• 1 ] Anaphylaxis, a severe, life-threatening systemic hypersensitivity reaction,[ 2 ] results from the rapid systemic release of mediators from mast cells and basophils. (bcmj.org)
  • When an allergen couples with the IgE antibodies, histamine and other mediators of anaphylaxis are released from the mast cells and basophils. (anaphylaxis.org)
  • The World Allergy Organization defines "anaphylaxis" as an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell and basophil-derived mediators into the circulation. (worldallergy.org)
  • Nonimmunologic anaphylaxis" is caused by agents or events that induce sudden, massive mast cell or basophil degranulation in the absence of immunoglobulins. (worldallergy.org)
  • Anaphylaxis is defined as an acute life-threatening systemic event triggered by the sudden release of mediators from basophils and mast cells after exposure to a triggering agent. (medscape.com)
  • Anaphylaxis is an acute, life-threatening reaction, usually mediated by an immunologic mechanism involving immunoglobulin E, that results in sudden systemic release of mast-cell and basophil mediators such as histamine and tryptase. (aap.org)
  • Fc epsilon RI alpha is a transmembrane protein that associates with beta and gamma subunits to form the high affinity IgE receptor on basophils and mast cells. (rndsystems.com)
  • Immunoglobulin E (IgE, which is the primary mediator of food allergic reactions)-mediated food allergies are classified as Type I or immediate hypersensitivity. (usda.gov)
  • The symptoms usually depend on the disorder that is causing the change in the number of basophils, but increased numbers of basophils can cause itching and other allergic reactions. (merckmanuals.com)
  • An H 1 antagonist is a histamine antagonist of the H 1 receptor that serves to reduce or eliminate effects mediated by histamine , an endogenous chemical mediator released during allergic reactions . (wikidoc.org)
  • In allergic reactions, an allergen (a type of antigen ) interacts with and cross-links surface IgE antibodies on mast cells and basophils . (wikidoc.org)
  • Back in 1985, Benveniste began experimenting with human white blood cells involved in allergic reactions, called basophils. (purewatergazette.net)
  • title{Protein Tyrosine Phosphatase Inhibition Mimics Fc$\varepsilon$RI-induced Anergy and Reveals the Immunomodulatory Role of Hydrogen Peroxide as a Signaling Molecule in Human Basophils\thanksref{grant}} %Really struggling with a title that captures this paper -- probably a bad sign! (openwetware.org)
  • In these experiments we compared the effect of zinc chloride on the release of chemical mediators from human basophils and mast cells isolated from human lung. (nih.gov)
  • Preincubation (5 min, 37 degrees C) of human basophils and lung mast cells with zinc chloride (10(-6)-3 X 10(-5) M) caused dose-related inhibition of histamine and peptide leukotriene C4 (LTC4) release induced by anti-IgE. (nih.gov)
  • Thus physiological concentrations of zinc inhibit the release of histamine from human basophils and lung mast cells, presumably by blocking Ca2+ uptake induced by anti-IgE activation. (nih.gov)
  • When an individual encounters the allergen again, the allergen can bind to IgE stuck to the surface of mast cells and basophils causing them to release the chemicals stored inside the cell. (labtestsonline.org.uk)
  • In allergic rhinitis, cross-linking of IgE molecules upon allergen contact induces degranulation of mast cells and basophils within the mucosal tissue and results in the release of typical mediators, which consecutively induce the well-known symptoms. (nih.gov)
  • IgE antibodies then attach to mast cells and basophils and upon a secondary exposure to allergen, antigen-antibody binding will occur at these sites. (tocris.com)
  • Cross-linking of FcεRI and IgE complexes with allergen induces basophil degranulation and release of inflammatory chemical mediators, leading to clinical symptoms. (nottingham.ac.uk)
  • Crosslinking of IgE-FcεRI complexes by multivalent allergen initiates complex signaling pathways, leading to the release of mediators of allergic inflammation. (q-bio.org)
  • CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. (biolegend.com)
  • Monocytes/macrophages and basophils. (biolegend.com)
  • Reexposure causes memory T-cell to release lymphokines that induce inflammatory reactions and activate macrophages to release inflammatory mediators with symptoms presenting after 24-72 hours. (fsahq.org)
  • In particular, the inflammatory response leads to injury of epithelial/endothelial cells and enhances the release of inflammatory mediators, including chemokines, cytokines and inflammatory cells (mainly neutrophils and macrophages , but also eosinophils , basophils, mast cells). (omicsonline.org)
  • Crosslinking of IgE on mast cells leads to their degranulation and the release of mediators responsible for the allergic reaction. (tocris.com)
  • Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. (wikidoc.org)
  • We have previously shown that physiological concentrations of zinc (congruent to 7 X 10(-6) M) inhibit the release of histamine from human basophil leukocytes (Marone et al. (nih.gov)
  • Basophils appear in many specific kinds of inflammatory reactions, particularly those that cause allergic symptoms. (wikipedia.org)
  • If symptoms reoccur after the first injection, a repeat injection can be given after 10-20 minutes while en route to emergency care. (anaphylaxis.org)
  • These mediators cause the common symptoms of an atopic reaction by causing vasodilation, capillary permeability, mucus production, smooth muscle spasm, eosinophil and T-infiltration into tissue as well as other inflammatory cells. (ceufast.com)
  • Skin chamber cell counts and inflammatory mediators [histamine, PGD 2 , and leukotriene C 4 (LTC 4 )] were measured at hourly intervals for 12 h. (johnshopkins.edu)
  • The other mediator is leukotriene. (christopherebright.com)
  • Mast cells were once thought to be basophils that migrated from the blood into their resident tissues (connective tissue), but they are now known to be different types of cells. (wikipedia.org)
  • Like all circulating granulocytes, basophils can be recruited out of the blood into a tissue when needed. (wikipedia.org)
  • It is present in tissue mast cells & basophils. (periobasics.com)
  • Another mediator contained within a MAST cell is tissue necrosis factor. (christopherebright.com)
  • The activation of these cells leads to the release of chemical mediators such as histamine and arachidonic acid metabolites, which increase vascular permeability and tissue swelling 9 . (bvsalud.org)
  • Basophils are the least common type of granulocyte, representing about 0.5% to 1% of circulating white blood cells. (wikipedia.org)
  • Basophils were discovered in 1879 by German physician Paul Ehrlich, who one year earlier had found a cell type present in tissues that he termed mastzellen (now mast cells). (wikipedia.org)
  • Recent studies in mice suggest that basophils may also regulate the behavior of T cells and mediate the magnitude of the secondary immune response. (wikipedia.org)
  • Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells. (wikipedia.org)
  • There are other substances that can activate basophils to secrete which suggests that these cells have other roles in inflammation. (wikipedia.org)
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
  • Pro-inflammatory immune cells, primarily mast cells and basophils, perpetuate the immune response by releasing histamine and other immune mediators. (livestrong.com)
  • Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)
  • These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. (mdpi.com)
  • Basophil - These cells have blue-staining granules and make up less than 1% of circulating leukocytes. (pearson.com)
  • It is normally found in very small amounts in the blood and can be attached to the surface of certain specialised cells like mast cells and basophils . (labtestsonline.org.uk)
  • Mast cells are found in tissues, for example the gastrointestinal tract and respiratory tract, whereas basophils are found in the blood. (labtestsonline.org.uk)
  • Both specialised types of cells contain chemicals or mediators inside like histamine. (labtestsonline.org.uk)
  • It is most frequently associated with exposure to allergens and the release of mediators from mast cells and basophils. (onteenstoday.com)
  • When re-exposure occurs, inflammatory mediators like histamine are released from basophils and mast cells. (fsahq.org)
  • Some of the immunological properties of allergenic proteins include their ability to stimulate Th-2 type T-cell proliferation, bind serum IgE, elicit a positive prick skin test, and cause histamine and mediator release from mast cells and basophils of sensitive individuals. (usda.gov)
  • H1-type antihistamines have recently been reported to inhibit cytokine secretion from human and murine mast cells and basophils. (citationimpact.com)
  • At the mRNA level, inhibition was only seen with KU812 cells and IL-8 in the presence of azelastine at 10−10 M. These data show thus distinct inhibitory patterns for different antihistamines during cytokine production from human mast cells and basophils which may contribute to the anti-inflammatory effects of these drugs during treatment of allergic diseases. (citationimpact.com)
  • In order to mimic the allergic response and generate an in vitro diagnostic device to address these issues, a basophil-microarray platform that couples the diversity of a protein array with the biological output of basophilic cells is being developed. (nottingham.ac.uk)
  • FcεRI is expressed on mast cells, basophils, and at lower levels, on dendritic cells and monocytes. (bdbiosciences.com)
  • An increase in the amount of cyclic GMP within these cells increases mediator release whereas and the increase in cyclic AMP decreases the release. (periobasics.com)
  • The activation phase is when re-exposure of antigen causes the release of contents of basophils and mast cells. (periobasics.com)
  • Since MAST cells are located around blood vessels, the ensuing histamine-induced vasodilation compounds the hypotension and swelling caused by the basophils. (christopherebright.com)
  • Normally, it is very effective in "calling in the cavalry" - attracting T cells, basophils, and other white blood cells to the area of invasion. (christopherebright.com)
  • Basophils are the least common of the granulocytes , representing about 0.01% to 0.3% of circulating leukocytes (white blood cells). (wikidoc.org)
  • As long as the antigen that caused its initial formation does not invade the body again, the MAST cell or basophil remains dormant (the lock doesn't open because the key isn't turned). (christopherebright.com)
  • The role of basophils in the immune response to these viruses is further supported by findings that the CD200 receptor is expressed more frequently in basophils than in other circulating leukocytes. (wikipedia.org)
  • Basophils have protein receptors on their cell surface that bind IgE, an immunoglobulin involved in macroparasite defense and allergy. (wikipedia.org)
  • These mediators cause blood vessels to leak (which leads to swelling and drop in blood pressure) and airways to narrow (wheezing). (anaphylaxis.org)
  • Basophils contain large cytoplasmic granules which obscure the cell nucleus under the microscope when stained. (wikipedia.org)
  • Their granules contain chemicals that mediate inflammation, including the potent inflammatory mediator, histamine. (pearson.com)
  • Herpesvirus-6, herpesvirus-7, and herpesvirus-8 produce a CD200 homolog which also inhibits basophil function. (wikipedia.org)
  • Eosinophils, neutrophils and monocytes are recruited in the late phase and release additional mediators to sustain the allergic response. (tocris.com)
  • Zinc chloride was a competitive antagonist of the action of Ca2+ in histamine secretion induced by anti-IgE with a dissociation constant (Kd) of about 10(-5) M in both the basophil and mast cell systems. (nih.gov)
  • These mediators increase mucus secretion and promote vascular permeability and smooth muscle contraction. (tocris.com)
  • We suggest that the selective blockade of eosinophil and basophil influx by prednisone and the associated decrease in inflammatory mediators may contribute to the blockade of the clinical expression of the cutaneous LPR. (johnshopkins.edu)
  • Its mechanism of action is thought to be through modulation of the immune system with reduction of inflammatory mediators involved in eczematous reactions. (medscape.com)
  • When the cross-linkage occurs, the chemical mediators are released within minutes. (periobasics.com)
  • Basophils arise and mature in bone marrow. (wikipedia.org)
  • Mediator of monocyte chemotaxis and bone marrow homeostasis. (biolegend.com)
  • The platform in development relies upon the use of a humanised rat basophilic leukaemia (RBL) cell line RBL-703/21 and different methods to measure the levels of basophil activation. (nottingham.ac.uk)
  • A consortium of four independent research laboratories in France, Italy, Belgium, and Holland, led by Professor M Roberfroid at Belgium's Catholic University of Louvain in Brussels, used a refinement of Benveniste's original experiment that examined another aspect of basophil activation. (purewatergazette.net)
  • The team knew that activation of basophil degranulation by aIgE leads to powerful mediators being released, including large amounts of histamine, which sets up a negative feedback cycle that curbs its own release. (purewatergazette.net)
  • Pilot study on basophil activation induced by contrast medium. (bdbiosciences.com)
  • Prednisone altered cellular traffic more dramatically than it did inflammatory mediators. (johnshopkins.edu)
  • In a recent study [ 9 ] it was indicated for the first time that among various mediators involved in the inflammation-driven differentiation of fibroblast to an activated myofibroblast, a main architect is the neutrophil, a cell whose role in fibrosis was obscure up to now. (omicsonline.org)