• Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
  • PVAT inflammation could induce various crucial stages of atherosclerosis by disturbing secretion of inflammatory and anti-inflammatory adipokines, inhibiting PVAT cell autophagy, and activating angiogenesis in arterial adventitia, thereby promoting the onset and progression of atherosclerosis. (magtechjournal.com)
  • Research progress on the mechanism of perivascular adipose tissue inflammation promoting atherosclerosis[J]. Basic & Clinical Medicine, 2023, 43(4): 685-689. (magtechjournal.com)
  • Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis[J]. Br J Pharmacol, 2017, 174:4055-4069. (magtechjournal.com)
  • Evidence continues to accumulate to suggest important roles for inflammation and genetic factors in the process of atherosclerosis and specifically in stroke. (medscape.com)
  • It is generally accepted that dysregulated liver lipid metabolism and inflammation are two crucial mechanisms involved in NAFLD development, although the transcription network and the related epigenome remodeling events remain largely unclarified. (ki.se)
  • In rheumatic patients with accelerated inflammatory atherosclerosis and bone loss, the rapid and effective suppression of inflammation in a treat-to-target regime, aiming at clinical remission, is necessary to effectively control comorbidities. (amsterdamumc.org)
  • Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)
  • Therefore, with the aim to summarize the current knowledge on the initiation of the atherosclerotic process, in this paper, we review the early markers of atherosclerosis and we address the main therapeutic targets for preventing atheroma formation at its very initial stages focusing on inflammation, oxidative stress, endothelial dysfunction, and the interaction between platelets and endothelium. (hindawi.com)
  • The role of oxidized phospholipid in atherosclerosis and inflammation. (uclahealth.org)
  • The aim of the present study was to determine the pro-angiogenic effects and mechanism of SBP during inflammation or ischemic pathological conditions and elucidate its regulatory effects on endothelial cell function and signaling pathways mediated by macrophages. (visualsonics.com)
  • suggests that bilirubin is a potent physiolog- ical antioxidant that may provide important protection against atherosclerosis, CAD and inflammation. (who.int)
  • The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
  • Vascular endothelial cells serve a key role in the pathogenesis of atherosclerosis by regulating vascular tension, platelet adhesion, inflammation and fibrinolysis ( 5 ). (spandidos-publications.com)
  • The etiology of atherosclerosis is unknown, but there are multiple factors that contribute to atherosclerotic plaque progression. (medscape.com)
  • From early fatty-streak lesions to advanced plaques, macrophage-derived foam cells are integral to the development and progression of atherosclerosis. (ox.ac.uk)
  • For example, serum biomarkers, such as high sensitivity C-reactive protein (hsCRP) and cytokine levels, predict progression of atherosclerosis and risk of stroke. (medscape.com)
  • In this review, we briefly summarize the pathogenesis of NAFLD and factors that influence the progression of NAFLD, and focus on the potential mechanisms of BBR in the treatment of NAFLD. (mdpi.com)
  • The goals of therapy should include arresting atherosclerosis or even reversing its progression. (medscape.com)
  • The primary such as hs-CRP, total homocysteine, as well enzymatic defences are intracellular, but as oxidative stress, have been proposed other antioxidant defences are largely ex- as risk factors for the development and tracellular, including antioxidative sub- progression of atherosclerosis and athero- strates such as uric acid and unconjugated thrombotic cardiovascular disease [10-13]. (who.int)
  • During this process, many inflammatory factors are released, leading to aggravated progression of atherosclerosis and the formation of atherosclerotic plaques ( 7 ). (spandidos-publications.com)
  • To identify targetable mechanisms and pathways underlying initiation and progression of MARD and CVD. (lu.se)
  • E-LDL is recognised by the C1q subunit of C1 and triggers direct C1 activation, suggesting that complement activation by E-LDL may play a crucial role in the pathogenesis of atherosclerosis. (europa.eu)
  • It is also emerging as an important factor in atherosclerosis: complement activation, and formation of the terminal C5b-9 membrane attack complex of complement were shown to occur in atherosclerotic lesions. (europa.eu)
  • Atherosclerosis is the principal cause of coronary artery disease (CAD), in which atherosclerotic changes are present within the walls of the coronary arteries. (medscape.com)
  • The term atherosclerosis is derived from the Greek "athero," meaning gruel, or wax, corresponding to the necrotic core area at the base of the atherosclerotic plaque, and "sclerosis" for hardening, or induration, referring to the fibrous cap of the plaque's luminal edge. (medscape.com)
  • 1998. Atherosclerotic risks from chemicals: Part I. Toxicological observations and mechanisms of atherosclerosis. (cdc.gov)
  • Alogliptin improves endothelial function by promoting autophagy in perivascular adipose tissue of obese mice through a GLP-1-dependent mechanism[J]. Vascul Pharmacol, 2019, 115:55-63. (magtechjournal.com)
  • Heterogeneity in arterial stiffening mechanisms with aging may influence cardiovascular disease development. (bvsalud.org)
  • Atherosclerosis is an arterial condition characterized by the accumulation mainly of lipid tissue, resulting in the narrowing and stiffening of arteries. (tudelft.nl)
  • Atherosclerosis is the most common form of arteriosclerosis, which is a general term for several disorders that cause thickening and loss of elasticity in the arterial wall. (msdmanuals.com)
  • These LDL particles are modified by a number of mechanisms, including enzymatic degradation, aggregation and oxidation. (europa.eu)
  • Oxidation of low-density lipoprotein (LDL) cholesterol is one of the key factors for the development of atherosclerosis. (hindawi.com)
  • Oxidation of low-density lipoprotein (LDL) cholesterol is crucial in the development of atherosclerosis, and low LDL levels reduce the risk of major events in patients with CVD [ 6 ]. (hindawi.com)
  • Recently, trimethylamine-N-oxide (TMAO) has been identified as a novel and independent risk factor for promoting atherosclerosis (AS) partially through inhibiting hepatic bile acid (BA) synthesis. (nih.gov)
  • This publication pulled together data from several studies, both mouse and human, to assess the role of trimethylamine-N-oxide (TMAO) on atherosclerosis. (naturalmedicinejournal.com)
  • The chronic endothelial injury hypothesis is one of two major mechanisms postulated to explain the underlying cause of atherosclerosis and coronary heart disease (CHD), the other being the lipid hypothesis. (wikipedia.org)
  • According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury. (medscape.com)
  • Infections and inflammatory conditions also contribute to endothelial injury and atherosclerosis. (medscape.com)
  • Periodontal pathogens can, thus, disseminate through the blood and can contribute to development of adverse systemic effects by direct (endothelial injury or dysfunction) indirect (through lipopolysaccharide (LPS) activated cytokine profiles) mechanisms [8]. (bvsalud.org)
  • A team of researchers from Japan and the U.S. compiled and described possible molecular mechanisms by which statins could actually accelerate heart disease. (drfuhrman.com)
  • But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. (springer.com)
  • There are many researches on Rhizoma coptidis, but most of them are only a small part of the whole molecular mechanisms. (springer.com)
  • As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
  • Systemic conditions may modify the extent of periodontitis principally through their effects on normal immune and inflammatory mechanisms. (medscape.com)
  • The limited efficacy of current treatment strategies for targeting atherosclerosis and its complications requires new therapeutic options to be explored. (ox.ac.uk)
  • Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)
  • Mechanisms and therapy of atherosclerosis and its clinical complications. (bvsalud.org)
  • Name physiological mechanisms where transport is operational? (fsu.edu)
  • The underlying physiological mechanisms behind the increased risk for cardiovascular disease remain unresolved. (cdc.gov)
  • Recognition of ATP-binding cassette cholesterol transport mechanisms and cellular interactions with cholesterol-accepting apolipoproteins (or synthetic mimetics) opens up new potential therapies to induce atherosclerosis regression in humans. (ox.ac.uk)
  • Atherosclerosis is initiated by endothelium dysfunction, followed by immune cell (including monocytes) infiltration into the vascular intima to induce forming of plaques. (ki.se)
  • Since endothelial dysfunction precedes overt atherosclerosis, investigating the ability of drugs to activate cytoprotective signalling pathways that prevent or reverse endothelial dysfunction is an attractive research strategy. (bmj.com)
  • From the beginning of this epidemic, NIMH has supported a rigorous and integrated research agenda to understand the mechanisms involved in the pathophysiology of HIV-induced CNS dysfunction and the establishment and persistence of the HIV reservoir in CNS. (nih.gov)
  • Carotid Artery Stiffening With Aging: Structural Versus Load-Dependent Mechanisms in MESA (the Multi-Ethnic Study of Atherosclerosis). (bvsalud.org)
  • Changes in carotid artery stiffness mechanisms over 10 years were compared by age groups with ANCOVA models adjusted for baseline cardiovascular disease risk factors . (bvsalud.org)
  • Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice. (usda.gov)
  • However, the underlying genetic mechanisms and brain structural changes are unknown. (nature.com)
  • This indicates that possible genetic mechanisms and brain structural changes may underlie the nonlinear relationship between sleep duration and cognition and mental health. (nature.com)
  • These results offer new insights into the mechanisms responsible for RSV's anti-AS effects and indicate that the gut microbiota may become an interesting target for pharmacological or dietary interventions to decrease the risk of developing cardiovascular diseases. (nih.gov)
  • Translational control mechanisms in angiogenesis and vascular biology. (rochester.edu)
  • Atherosclerosis is generally considered to be a chronic inflammatory process. (europa.eu)
  • Nevertheless, prevention of cardiac events is likely to have the largest impact on decreasing the burden of atherosclerosis. (medscape.com)
  • Here, we aimed to explore the mechanism of immune escape in AML with DNMT3A mutation. (frontiersin.org)
  • Immunosuppressive drug therapy and any disease (eg, HIV infection) resulting in suppression of the normal inflammatory and immune mechanisms can cause or enhance severe periodontal diseases. (medscape.com)
  • Atherosclerosis is characterized by patchy intimal plaques (atheromas) that encroach on the lumen of medium-sized and large arteries. (msdmanuals.com)
  • Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
  • Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production[J]. Sci Adv, 2021, 7:eabl4024. (magtechjournal.com)
  • In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate the underlying mechanisms. (mdpi.com)
  • These findings strongly suggest that the largest impact on decreasing the global burden of atherosclerosis will come from prevention of events. (medscape.com)
  • Increased evidence indicates that berberine (BBR), a natural plant product, has beneficial effects on NAFLD, though the mechanisms are not completely known. (mdpi.com)
  • Although statins appear to have side effects that are helpful, such as improving endothelial function (ability of endothelial cells to regulate dilation and contraction of the smooth muscle layer of blood vessels) and reducing inflammatory markers, 10 the question is now being raised whether statins have effects that actually promote atherosclerosis and heart failure, negating these potential benefits. (drfuhrman.com)
  • however, its mechanisms of action remain unclear. (nih.gov)
  • DNA (cytosine-5)-methyltransferase 3A (DNMT3A)-mutated acute myeloid leukemia (AML) has a poor prognosis, but the exact mechanism is still unclear. (frontiersin.org)
  • DNMT3A-mutated AML has high-risk characteristics and shows significantly worse overall survival (OS) ( 2 ), but its mechanism is unclear ( 3 ). (frontiersin.org)
  • However, the underlying mechanisms for the increased cardiovascular risk are still unclear. (lu.se)