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  • nevus
  • Although melanoma ultimately progresses to a highly aggressive and metastatic disease that is typically resistant to currently available therapy, it often begins as a benign nevus consisting of a clonal population of hyperplastic melanocytes that cannot progress because they are locked in a state of cellular senescence. (nih.gov)
  • The term nevus is applied to a number of conditions caused by neoplasias and hyperplasias of melanocytes, as well as a number of pigmentation disorders, both hypermelanotic (containing increased melanin, the pigment responsible for skin color) and hypomelanotic (containing decreased melanin). (wikipedia.org)
  • significantly
  • Moreover, in the absence of p16 depletion or exogenous oxidative insult, melanocytes exhibited significantly higher basal levels of reactive oxygen species (ROS) than these other epidermal cell types. (hindawi.com)
  • known
  • Here we review what is known about melanocyte senescence, and how such knowledge may provide a much-needed edge in our struggles to contain or perhaps vanquish this often-fatal malignancy. (nih.gov)
  • Melanocyte-inhibiting factor (also known as Pro-Leu-Gly-NH2, Melanostatin, MSH release-inhibiting hormone or MIF-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body. (wikipedia.org)
  • activity
  • The symptoms of type II Griscelli syndrome have shown that Rab27 is involved in melanosome transport in melanocytes and in cytotoxic killing activity in cytotoxic T lymphoblasts. (wikipedia.org)
  • role
  • Given the role of oxidative stress in melanoma development, we speculated that this increased susceptibility of melanocytes to oxidative stress (and greater reliance on p16 for suppression of ROS) may explain why genetic compromise of p16 is more commonly associated with predisposition to melanoma rather than other cancers. (hindawi.com)
  • level
  • E. p16-deficient melanocytes at the same passage level as in A and B by bright field microscopy (no SA-β-gal staining). (nih.gov)
  • presence
  • Here we show that the presence of melanin accounts for this differential oxidative stress in normal and p16-depleted melanocytes. (hindawi.com)
  • E ditor ,-Although the presence of melanocytes located within and under the epithelium of the nasal cavity and paranasal sinuses has been reported, it appears to be a rare finding. (bmj.com)