molvis.org)
  • Indeed, when appropriate parameters are used for laser ray administration, the laser impacts break Bruch's membrane and induce subretinal neovascularization. (molvis.org)
  • Consider that they tend to arise from the retina above Bruch's membrane. (eyecancer.com)
  • The lamina vitrea is also referred to as Bruch's membrane. (histology-world.com)
  • The outer blood-retina barrier consists of the retinal pigment epithelium (RPE), separated by Bruch's membrane from the blood-vessel rich choriocapillaris. (neurosciencenews.com)
  • Bruch's membrane regulates the exchange of nutrients and waste between the choriocapillaris and the RPE. (neurosciencenews.com)
  • In AMD, lipoprotein deposits called drusen form outside Bruch's membrane, impeding its function. (neurosciencenews.com)
  • The outer blood-retina barrier is the interface of the retina and the choroid, including Bruch's membrane and the choriocapillaris. (neurosciencenews.com)
  • For example, presence of RPE cells induces gene expression changes in fibroblasts that contribute to the formation of Bruch's membrane-something that was suggested many years ago but wasn't proven until our model. (neurosciencenews.com)
  • There is the external vessel layer, the capillary layer and the internal sheet-like Bruch's membrane. (optos.com)
  • There are three layers of tissue that support the retina - the choroid, Bruch's membrane and the retinal pigment epithelium. (webrn-maculardegeneration.com)
  • Observation of patients with Sorsby's fundus dystrophy has shown that a prolonged choroidal filling phase on fluorescein angiography may indicate the presence of diffuse thickening of Bruch's membrane. (nih.gov)
  • We analyzed fluorescein angiography transit photographs in 100 eyes of 100 consecutive patients with age-related changes at the level of Bruch's membrane. (nih.gov)
  • We suggest that this may represent a clinical correlate of diffuse thickening of Bruch's membrane, and that the two features are causally related. (nih.gov)
  • To examine if racial differences in Bruch's membrane opening-minimum rim width (BMO-MRW) in spectral domain optical coherence tomography (SDOCT) exist, specifically between people of African descent (AD) and European descent (ED) in normal ocular health. (cdc.gov)
  • Recently, a novel neuroretinal rim parameter, based on the minimum rim width from Bruch's membrane opening to the neuroretinal surface (BMO-MRW), has demonstrated much greater effectiveness in evaluating the ONH for glaucoma than other optic disc margin measurements such as cup-to-disc ratio and rim area. (cdc.gov)
Retinal2
  • Racial differences in the anatomy of the optic nerve head (ONH), such as larger optic discs and disc area, deeper cups, variation in lamina cribrosa position, and thicker overall retinal nerve fiber layer (RNFL) and peripapillary choroid thicknesses in AD individuals, have also been previously described. (cdc.gov)
  • Although intravitreal administration of therapeutics increases concentration in the area of diseased tissue (i.e. retina, choroid, retinal pigment epithelium), while reducing systemic side effects, other drug delivery options reviewed in this manuscript offer promise for posterior segment conditions. (medscape.com)
Choroidal5
  • Choroidal melanomas typically start as dome-shaped lesions and, as they grow and break through Bruch membrane, they acquire a mushroom or collar-button shape (Fig 12-20). (aao.org)
  • Thick-choroid CSC was defined as mean subfoveal choroidal thickness more than 300.0 μ m. (plos.org)
  • The choroid plexuses-CSF system shapes the central nervous system response to inflammation at the adult stage, but little is known on the neuroimmune interactions that take place at the choroidal blood-CSF barrier during development. (biomedcentral.com)
  • Combining light sheet microscopy imaging of choroid plexus, a differentiated model of the blood-CSF barrier, and multiplex cytokine assays, we showed that the choroidal epithelium responds to the bacterial insult by a specific pattern of cytokine secretion, leading to a selective accumulation of neutrophils in the choroid plexus and to their trafficking into CSF. (biomedcentral.com)
  • N-acetylcysteine acted by blocking neutrophil migration across both the endothelium of choroidal stromal vessels and the epithelium forming the blood-CSF barrier, without interfering with neutrophil blood count, neutrophil tropism for choroid plexus, and choroidal chemokine-driven chemotaxis. (biomedcentral.com)
Epithelium3
  • Complement and Humoral Adaptive Immunity in the Human Choroid Plexus: Roles for Stromal Concretions, Basement Membranes, and Epithelium. (ox.ac.uk)
  • Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
  • The choroid plexus epithelium (CPe) is primarily responsible for secreting CSF and regulating its composition by mechanisms currently not fully understood. (escholarship.org)
Ciliary body3
  • The most common primary intraocular malignancy in adults is melanoma arising from the ciliary body and/or choroid. (aao.org)
  • When this type of tumor grows to a significant size, it may extend beyond its site of origin (ie, from the choroid to the ciliary body and vice versa). (aao.org)
  • It consists of the iris, choroid and ciliary body. (histology-world.com)
Eyeball1
  • The outer layer of the eyeball is a tough, white, opaque membrane called the sclera (the white of the eye). (peacehealth.org)
Epithelial3
  • Among the baseline characteristics, serous pigment epithelial detachment (B = - 2.580, P = 0.032) and thick-choroid (B = 1.980, P = 0.019) were significantly associated with recurrence. (plos.org)
  • Thinner choroid and serous pigment epithelial detachment appear protective for recurrences. (plos.org)
  • In the brain, Klotho is mainly localized in the apical plasma membrane of epithelial cells of the choroid plexus and, to a lesser extent, hippocampal neurons. (neurodegenerationresearch.eu)
Tissue3
  • Here, using Kcne2(-/-) tissue as a negative control, we found cerebral expression of KCNE2 to be markedly enriched in the CPe apical membrane, where we also discovered expression of KCNQ1. (escholarship.org)
  • Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes. (msdmanuals.com)
  • Distribution equilibrium (when entry and exit rates are the same) between blood and tissue is reached more rapidly in richly vascularized areas, unless diffusion across cell membranes is the rate-limiting step. (msdmanuals.com)
Sclera1
  • The choroid is the pigmented, highly vascular layer of the globe, lying between the sclera (on the outside) and the retina (on the inside). (optos.com)
Protein6
  • Nestin was also observed in some vascular cells, as demonstrated by the co-immunoreactivity of the protein with vWF in the choroid and retina. (molvis.org)
  • The transcript is predominantly expressed in RPE/choroid and encodes bestrophin, a 580-amino acid protein of 66 kDa. (upenn.edu)
  • Immunocytochemistry of normal canine retina demonstrated specific localization of protein to the RPE basolateral plasma membranes. (upenn.edu)
  • Klotho is an aging-suppression protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain. (aspetjournals.org)
  • The extracellular domain of Klotho, a type-1 membrane protein, is secreted into urine and blood and may function as an endocrine or paracrine hormone. (aspetjournals.org)
  • Integral membrane protein. (lu.se)
Cerebrospinal2
  • The choroid plexus (CP) provides a barrier to entry of toxic molecules from the blood into the brain and transports vital molecules into the cerebrospinal fluid. (ox.ac.uk)
  • Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
Encodes1
Uvea1
Tumor cells1
  • Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
Extracellular1
  • Binding to galectin-1 at the extracellular surface prevents clathrin-mediated endocytosis of ROMK1 and leads to accumulation of functional channel on the plasma membrane. (aspetjournals.org)
Basement3
  • In multiple sclerosis CP, basement membrane C9 or stromal IgA patterns were common but were not specific for the disease. (ox.ac.uk)
  • Histologically, adenomas in this layer typically retain characteristics of RPE cells, including basement membranes, cell junctions, and microvilli. (aao.org)
  • Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
Cornea1
  • Around the cornea, a thin, clear membrane called the conjunctiva helps to protect the rest of the front of your eye and the inside of your eyelids. (acuvue.co.uk)
Lateral1
  • This coronal T1-weighted magnetic resonance image (MRI) following contrast administration shows a homogeneously enhancing choroid plexus papilloma within the right lateral ventricle of a 1-year-old boy. (medscape.com)
Drusen1
  • The associated choriocapillaris may become compressed or obliterated, and drusen may form along Bruch membrane overlying the nevus. (aao.org)
Layer2
Arise4
  • Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
  • The vast majority of choroid plexus neoplasms arise within the ventricles. (medscape.com)
  • Choroid plexus tumors , which arise from cells lining the ventricles of the brain. (cincinnatichildrens.org)
  • Meningeal tumors , such as meningioma, which arise from the membranes (meninges) surrounding the brain and spinal cord. (cincinnatichildrens.org)
Plasma3
  • AE1 is also activated by interaction with glycophorin which also functions to target it to the plasma membrane ( Young and Tanner, 2003 ). (tcdb.org)
  • It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (ihcworld.com)
  • The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. (antibodypedia.com)
Abnormality1
Adenocarcinoma1
Integral1
  • The animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. (tcdb.org)
Macular1
  • Other complications were also minimal such as silicon oil in anterior chamber in 1 eye, epiretinal membrane in 3 eyes and macular hole in 2 eyes. (bvsalud.org)
Inflammatory2
  • The choroid can be subject to inflammatory disorders (often in conjunction with the retina - see the separate Chorioretinal Inflammation article), tumor formation, and a number of other disorders. (optos.com)
  • They also point to the efficacy of N-acetylcysteine in reducing the deleterious effects of inflammation-associated perinatal injuries by a previously undescribed mechanism, i.e. the inhibition of innate immune cell migration across the choroid plexuses, without interfering with the systemic inflammatory response to infection. (biomedcentral.com)
Occur1
Tissues1
Diabetic1
  • Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
Renal1
  • Here, we report that KLe treatment increases the cell-membrane abundance of the renal K + channel renal outer medullary potassium channel 1 (ROMK1) by removing terminal sialic acids from N -glycan of the channel. (aspetjournals.org)
Walls1
  • The CNS is protected against the invasion of immune cells by cellular barriers which comprise the cerebrovascular walls and the choroid plexuses (ChPs). (biomedcentral.com)
Brain3
  • [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
  • Folate receptor alpha is produced in largest amounts in the brain, specifically in an area of the brain called the choroid plexus. (medlineplus.gov)
  • It transports folate across the choroid plexus and into the CSF, ultimately reaching the brain. (medlineplus.gov)
Cell2
AGEs1
Administration1
  • Here we showed in neonatal rats exposed to P3C that the migration of neutrophils into the CSF, which occurred through the choroid plexuses, is abolished following administration of the antioxidant drug N-acetylcysteine. (biomedcentral.com)
Location1
Area1
Image1
  • Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
Common2
  • Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
  • Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
Eyes1