• This process, called recombination, where pairs of homologous chromosomes-one paternal and one maternal-break, and equal segments are swapped, increases genetic diversity in offspring because the chromosomes at the end of meiosis differ both from the parent and from each other. (stowers.org)
  • Specific regions along the short arms of chromosomes 13, 14, 15, 21, and 22 are remarkably similar, indicating that recombination is occurring between chromosomes of mismatched pairs (for example, chromosomes 13 and 14 are exchanging information). (stowers.org)
  • The authors termed these "pseudohomologous" regions, to indicate that although they occur on different chromosomes, during meiotic recombination, they exchange sequences with other members of the acrocentric chromosome community as if they were homologs, or true pairs. (stowers.org)
  • Morgan, Sturtevant, Bridges and Muller constructed the first genetic linkage maps from recombination studies in crosses made in the fruit fly and from cytological preparations of its polytene salivary gland chromosomes [ 4 - 6 ]. (biomedcentral.com)
  • PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
  • Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs), generated by SPO11 and accessory proteins (de Massy 2013 ). (springer.com)
  • Meiotic recombination introduces variation around that expectation (Mendelian noise) and related pedigree founders systematically bias Pedigree F downward. (nature.com)
  • Effects of meiotic recombination on Marker F were reversed, such that the same number of molecular markers yielded more precise estimates of GWIBD in zebra finches than in humans. (nature.com)
  • Homologous chromosome synapsis and recombination are key events that occur during meiotic prophase and result in the formation of chromatin structures called chiasmata. (uni-goettingen.de)
  • Kinesins and cytoplasmic dyneins play essential roles in intracellular transport such as axonal transport and in the formation of the spindle apparatus and the separation of the chromosomes during mitosis and meiosis. (wikipedia.org)
  • 4. During meiosis, chromosomes pair up during the division. (yale.edu)
  • During meiosis, a type of cell division that gives rise to sperm and eggs, genetic material can be exchanged or swapped between two paired chromosomes. (stowers.org)
  • A model system where the targeting of the chromosomes to the spindle can be studied is meiosis I in the fission yeast Schizosaccharomyces pombe ( S. pombe ). (nature.com)
  • Mechanisms whereby chromosomes paired during meiosis may undergo unequal crossover resulting in Williams syndrome have typically been thought to result from an unequal overlap of repetitive Alu sequences flanking the region, resulting in a type of misalignment of the chromosomal regions during a crossover event. (medscape.com)
  • Cyril Darlington pioneered plant cytogenetics in 1920-30 and made important advances in our understanding of mechanisms of chiasma formation and the behavior of sex chromosomes in meiosis [ 7 ]. (biomedcentral.com)
  • Meiosis begins with DNA replication and meiotic crossing over. (wikipedia.org)
  • As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
  • In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
  • Como primer paso, se estudio la viabilidad del polen y la meiosis en una muestra de 56 plantas. (sag.org.ar)
  • In normal conventional meiosis, the first meiotic division is reductional, resulting in segregation of chromosomal homologs, whereas the second meiotic division is equational, resulting in separation of sister chromatids. (frontiersin.org)
  • BACKGROUND: Meiosis-I is a unique type of chromosome segregation where each chromosome aligns and segregates from its homolog. (bvsalud.org)
  • Mammalian oocytes are maintained in meiotic prophase arrest for a very long time-months in mice, years in humans. (wikipedia.org)
  • this is due to higher rates of degeneration of germ cells during meiotic prophase. (iiab.me)
  • Here, we show that truncation of the KRAB domain of mouse PRDM9 leads to loss of PRDM9 function and altered meiotic prophase and gametogenesis. (springer.com)
  • Of particular biological significance, the short arms of acrocentric chromosomes contain the genes required for the synthesis of ribosomes and ribosomal RNA. (stowers.org)
  • Genes & Development, 22 (15). (sussex.ac.uk)
  • In 1944 it was realized that genetic transformation in bacteria was due to DNA and not protein and that DNA was the molecule responsible for heredity in genes and chromosomes [ 8 ]. (biomedcentral.com)
  • Thus, about 100 human "twin genes", were found in the Arabidopsis genome, including, those responsible for such severe diseases as cystic, fibrosis and breast cancer [50]. (centrocardiobogota.com)
  • With the human DNA probe, signals were detected in the major sites of the ribosomal genes on chromosomes 5I (7H) and 6I (6H) only when the chromosome preparations were obtained using an optimized technique with obligatory pepsin treatment followed by hybridization. (centrocardiobogota.com)
  • Genetic engineering deals with the manipulation of genes according to human will. (smartindia.net.in)
  • The early stages of human differentiation appear to be quite similar to the same biological processes in other mammals and the interaction of genes, hormones and body structures is fairly well understood. (en-academic.com)
  • The various ways that genes, hormones, and upbringing affect different human behaviors and mental traits are difficult to test experimentally and charged with political conflict. (en-academic.com)
  • Investigation of other cases of human sex reversal ( XX males , XY females ) has led to discovery of other genes crucial to testicular differentiation on autosomes (e.g. (en-academic.com)
  • AceView: gene:him-8, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
  • Fission yeast is a single-celled organism with chromosomes very similar to those in humans, and uses the same genes to maintain those chromosomes. (usc.edu)
  • Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. (animbiosci.org)
  • Accurate duplication and segregation of our chromosomes is critical for human development and well-being. (usc.edu)
  • Kovacikova Ines, Polakova Silvia, Benko Zsigmond, Čipák Ľuboš, Zhang Lijuan, Rumpf Cornelia, Miadokova Eva, Gregan Juraj: A knockout screen for protein kinases required for proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe. (sav.sk)
  • The expression of these proteins in mitotically dividing cells caused co-orientation of the chromosomes, which lead to the cell death followed by miss-segregation of chromosomes. (bvsalud.org)
  • Note especially the second meiotic division in oogenesis. (yale.edu)
  • 3. The second meiotic division is completed only if occurs. (yale.edu)
  • Professor Forsburg studies how chromosome duplication and maintenance contributes to overall genome stability using a simple model genetic system, the fission yeast Schizosaccharomyces pombe . (usc.edu)
  • Fission yeast is a simple, single-celled organism with chromosomes very similar to those in humans, and has proven to be an important model for cell division. (usc.edu)
  • The mechanisms of transmission of both discontinuous and continuous characteristics across the generations were unknown before Mendel's laws were explained at the turn of the 20th Century by the behavior of chromosomes in germ cells [ 2 , 3 ]. (biomedcentral.com)
  • These data demonstrate that MAP3K4-dependent signalling events are required for normal expression of Sry during testis development, and create a novel entry point into the molecular and cellular mechanisms underlying sex determination in mice and disorders of sexual development in humans. (plos.org)
  • Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R, Brown PO "Transcriptional program induced by wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. (openwetware.org)
  • 2013 ). Interestingly, the molecular mechanisms underlying the patterning of meiotic DSBs are quite distinct in different species with apparently two major pathways. (springer.com)
  • Mechanisms and consequences of small supernumerary marker chromosomes: from Barbara McClintock to modern genetic-counseling issues. (upd-tl.com)
  • New research published in Nature on May 10, 2023, assembled 94 human genomes to investigate natural genetic variation between humans. (stowers.org)
  • Artificial intelligence (AI) represents a set of technologies that includes automated systems able to perform tasks that normally require human intelligence, such as visual perception, speech recognition, and decision-making (source: GAO 2023). (bayareascience.org)
  • Human reproduction open 2022 12 2023 (1): hoac055. (cdc.gov)
  • Over 200 different proteins are associated with chromatin [ 15 ]. (biomedcentral.com)
  • 2009 ). At a larger scale, DSB formation occurs in the context of a specific chromosome architecture that consists of chromatin loops anchored to a proteinaceous axis (Zickler and Kleckner 1999 ). (springer.com)
  • DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
  • They are vital to spindle formation in mitotic and meiotic chromosome separation during cell division and are also responsible for shuttling mitochondria, Golgi bodies, and vesicles within eukaryotic cells. (wikipedia.org)
  • Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division. (wikipedia.org)
  • The karyological studies are usually made during mitosis, though the chromosome structure and details can also be best done in meiotic preparations. (smartindia.net.in)
  • These analyses are fundamental in the design of control specimens present C-heterochromatic blocks in most of campaigns because their results will help determine the their 22 chromosomes, whereas non-Andean specimens have only 4-7 autosomes with C-banding. (cdc.gov)
  • pairs of autosomes and 1 pair of sex chromosomes (XY in Institut de Recherche pour le Développement, Montpellier, males, XX in females) (8). (cdc.gov)
  • A Series of supernumerary small ring marker autosomes identified by FISH with chromosome probe arrays and literature review excluding chromosome 15. (upd-tl.com)
  • Meiotic DSBs are not randomly distributed within the genome but mostly occur at discrete regions, called hotspots (Baudat et al. (springer.com)
  • In Saccharomyces cerevisiae , meiotic DSBs preferentially occur at nucleosome-depleted regions in gene promoters (Ohta et al. (springer.com)
  • Indeed, in the absence of PRDM9, meiotic DSBs occur at transcription regulatory regions, such as promoters and enhancers (Brick et al. (springer.com)
  • Shown is the order of regions of interest for human cytoplasmic dynein 2 motor domains as they occur from the linker to C-terminal. (wikipedia.org)
  • Chromosomal dynamics of human neocentromere formation. (upd-tl.com)
  • Trisomy 18 , also known as Edwards syndrome , is a genetic disorder caused by the presence of a third copy of all or part of chromosome 18 . (wikipedia.org)
  • [3] Occasionally, not all cells have the extra chromosome, known as mosaic trisomy , and symptoms in these cases may be less severe. (wikipedia.org)
  • Trisomy 18 is a chromosomal abnormality characterized by the presence of an extra copy of genetic material on the 18th chromosome, either in whole ( trisomy 18) or in part (such as due to translocations ). (wikipedia.org)
  • Trisomy 18 occurs in all human populations, but is more prevalent in female offspring. (wikipedia.org)
  • Trisomy of chromosome 5 is one of the most severe forms of autosomal trisomy and only seven cases of mosaic trisomy 5 have been reported to date. (thieme-connect.com)
  • A prenatal diagnosis of mosaic trisomy 5 reveals a postnatal complete uniparental disomy of chromosome 5 with multiple congenital anomalies. (thieme-connect.com)
  • Genomic representation of myosin motors: Fungi (yeast): 5 Plants (Arabidopsis): 17 Insects (Drosophila): 13 Mammals (human): 40 Chromadorea ( nematode C. elegans): 15 Kinesins are a superfamily of related motor proteins that use a microtubule track in anterograde movement. (wikipedia.org)
  • Genomic representation of kinesin motors: Fungi (yeast): 6 Plants (Arabidopsis thaliana): 61 Insects (Drosophila melanogaster): 25 Mammals (human): 45 Dyneins are microtubule motors capable of a retrograde sliding movement. (wikipedia.org)
  • Since the genetic code was deciphered much has been learnt about the chromosome structure shared by all organisms from yeast to human. (biomedcentral.com)
  • We also generated genome-specific term association networks for yeast and human. (biomedcentral.com)
  • One locus important in embryogenesis, KIT , has been associated with white coat patterns in several mammalian species and piebaldism in humans. (creation.com)
  • Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
  • Phylogenomic studies using chromosome painting confirms the high conservation of DNA between even distantly related species [ 13 ]. (biomedcentral.com)
  • However, some species, especially plants and animals with holocentric chromosomes, are known to tolerate chromosomal heterozygosity even for multiple rearrangements. (frontiersin.org)
  • We argue that the observed process of chromosome sorting would, if continued, result in a new homozygous chromosomal race, i.e., in a new karyotype with intermediate chromosome number and, possibly, in a new incipient homoploid hybrid species. (frontiersin.org)
  • Termed human acrocentric chromosomes, these have asymmetric arm lengths, with one short arm and one long arm, compared with the remaining chromosomes. (stowers.org)
  • Human pangenome graph of the five acrocentric chromosomes with lines representing sequences with few variations and loops representing sequences with duplications and inversions. (stowers.org)
  • Group G : This group comprises the very short acrocentric chromosomes 21, 22 and Y belong to this category. (smartindia.net.in)
  • As part of this project, a novel chromosome translocation was identified, which provides a model for Robertsonian translocation. (usc.edu)
  • In some embodiments, the fitness is defined as a population genetic behavior, over multiple generations, of translocation chromosomes in populations comprising both translocation-bearing individuals and non-translocation-bearing individuals. (justia.com)
  • In some embodiments, the high frequency is defined as when translocation-bearing versions of chromosomes make up greater than about 90% of the total chromosomes in a population as compared to wild type versions of the chromosomes involved in generating the translocation. (justia.com)
  • In some embodiments, the rapid rate is defined as replacement of at least 90% of the wild type population chromosomes by the translocation-bearing altered insect population (translocation) after at most 5 generations. (justia.com)
  • These studies reaffirmed that chromosome structure and behavior in somatic and germ cell divisions were common to all plants and animals. (biomedcentral.com)
  • Here, we studied male meiotic chromosome behavior in four hybrid generations (F1-F4) between two chromosomal races of the Wood White butterfly Leptidea sinapis differentiated by at least 24 chromosomal fusions/fissions. (frontiersin.org)
  • These assemblies revealed patterns of genetic variation across chromosome regions which were previously inaccessible, letting us answer a longstanding question about the most common kind of chromosomal abnormality in humans. (stowers.org)
  • In order to distribute the genetic material equally, the cell forms a spindle, a precise micro-machine made of microtubules (MTs) to which all chromosomes have to be correctly targeted. (nature.com)
  • A number of scientific papers have been published indicating that LSD might cause structural changes in the chromosomes, genetic mutations, disturbances of embryonic development, and malignant degeneration of cells. (druglibrary.net)
  • The genetic controversy about LSD started in 1967 when Cohen, Marinello and Back (22) published a paper suggesting that LSD should be added to the list of substances capable of causing abnormalities in the chromosomes. (druglibrary.net)
  • Genetic diseases in human beings can be detected by this technique. (smartindia.net.in)
  • The pre- and postnatal genetic tests (noninvasive prenatal testing, array comparative genomic hybridization, karyotype in amniotic fluid cells, karyotype in peripheral blood, and uniparental disomy analysis) revealed the fetal chromosomal status and indicated etiology giving rise to the mosaicism, suggesting a prezygotic meiotic error corrected through late trisomic rescue in the zygote. (thieme-connect.com)
  • Chromosome Abnormalities and Genetic Counseling. (thieme-connect.com)
  • The fourth group consists of publications describing the consequences of LSD administration on the growth, development and differentiation of human and animal embryos. (druglibrary.net)
  • Group E : It consists of chromosomes 16,17 and 18. (smartindia.net.in)
  • For the first time, analysis of assemblies from the Human Pangenome Reference Consortium reveals how and when specific translocations-a piece of one chromosome breaks off and attaches or fuses to another-called Robertsonian translocations, can form. (stowers.org)
  • Robertsonian translocations are the most common type of chromosomal fusion in the human population, occurring in one in 1,000 individuals, and contribute to infertility and genomic abnormalities like those that cause Down syndrome. (stowers.org)
  • Identifying Balanced Chromosomal Translocations in Human Embryos by Oxford Nanopore Sequencing and Breakpoints Region Analysis. (cdc.gov)
  • Gonads (testes and ovaries) from adult insects (occa- sionally fifth-stage nymphs) were removed, fixed in ethano-acetic acid (3:1), and stored at -20°C. C-banding treatment was carried out on air-dried squash, as previous- ly described (13). (cdc.gov)
  • Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia. (upd-tl.com)
  • Small supernumerary marker chromosomes: cytogenetic identification, molecular characterization and correlation with the phenotype. (upd-tl.com)
  • The Human Genome Project-the complete sequencing of an individual genome-was a monumental milestone in modern biology. (stowers.org)
  • Adam Phillippy, Ph.D. , a collaborator at the National Human Genome Research Institute , added, "We did not anticipate this but it's a beautiful example of how curiosity and collaboration can lead to significant insights for human health. (stowers.org)
  • Diehn M, Bhattacharya R, Botstein D, Brown PO "Genome-Scale Identification of Membrane-Associated Human mRNAs. (openwetware.org)
  • results can serve as an important argument in favour of the proposal to develop a special program for sequencing the genome chromosomes and for, To estimate the possibility of plant genome mapping using human genome probes, the probes fluorescent in situ hybridization (FISH) of human 18S-28S rDNA (clon 22F9 from the LA-13NCO1 library) was carried out on chromosomes of the spring barleyHordeum vulgareL. (centrocardiobogota.com)
  • The creation of oogonia traditionally doesn't belong to oogenesis proper, but, instead, to the common process of gametogenesis , which, in the female human, begins with the processes of folliculogenesis , oocytogenesis, and ootidogenesis . (wikipedia.org)
  • The reproductive events in humans include the formation of gametes called gametogenesis, i.e., when the sperms in males, transfer into the female genital tract, and fusion with the female gametes which is called fertilisation leads to the formation of zygote. (careers360.com)
  • Investigation of the role of X chromosome inactivation and androgen receptor CAG repeat polymorphisms in patients with recurrent pregnancy loss: a prospective case-control study. (cdc.gov)
  • Confirmation of mosaicism and uniparental disomy in amniocytes, after detection of mosaic chromosome abnormalities in chorionic villi. (thieme-connect.com)
  • The future of molecular cytogenetics is likely to depend on a better knowledge of chromosome structure and function. (biomedcentral.com)
  • One of the purposes of this review is to encourage research into chromosome structure as this could help advance molecular cytogenetics. (biomedcentral.com)
  • Initially the arrest is due to lack of sufficient cell cycle proteins to allow meiotic progression. (wikipedia.org)
  • However, as the oocyte grows, these proteins are synthesized, and meiotic arrest becomes dependent on cyclic AMP . (wikipedia.org)
  • In mammals, whether an individual develops as a male or female depends on its sex chromosome constitution: those with a Y chromosome become males because of the development of the embryonic gonad into a testis. (plos.org)
  • The accuracy of chromosomal microarray testing for identification of embryonic mosaicism in human blastocysts. (thieme-connect.com)
  • Aberrant GLYAT expression is associated with human cancers, yet its role in cancer remains unknown. (sdbonline.org)
  • Soen Y, Mori A, Palmer TD, Brown PO "Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. (openwetware.org)
  • In transgenic XX mice (and some human XX males ), SRY alone is sufficient to induce male differentiation. (en-academic.com)
  • Telomeres specialized structures found at the ends of chromosomes are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. (cshlpress.com)
  • Humans have 23 pairs of chromosomes -the DNA/protein complex with two arms extending from the centromere, a region approximately at the center of the arms where duplicated chromosomes are held together prior to cell division. (stowers.org)
  • Cell Reports, 13 (10). (sussex.ac.uk)
  • Palmer C, Diehn M, Alizadeh AA, Brown PO "Cell-type specific gene expression profiles of leukocytes in human peripheral blood. (openwetware.org)
  • In the following table, ploidy, copy number and chromosome/chromatid counts listed are for a single cell, generally prior to DNA synthesis and division (in G 1 if applicable). (iiab.me)
  • The water diffuses into the cell and separates the chromosomes. (smartindia.net.in)
  • ISCN 2016: an International System for Human Cytogenomic Nomenclature. (thieme-connect.com)
  • No. 15/164,452, filed May 25, 2016, which claims the benefit of U.S. Provisional Application 62/166,281 filed on May 26, 2015, which is hereby incorporated by reference in its entirety. (justia.com)
  • Forty-two supernumerary marker chromosomes (SMCs) in 43 273 prenatal samples: chromosomal distribution, clinical findings, and UPD studies. (upd-tl.com)
  • A study of ten small supernumerary (marker) chromosomes identified by fluorescence in situ hybridization (FISH). (upd-tl.com)
  • Zvarik Milan, Martinický Dávid, Hunáková Ľubica, Šikurová Libuša: Fluorescence characteristics of human urine from normal individuals and ovarian cancer patients. (sav.sk)
  • mutant HIM-8 fails to suppress mutant egl-13 on a free transgenic array, and also fails to suppress native mutant egl-13 if transgenic excess copies of the egl-13 promoter are present. (nih.gov)
  • Kučerová Lucia, Školeková Svetlana, Matúšková Miroslava, Bohac Martin, Kozovská Zuzana: Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells. (sav.sk)
  • Small supernumerary marker chromosomes (SMCs): genotype-phenotype correlation and classification. (upd-tl.com)
  • 4 Riegel M, Wisser J, Baumer A, Schinzel A. Postzygotic isochromosome formation as a cause for false-negative results from chorionic villus chromosome examinations. (thieme-connect.com)
  • In virtually all cases of Williams syndrome, haploinsufficiency (loss of 1 of 2 copies) due to a deletion at chromosome band 7q11.23 that involves the elastin gene ( ELN ) is implicated. (medscape.com)
  • Rubins KH, Hensley LE, Wahl-Jensen V, Daddario Dicaprio KM, Young H, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW "The temporal program of peripheral blood gene expression in the response of non-human primates to Ebola hemorrhagic fever. (openwetware.org)
  • Sood R, Zehnder JL, Druzin ML, Brown PO "Gene expression patterns in human placenta. (openwetware.org)
  • gene is mapped on the wheat chromosome 5B, but, neither obtaining a physical marker nor microdissec-, tion of this chromosomal region gave practical results, [56]. (centrocardiobogota.com)
  • It is obvious that the Y chromosome must carry at least one essential gene which determines testicular formation (originally termed TDF ). (en-academic.com)
  • Yet, to uncover what underlies our individuality, along with our similarities, a comprehensive understanding of human genetics requires a comparative approach from diverse datasets. (stowers.org)
  • One such report appeared on January 26, 2001 on the, Genetics, Inc. regulating chromosome pairing in polyploid plants. (centrocardiobogota.com)
  • The underlying etiology is believed to be unequal meiotic crossover events that lead to interstitial deletions. (medscape.com)
  • MTs interact with a chromosome via the kinetochore (KC), a large protein complex located at the centromere. (nature.com)
  • A new multicolor-FISH approach for the characterization of marker chromosomes: centromere-specific multicolor-FISH (cenM-FISH). (upd-tl.com)
  • Neocentromeres: role in human disease, evolution, and centromere study. (upd-tl.com)
  • 1. There are ___ chromosomes in human cells. (yale.edu)
  • 1977. Pesticide induced DNA damage and its repair in cultured human cells. (cdc.gov)
  • Kinetochore pairing may be a general feature that increases capture efficiency in meiotic cells. (nature.com)
  • Maintenance of meiotic arrest also depends on the presence of a multilayered complex of cells, known as a follicle, that surrounds the oocyte. (wikipedia.org)
  • Secondary spermatocytes are haploid (N) cells that contain half the number of chromosomes. (iiab.me)
  • 22) * After my arrival in the United States, I participated in a major study concentrating on structural changes of the chromosomes in the white blood cells following LSD administration. (druglibrary.net)
  • The first group includes papers describing structural changes of the chromosomes produced by LSD in vitro , ** in these experiments various concentrations of LSD are added to cultures of cells from human, animal, or plant tissues in a test-tube. (druglibrary.net)
  • The cells studied were in most cases human white blood cells (lymphocytes). (druglibrary.net)
  • It is present in bacterial cells alongside their main chromosomes. (smartindia.net.in)
  • Also, although there were only two humans, Eve may have carried alleles in her egg cells that differed from those in her body. (creation.com)
  • The development of the human blood-CSF-brain barrier. (cdc.gov)
  • The events that have led to the development of cytogenetics as a specialty within the life sciences are described, with special attention to the early history of human cytogenetics. (biomedcentral.com)
  • We predict that loss of MAP3K4 or other MAPK components may underlie disorders of sexual development (DSD) in humans as well. (plos.org)
  • This article is about the development of sexual dimorphisms in humans. (en-academic.com)
  • Development of a high-density pericentromeric region BAC clone set for the detection and characterization of small supernumerary marker chromosomes by array CGH. (upd-tl.com)
  • The additional chromosome usually occurs before conception . (wikipedia.org)