AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Tumor Necrosis Factor-alphaReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIInterleukin-1CytokinesLipopolysaccharidesInterleukin-6Cells, CulturedNecrosisNF-kappa BRNA, MessengerInterferon-gammaMacrophagesMice, Inbred C57BLCell LineLymphotoxin-alphaSignal TransductionMonocytesRecombinant ProteinsApoptosisInflammationGene Expression RegulationMice, Inbred BALB CTumor Necrosis FactorsAntibodies, MonoclonalArthritis, RheumatoidInflammation MediatorsInterleukin-10Gene ExpressionInterleukin-8Transforming Growth Factor alphaDose-Response Relationship, DrugMice, KnockoutMolecular Sequence DataTumor Necrosis Factor Decoy ReceptorsDisease Models, AnimalReverse Transcriptase Polymerase Chain ReactionMacrophage ActivationAntirheumatic AgentsAntigens, CDTime FactorsBase SequenceSynovial MembraneCell Line, TumorUp-RegulationInterleukin-1betaLeukocytes, MononuclearEnzyme-Linked Immunosorbent AssayTransfectionTumor Cells, CulturedNeutrophilsMembrane GlycoproteinsEndotoxinsMacrophages, PeritonealBlotting, WesternFlow CytometryCell SurvivalFibroblastsDrug SynergismT-LymphocytesDown-RegulationI-kappa B ProteinsAnti-Inflammatory AgentsCell DivisionTranscription, GeneticEnzyme ActivationImmunohistochemistryPromoter Regions, GeneticPentoxifyllineEndothelium, VascularI-kappa B KinaseTNF Receptor-Associated Factor 2LiverInterleukin-12Transcription Factor RelAImmunoglobulin GMice, Inbred C3HPhosphorylationNitric OxideIntercellular Adhesion Molecule-1LungReceptors, Cell SurfaceGranulocyte-Macrophage Colony-Stimulating FactorKineticsTumor Markers, BiologicalTumor Necrosis Factor Receptor-Associated Peptides and ProteinsAntigens, CD14InterleukinsShock, Septicp38 Mitogen-Activated Protein KinasesTNF-Related Apoptosis-Inducing LigandSpleenAntibodiesEnzyme InhibitorsMitogen-Activated Protein KinasesPolymerase Chain ReactionLymphocyte ActivationDendritic CellsProtein Binding
InflammCytokinesProteinAnti-inflammatoryOxidative stressInterleukinProteinsApoptosisBiomarkersPathologicalSelectivelyAirwayMetabolismInhibitsInflammatory processesPotentMarkersDietaryExpressionReactive oxygenPathogenesisCardiovascularPathwaysInhibitionVascular endothPulmonaryMethodsGeneCellSyndromeNuclear factorCancerObesityRoleImportantEndotoxinLevelsRegulationCellsBloodReleaseGrowthAllergicDiseaseProductionTherapyRisk
Inflamm2
Cytokines6
  • Severe cases of SARS-COV-2 infected patients experience lymphocytopenia and a high activation of metabolic proinflammatory cytokines mechanisms which leads to an elevated blood concentration of interleukin (IL) 2 (IL-2), IL-6, IL-7, interferon gamma (IFN-γ), macrophage inflammatory protein- 1 alpha (MIP1A), and tumor necrosis factor alpha (TNF-α) pro-inflammatory cytokines ( 4 , 13 ). (frontiersin.org)
  • This high level of cytokines, known as cytokine storm syndrome (CSS), tends to be a critical factor of morbidity and mortality for COVID-19 patients. (frontiersin.org)
  • Macrophages and lymphocytes produce pro-inflammatory cytokines and chemokines (eg, tumor necrosis factor [TNF]-alpha, granulocyte-macrophage colony-stimulating factor [GM-CSF], various interleukins, interferon-gamma) in the synovium. (merckmanuals.com)
  • Severe cases are characterised by a systemic inflammatory reaction driven by the release of pro-inflammatory cytokines such as IL-6 and tumour-necrosis-factor alpha (TNF-α). (biomedcentral.com)
  • Healthy animals injected with pro-inflammatory IL-1β and tumor necrosis factor alpha (TNF-α) cytokines demonstrate 'sickness behavior' associated with social withdrawal [ 12 ]. (biomedcentral.com)
  • Cytokines are regulatory compounds produced by cells of the immune system [T(H)1 and T(H)2] and act as intracellular mediators and control the immune and inflammatory reponses 9 . (bvsalud.org)
Protein7
  • The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. (wikipedia.org)
  • This protein is one of the major receptors for the tumor necrosis factor-alpha. (wikipedia.org)
  • In part, this occurs because these mediators suppress a type of inflammatory protein called tumor necrosis factor alpha (TNF-alpha). (news-medical.net)
  • But Actos also improved several heart disease risk factors, including cholesterol and markers of inflammation, such as C-reactive protein. (natap.org)
  • Furthermore, we observed that IL1R1 activation on IL1R1 CD11cWT BMDC preferentially augmented expression of anti-inflammatory mediators tumor necrosis factor alpha induced protein 3 (A20) and interleukin-1 receptor antagonist (IL1Ra/Il1rn), effects that were abrogated by IL1R1 CD11cKO BMDC. (asn-online.org)
  • We found that CYN potentiated the effect of bacterial and cyanobacterial LPS that was documented by activation of inflammatory signaling pathways including mitogen-activated protein kinase p38 as well as consequent expression of inducible nitric oxide synthase (iNOS) and increased production of pro-inflammatory mediators such as nitric oxide (NO), TNF-alpha, interleukin-6 (IL-6). (muni.cz)
  • The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. (thermofisher.com)
Anti-inflammatory1
  • Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. (diabetesjournals.org)
Oxidative stress2
  • Nuclear factor kappa beta (NFkappabeta) is the major upstream, intracellular mechanism which regulates inflammatory and oxidative stress mediators. (nel.edu)
  • Mild hypothermia inhibits oxidative stress, apoptosis and necrosis in hepatocyte suspension culture. (edu.au)
Interleukin3
Proteins5
  • Furthermore, cardiovascular comorbidities have been determined as key factors of mortality for SARS-CoV-2 infected patients, which present high blood levels of cardiac-specific proteins troponin I and/or T, indicative signs of hypoxia, tachyarrhythmia, myocarditis, and myocardial injury ( 3 - 8 ). (frontiersin.org)
  • In this protocol you will learn about factors both inside your body and from the external environment that can damage skin, hair and nail proteins. (lifeextension.com)
  • The problem is intrinsic factors, such as the biological aging process, as well as extrinsic factors, such as ultraviolet radiation from sun exposure, compromise the structure and function of these proteins. (lifeextension.com)
  • These proteins can serve as inhibitors or mediators of the inflammatory processes. (bvsalud.org)
  • Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers. (bvsalud.org)
Apoptosis3
  • This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. (wikipedia.org)
  • Cyclooxygenase (Cox-2), a pro-inflammatory mediator, is a CREB target that induces prostaglandin E(2) (PGE(2)) and suppresses apoptosis. (nih.gov)
  • Methods: Three potential assays were examined-assays of apoptosis focusing on caspase activation, assays of phosphatidyl serine externalization (PS+) on PBMCs, and measurement of tumor necrosis factor alpha (TNFα) levels using rapid ELISA methods. (bvsalud.org)
Biomarkers1
  • The study of mediators involved in the regulation and maintenance of epithelial barrier integrity could add new insights in the search for reproducible biomarkers of the pathophysiology of IBS [ 12 ]. (hindawi.com)
Pathological2
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
  • The genetic components most responsible for differences in individual disease risk are thought to be DNA variants (polymorphisms) that influence the expression or function of mediators involved in the pathological processes. (cdc.gov)
Selectively2
Airway1
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
Metabolism2
  • Tumor necrosis factor-alpha (TNF-alpha), a pivotal pro-inflammatory cytokine in RA may be involved in the development of the disturbed lipid metabolism. (researchgate.net)
  • Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
Inhibits1
  • Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. (oregonstate.edu)
Inflammatory processes1
  • Our findings represent new evidence suggesting the possibility that omega-3 fatty acids act as protective factors in diseases that affect retinal blood vessels, said John Paul SanGiovanni, Sc.D., NEI staff scientist and the other lead author of the study.This is a major conceptual advance in the effort to identify modifiable factors that may influence inflammatory processes implicated in the development of common sight-threatening retinal diseases. (news-medical.net)
Potent2
  • Experimental tumor models in mice revealed that Tregs are potent inhibitors of an antitumor immune response. (nel.edu)
  • 9-alpha, 11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways. (mcgill.ca)
Markers2
  • During the same liest markers in patients with atherogenic period, 20 healthy age- and sex-matched risk factors (e.g. male sex, ageing, hyper- personnel whose medical records showed tension, diabetes mellitus, smoking, fam- total cholesterol and triglycerides were ily history) in the absence of angiographic within normal levels and who had no car- evidence of atherosclerosis [1]. (who.int)
  • In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk. (diabetesjournals.org)
Dietary1
Expression8
  • In addition, expression studies were carried out to determine the mode of action by determining the levels of NF-kB, TNF-alpha, TGF-beta and Caspases. (ac.ir)
  • The same was also confirmed in the expression studies which shows significant upregulation of the antiapoptotic characteristics and down regulation of pro-carcinogenic factors. (ac.ir)
  • Zhang J, Wang WL, Li Q, Qiao Q. Expression of transforming growth factor-alpha and hepatitis B surface antigen in human hepatocellular carcinoma tissues and its significance. (ac.ir)
  • Additionally, tacrolimus may inhibit release of preformed mediators from skin mast cells and basophils and may down-regulate expression of high-affinity IgE receptor (FCeRI) on Langerhans cells. (medscape.com)
  • These results show that melatonin increases antioxidant enzymes and Nrf2 expression, and limits inflammatory mediators in cerulein‐induced AP. (scite.ai)
  • Melatonin reduced the infiltration of inflammatory cells and necrosis in the liver, and increased the expression of NADPH: quinone oxidoreductase-1, heme oxygenase-1, and superoxide dismutase-2, which were decreased by DMN. (scite.ai)
  • Our results show that melatonin increases antioxidant enzymes and Nrf2 expression in parallel with the decrease of inflammatory mediators in DMN-induced liver injury, suggesting that melatonin may play a role of antioxidant defense via the Nrf2 pathway, by reducing inflammation by NF-kappaB inhibition. (scite.ai)
  • As microglial activation and up-regulation of TNF-alpha expression is a common feature of several CNS diseases, as well as chronic opioid exposure and neuropathic pain, modulating TNF-alpha signaling may represent a valuable target for intervention. (nrimed.com)
Reactive oxygen1
  • CYN has had a significant effect on production on pro-inflammatory mediator tumor necrosis factor alpha (TNF-alpha) which correlates with its effect on reactive oxygen species (ROS) production. (muni.cz)
Pathogenesis1
  • Inflammatory mediators play a critical role in the pathogenesis and potential management of intra-abdominal sepsis. (nature.com)
Cardiovascular3
  • Case studies performed on COVID-19 patients, and autopsies conducted on those who died due to cardiovascular complications such as stroke and acute coronary syndromes, point to thrombotic disease as a critical factor of mortality in severe cases of COVID-19 ( 9 - 12 ). (frontiersin.org)
  • Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and genetic factors. (cdc.gov)
  • Common diseases of a chronic inflammatory nature such as asthma, Alzheimer disease, and cardiovascular disease are complex in nature, as they are variably influenced by genetic inheritance as well as environmental, physical, and lifestyle factors. (cdc.gov)
Pathways2
  • Patients with severe COVID-19 pneumonia progress to ARDS, accompanied by disseminated intravascular coagulation (DIC) ( 17 ), which may upregulate the coagulation pathways by activation of procoagulant factors, such as tissue factor, leading to both arterial and venous thrombotic disease. (frontiersin.org)
  • 2012) . Sterile inflammation associat- The key mechanistic pathways and vation of inflammatory cel s (Balkwill, ed with inhalation of crystal ine silica mediators involved in inflamma- 2012 ). (who.int)
Inhibition2
  • The aim of this study was to determine whether melatonin could prevent cerulein‐induced AP through nuclear factor erythroid 2‐related factor 2 (Nrf2) and curtail inflammation by inhibition of NF‐κB. (scite.ai)
  • Tobinick EL, Britschgi-Davoodifar S. Perispinal TNF-alpha inhibition for discogenic pain . (nrimed.com)
Vascular endoth1
  • And then we have what's called the VEGF, which is the vascular endothelial growth factor, which is responsible for formation of blood vessels, and then bFGF. (chiroeco.com)
Pulmonary1
  • Tumor-necrosis-factor-alpha also appears to be an important mediator of cotton dust induced pulmonary inflammation. (cdc.gov)
Methods1
  • This single-arm exploratory pilot study of adult patients with AIH aimed to define the impact of an 8-week MBSR program on quality of life, disease activity, and cytokine mediators.Methods: The perceived stress survey-10 (PSS) and the brief self-control scale (BSCS) measured subjective distress and self-control. (stanfordchildrens.org)
Gene1
  • In addition, there is evidence that this gene behaves as a suppressor of tumor growth. (thermofisher.com)
Cell3
  • TNF-alpha is found in one type of cell, called microglia, that can be closely associated with retinal blood vessels. (news-medical.net)
  • Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. (nel.edu)
  • We recently showed that Nexrutine, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. (nih.gov)
Syndrome1
  • Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome. (wikipedia.org)
Nuclear factor1
  • The increased nuclear binding of nuclear factor-kappa B (NF-kappaB) in the DMN-induced liver injury group was inhibited by melatonin. (scite.ai)
Cancer1
  • We provide evidence of an increased pool of CD4+CD25high in the peripheral blood of cancer patients, which may be related to immunosuppression and tumor progress in cancer patients. (nel.edu)
Obesity1
  • Risk factors for asthma include a family history of allergic disease, the presence of allergen-specific immunoglobulin E (IgE), viral respiratory illnesses , exposure to aeroallergens , cigarette smoke, obesity , and lower socioeconomic status. (medscape.com)
Role4
  • One recent study conducted in Japan demonstrated that the relative risk of narcolepsy in affected first-degree family members is 10- to 40-fold higher than in the general population, suggesting that genetic factors play an important role in this disease 12 . (nature.com)
  • In order to examine the role of NFkappabeta in the pathophysiology of CFS, this study examines the production of NFkappabeta p50 in unstimulated, 10 ng/mL TNF-alpha (tumor necrosis factor alpha) and 50 ng/mL PMA (phorbolmyristate acetate) stimulated peripheral blood lymphocy tes of 18 unmedicated patients with CFS and 18 age-sex matched controls. (nel.edu)
  • Unknown or unconfirmed environmental factors (eg, viral infections, cigarette smoking) are thought to play a role in triggering and maintaining joint inflammation. (merckmanuals.com)
  • and (v) the role of hypoxia-inducible factor-1 in lung development. (stanford.edu)
Important1
  • this de novo production of TNF-alpha is an important component of the so-called neuroinflammatory response that is associated with several neurological disorders. (nrimed.com)
Endotoxin1
  • To date, three broad approaches to adjunctive (non-antibiotic) therapy have been considered for the treatment of sepsis: (1) optimizing oxygen delivery through oxygenation/ventilation strategies and fluid/vasopressor use to maintain peripheral perfusion, (2) reducing bacterial virulence factors via anti-endotoxin antibodies and endotoxin removal columns and (3) targeting host response factors using corticosteroids, anti-cytokine drugs, and anticoagulants. (nature.com)
Levels2
  • Serum samples taken on day 9 from neutralizing anti-SAg antibodies appears to be a key risk this patient showed evidence of seroconversion with high factor for the development of staphylococcal and strepto- levels of anti-SMEZ antibodies that neutralized SMEZ-1 and 12 other SMEZ-variants. (cdc.gov)
  • Protecting yourself from environmental factors like too much sun, and internal factors like elevated sugar levels, can help. (lifeextension.com)
Regulation1
  • The intestinal barrier functions are affected by the enteric nervous system (ENS), both directly through regulation of tight junctions via neurotransmitters and neurotrophic factors [ 10 ] and indirectly through neuroimmune modulation during inflammation [ 11 ]. (hindawi.com)
Cells2
  • Plasma cells produce antibodies (eg, rheumatoid factor [RF], anticyclic citrullinated peptide [anti-CCP] antibody) that contribute to these complexes, but destructive arthritis can occur in their absence. (merckmanuals.com)
  • Treatment of LNCaP cells with Nexrutine reduced tumor necrosis factor alpha-induced enzymatic as well as promoter activities of Cox-2. (nih.gov)
Blood2
  • Omega-3 fatty acids create chemical compounds known as bioactive mediators, which protect against the growth of abnormal blood vessels, a condition that characterizes some forms of retinopathy. (news-medical.net)
  • These biochemical mechanisms are main factors associated with disturbance of blood coagulation in COVID-19 patients. (frontiersin.org)
Release1
  • The effects of the two macrolides on tumor necrosis factor-α (TNF-α) release were also examined. (karger.com)
Growth2
  • And it also has really key growth factors. (chiroeco.com)
  • So TGF-β, which is the transforming growth factor, IGF, which is insulin growth factor, which we know is related to growth hormone. (chiroeco.com)
Allergic1
  • New target molecules and mediators as well animal model, diisocyanate, diphenyl-methane diisocyanate, as new therapeutic approaches for allergic asthma have hexamethylene diisocyanate, murine model, occupational been identified using animal models. (cdc.gov)
Disease1
  • The factors that cause normally harmless episodes of inflammation to culminate in disease are largely unknown but likely include genetic and environmental influences. (nih.gov)
Production1
  • The unstimulated (F=19.4, df=1/34, p=0.0002), TNF-alpha-(F=14.0, df=1/34, p=0.0009) and PMA-(F=7.9, df=1/34, p=0.008) stimulated production of NFkappabeta were significantly higher in CFS patients than in controls. (nel.edu)
Therapy1
  • We investigated whether infliximab, an anti-TNF-alpha therapy, may modify the lipid profile. (researchgate.net)
Risk1
  • Data from the Prevention of Allergy: Risk Factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle (PARSIFAL) Study and the Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community Advanced (GABRIELA) reinforce the concept of the hygiene hypothesis. (medscape.com)