Mediates interact factor. Medical search. Frequent questions

ETS proteins share a conserved ETS domain that mediates specific DNA binding. (wikipedia.org)
14-3-3 homologues mediates signal transduction by binding to phosphoserine-containing proteins. (nih.gov)
Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. (biologists.com)
Regulation of the proteasome complex is mediated by proteasome interacting proteins (PIPs). (tocris.com)
Using a targeted systems biology approach, we identified new factors, HECATE proteins that promote photomorphogenesis by negatively regulating the function of PIF1. (utexas.edu)
The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
The best-characteristic properties of E6 and E7 proteins from HR-HPVs are their ability to mediate the degradation of p53 and pRb, respectively. (bvsalud.org)
These viral proteins also interact with other several cellular factors and lead to revoke normal cell cycle checkpoint stand cell death mechanisms 13 . (bvsalud.org)
Various tradd-interacting proteins such as trafs, rip and possibly fadd, are recruited to the complex by their association with tradd. (lu.se)

We hypothesized that FO might regulate related genes in apoptosis and PI3K-AKT pathways to mediate the proliferation and apoptosis of liver cancer cells. (hindawi.com)
Fox's latest animal study in PNAS sheds some light on the mechanisms responsible for lead-mediated cell death, or apoptosis, in the eye, and may suggest possible treatment options for patients suffering from various forms of retinal degeneration. (sciencedaily.com)
In U87 and U251 cells, TMZ (200 μM) induced DNA double strand breaks (DSBs) and nuclear translocation of apoptosis inducing factor (AIF), which was accompanied by BNIP3-mediated mitophagy and FOXO3a accumulation in nucleus. (chinaphar.com)
The resulting death-inducing signaling complex (disc) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. (lu.se)

MIM 164720) transcription factors. (wikipedia.org)
Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
However, Brm does not affect on several other transcription factors. (bdbiosciences.com)
Phys transduce light signals via a sub-family of the basic Helix-Loop-Helix (bHLH) transcription factors called Phytochrome Interacting Factors (PIFs). (utexas.edu)
To date, the central role of specific transcription factors in positively regulating these distinct differentiation processes to acquire a B cell-specific genetic program is well established. (eur.nl)

PIFs function as negative regulators in the phy-mediated light signaling pathways. (utexas.edu)
Taken together, these results indicated that NF-$\kappa$8 activation, homoaggregation, and the induction of CD25 and CD54 on YT cells could be mediated independently through individual TNFRs via separate signaling pathways. (jefferson.edu)
They further provide support for the role of interacting psychological factors in pathways to homelessness. (soton.ac.uk)

They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
Receptor-interacting protein kinase 1 (RIPK1), a key molecule mediating necroptosis and regulated by transforming growth factor β-activated kinase 1 (TAK1), was reported to be associated with cognitive impairment in several neurodegenerative diseases. (imperial.ac.uk)

We showed that the GPI-anchor, which is necessary for CD59 complement inhibitory function, is not necessary for its ability to mediate insulin secretion. (lu.se)

The cloning and characterization of these mutants will help identify the factors, such as the kinase and E3 ligase, responsible for the light-induced degradation of PIF1. (utexas.edu)
The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. (nih.gov)

While the defined roles of the c-Jun N-terminal kinase (JNK) pathway in regulating cell death have been well-established, additional factors that modulate JNK-mediated cell death have yet to be fully elucidated. (sdbonline.org)
Psychologic factors modulate pain intensity to a highly variable degree. (msdmanuals.com)
Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. (bvsalud.org)

Regulation of the Later Stages of Nodulation Stimulated by IPD3/CYCLOPS Transcription Factor and Cytokinin in Pea Pisum sativum L. (biologists.com)
Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
EMT was mediated via canonical TGF-β1 signaling with concomitant up-regulation of SMAD-interacting protein 1. (aacrjournals.org)
This study provides a theoretical basis for elucidating the regulation mechanism of VitA-mediated muscle development and the development of therapeutic drugs for muscle diseases in animals. (bvsalud.org)
However, the molecular mechanism involved in the VC-mediated regulation of muscle development is still unclear. (bvsalud.org)
This study provided a theoretical basis for elucidating the mechanism underlying the VC-mediated regulation of muscle development, as well as for developing animal nutritional supplements and therapeutic drugs for muscle diseases. (bvsalud.org)

To gain insight into the molecular mechanisms mediating HDAC7 repression in pre-B cells, we undertook co-immunoprecipitation and chromatin immunoprecipitation experimental approaches. (eur.nl)
Epidemiological and molecular studies have determined that the persistence of infection with high-risk human papillomaviruses (HR-HPVs) types is the most common risk factor for the development of head and neck malignancies 10-12 . (bvsalud.org)
The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of tradd. (lu.se)

eIF3 (eukaryotic initiation factor 3) is the largest and most complex eukaryotic mRNA translation factor in terms of the number of protein components or subunits. (manchester.ac.uk)

Promoters of housekeeping genes contain built-in activating motifs for factors such as GABPA and YY1, which decrease the responsiveness of promoters to distal enhancers. (nature.com)
We found that HDAC7 specifically interacted with the transcription factor MEF2C in pre-B cells and was recruited to MEF2 binding sites located at the promoters of genes critical for macrophage function. (eur.nl)

These changes are thought to lead to tumor-microenvironment interactions via factors secreted by stromal or epithelial cells in response to lymphoma cell-produced cytokines ( 7 ). (spandidos-publications.com)

Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. (bvsalud.org)

Of our identified host factors, 54 significantly alter IAV infection upon siRNA knockdown, and two factors, AHNAK and coatomer subunit COPB1, are also essential for productive infection by SARS-CoV-2. (cdc.gov)

protein factors related to the ubiquitylation system such as the deubiquitinating enzyme , USP14, and auxillary factors that regulate proteasome functions via direct binding, for example Ecm29. (tocris.com)

The human Brm protein has been reported to be a 180 kDa nuclear factor that acts as a transcriptional activator when fused to a heterologus DNA binding domain. (bdbiosciences.com)
We report that chick Dach1 interacts with the Smad complex and the corepressor mouse Sin3a, thereby acting as a repressor of BMP-mediated transcriptional control. (biologists.com)

The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)

These data suggest that TGF-β1-mediated EMT may be relevant in esophageal carcinogenesis. (aacrjournals.org)

They have also been shown to induce expression of tumor necrosis factor (TNF), induce F-actin depolymerization, and activate a Src kinase. (listlabs.com)

To identify novel regulators of JNK-dependent cell death, this study performed a dominant-modifier screen in Drosophila and found that the Toll pathway participates in JNK-mediated cell death. (sdbonline.org)

Finally, gain of Toll signalling exacerbates JNK-mediated cell death and promotes cell death independent of caspases. (sdbonline.org)

Our data introduce a new paradigm of BMP antagonism during limb development mediated by Dach1, which is now proven to function in different signaling cascades with distinct interacting partners. (biologists.com)
It suggests that the two receptors interact with separate signal molecules which mediate distinct biological activities. (jefferson.edu)
They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. (bvsalud.org)

Robust activation of wound-induced transcription from ple and Ddc requires Toll pathway components ranging from the extracellular ligand Spatzle to the Dif transcription factor. (sdbonline.org)

We hypothesize that a neutrophil-mediated endogenous analgesic mechanism is responsible for sex differences in nociception secondary to oral squamous cell carcinoma (SCC). (frontiersin.org)

Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
Adalimumab belongs to a class of medications known as tumor necrosis factor (TNF) blockers. (medicalnewstoday.com)
In those cell types, the receptor concentration and binding is modulated by factors such as tumor necrosis factor (TNF), interleukins, and fatty acid content of the membranes. (listlabs.com)
Extracellular Domain Of The 55Kda Tumor Necrosis Factor Receptor. (lu.se)
Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor. (lu.se)

Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)

Like Brm, Rb up-regulates glucocorticoid-receptor-mediated transcription. (bdbiosciences.com)
BNIP3 (Bcl-2/ adenovirus E1B 19-kDa-interacting protein 3) is a receptor accounting for priming damaged mitochondria for autophagic removal. (chinaphar.com)
Because another growth/trophic factor that signals via a receptor tyrosine kinase (brain derived neurotrophic factor) elicits a long-lasting facilitation of respiratory motor activity in the phrenic nerve, we tested the hypothesis that VEGFA-165 elicits similar phrenic motor facilitation (pMF). (jneurosci.org)
The functional roles of the two TNFRs in mediating NF-$\kappa$B activation, and inducing IL-2R$\alpha$ chain (CD25) and ICAM-1 (CD54) expression, were examined using receptor-specific antisera and TNF mutants, Northern blot analysis, gel shift assay and flow cytometry on human NK-like YT cells. (jefferson.edu)
Shiga toxins then enter the cells by receptor-mediated endocytosis. (listlabs.com)

Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
and mediates signaling between the ECM and the cellular interior. (jneurosci.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)

FOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. (chinaphar.com)

HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains. (scielo.br)
Pleiotropic TNF activities are mediated through the two cell surface receptors (TNFRs). (jefferson.edu)
Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. (bvsalud.org)

Brm and Rb interact in vitro and in vivo , requiring the Rb-pocket domain and the consensus Rb-binding motif of Brm. (bdbiosciences.com)

Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)

Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. (plos.org)
Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
In this study we investigated the role of FOXO3a in regulating the sensitivity of glioma cells to temozolomide (TMZ) and its relationship with BNIP3-mediated mitophagy. (chinaphar.com)
These results demonstrate that FOXO3a attenuates temozolomide-induced DNA double strand breaks in human glioma cells via promoting BNIP3-mediated mitophagy. (chinaphar.com)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
As a postdoc in Manoj Duraisingh's lab at Harvard School of Public Health she performed a genetic screen to identify critical host factors for Plasmodium falciparum malaria using red blood cells derived from hematopoietic stem cells. (stanford.edu)
When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)
Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. (lu.se)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Additionally, VC promoted the differentiation of C2C12 cells and the repair of mouse muscle injury by upregulating the nuclear translocation of CSRP3, which subsequently interacted with MyoD and MyoG. (bvsalud.org)
We found that C3 is upregulated in pancreatic islets during T2D as a factor against β cells dysfunction caused by attenuated autophagy. (lu.se)

The host genetic factors are assumed to play a critical role in tuberculosis pathogenesis, through impact on the gene expression of cytokines and chemokines, which are implicated in the host immune response. (cdc.gov)

The process of myelination is controlled in part by cell extrinsic factors derived from the extracellular matrix (ECM). (jneurosci.org)

We identified the replication licencing factor CDC6 as a new partner of the Polycomb group member BMI1. (plos.org)
Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M (2009) Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence. (plos.org)
Her PhD in Matthew Waldor's lab focused on defining essential replication factors for the two Vibrio cholerae chromosomes. (stanford.edu)
Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR. (nih.gov)
Finally, 16 compounds targeting our identified host factors suppress IAV replication, with two targeting CDK2 and FLT3 showing pan-antiviral activity across influenza and coronavirus families. (cdc.gov)

Although vascular endothelial growth factor (VEGFA-165) is primarily known for its role in angiogenesis, it also plays important neurotrophic and neuroprotective roles for spinal motor neurons. (jneurosci.org)

Furthermore, the study characterized an RTX variant, named NAV‑006 (RTX‑N109D), which was more refractory to the immunosuppressive effects mediated by CA125 as evidenced by its reduced CA125 interaction and increased activity of ADCC and CDC when compared with parent RTX. (spandidos-publications.com)
This activity renders the 28S rRNA unable to interact with the elongation factors EF-1 and EF-2, thus inhibiting protein synthesis. (listlabs.com)

In studies during the early 1990's, Gregg Semenza identified, and then in 1995 purified and cloned, a transcription factor that regulates these oxygen-dependent responses. (nobelprize.org)

The sulfation pattern of heparan sulfate chains influences signaling events mediated by heparan sulfate proteoglycans located on the cell surface. (scielo.br)

Previous studies have established CA125 as a tumor-microenvironment factor that can be detected and found elevated (above normal 35 U/ml levels) in the serum of up to 40% of FL patients and other NHL patients. (spandidos-publications.com)
In a sample of 79 homeless adults, a significant relationship between childhood trauma and experiential avoidance was found which was mediated by internalised shame. (soton.ac.uk)
Support was found for moderated mediation relationships whereby surface acting mediated the associations between all types of conflict with depressive symptoms, as well as the association between relationship and non-task organizational conflict with physical symptoms, when conflict was infrequent. (cdc.gov)
The authors found that P-scca revealed considerably better prognostic factors and limited survival rates and longer duration of disease in compare to c-scca. (bvsalud.org)
According to the analyzed scientific literature, it found that childhood abuse have negative relationship with the development of resilience and positive with the emergence of depressive and anxiety symptoms, as well as, positive factors such as social and family support has positive relationship with resilience. (bvsalud.org)
We found that expression of both IRIS-1 and IRIS-2 is markedly reduced in islets isolated from T2D patients compared to healthy controls, suggesting that hyperglycaemia may be one of the factors resulting in reduced IRIS-1 and IRIS-2 expression in T2D individuals. (lu.se)

Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)
The platelet GP IIb/IIIa complex mediates platelet-to-platelet interactions (platelet aggregation). (medscape.com)

Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
Hypersensitivity pneumonitis, also known as extrinsic allergic alveolitis, is an uncommon non-immunoglobulin E (IgE), T-helper cell type 1 (Th1)-mediated inflam- matory pulmonary disease with systemic symptoms resulting from repeated inhalation and subsequent sensitization to a large variety of aerosolized antigenic organic dust particles. (cdc.gov)

Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)

They are involved in growth factor signalling and also interact with MEK kinases. (nih.gov)
In addition, we showed that treatment with TMZ (100 mg·kg−1·d−1, ip) for 12 days in C6 cell xenograft mice markedly inhibited tumor growth accompanied by inducing FOXO3a upregulation, oxidative stress and BNIP3-mediated mitophagy in tumor tissues. (chinaphar.com)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)

This initial interaction (platelet adhesion) sets the stage for other adhesive reactions that allow the platelets to interact with other agonists in the vicinity of vessel injury, such as adenosine 5'-diphosphate (ADP), subendothelial collagen, and thrombin. (medscape.com)

Numerous studies in Europe (Ireland, Netherlands, United Kingdom, France) and in the United states suggest that the dietary factors in children may be as important as they are in adults. (medscape.com)
The authors suggest that an adequate nutritional status of calcium and vitamin D could be an additional factor that may help preserve a good oral health. (medscape.com)

Proteins9

Apoptosis4

Transcription factors5

Pathways3

Protein kinase2

Ability to mediate1

Degradation2

Modulate3

Regulation6

Molecular3

MRNA1

Genes2

Epithelial1

Molecule1

Knockdown1

Proteasome1

Transcriptional2

Canonical1

Carcinogenesis1

Actin1

Drosophila1

Caspases1

Distinct3

Pathway1

Mechanism1

Tumor necros5

Proliferation1

Receptor5

Cellular4

Biological processes1

Receptors3

Vitro1

Mechanisms2

Cells14

Gene expression1

Extracellular matrix1

Replication5

Roles1

Activity2

Regulates1

Pattern1

Found6

Interactions2

Symptoms2

Role1

Growth4

Interaction1

Suggest2