• In brief, after a test dose to exclude immediate hypersensitivity, intravenous suramin (reconstituted in sterile water to a 10% solution, with the required dose added to 200 mL 5% dextrose and infused over 2 hours) is administered at doses of 5, 10, and 20 mg/kg on days 1, 3, and 5, respectively (maximum 1.5 g/dose). (cdc.gov)
  • Fresh CSF samples are examined on day 5 to determine whether there is evidence of central nervous system (CNS) involvement, as defined by elevated IgM, pleocytosis, or presence of trypomastigotes. (cdc.gov)
  • Suramin is recommended for treating the hemolymphatic stage of African trypanosomiasis, but because it does not cross the blood-brain barrier, it is ineffective against trypanosomes in the CNS. (cdc.gov)
  • Any individual with African trypanosomiasis should be monitored for evidence of CNS involvement during treatment and at regular intervals for 1-2 years thereafter (4). (cdc.gov)
  • Treatment with suramin (1 g intravenously on days 1, 3, 7, 14, and 21) was initiated on September 22, and within 48 hours of the first dose, neck swelling decreased noticeably, and rash and fever disappeared. (cdc.gov)
  • Physicians caring for the patient reported here elected to use suramin alone, and the decreased CSF cell count after 10 days of treatment was reassuring. (cdc.gov)
  • The trypomastigotes of T. b. rhodesiense are indistinguishable morphologically from those of T. b. gambiense , but from the epidemiology of these infections the patient was presumed to have T. b. rhodesiense infection, for which the recommended initial therapy is intravenous suramin. (medscape.com)
  • Melarsoprol, a relatively toxic drug, is used either alone or in combination with suramin when infection has progressed to involve the CNS (2). (cdc.gov)
  • Melarsoprol is the drug of choice for late disease with central nervous system involvement (infections by T.b. gambiense or T. b. rhodiense ). (wikidoc.org)
  • Although neurological involvement is common in have a higher risk of illness of heart disease. (camplife-media.com)
  • In brief, after a test dose to exclude immediate hypersensitivity, intravenous suramin (reconstituted in sterile water to a 10% solution, with the required dose added to 200 mL 5% dextrose and infused over 2 hours) is administered at doses of 5, 10, and 20 mg/kg on days 1, 3, and 5, respectively (maximum 1.5 g/dose). (medscape.com)
  • Melarsoprol 2-3.6 mg/kg/day IV for 3 days. (wikidoc.org)
  • he was also treated successfully with suramin alone, and has shown no signs of CNS involvement during the past 2 years (3). (cdc.gov)