• Mice
  • We used mice lacking Runx1 specifically in megakaryocytes MK to characterized Runx1-mediated transcriptional program during advanced stages of MK differentiation. (duhnnae.com)
  • form
  • Platelet production begins with the extension of large pseudopodia from the megakaryocyte cell surface that form thin tube-like cytoplasmic extensions (with bulbous thickenings) called proplatelets. (sciencephoto.com)
  • cell
  • During megakaryocyte maturation the cell grows in size and replicates its DNA without cytokinesis, a process called endomitosis. (sciencephoto.com)
  • As a result, the nucleus of the megakaryocyte may contain up to 32 copies of the normal complement of DNA in a human cell. (sciencephoto.com)
  • Establishment of an ES cell-derived murine megakaryocytic cell line, MKD1, with features of primary megakaryocyte progenitors. (ox.ac.uk)
  • The cells are factor-dependent, their cell surface immunophenotype and gene expression profile closely resemble that of primary megakaryocyte progenitors (MkPs) and they further differentiate along the megakaryocyte lineage upon valproic acid treatment. (ox.ac.uk)