• Vitiligo
  • The purpose of this study is to evaluate the hypothesis that, in patients with stable vitiligo unresponsive to conventional treatments including traditional phototherapy and/or topical steroids, the application of a non-cultured autologous hair follicle outer-root-sheath melanocytes suspension in the area affected by the disease followed by targeted ultraviolet B (UVB) phototherapy can lead to a significant skin repigmentation. (clinicaltrials.gov)
  • The treatment consists in depositing a suspension of autologous outer-root-sheath melanocytes, derived from patient's plucked hair follicles, and patient's own serum on the area affected by vitiligo, after properly preparation with dermabrasion. (clinicaltrials.gov)
  • Variations in genes that are part of the immune system or part of melanocytes have both been associated with vitiligo. (wikipedia.org)
  • receptor
  • People with red hair usually have a variant form of the receptor protein on the melanocyte surface, and their variant form often is unable to respond to MSH, which explains why red-headed individuals rarely tan. (cosmeticsandtoiletries.com)
  • Alpha-MSH is a cleavage product of ACTH that has an equal affinity for the MC1 receptor on melanocytes as ACTH. (wikipedia.org)
  • eumelanin
  • The difference in skin color between lightly and darkly pigmented individuals is due not to the number (quantity) of melanocytes in their skin, but to the melanocytes' level of activity (quantity and relative amounts of eumelanin and pheomelanin). (wikipedia.org)
  • protein
  • Loss of Slp2-a protein also induced a change in melanocyte morphology, from their normal elongated shape to a more rounded shape, which depended on the phospholipid-binding activity of Slp2-a, but not on its Rab27A-binding activity. (nih.gov)
  • migration
  • The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential. (hindawi.com)
  • known
  • Melanocyte-inhibiting factor (also known as Pro-Leu-Gly-NH2, Melanostatin, MSH release-inhibiting hormone or MIF-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body. (wikipedia.org)
  • presence
  • E ditor ,-Although the presence of melanocytes located within and under the epithelium of the nasal cavity and paranasal sinuses has been reported, it appears to be a rare finding. (bmj.com)
  • Results
  • CONCLUSION: These results suggest that MKK6 is an authentic regulator for melanocytes dendricity, through the modulation of Rho family GTPases. (uniprot.org)