• As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
  • In this process, each sperm is haploid, containing a single copy of each chromosome.In order to create the haploid gamete, a cell undergoes the process of meiosis in which the genome is replicated and divided twice to produce four haploid gametes. (powtoon.com)
  • Nonrandom chromosome arrangements in germ line nuclei of Sciara coprophila males: the basis for nonrandom chromosome segregation on the meiosis I spindle. (rupress.org)
  • Meiosis I in males of the Dipteran Sciara coprophila results in the nonrandom distribution of maternally and paternally derived chromosome sets to the two division products. (rupress.org)
  • 2013. "A Wisp3 Cre-knockin Allele Produces Efficient Recombination in Spermatocytes during Early Prophase of Meiosis I." PLoS ONE 8 (9): e75116. (harvard.edu)
  • The only tissue that had high levels of Cre-mediated recombination was the testis, where recombination in spermatocytes occurred by early prophase of meiosis I. As a consequence, males that were double heterozygous for a Wisp3GFP-Cre and a floxed allele only contributed a recombined allele to their offspring. (harvard.edu)
  • We conclude that although WISP3 is dispensable in mice, male mice with a Wisp3GFP-Cre allele (Jackson Laboratory stock # 017685) will be useful for studying early prophase of meiosis I and for efficiently recombining floxed alleles that are passed to offspring. (harvard.edu)
  • During meiosis, germ cell and stage-specific components impose additional layers of regulation on the core cell cycle machinery to set up an extended G2 period termed meiotic prophase. (stanford.edu)
  • In Drosophila males, meiotic prophase lasts 3.5 days, during which spermatocytes upregulate of over 1800 genes and grow 25-fold. (stanford.edu)
  • Thus a set of spermatocyte-specific regulators choreograph the timing of expression of CycB protein during male meiotic prophase. (stanford.edu)
  • Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes. (riken.jp)
  • Although spermatocytes that divide mitotically and meiotically are sensitive to radiation and cancer , spermatogonial stem cells are not. (iiab.me)
  • Spermatogenesis is a complicated process involving mitotically proliferating spermatogonial cells, meiotically dividing spermatocytes, and spermatid going through maturation into spermatozoa. (bvsalud.org)
  • Beaded structure in spermatocyte nuclei spreads at pachytene and diplotene. (ed.ac.uk)
  • Gray bars indicate the germline cell types that are presented in the testes of bam or meiosis arrest mutants and contribute to the DamID and expression profiling experiments in this study. (biomedcentral.com)
  • As high throughput sequencing technology develops, a substantial number of lncRNAs have been found to be related to a variety of biological processes, such as development of the testes, maintaining the self-renewal and differentiation of spermatogonial stem cells, and regulating spermatocyte meiosis. (bvsalud.org)
  • On Thursday, Oct. 12, Associate Professor in the Department of Molecular Biosciences at Northwestern University Sadie Wignall shared her findings on the mechanisms oocytes employ to regulate spindles without centrosomes during meiosis. (jhunewsletter.com)
  • Primary oocytes and primary spermatocytes follow a similar pattern of development through meiosis. (pearson.com)
  • As a major part of differentiation, sperm undergo extensive post-meiotic maturation en route to the oocyte. (silverchair.com)
  • Immature sperm cells, known as spermatocytes, can get stuck part way through the chromosomal-sorting process called meiosis. (riken.jp)
  • Previous work showed that the cell cycle regulator Cyclin B (CycB) is subject to translational repression in immature spermatocytes, mediated by the RNA-binding protein Rbp4 and its partner Fest. (stanford.edu)
  • In practice, known sex ratio disruptors (citations very needed but no links here) work by destroying female chromasomes (for us it would be the X chromasome - I am going to be sloppy and call it the X chromasome from now on even though there are different letters used for different species) in spermatocytes (the diploid cells which will become spermatazoa through meiosis). (angrybearblog.com)
  • In situ hybridization analysis in adultmouse testis showed that tesmin is specifically expressed in spermatocytes.Quantitative RT-PCR at different stages of mouse postnatal development (days 4,8, 12, 18, and 42) revealed that tesmin is expressed as early as day 8 andcoincides with the entry of germ cells into meiosis. (embl.de)
  • The seminar , titled "Stabilizing a Dynamic Structure: Mechanisms that Maintain Acentrosomal Spindle Integrity During Oocyte Meiosis," was hosted by the Department of Biology at Hopkins for their seminar series. (jhunewsletter.com)
  • The events of meiosis I in a living insect spermatocyte beginning at metaphase with meiotic bivalents at the spindle equator followed by anaphase , segregation of bivalents to the spindle poles and t. (ucsd.edu)
  • Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. (shibuyahiroki.com)
  • A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. (shibuyahiroki.com)
  • Once spermatogonia enter the "differentiation" pathway, they become known as A1 spermatogonia in the mouse and A- pale spermatogonia in humans and begin a series of irreversible differentiation steps leading to meiosis and spermiogenesis ( 1 ) (Figure 1 ). (jci.org)
  • In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
  • The formation of primary spermatocytes (a process known as spermatocytogenesis) begins in humans when a male is sexually matured at puberty , around the age of 10 through 14. (iiab.me)
  • In males mutant for rbp4 or lut, spermatocytes enter and exit meiotic division 6-8 hours earlier than in wild-type. (stanford.edu)
  • Seminiferous tubules are located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. (ncertmcq.com)
  • Through a simple tweak to developing egg cells, RIKEN researchers have found a way to restore these abnormal spermatocytes and produce viable offspring. (riken.jp)
  • The egg adjustment also allowed for the production of pups from mouse spermatocytes containing a genetic defect linked to male infertility in humans. (riken.jp)
  • Here we show that the spermatocyte-specific protein Lut is required for translational repression of cycB in an 8-hour window just before spermatocytes are fully mature. (stanford.edu)
  • In addition, spermatocyte-specific isoforms of Syncrip (Syp) are required for expression of CycB protein in mature spermatocytes and normal entry into the meiotic divisions. (stanford.edu)
  • In some invertebrate species, BOULE protein play a pivotal role in germline specification and a conserved regulatory role in meiosis. (ijbs.com)
  • For example, in the mouse, NANOS2 plays a role in meiosis suppression by preventing Stra8 expression in male foetal gonads 4 . (nature.com)
  • Spermatocytes are a type of male gametocyte in animals. (iiab.me)
  • All male animals produce spermatocytes, even hermaphrodites such as C. elegans , which exist as a male or hermaphrodite. (iiab.me)
  • Flies lacking a 54 amino-acid region in the C terminus of Milton completely lacked mitoballs, had swollen mitochondria in their spermatocytes and showed reduced male fertility. (cam.ac.uk)