AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Carcinoma, Lewis LungMelanomaCarcinomaLungLung NeoplasmsMelanoma, ExperimentalCarcinoma, Squamous CellLewis Blood-Group SystemCarcinoma, HepatocellularSkin NeoplasmsNeoplasms, ExperimentalNeoplasm TransplantationLewis AcidsMice, Inbred C57BLNeoplasm MetastasisCell Line, TumorTumor Cells, CulturedLung DiseasesCarcinoma in SituImmunohistochemistryLiver NeoplasmsCarcinoma, PapillaryNeovascularization, PathologicUveal NeoplasmsAntineoplastic AgentsRats, Inbred LewCarcinoma, Non-Small-Cell LungSemustineNeoplasm InvasivenessGene Expression Regulation, NeoplasticCarcinoma, Basal CellMelanoma, AmelanoticAdenocarcinomaCarcinoma, Ductal, BreastMice, NudeNeoplasm ProteinsTumor Markers, Biologicalgp100 Melanoma AntigenLung InjuryCarcinoma, Small CellCell ProliferationAntigens, NeoplasmLeukemia P388PrognosisAntigens, CD15Neoplasm StagingTetrahydrouridineLung TransplantationCell DivisionApoptosisCarcinoma, BronchogenicCarcinoma, Transitional CellRNA, MessengerColonic NeoplasmsChoroid NeoplasmsLeukemia L1210Nevus, PigmentedCell SurvivalMice, Inbred BALB CReverse Transcriptase Polymerase Chain ReactionLymphatic MetastasisCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticFucosyltransferasesProto-Oncogene Proteins B-rafBreast NeoplasmsCarcinoma, MedullaryTime FactorsTumor BurdenAcute Lung InjuryTransplantation, HeterologousCell MovementCarcinoma, LobularCell AdhesionCarcinoma, NeuroendocrineThyroid NeoplasmsNasopharyngeal NeoplasmsMelanoma-Specific AntigensMolecular Sequence DataMonophenol MonooxygenaseMART-1 AntigenCell LineDose-Response Relationship, DrugAngiogenesis InhibitorsDNA, NeoplasmDisease ProgressionTransfectionCarcinoma, AdenosquamousNitrosourea CompoundsHead and Neck NeoplasmsMopidamolImmunoenzyme TechniquesAntibodies, MonoclonalNeoplasmsSurvival AnalysisCisplatinBlotting, WesternSyndecan-2ImmunotherapySurvival Rate
Renal cell carcMetastaticTumorsAdenocarcinomaChromophobe renal carcinomaMetastasisSquamous cell carcMetastasesC57BLMiceHepatocellularCancersPrognosisCystsCellsTumor growthNSCLCLesionsCommonlyImmunohistochemistryMalignanciesMurineBromelainCancerPatientsFibroblastsTissuesDiseasesImmuneOncologyDiagnosticExpressionMultiplePrimary
Renal cell carc4
  • Bilateral renal cell carcinoma in the Birt-Hogg-Dubé syndrome. (medscape.com)
  • Lin Z, Gong K, Pang B, Zeng C, Zhang D. Birt-Hogg-Dubé syndrome with clear cell renal cell carcinoma in a Chinese family. (medscape.com)
  • Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series. (medscape.com)
  • Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant disorder clinically manifested by fibrofolliculomas, renal cell carcinoma, lung cysts, and spontaneous pneumothorax. (medscape.com)
Metastatic6
  • Here, we examined the anti-lung-metastatic effects and the mechanism of lycopene in combination with sorafenib in C57BL/6 mice xenografted with Lewis lung carcinoma (LLC) cells. (frontiersin.org)
  • The results showed that lycopene reduced the number of metastatic tumors in the lungs, which was further suppressed by the combined treatment with sorafenib. (frontiersin.org)
  • reported that transgenic expression of IL-33 may activate CD8(+) T cells and NK cells, and inhibit tumor growth and metastasis in B16 melanoma and Lewis lung carcinoma metastatic models ( 12 ). (frontiersin.org)
  • Melanoma Filgotinib may be the many aggressive epidermis tumor with high metastatic potential. (biospraysehatalami.com)
  • The earliest attempt of TIL therapy in the clinic can be traced back to 1988 and achieved a 60% objective response rate (ORR) in metastatic melanoma [ 1 ]. (biomedcentral.com)
  • Locally advanced or metastatic hepatocellular carcinoma (HCC). (medscape.com)
Tumors8
  • Methods To evaluate synergy between ICB (anti-CTLA-4 and anti-PD-1 or anti-PD-1 and anti-Lag-3) and VLA-4 integrin blocker, once mice with B16 melanoma, Lewis lung carcinoma (LLC) or pancreatic adenocarcinoma (PAN-02) had developed tumors of approximately 20mm 2 , they were treated with either IgG control, VLA-4 blocker, ICB, or combination of both therapies together. (bmj.com)
  • The antineoplastic activity of an organometallic complex of ruthenium(II), [cis-RuCl2(DMSO)4]o, has been examined in comparison with that of cis-PDD, using three metastasizing tumors of the mouse: Lewis lung carcinoma, B16 melanoma and MCa mammary carcinoma. (units.it)
  • cis-RuCl2(DMSO)4]o significantly reduces primary tumor growth in all the tumors tested, and its activity is similarly pronounced at three different dosages in mice bearing Lewis lung carcinoma. (units.it)
  • The antineoplastic activity of cis-PDD appears to be less pronounced than that of [cis-RuCl2(DMSO)4]o, and is limited to mice bearing B16 melanoma, which, among the three tumors used, appears to be naturally more responsive to cis-PDD and [cis-RuCl2(DMSO)4]o. (units.it)
  • Aside from having a pleasant scent and forcing cancer cells to commit suicide, researchers have discovered that it also inhibits the development of tumors in the digestive tract, on the skin, colon, lung, and possibly even in the ovaries. (cancerdoctor.com)
  • Multiple or bilateral renal carcinomas have been reported in association with this syndrome, most commonly hybrid oncocytic tumors with features of chromophobe renal carcinoma (50%), followed by chromophobe renal cancer, clear cell renal carcinoma, and renal oncocytoma. (medscape.com)
  • Lewis observed: "The August 2021 FDA approval of belzutifan for vHL [Von Hippel-Lindau syndrome]-associated tumors was a landmark in the treatment of hereditary cancer syndromes and it's plausible that the drug's mechanism of action can be used to exploit other tumors with deranged angiogenesis. (medscape.com)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
Adenocarcinoma5
Chromophobe renal carcinoma1
  • Multiple or bilateral renal carcinomas, commonly chromophobe renal carcinoma and renal oncocytomas, and rarely, clear cell renal carcinomas have been reported in association with this syndrome. (medscape.com)
Metastasis7
  • Main methods: Anticancer activity of the I. obliquus extract was examined in mouse models of Lewis lung carcinoma growth and spontaneous metastasis after 3 weeks of continuous extract intake at the dose of 6 mg/kg/day, which corresponded to that ingested daily with Chaga infusion in Japan. (researchgate.net)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
  • Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU. (greenmedinfo.com)
  • In studies on mouse mammary carcinoma, the IL-33/ST2 pathway promotes BC progression and metastasis through increased intratumoral accumulation of immunosuppressive cells and by diminishing innate anti-tumor immunity ( 11 ). (frontiersin.org)
  • and studies with a pulmonary metastasis model have indicated that l-NAME, a methyl ester of NNLA, increased the number of metastases induced by Lewis lung carcinoma and B16 melanoma cells [29]. (e-core.org)
  • In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
Squamous cell carc2
  • The objective of this study was to determined whether SAA level could be used as a prognostic parameter in patients with esophageal squamous cell carcinoma (ESCC). (biomedcentral.com)
  • A previous study in sera from patients with esophageal squamous cell carcinoma (ESCC) that used mass spectrometry and proteomic technologies found that SAA was upregulated and could be used to differentiate patients from healthy individuals [ 18 ]. (biomedcentral.com)
Metastases1
  • Uterine leiomyosarcoma (ULMS) and endometrial stromal sarcoma (ESS) are among the most frequent uterine sarcomas, which, in adults, lead to fatal lung metastases and patients have an extremely poor prognosis (Tsuyoshi and Yoshida 2018 ). (biomedcentral.com)
C57BL3
Mice4
  • On the host side, antibiotic-induced dysbiosis caused elongated small intestines and ceca, and B16-F10 melanoma and Lewis lung carcinoma progressed more quickly than in control mice. (aacrjournals.org)
  • The antitumor aftereffect of PSB1115 had not been seen in melanoma-bearing nude mice. (biospraysehatalami.com)
  • The Filgotinib development of Lewis lung carcinoma was low in A2bR-deficient mice in comparison to that Filgotinib in wild-type handles. (biospraysehatalami.com)
  • Using a syngeneic B16F1 melanoma model in wild type and ADAMTS1 knockout mice we found distinct stroma versus tumor functions for this protease. (oncotarget.com)
Hepatocellular2
  • Recent studies demonstrated that high serum levels of soluble ST2 (sST2) are a worse prognostic factor in hepatocellular carcinoma ( 9 ), and that serum IL-33 is a diagnostic and prognostic marker in non-small cell lung cancer, independent of the therapeutic intervention ( 10 ). (frontiersin.org)
  • Reducing Postoperative Recurrence of Early-Stage Hepatocellular Carcinoma by a Wound-Targeted Nanodrug. (ucas.ac.cn)
Cancers7
  • According to the World Health Organization, lung cancer has the highest mortality rate of all cancers. (frontiersin.org)
  • TIL-based treatments hold great promise in improving outcomes for many types of cancers, including melanoma and ovarian cancer. (blogsunit.com)
  • Afatinib is a medication that has shown potential in treating several advanced cancers, including those of the lung and breast. (blogsunit.com)
  • The morbidity of lung cancer ranks first among all cancers. (biomedcentral.com)
  • Lung cancer is a recognized human health killer, with its mortality ranks first among all cancers for several years (about 11.6% in 2018) and its morbidity is relatively high [ 1 ]. (biomedcentral.com)
  • It can pick up early lung cancers and can reduce mortality from lung cancer by about 20%, but a large number of the early lesions that are seen probably never would go on to being lethal cancer and being able to discriminate between those that will cause trouble and those that won't make a huge difference in cancer therapy. (bigthink.com)
  • Lewis commented: "Few GI malignancies have seen their therapeutic paradigm shift more in recent years than biliary tract cancers, but immunotherapy and MEK inhibition have yet to yield the same dividends in BTC as they have in melanoma. (medscape.com)
Prognosis3
  • Yet in most situations of advanced melanoma the prognosis continues to be dismal and the existing scientific challenge would be to further enhance the efficiency of melanoma therapy. (biospraysehatalami.com)
  • Although great efforts have been devoted to developing new treatment of lung cancer in recent years, the prognosis of malignant patients remains poor with a 5-year survival rate less than 10% [ 5 , 6 ]. (biomedcentral.com)
  • It was noted that in clinical samples of breast cancer, ALDH + accounted for 39.4% in samples of BLBC, and similar results were obtained in studies on breast cancer cell lines [ 7 ] , while lower expression was observed in intraductal carcinoma and luminal type with better prognosis [ 8 ] . (ijbs.com)
Cysts1
  • Further, the study demonstrated 24% of Birt-Hogg-Dubé syndrome patients and 34% of Birt-Hogg-Dubé syndrome family members screened for lung cysts had a history of spontaneous pneumothorax. (medscape.com)
Cells5
  • and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (issca.us)
  • We assume that the immune system at least at that time point, was powerful enough to get that melanoma on the skin surface to go away, yet, it had already spread its cancer cells throughout the body and those then grow and the immune system at that time point is not able to handle it. (bigthink.com)
  • Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. (nature.com)
  • 43] Additionally, knockdown of slingshot 2 (SSH2) serine phosphatase was demonstrated to induce caspase 3/7 activation that can trigger apoptosis in human carcinoma cells with a FLCN mutation. (medscape.com)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
Tumor growth1
  • Basically, Afatinib 30mg tablet uses for treating lung cancer by blocking certain molecules that promote tumor growth. (blogsunit.com)
NSCLC1
  • However, the mechanisms involved in CDK7-mediated immune evasion are unclear in non-small cell lung cancer (NSCLC). (biomedcentral.com)
Lesions2
  • PSB1115 treatment decreased both known degrees of IL-10 and MCP-1 and Compact disc11b+Gr1+ cellular number in melanoma lesions. (biospraysehatalami.com)
  • Well for example it's very likely that early breast lesions that are called introductoral carcinomas called in situ lesions frequently will probably never progress and we need ways to be able to predict which will and which won't progress. (bigthink.com)
Commonly1
Immunohistochemistry1
  • In this study, we aim to determine the serum level and to detect the expression of IL-33 in human tissues in patients with breast carcinoma, using Luminex-based measurements and immunohistochemistry, to further explore the role of IL-33 in anti-tumor immunity in BC. (frontiersin.org)
Malignancies1
  • Immunotherapy shows guarantee in preclinical and scientific studies and presently melanoma is normally among few malignancies that there's a Meals and Medication Administration (FDA)-accepted immunotherapeutic agent ipilimumab [14-17]. (biospraysehatalami.com)
Murine1
  • Murine breast carcinoma models suggest disruption of ST2 signaling may enhance the anti-tumor immune response, suggesting IL-33 impedes anti-tumor immunity. (frontiersin.org)
Bromelain1
  • With the exception of MB-F10 melanoma, all other tumor-bearing animals had a significantly increased survival index after bromelain treatment. (greenmedinfo.com)
Cancer8
  • In the United States, statistics from 2013 to 2018 show that men account for approximately 46.9% of lung cancer and women account for 32.0% ( 1 ). (frontiersin.org)
  • The combination was used to treat mouse syngenic cancer models: MBT-2 bladder transitional cell carcinoma, B16-F10 melanoma and LL/2 Lewis lung carcinoma. (spandidos-publications.com)
  • In cancer tissues, expression of IL-33 was higher than matched normal breast tissues from the same patients, and was also associated with a well-differentiated phenotype, HER2 overexpression, more lymph nodes involvement, and a family history of malignant carcinoma. (frontiersin.org)
  • The data from this study identify a new class of compounds, NOS inhibitors, especially the iNOS inhibitors (in addition to their other desirable biologic activities described above) as effective chemopreventive brokers that can be designed as brokers for lung cancer prevention. (e-core.org)
  • This review article is based on the therapeutic outcomes of polymer-drug conjugates against breast and lung cancer. (mdpi.com)
  • Although our understanding of the function of A2bR to advertise cancer development keeps growing the antitumor activity of A2bR blockade in melanoma is not looked into. (biospraysehatalami.com)
  • Combination of IL-2/15/21 can enhance TIL expansion in lung and colorectal cancer and promote CD8+ T cell percentage as well as TCR clone diversity compared to IL-2 alone [ 13 ]. (biomedcentral.com)
  • After a quality assessment, the monthly numbers of newly diagnosed cancer cases were extracted for six cancer types: colorectal, female breast, lung, pancreas, prostate, and thyroid. (cdc.gov)
Patients2
  • In patients with mammary carcinoma, Koç et al. (issca.us)
  • The data were confirmed in patients with liver cirrhosis using 111In-oxine labeled MSCs, which were found to first accumulate in the lungs followed by continuous increases in liver and spleen up to day 10 after administration [14]. (issca.us)
Fibroblasts1
  • Interleukin-33 (IL-33) is an important member of the IL-1 family, and in humans is expressed predominantly in skin, lung, adipocytes, and synovial fibroblasts ( 4 ). (frontiersin.org)
Tissues1
  • 35] Expression of the Birt-Hogg-Dubé syndrome protein has been widespread in a variety of tissues, including the kidneys, lungs, and skin. (medscape.com)
Diseases1
  • The second query, which used a signature of silencing of the transcription factor p63 (a key regulator of epidermal differentiation), identified datasets related to stratified squamous epithelia or epidermal diseases such as melanoma. (biomedcentral.com)
Immune2
  • immune system suppression within the tumor microenvironment resulting in a substantial melanoma development delay. (biospraysehatalami.com)
  • Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC: Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma. (exbio.cz)
Oncology1
  • Mark Lewis, MD, director of GI oncology at Intermountain Healthcare in Murray, Utah, and a regular Medscape contributor, was approached for comment on this study. (medscape.com)
Diagnostic1
  • Inhaling a prescription form of N-acetyl cysteine is helpful to prepare people for diagnostic lung tests. (medlineplus.gov)
Expression2
  • Carcinoma demonstrating CD3 expression in new vessels. (compbio.com)
  • In addition, ex-vivo assays supported a chief role for ADAMTS1 in vascular sprouting, and melanoma xenografts showed a relevant induction of its expression in stroma compartments. (oncotarget.com)
Multiple1
  • This tripartite approach aims to target multiple pathways simultaneously in a histology-agnostic fashion," said Lewis. (medscape.com)
Primary1
  • Author Manuscript diagnosed with a primary invasive carcinoma, identified through the annual linkages of the CTS to the CCR, after joining the cohort and before January 1, 2012. (cdc.gov)