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  • chromosomal
  • Pch2 impacts multiple aspects of meiotic chromosome metabolism, including negative regulation of Hop1 chromosomal abundance. (csic.es)
  • In this study, we identified additional proteins that act at the nuclear periphery from meiotic cell extracts, including Nup2, a nonessential nucleoporin with a known role in tethering interstitial chromosomal loci to the nuclear pore complex. (genetics.org)
  • spindles
  • In addition, apyrene meiotic spindles are missing a subset of microtubules, which likely include kinetochore microtubules. (jax.org)
  • genes
  • Theophilus Shickel Painter (August 22, 1889 - October 5, 1969) was an American zoologist best-known for his work on the structure and function of chromosomes, especially the sex-determination genes X and Y in humans. (wikipedia.org)
  • checkpoint
  • We are studying this meiotic checkpoint at different levels. (csic.es)
  • Pch2 is an evolutionarily conserved AAA+ ATPase initially discovered as a checkpoint protein required for the zip1-induced meiotic arrest in budding yeast. (csic.es)
  • Taken together, these observations imply that Pch2 activity is required for proper accumulation of phosphorylated Hop1-T318 on unsynapsed chromosome axes and argue that Pch2 regulates Hop1 in different and even opposite manners in a wild type (checkpoint off) versus a zip1 (checkpoint on) situation. (csic.es)
  • Therefore the unsynapsed chromosomes in Spo11 cells can be a target of checkpoint. (wikipedia.org)
  • homology
  • In placental mammals, the X and Y chromosomes share homology only in the pseudoautosomal regions (PAR). (biomedcentral.com)
  • Sex chromosome homology in the asynaptic and occasionally synaptic species is interspersed along chromosomes and largely restricted to low-complexity sequences, including a striking enrichment for the telomeric repeat sequence, TTAGGG. (genetics.org)
  • In contrast, homology is concentrated in high complexity, and presumably euchromatic, sequence on the X and Y chromosomes of the synaptic vole species, M. montanus . (genetics.org)
  • localization
  • thus, the pch2 single mutant exhibits more continuous Hop1 localization along synapsed chromosomes. (csic.es)
  • Localization of Nup2-MAR to meiotic chromosomes does not require Ndj1, nor does Ndj1 localization require Nup2, suggesting these proteins function in different pathways, and their interaction is weak or indirect. (genetics.org)
  • subset
  • We identified a previously uncharacterized 125 aa region of Nup2 that is necessary and sufficient for its meiotic function, thus behaving as a meiotic autonomous region (MAR). Nup2-MAR forms distinct foci on spread meiotic chromosomes, with a subset overlapping with Ndj1 foci. (genetics.org)
  • microtubules
  • The conserved kinases Mps1 and Ipl1/Aurora B are critical for enabling chromosomes to attach to microtubules such that partner chromosomes will be segregated correctly from each other, but the precise roles of these kinases have been unclear. (sciencemag.org)
  • thus
  • HOP1 overexpression restored full Mek1 activation in zip1 pch2, thus explaining the reestablishment of the meiotic block. (csic.es)