Mechanisms organ specificity. Medical search. Frequent questions

Some of these optical methods complement advances in targeted or activated optical contrast agents that may provide better sensitivity and specificity at the molecular level than other modalities. (nih.gov)
Organisms seen by Gram stain yielded a sensitivity of 96.6%, specificity of 88.9%, positive predictive value of 97.7% and negative predictive value of 84.2% when used to predict positive culture results for bacterial wound infection. (who.int)
Our quantitative imaging group uses their knowledge of physics, engineering, applied mathematics, imaging and computer sciences, as well as key insights gleaned from our tissue-sciences research, to discover and develop novel quantitative imaging biomarkers that can detect changes in tissue composition, microstructure, and/or microdynamics with high sensitivity and specificity. (nih.gov)
Several novel biomarkers have emerged during the last few years, demonstrating reasonable sensitivity and specificity for AKI prediction and protection [5]. (webmedcentral.com)
Although not applicable to living cells, MSI can detect many types of metabolites in a single scan with unprecedented specificity and sensitivity. (ascb.org)
Sensitivity, specificity, and positive and negative predictive values (PPV and NPV) for identifying intraabdominal injury were calculated for the physical examination and the FAST, both individually and when combined. (scielo.org.za)
The sensitivity of the physical examination was 0.80, specificity 0.83, PPV 0.42 and NPV 0.96. (scielo.org.za)
The sensitivity of the FAST was 0.50, specificity 1.00, PPV 1.00 and NPV 0.93. (scielo.org.za)
The combined sensitivity was 0.86 [0.73-0.92], and the combined specificity was 0.78 [0.68-0.86]. (biomedcentral.com)
There are various algorithms used in diagnosis with varying levels of sensitivity (true positive) and specificity (true negative). (minoritynurse.com)

MicroRNAs are ~22 nucleotide long RNA molecules that provide substrate specificity to a protein complex known as the RNA-induced silencing complex. (eurekalert.org)
In the rat, there are at least three enzymatic iodothyronine-deiodinating pathways which can be distinguished by kinetics and substrate and inhibitor specificities. (karger.com)
A gatekeeper helix determines the substrate specificity of Sjogren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. (i-med.ac.at)

however, abrin toxicity is similar in its mechanism of action. (cdc.gov)
The specificity of Pharmorubicin toxicity appears to be related primarily to proliferative activity of normal tissue. (azurewebsites.net)
This high target specificity minimizes off-target effects and reduces toxicity compared to traditional therapies, making bispecific antibodies an attractive option for cancer treatment. (grandviewresearch.com)

Once activated by the binding of antigen specific for only that receptor, the B cell produces a large quantity of antibody of the exact specificity as the original immunoglobulin receptor. (medscape.com)
In short, the theory is an explanation of the mechanism for the generation of diversity of antibody specificity. (wikipedia.org)
In laboratory tests, scientists have succeeded in reducing the resistance of the tumour cells to a natural resistance mechanism with the help of a monoclonal antibody. (scienceblog.com)
Invaluable assistance in this task was provided by a monoclonal antibody, a special protein that identifies cell structures with a high degree of specificity. (scienceblog.com)

Thus, bone marrow, gastrointestinal tract, lymphoid organs and the gonads are the main normal tissues damaged. (azurewebsites.net)
Exposure to toxic metal contaminants, such as cadmium compounds (Cd2+), has been shown to induce adverse effects on various organs and tissues. (bvsalud.org)
Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (eurekalert.org)
The immune system is a collection of cells, tissues, and organs that work together to defend the body against attacks by pathogens or foreign invaders (such as microbes, viruses, bacteria, and parasites). (nursingce.com)
The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs. (umassmed.edu)
BACKGROUND: A major focus of xenotransplantation research is the interaction between human immune effector mechanisms and porcine tissues. (ox.ac.uk)
Systemic lupus erythematosus (SLE) is a genotypically and phenotypically heterogeneous, systemic autoimmune disease that affects multiple organs and connective tissues. (goldlabfoundation.org)
Cells Tissues Organs (2011) 193 (4): 239-252. (karger.com)
Histological examination of tissues (kidney, liver, spleen and lung) harvested 24 h post-administration indicated that organ accumulation depended on the degree of ammonium (NH(3)(+)) functionalization at the f-MWNT surface. (cnrs.fr)

This property of specificity is what differentiates the lymphoid cell from the myeloid cell, which can react with any antigen. (medscape.com)
Primary lymphoid tissue consists of "central" organs that serve as major sites of lymphopoiesis (Figure 10). (medscape.com)
This activation occurs in secondary lymphoid organs such as the spleen and the lymph nodes. (wikipedia.org)

The interaction of neurotransmitters and growth factors with their receptors, signal transduction mechanisms and the role of protein phosporylation in the function of specific neural proteins are a major focus of our research. (cuanschutz.edu)
2014 ). The evolutionary conserved ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway are the two major protein clearance mechanisms in eukaryotes. (springer.com)
Protein clearance mechanisms in health and disease. (springer.com)
Deficits in protein folding and clearance mechanisms are linked to multiple disorders that involve protein aggregation, i.e., proteinopathies. (springer.com)

The SPARC program invests in high-risk, goal-driven projects to discover the underlying mechanisms and pathways by which the peripheral nervous system controls internal organ function," said SPARC Program Manager Gene Civillico, Ph.D. "This is achieved through a unique program management structure that allows SPARC to swiftly adopt new breakthroughs and emerging technologies, and nimbly incorporate ideas and expertise. (nih.gov)
Inflammatory and autoimmune disorders have complex and multifaceted mechanisms, including dysregulated immune responses, cytokine imbalances, and abnormal cell signaling pathways. (grandviewresearch.com)
Fibrogenic processes share conserved core cellular and molecular pathways across organs. (rug.nl)

1 Neoplasia & Endocrine Differentiation P0L5, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain. (nih.gov)
Future studies may use these data as a reference to identify markers of perturbed differentiation and disease-related pathogenic mechanisms. (nih.gov)

The clonal selection theory can be summarised with the following four tenets: Each lymphocyte bears a single type of receptor with a unique specificity (generated by V(D)J recombination). (wikipedia.org)
The differentiated effector cells derived from an activated lymphocyte bear receptors of identical specificity as the parent cell. (wikipedia.org)
The porcine antibodies in the human blood have specificity for human lymphocyte antigens. (ox.ac.uk)
In fact, with increasing duration of perfusion, 40% of the xenoperfusions showed increasing titers of porcine antibodies with specificity for human lymphocyte antigens suggesting a response by primed porcine lymphocytes. (ox.ac.uk)

Unfortunately, the demand for kidney transplants continues to exceed the supply of donor organs. (medscape.com)
While liver transplantation is an effective mode of therapy, there are a shortage of donor organs. (selectbiosciences.com)

We also detected apelin-like immunoreactivity localized within the endothelia of small arteries in various organs. (nih.gov)

2000 differentially expressed genes affecting similar biological processes, thereby indicating consistent cross-organ actions of DMSO. (nature.com)
The functional mechanisms defined under different immune settings, while largely similar, differentially control disease pathogenesis. (frontiersin.org)
A vast number of tissue-specific differentially methylated regions are identified and considered likely mediators of tissue-specific gene regulatory mechanisms since the hypomethylated regions are closely related to known functions of the corresponding tissue. (nih.gov)
PCTS displayed substantial differences in their baseline gene expression profiles: 70% of the extracellular matrix (ECM)-related genes were differentially expressed across the organs. (rug.nl)

Classification of haemolytic anaemias (thalassemia and sickle cell disorders) is found in Chapter III: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89). (cdc.gov)
We present evidence that a transplanted porcine organ might also mount a significant immune response to a human recipient. (ox.ac.uk)
Intrinsic and extrinsic cellular and molecular mechanisms function to prevent maturation of adaptive immune cells with self-reactive receptors and limit and control self-reactive or otherwise harmful innate and adaptive immune responses when they occur. (goldlabfoundation.org)
The organs may delete recognized with the study of herein including cystic to generate multiple, prooxidant-antioxidant policy, or swelling studies( cell Fatigue) and may minimally result randomized by immune care( phosphate nervosa). (worldclassbows.com)

Genome-wide methylation patterns also revealed tissue-specificity. (nature.com)
While hepatic microtissues demonstrated non-significant changes, findings from cardiac microtissues suggested disruption of DNA methylation mechanisms leading to genome-wide changes. (nature.com)

There are marked interindividual differences in the content of UGTs in the liver and other organs including the gastrointestinal tract. (aspetjournals.org)

In vivo optical measurements extend across a wide range of resolution, from molecular and cellular to tissue and organ levels. (nih.gov)
However, the related molecular mechanism remains unelucidated. (bvsalud.org)
We are using using genetics, molecular genetics, cell biology, and computational modelling to understand the mechanisms underlying gravity-dependent and gravity-independent growth angle control. (leeds.ac.uk)

Biological projects will develop detailed anatomical and functional maps that illustrate how peripheral nerves control organ function, while technology development projects will create or improve tools to measure and manipulate nerve-organ interactions and isolate their functions. (nih.gov)
Many of these metabolites exhibit unique distribution patterns among different organelles in the cell, and their spatial specificity contributes to their functional specificity. (ascb.org)

There are multiple neural circuits connecting the masticatory organs and the hippocampus. (medsci.org)

Profiling the tissue-specific DNA methylome patterns will provide novel insights into normal and pathogenic mechanisms, as well as help in future epigenetic therapies. (nih.gov)

It is characterized with high mortality rate depending on the number of organs involved. (scirp.org)
Multiple organ dysfunction syndrome (MODS) is a systemic, dysfunctional inflammatory response that requires long intensive care unit (ICU) stay and has high mortality rate of 27% - 100% depending on the number of organs involved [1-3]. (scirp.org)
Many of these mRNAs occur less than one copy per every ten cells, suggesting a high degree of cellular specificity in neural gene expression. (cuanschutz.edu)
It may lead to a number of complications, including metabolic acidosis, high potassium levels, uremia, changes in body fluid balance, and adversely effects other organ systems [3,4]. (webmedcentral.com)
This technique targets metabolites based on their chemical structures, and offers high detection specificity independently of cellular environment. (ascb.org)
A dipstick positive for blood, nitrite, and leukocyte esterase in addition to one or more patient symptoms (frequency, urgency, pain, or discharge) has a high specificity for a UTI. (minoritynurse.com)

Further work in this field is likely to elucidate both mechanisms of control of pituitary hormone secretion and mechanisms of action of thyroid hormone. (karger.com)
In this study, we aimed to elucidate shared and organ-specific features of fibrosis using murine precision-cut tissue slices (PCTS) prepared from small intestine, liver and kidneys. (rug.nl)

Pluripotent stem cell-derived liver tissue represents a potential alternative to cadaver derived hepatocytes and whole organ transplant. (selectbiosciences.com)

In order to understand topics covered in this paper, a basic explanation of structures of the eye, their functions, as well as mechanisms and associated pathogens must be explained. (ukessays.com)

Accordingly, the objective of this request for applications (RFA) is to encourage innovative, mechanistically based research using transgenic technologies to investigate the alterations of gene expression induced by environmental agents in specific target cells and organs, and to determine how this response varies at critical times during exposure. (nih.gov)
The specificity and versatility of RNAi make it an attractive therapeutic approach for genetic disorders caused by single gene mutations. (scitechnol.com)

In considering this premise evolutionary psychology suggests that a lot of domain specific mechanism is the reason for a large number of adaptive problems with humans. (allbestessays.com)

Herein we reviewed the literatures published in English language through the research engines (MEDLINE, Scopus, and EBASE) from 1982 to 2011 using key words: "multiorgan dysfunction", "organ failure", "intensive care units" to highlight the definition, mechanism, diagnosis and prediction of MODS particularly at its earliest stages. (scirp.org)

Multiple organ dysfunction syndrome (MODS) is a systemic, dysfunctional inflammatory response that requires long intensive care unit (ICU) stay. (scirp.org)

Spatial partitioning of metabolic functions is a phenomenon fundamental to life, and these partitions constitute a hierarchy ranging from organs to cells to subcellular organelles. (ascb.org)

In COVID-19, unresolved issues include the causes of severe pneumonia, cytokine storm and corresponding lymphopenia, species specificity, and the mechanism of damage to cells of multiple organs [ 3 , 4 ]. (e-cep.org)

B cells are important in defense against pyrogenic bacterial infections, and can destroy transplanted organs by mediating hyperacute graft rejection. (medscape.com)

This connection between fMRI findings and TCM indications confirms the specificity of GB37 for the treatment of visual disorders. (bellaomacupuncture.com)

The Kepinski lab is focused on understanding the regulation of plant development by the hormone auxin with projects ranging from the earliest events of auxin receptor complex formation to root hair development and the control of growth angle of plant organs. (leeds.ac.uk)

Whether you exist used the specificity or pharmaceutically, if you suffer your prevalent and hemodynamic factors biologically brochures will do Coronary years that produce currently for them. (augenta.net)
Therefore, it is of major relevance to enhance our knowledge of the underlying mechanisms of this prevalent disease in order to develop new treatment strategies. (medsci.org)

10°C) by hibernating mammals without sustaining bodily injury and organ failure is an extraordinary achievement with potential clinical applications. (immunochemistry.com)
In this premise you should consider the functioning of our bodily organs. (allbestessays.com)

At this time, the mechanisms for conferring genetic specificity to lymphocytes develop. (medscape.com)
The ICD-10 codes lack specificity for uniquely coding some congenital anomalies and most genetic syndromes. (cdc.gov)
The mechanisms by which these molecules act, and the cellular controls over their genetic expression have begun to be elucidated. (cuanschutz.edu)

Methods This observational longitudinal clinical cohort study included patients with NSCLC with LM receiving immunotherapy was conducted to evaluate organ-specific tumor response of PL and LM. (bmj.com)

These disorders often have a significant impact on a patient's quality of life and can lead to chronic inflammation, tissue damage, and organ dysfunction. (grandviewresearch.com)
The researchers add that brain networks accessed by specific acupuncture points relate to specific medical disorders and suggest an "acupoint-brain-organ" pathway. (bellaomacupuncture.com)

Studies on the mechanisms that regulate UGT genes, in a temporal and tissue-specific manner, should contribute significantly to understanding the basis for these differences. (aspetjournals.org)

MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
Androstenedione from the adrenal gland can be converted to estrogen in adipose tissue and may stimulate cell division in the target organs of obese individuals (Siiteri 1987). (nih.gov)
There is extensive deiodinative metabolism of thyroxine (T4) in thyroid hormone target organs, including the pituitary and brain. (karger.com)

The mRNA levels in a cell are fine tuned by different mechanisms, one of which is driven by microRNA molecules. (eurekalert.org)

While the eye is highly developed, certain post trauma mechanisms have evolved in such a way that our visual axis will not be altered, which would normally lead to instant blindness. (ukessays.com)
Blood in the urine can come from trauma (kidney stones) or bacterial mechanisms that lyse red blood cells and so blood can be detected either as whole blood cells or as hemoglobin, the molecule within the cell which has been spilled out by the bacteria. (minoritynurse.com)

However, the mechanisms by which CdCl2-induced COX-2 overexpression leads to cardiovascular dysfunction remain unclear. (bvsalud.org)
Multiple Organ Dysfunction Syndrome (MODS): Is It Preventable or Inevitable? (scirp.org)
It has been recognized that organ failure does not occur as an all-or-none rule, but rather a range of organ dysfunction exists resulting in clinical organ failure. (scirp.org)
Causes, mechanism and types of multiorgan dysfunction syndrome. (scirp.org)
The multiple organ dysfunction syndrome (MODS) is the final common pathway to death for most critically ill patients who die within the contemporary health care system. (basicmedicalkey.com)

Moreover, various indicators of serum and urine analyses also confirmed that MWNT-NH(3)(+) injections did not induce any physiological abnormality in all major organs within the first 24 h post-injection. (cnrs.fr)

Each preferred specificity cathepsin B, K, and L detection kit contains the preferred dipeptide targeting sequences for the respective B, K, or L cathepsin enzymes. (immunochemistry.com)

1. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment. (nih.gov)

The human body also has a protective mechanism of this kind that acts against ovarian cancer cells. (scienceblog.com)
Flow cytometry was used to determine the specificity and class of porcine immunoglobulin in human blood after xenoperfusion and to determine whether porcine immunoglobulins had bound to the human lymphocytes in the blood perfusing the porcine livers. (ox.ac.uk)
The utilization of multi-organ human-on-a-chip or body-on-a-chip systems for toxicology and efficacy, that ultimately should lead to personalized medicine applications, is a topic that has received much attention recently for drug discovery and subsequent regulatory approval. (selectbiosciences.com)
MRI studies reveal the neurological mechanisms of acupuncture on human health. (bellaomacupuncture.com)
Preclinical models that closely mimic human T1DM have been widely recognized as indispensable tools to dissect the mechanisms underlying T1DM initiation and progression, ultimately aiding in the preparation for human clinical trials (Figure 1 ). (medsci.org)

Optical contrast mechanisms: Optical measurements of either intrinsic or extrinsic contrast yield optical signatures comprised of optical spectra or multi-spectral images. (nih.gov)

In conclusion, regardless the many common features in pathophysiology of organ fibrosis, PCTS displayed diversity in culture-induced responses and in response to the treatment with TGFβRI kinase inhibitor galunisertib, even though it targets a core fibrosis pathway. (rug.nl)

Injury to the abdominal organs occurs in 8% of children, can be life threatening, and a careful systematic approach is required to identify it. (scielo.org.za)

These awards have the potential to catalyze next-generation neuromodulation therapies that could bring improved specificity for patients over both drug therapies and previous-generation devices. (nih.gov)
AIM OF THE STUDY: This study assessed the potential mechanism of BXHYD against DUs by using network pharmacology and animal experiments. (bvsalud.org)
This study aimed to analyze whether tumor response to immunotherapy differs between pulmonary lesions (PL) and LM in NSCLC and to explore potential mechanisms through multiomics analysis. (bmj.com)
Moreover, these same treatments prevented cold-stored kidneys from microtubule and other damage, demonstrating the potential clinical utility for increasing shelf-life of organ transplants. (immunochemistry.com)
Cytoplasmic interactions can influence the function of the ectodomain by a number of potential mechanisms, including redistribution of binding sites into clusters, providing cytoskeletal anchorage, and mediating physiological regulation of cadherin function. (embl.de)
In cooperation with the Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, we explore potential and mechanism of action of tetrahydrobiopterin derivatives to attenuate the ischemia-reperfusion injury harming transplanted organs (7). (i-med.ac.at)

A mechanism found in the bodies of higher organisms, known as "regulated cell death" or apoptosis, actually eliminates potentially harmful cells. (scienceblog.com)

The mechanism is initiated by the messenger substance TRAIL (Tumour Necrosis Factor Related Apoptosis Inducing Ligand) which binds to receptors on tumour cells and triggers a suicide program. (scienceblog.com)
The fact that ovarian tumours emerge despite this - making ovarian cancer the most fatal form of the diseases affecting the female sexual and reproductive organs - is due to resistance to TRAIL: some tumour cells simply fail to react to the suicide signal. (scienceblog.com)

19. Formation of tamoxifen-DNA adducts in multiple organs of adult female cynomolgus monkeys dosed with tamoxifen for 30 days. (nih.gov)

The following sections provide background on developments of optical contrast mechanisms and optical devices, with examples of clinical applications and kinds of validation studies anticipated under this RFA. (nih.gov)

This write-up aims to delve into the effects and mechanism of the steroid-like chemical Testolone. (mynewsdesk.com)

In this review, we discuss recent findings and open questions on how targeting proteolytic mechanisms could be applied for disease intervention. (springer.com)

SPARC focuses on understanding peripheral nerves - nerves that connect the brain and spinal cord to the rest of the body - and how their electrical signals control internal organ function. (nih.gov)
The search for function should involve identifying the specific adaptive problem for which the mechanism is an evolved solution according to Larsen and Buss. (allbestessays.com)
The administration of CNTs may, however, impact the physiological function of organs through which CNTs traverse or accumulate. (cnrs.fr)

Anatomy2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Health Care1

Sensitivity10

Substrate3

Toxicity3

Antibody4

Tissues9

Lymphoid3

Protein4

Pathways3

Differentiation2

Lymphocyte4

Donor organs2

Various organs1

Differentially4

Immune4

Methylation2

Gastrointestinal tract1

Molecular3

Functional2

Hippocampus1

Patterns1

High6

Elucidate2

Liver1

Structures1

Gene2

Humans1

Prediction1

Systemic1

Metabolic1

Cytokine1

Graft1

Indications1

Receptor1

Prevalent2

Bodily2

Genetic3

Methods1

Disorders2

Genes1

Target3

Molecules1

Trauma2

Dysfunction5

Induce1

Detection1

Carcinogenicity1

Human5

Extrinsic1

Diversity1

Occurs1

Potential6

Cell1

Cells2

Formation1

Clinical applications1

Chemical1

Findings1

Function3