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Gene Expression RegulationGene Expression ProfilingGene Expression Regulation, PlantOligonucleotide Array Sequence AnalysisMicroRNAsGene Expression Regulation, DevelopmentalGene ExpressionRNA, MessengerTranscription, GeneticPromoter Regions, GeneticRNA, UntranslatedGene Expression Regulation, EnzymologicBase SequenceTranscription FactorsMolecular Sequence DataComputational BiologyChromatinGenomeGene Expression Regulation, NeoplasticGene Expression Regulation, ArchaealModels, GeneticBinding SitesGene Expression Regulation, FungalAlgorithmsNucleic Acid ConformationReverse Transcriptase Polymerase Chain ReactionTranscriptomeRNA StabilitySignal TransductionCell LineGene Regulatory NetworksDown-RegulationDNA-Binding ProteinsGene Expression Regulation, ViralGene Expression Regulation, BacterialUp-Regulation3' Untranslated RegionsSequence Analysis, RNA5' Untranslated RegionsEpigenesis, GeneticCells, CulturedEvolution, MolecularAlternative SplicingCell Line, TumorArabidopsisHistonesDNA MethylationGene Expression Regulation, LeukemicModels, BiologicalConserved SequenceSequence Analysis, DNAAmino Acid SequenceSoftwareCluster AnalysisGenes, ReporterMicroarray AnalysisBlotting, NorthernTransfectionCell DifferentiationRNATranscriptional ActivationMutationDNA PrimersIn Situ HybridizationTrans-ActivatorsNuclear ProteinsRepressor ProteinsPolymerase Chain ReactionMice, Inbred C57BLDNA, ComplementaryPhenotypeReal-Time Polymerase Chain ReactionTime FactorsLiverLuciferasesDNAHomeodomain ProteinsTumor Cells, CulturedBlotting, WesternOrgan SpecificityCell NucleusProtein BindingDatabases, GeneticPlasmidsReproducibility of ResultsGenetic VectorsMice, TransgenicRats, Sprague-DawleyCloning, MolecularRegulatory Sequences, Nucleic AcidImmunohistochemistryGene SilencingEnhancer Elements, GeneticExpressed Sequence TagsResponse ElementsChromatin ImmunoprecipitationMultigene FamilyNF-kappa BRNA InterferenceBacterial Proteins
HumansDevelopmentalMatrix MetalloproteinasesGlucocorticoidsMolecular mechanismsNeoplasticMetabolismTumorEpigeneticProteinsElucidateEpistaticMethylationActivationMRNA expressionCholesterol 7alpha-hydroxylasePathwaysGeneticChromatinEncodesSpecificityPromoterHaemHepatocytesMiceInhibitEmbryonicEnzymeRepressionBile acidProtein expressionChromosomeCellsViralTranscriptionalDifferentialTherapeuticTranscript variantsCellularCalciumHepaticUpstreamRevealInductionTranscription factorsFindingsFactorsLiverRole
Humans3
  • Intestinal expression of genes involved in iron absorption in humans. (wakehealth.edu)
  • Transcriptional regulation of the human MMP-1 promoter was strongly influenced by the presence of the -1607GG polymorphism, present in 60-80% of humans, which led to striking up-regulation of MMP-1 transcriptional activation. (duke.edu)
  • The molecular basis of cortisone reductase deficiency, the putative "11beta-HSD1 knockout state" in humans, has been defined and is caused by intronic mutations in HSD11B1 that decrease gene transcription together with mutations in hexose-6-phosphate dehydrogenase, an endoluminal enzyme that provides reduced nicotinamide-adenine dinucleotide phosphate as cofactor to 11beta-HSD1 to permit reductase activity. (ox.ac.uk)
Developmental3
  • Gene Expression Regulation, Developmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • This graph shows the total number of publications written about "Gene Expression Regulation, Developmental" by people in this website by year, and whether "Gene Expression Regulation, Developmental" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "Gene Expression Regulation, Developmental" by people in Profiles. (jefferson.edu)
Matrix Metalloproteinases2
  • Membrane-type matrix metalloproteinases: Their functions and regulations. (ox.ac.uk)
  • therefore, we examined matrix metalloproteinases expression (MMP-1, MMP-13 and MT1-MMP) and apoptosis in tumours from 49 patients with advanced colorectal disease. (ox.ac.uk)
Glucocorticoids1
  • Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. (ox.ac.uk)
Molecular mechanisms3
  • OBJECTIVE: We elucidated the molecular mechanisms of DEPs' up-regulation of MMP-1. (duke.edu)
  • These results demonstrate that there are regulatory regions in the 5'-flanking region of the cALAS-1 gene that respond to haem and provide a basis for further investigations of the molecular mechanisms by which haem down-regulates expression of the ALAS-1 gene. (umassmed.edu)
  • however, the molecular mechanisms of this specificity remain unclear. (cnrs.fr)
Neoplastic1
  • ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. (edu.au)
Metabolism2
  • In addition to Northern and polymerase chain reaction (PCR) analyses, in situ hybridization experiments further demonstrated that the embryonic regions within which the PLC-deltasu transcript can be detected during early embryonic development are associated with the highest levels of proliferative activity, suggesting a possible involvement with metabolism or cell cycle regulation. (ox.ac.uk)
  • Studying an enzyme's kinetics in this way can reveal the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled, and how a drug or a modifier (inhibitor or activator) might affect the rate. (wikipedia.org)
Tumor1
  • Further, we found that chemically inhibiting or activating AhR reciprocally modulated the expression levels of cytokines induced by infection, specifically, interleukin 1ß (IL-1ß), IL-10, and tumor necrosis factor alpha (TNF-α), consistent with a role for AhR activation in the host response to MHV infection. (bvsalud.org)
Epigenetic3
  • Glucose induces CYP7A1 gene expression mainly by epigenetic mechanisms. (omeka.net)
  • Here, we demonstrate that the transcription factor E2F6, a member of the polycomb repressive complex 1.6 (PRC1.6), is critical to target and initiate epigenetic silencing at germline genes in early embryogenesis. (cnrs.fr)
  • Our findings elucidate the mechanisms of epigenetic targeting of germline genes and provide a paradigm for how transient repression signals by DNA-binding factors in early embryonic cells are translated into long-term epigenetic silencing during mouse development. (cnrs.fr)
Proteins3
Elucidate1
  • Evans LM, Arehart CH, Grotzinger AD, Mize TJ, Brasher MS, Stitzel JA, Ehringer MA, Hoeffer CA. Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits. (ucdenver.edu)
Epistatic1
  • Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. (edu.au)
Methylation2
Activation5
  • Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin-dependent manner via activation of RAS. (duke.edu)
  • METHODS/RESULTS: Using permanent and primary human bronchial epithelial (HBE) cells at air-liquid interface, we show that DEPs activate the human MMP-1 gene via RAS and subsequent activation of RAF-MEK-ERK1/2 mitogen-activated protein kinase signaling, which can be scaffolded by beta-arrestins. (duke.edu)
  • It also briefly describes the complement system, its activation pathways and the regulation of these pathways. (nusl.cz)
  • Furthermore, while indoleamine 2,3-dioxygenase (IDO1) drives AhR activation in other settings, MHV infection induced equal expression of downstream genes in wild-type (WT) and IDO1-/- macrophages, suggesting an alternative pathway of AhR activation. (bvsalud.org)
  • In summary, we show that coronaviruses elicit AhR activation by an IDO1-independent pathway, contributing to upregulation of downstream effectors, including the proviral factor TiPARP, and to modulation of cytokine gene expression, and we identify a previously unappreciated role for AhR signaling in CoV pathogenesis.IMPORTANCE Coronaviruses are a family of positive-sense RNA viruses with human and agricultural significance. (bvsalud.org)
MRNA expression3
  • Parallel microRNA and mRNA expression profiling of (genotype 1b) human hepatoma cells expressing hepatitis C virus. (wakehealth.edu)
  • MKP-1, but not MKP-3, mRNA expression was 10-fold up-regulated in both mouse and human osteoblast cell lines within 30 min of Dex treatment and remained elevated for 24 h. (ox.ac.uk)
  • Thirty-three fresh-frozen HPV-16 positive OPSCC samples with known integration status were analyzed by mRNA expression profiling. (cancer-genetics.org)
Cholesterol 7alpha-hydroxylase3
  • Transgenic expression of cholesterol 7alpha-hydroxylase (CYP7A1) prevented high fat diet-induced diabetes and obesity in mice. (omeka.net)
  • Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. (omeka.net)
  • Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. (omeka.net)
Pathways2
Genetic3
  • The GENETIC RECOMBINATION of the parts of two or more GENES resulting in a gene with different or additional regulatory regions, or a new chimeric gene product. (edu.au)
  • A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. (bvsalud.org)
  • Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms. (ucdenver.edu)
Chromatin1
  • Moreno DF, Acar M. Chromatin regulatory genes differentially interact in networks to facilitate distinct GAL1 activity and noise profiles. (ucdenver.edu)
Encodes3
  • from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin. (lookformedical.com)
  • This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. (cancerindex.org)
  • We have recently identified a hematopoietic cell-specific immediate-early gene, DUB-1, that encodes a growth-regulatory deubiquitinating enzyme. (ox.ac.uk)
Specificity1
  • Coupled with the rapidity of Dex action, this indicates immediate-early gene phosphatase involvement, and we therefore used quantitative, real-time PCR to examine expression profiles of the dual-specificity MAPK phosphatases, MKP-1 and MKP-3. (ox.ac.uk)
Promoter2
  • In streptozocin-induced type I diabetic mice and genetically obese type II diabetic ob/ob mice, hyperglycemia increased histone acetylation status on the CYP7A1 gene promoter, leading to elevated basal Cyp7a1 expression and an enlarged bile acid pool with altered bile acid composition. (omeka.net)
  • We investigated the effects on the avian ALAS-1 gene promoter of a phenobarbital-like chemical, Glut (glutethimide), and a haem synthesis inhibitor, DHA (4,6-dioxoheptanoic acid), using a reporter gene assay in transiently transfected LMH (Leghorn male hepatoma) hepatoma cells. (umassmed.edu)
Haem2
Hepatocytes3
  • The protein expression as well as the mRNA levels of CYP2D were similar in hepatocytes incubated with serum from either control or CRF rats. (nih.gov)
  • 4. In conclusion, uremic serum contains mediator(s) that down-regulate the cytochrome p450 of normal hepatocytes secondary to reduced gene expression. (nih.gov)
  • Reciprocal effects of micro-RNA-122 on expression of heme oxygenase-1 and hepatitis C virus genes in human hepatocytes. (wakehealth.edu)
Mice4
  • Refeeding of a chow diet to fasted mice increased CYP7A1 expression, bile acid pool size, and serum bile acids in wild type and humanized CYP7A1-transgenic mice. (omeka.net)
  • Refeeding also induced CYP7A1 in fxr-deficient mice, indicating that FXR signaling did not play a role in postprandial regulation of bile acid synthesis. (omeka.net)
  • However, refeeding did not further increase CYP7A1 expression in diabetic mice. (omeka.net)
  • We also show that MHV replication induced the expression of other genes known to be downstream of AhR in macrophages and dendritic cells and in livers of infected mice. (bvsalud.org)
Inhibit2
  • Therefore, MKP-1 up-regulation provides a novel and rapid mechanism, whereby GCs inhibit osteoblast proliferation. (ox.ac.uk)
  • Genes that inhibit expression of the tumorigenic phenotype. (edu.au)
Embryonic2
  • Cloning of a novel phospholipase C-delta isoform from pacific purple sea urchin (Strongylocentrotus purpuratus) gametes and its expression during early embryonic development. (ox.ac.uk)
  • E2F6 cooperates with MGA to silence a subgroup of germline genes in mouse embryonic stem cells and in embryos, a function that critically depends on the E2F6 marked box domain. (cnrs.fr)
Enzyme2
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis. (lookformedical.com)
  • Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. (ox.ac.uk)
Repression1
Bile acid3
  • Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. (omeka.net)
  • In summary, this study demonstrates that glucose and insulin are major postprandial factors that induce CYP7A1 gene expression and bile acid synthesis. (omeka.net)
  • On the mechanism of bile acid inhibition of rat sterol 12alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha. (omeka.net)
Protein expression5
  • protein expression and mRNA levels of major p450 isoforms, and (3). (nih.gov)
  • Vascular endothelial growth factor increases heme oxygenase-1 protein expression in the chick embryo chorioallantoic membrane. (wakehealth.edu)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
  • The experimental part includes the cloning of plasmids to produce C1 inhibitor and various forms of merozoite surface protein PfMSP3.1, transfection of S2 insect cells with these plasmids, subsequent protein expression in S2 cells and their purification. (nusl.cz)
Chromosome1
  • This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancer-genetics.org)
Cells9
  • Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response. (wakehealth.edu)
  • Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. (wakehealth.edu)
  • Increased heme oxygenase-1 gene expression in liver cells and splanchnic organs from portal hypertensive rats. (wakehealth.edu)
  • Effects of phenylarsine oxide on expression of heme oxygenase-1 reporter constructs in transiently transfected cultures of chick embryo liver cells. (wakehealth.edu)
  • Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. (wakehealth.edu)
  • Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells. (wakehealth.edu)
  • Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS. (lookformedical.com)
  • Furthermore, single-cell RNA-sequencing of airway cells from patients with COVID-19 demonstrated that TMEM106B expression correlates with SARS-CoV-2 infection. (bvsalud.org)
  • Here, we show that the aryl hydrocarbon receptor (AhR) is activated in cells infected with a prototypic coronavirus, mouse hepatitis virus (MHV), resulting in the expression of several effector genes. (bvsalud.org)
Viral3
  • Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancer-genetics.org)
  • Knockdown of TiPARP reduced viral replication and increased interferon expression, suggesting that TiPARP functions in a proviral manner during MHV infection. (bvsalud.org)
  • AhR is important for modulation of the host immune response to MHV and plays a role in the expression of TiPARP, which we show is required for maximal viral replication. (bvsalud.org)
Transcriptional1
  • This inhibition is reversed by cotreatment with the protein synthesis inhibitor, cycloheximide, and by the GC receptor antagonist, RU486, suggesting a classical transcriptional mechanism. (ox.ac.uk)
Differential1
  • Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin. (wakehealth.edu)
Therapeutic1
  • Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future. (ox.ac.uk)
Transcript variants2
  • Alternative splicing of this gene results in multiple transcript variants. (cancerindex.org)
  • Three transcript variants encoding different isoforms have been found for this gene. (cancer-genetics.org)
Cellular2
  • Various cellular mechanism are involved in repairing, extending, and recapping the telomere ends. (lookformedical.com)
  • In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. (ox.ac.uk)
Calcium1
  • One of the key mechanisms involved in triggering intracellular calcium release is the generation of the second messenger inositol-1,4,5-phosphate (IP(3)) by the phospholipase C (PLC) class of enzymes. (ox.ac.uk)
Hepatic1
  • Heme status affects human hepatic messenger RNA and microRNA expression. (wakehealth.edu)
Upstream1
  • Digital expression patterns results suggested that the 4 genes including ODC, ADC, AIH and CPA involved in the upstream pathway of TAs, and the 2 branch pathway genes including SPDS and TRII were found to be expressed in all the detected tissues with high expression level in secondary root. (bvsalud.org)
Reveal1
  • CONCLUSIONS: These findings reveal that MT1-MMP and MMP-1 expression levels and AI are useful prognostic indicators in advanced colorectal carcinoma and suggest that markers of MMP expression might be used in identifying patients who would benefit from new treatment modalities involving MMP inhibitors. (ox.ac.uk)
Induction1
Transcription factors1
Findings1
  • Our findings provide the first evidence that PLCzeta may be expressed in the egg, rather than the sperm, in some vertebrate species, and that its mechanism of action and physiologic role at fertilization may differ in different vertebrate species. (ox.ac.uk)
Factors1
  • However, mechanisms of damage by DEP exposure to human respiratory health and human susceptibility factors are only partially known. (duke.edu)
Liver1
  • Regulation of expression of the human heme oxygenase-1 gene in transfected chick embryo liver cell cultures. (wakehealth.edu)
Role3
  • Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin. (wakehealth.edu)
  • These mechanisms include a role for the human -1607GG polymorphism as a susceptibility factor for an accentuated response, which critically depends on the ability of beta-arrestin1/2 to generate scaffolding and nuclear trafficking of phosphorylated ERK1/2. (duke.edu)
  • and even the role of particular amino acid residues in the mechanism. (wikipedia.org)