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  • precursor
  • Clearance of Heparin via Heparinases The various cell types of the mononuclear phagocyte system are all part of the myeloid lineage from the CFU-GEMM (precursor of granulocytes, erythrocytes, monocytes and megakaryocytes. (wikipedia.org)
  • Deletion
  • The 5q-syndrome is characterized by macrocytic anemia, often a moderate thrombocytosis, erythroblastopenia, megakaryocyte hyperplasia with nuclear hypolobation, and an isolated interstitial deletion of chromosome 5. (wikipedia.org)
  • receptor
  • Indeed, we demonstrate that megakaryocytes express the major candidates to mediate Store-Operated Calcium Entry, stromal interaction molecule 1, Orai1 and canonical transient receptor potential 1, which are activated upon either pharmacological or physiological depletion of the intracellular calcium pool. (haematologica.org)
  • anaphase
  • E) Megakaryocyte in anaphase A was stained with DAPI (a), anti-α-tubulin antibody (b), anticentromere antibody (c), or all three (d). (nih.gov)
  • nucleus
  • As a result, the nucleus of the megakaryocyte may contain up to 32 copies of the normal complement of DNA in a human cell. (sciencephoto.com)
  • Anticentriole antibody (Fig. 3 A, c) and anti-α-tubulin antibody (Fig. 3 A, b) stainings confirmed that multiple mitotic spindle poles were formed and assembled outside the nucleus in a megakaryocyte in prophase, as described above. (nih.gov)
  • As a result, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. (wikipedia.org)
  • nuclear
  • 1 The transition from proliferating to differentiating megakaryocytes is accompanied by loss of nuclear-associated acetylcholinesterase activity. (ahajournals.org)
  • With each replicative event, the entire DNA content is duplicated such that megakaryocytes have multiples of a normal diploid DNA content (i.e., 4N, 8N, 16N, 32N, etc., where 2N is the normal nuclear DNA content of a cell in G 0 /G 1 phase of the cell cycle). (rupress.org)
  • erythrocyte
  • It matures into the megakaryocyte, erythrocyte, mast cell or myeloblast based on the presence of specific factors that encourage the cell to choose a lineage to follow. (wikipedia.org)
  • HUMAN
  • Here we show that adenosine diphosphate elicits, in human megakaryocytes, an increase in cytosolic calcium concentration, followed by a plateau, which is lowered in absence of extracellular calcium, suggesting the involvement of Store-Operated Calcium Entry. (haematologica.org)
  • These findings provide the first evidence that both calcium mobilization from intracellular stores and extracellular calcium entry specifically regulate human megakaryocyte functions. (haematologica.org)