Mechanisms acute lung injury. Medical search. Frequent questions

Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. (wikipedia.org)
In effect, ARDS impairs the lungs' ability to exchange oxygen and carbon dioxide. (wikipedia.org)
Although the terminology of "adult respiratory distress syndrome" has at times been used to differentiate ARDS from "infant respiratory distress syndrome" in newborns, the international consensus is that "acute respiratory distress syndrome" is the best term because ARDS can affect people of all ages. (wikipedia.org)
This complication typically occurs due to the restriction of the blood vessel due to inflammation of the mechanical ventilation There are direct and indirect causes of ARDS depending whether the lungs are initially affected. (wikipedia.org)
ARDS is a form of fluid accumulation in the lungs not explained by heart failure (noncardiogenic pulmonary edema). (wikipedia.org)
Of these, the pathology most commonly associated with ARDS is DAD, which is characterized by a diffuse inflammation of lung tissue. (wikipedia.org)
The effects of vitamin C on acute respiratory distress syndrome (ARDS) frequently complicating COVID-19 pneumonia should be considered. (frontiersin.org)
In addition, in septic mice with acute respiratory distress syndrome (ARDS), vitamin C administration downregulated proinflammatory genes, enhanced epithelial barrier function, and improved alveolar fluid clearance ( 9 , 10 ). (frontiersin.org)
If pathological changes were not timely curbed, acute respiratory distress syndrome (ARDS) could be developed [ 8 - 10 ] . (researchsquare.com)
The indications of HBO for the treatment of lung diseases include pulmonary edema, ARDS, etc., and the earlier the treatment is implemented, the better results will be achieved. (researchsquare.com)
Prone position has been used to treat severe hypoxemia in patients with acute respiratory distress syndrome (ARDS) since the 1970s. (springer.com)
4] Zhou M. Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention. (signavitae.com)
Dr. Ciara Shaver's laboratory is focused on understanding the mechanisms of acute lung injury and the acute respiratory distress syndrome (ARDS). (vumc.org)
Her scientific approach combines data from multiple animal models of acute lung injury with translational data from patients with ARDS. (vumc.org)
Backgound Acute respiratory distress syndrome (ARDS) is a highly fatal syndrome especially in resource constrained settings. (rcpe.ac.uk)
Acute respiratory distress syndrome (ARDS) is a life-threatening disorder of the lungs seen in critically ill patients. (rcpe.ac.uk)
To date, the only best available effective treatment for ARDS is mechanical ventilation with low tidal volumes (TVs) as a lung protective strategy along with good supportive care. (rcpe.ac.uk)
Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome (ARDS) with high mortality in patients with severe coronavirus disease 2019 (COVID-19). (uni-kiel.de)
The intestinal ischemia and reperfusion injury (intestinal-I/R) is a clinical problem associated with systemic inflammation, pulmonary microcirculation dysfunction and Acute Respiratory Distress Syndrome (ARDS). (fapesp.br)
ARDS is a form of acute pulmonary injury characterized by tissue and microvascular injury. (fapesp.br)
Although neutrophils exert a pivotal role in this disorder, a definitive pharmacological approach to ARDS treatment is yet unavailable probably due the complexity of mechanisms involved to pulmonary inflammation. (fapesp.br)

Background and Purpose: Sepsis is a life-threatening condition associated with secondary multiple organ injury. (figshare.com)
Acute lung injury (ALI) caused by sepsis has high morbidity and mortality in critical care units. (figshare.com)
Our study aimed to evaluate the effect of LHQW on sepsis-induced ALI and its underlying mechanism. (figshare.com)
For a long time we haven't known why people, when they are critically ill from sepsis, trauma, COVID-19, a bacterial infection, or parasite infection, develop an acute anemia. (news-medical.net)
To understand the role of various inflammatory pathways in sepsis and SIRS using mouse models of Caecal Ligation and Puncture (CLP), Lipopolysaccharide (LPS), and acute lung injury mouse models. (edu.au)
BACKGROUND: Sepsis can result in acute lung injury (ALI). (bvsalud.org)
However, the regulatory mechanisms of ferroptosis in sepsis-induced ALI remain unclear. (bvsalud.org)
METHODS: Transcriptome sequencing was performed on lung tissue samples from 10 sepsis-induced mouse models of ALI and 10 control mice. (bvsalud.org)
Endothelial barrier dysfunction occurs at every stage of acute lung injury (ALI) in severe sepsis, leading to vascular leakage, edema, and respiratory failure. (umaryland.edu)

To investigate this in detail, we will use intravital and ex vivo microscopy, whole-body imaging, and light sheet microscopy to analyze NET formation in the kidney during sterile inflammation, and in the lung during bacterial infection (1, 2). (uni-muenster.de)
Therefore, methane exerts therapeutic effects on acute orchitis and might be a new and convenient strategy for the treatment of inflammation-related testicular diseases. (hindawi.com)
Oxidative stress and reactive oxygen species (ROS), which are majorly sourced from macrophages [ 5 ], may be the major contributory factors leading to testicular cell apoptosis and acute inflammation of testes [ 6 ]. (hindawi.com)
Can we prevent the spread of focal lung inflammation? (healthpartners.com)
Recently we showed that the magnitude of the inflammation and the pulmonary microvascular injury caused by the intestinal-I/R is modulated by factors drained from lymph of the mesenteric system. (fapesp.br)
Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation. (biomedcentral.com)
Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
3) ultrafine particles have been linked to respiratory (such as lung inflammation and fibrosis) and cardiovascular health effects (Farina et al. (cdc.gov)

This article reviewed the natural source and pharmacokinetics of AG and systematically summarized the pharmacological activities and potential mechanisms of AG in treating diverse diseases in order to promote the development of AG as a functional food, in doing so providing references for its clinical application in disease therapy. (frontiersin.org)
Potential molecular mechanisms of AG in treating various diseases. (frontiersin.org)
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. (signavitae.com)
3] Steer ML. Relationship between pancreatitis and lung diseases. (signavitae.com)
His research interests are acute and chronic oxidant-induced lung injury, liver neoplasms, alcoholic and non-alcoholic liver diseases, colorectal cancer and underlying molecular mechanisms. (yale.edu)
This mechanistic discovery opens the door to research on how to block this specific receptor and create targeted therapies for autoimmune diseases, infectious diseases, and a whole host of inflammatory illnesses associated with acute anemia. (news-medical.net)
The Center's goal is to further our conceptual and mechanistic understanding of diseases that affect the airways of the lungs. (unclineberger.org)
It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted. (rutgers.edu)
Evidence linking environmental risks to noncommunicable for protecting health from environmental risks in the diseases and injuries is also emerging rapidly. (who.int)
Public health surveillance is vital to preventing occupational diseases, injuries, and fatalities ( 4 ). (cdc.gov)
Although surveillance of occupational diseases and injuries in the United States has improved substantially during the last decade, it remains inadequate. (cdc.gov)
State health agencies that have access to various public health data systems are uniquely positioned to 1) provide critical data on occupational diseases, 2) generate information necessary to evaluate the conventional occupational injury data sources, 3) link surveillance findings with intervention efforts, and 4) integrate occupational health into mainstream public health ( 5 ). (cdc.gov)
In the with underlying diseases of various origins the lungs to translocate to epithelial cells study by Lehnert et al. (cdc.gov)

Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear. (nih.gov)
Guidelines for the diagnosis and treatment of acute lung injury/acute respiratory distress syndrome (2006). (signavitae.com)

The underlying mechanism involves diffuse injury to cells which form the barrier of the microscopic air sacs of the lungs, surfactant dysfunction, activation of the immune system, and dysfunction of the body's regulation of blood clotting. (wikipedia.org)
Inhaled methane limits mitochondrial electron transport chain dysfunction and confers protection against mitochondrial dysfunction during experimental liver ischemia-reperfusion injury [ 11 ]. (hindawi.com)
Our study for the first time uncovered the existence of NOX2/eNOS uncoupling/Rho signaling pathway, which is involved in the mechanism of endothelial barrier dysfunction. (umaryland.edu)
Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury. (umaryland.edu)
Menthol flavoring in e-cigarette condensate causes pulmonary dysfunction and cytotoxicity in precision cut lung slices. (rutgers.edu)

Acute lung injury is a critical illness syndrome consisting of acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension. (nih.gov)
Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. (biomedcentral.com)
The purpose of this study is to investigate the efficacy and safety of Zilucoplan in improving oxygenation and short- and long-term outcome of COVID-19 patients with acute hypoxic respiratory failure. (biomedcentral.com)

A single-center, randomized controlled trial of pediatric patients with acute lung injury after surgery for congenital heart disease who will receive prone position ventilation or usual care (control group). (springer.com)
To develop an XGBoost model to predict the occurrence of acute lung injury (ALI) in patients with acute pancreatitis (AP). (signavitae.com)

Herter JM, Kraft F, Van Aken H, Meersch M, Zarbock A , Rossaint J . GDF-15 prevents ventilator-induced lung injury by inhibiting the formation of platelet-neutrophil aggregates. (uni-muenster.de)
Spontaneous breathing, extrapulmonary CO(2) removal, and ventilator-induced lung injury risk: less power to the people [editorial]? (healthpartners.com)

These findings explain one of the mechanisms for the development of acute inflammatory anemia for the first time. (news-medical.net)
The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models. (ucsf.edu)

Targeting this TLR9 may also be a way to dampen some of the innate immune activation without blocking this receptor in immune cells, which are very important for the host when fighting a pathogen or injury. (news-medical.net)
Her previous graduate work investigated the interactions between bacterial exotoxins and innate immune cells during acute bacterial pneumonia. (vumc.org)
Doerschuk's research addresses host defense mechanisms in the lungs, particularly the inflammatory and innate immune processes that are important in the pathogenesis and course of bacterial pneumonia, acute lung injury/acute respiratory distress syndrome, and lung disease induced by tobacco products. (unclineberger.org)
Her studies pursue the functions of lung macrophage subpopulations, NK cells and neutrophils during innate immune responses. (unclineberger.org)
In platelet refractoriness, his group studies the pro-inflammatory nature of platelets responsible for adverse reactions during platelet transfusions, particularly how platelet Toll-like receptor expression modulates innate immune mechanisms. (lu.se)

Doerschuk is interested in the mechanisms through which the lungs produce cytokines, chemokines and other regulatory inflammatory mediators in response to bacterial, viral, and other pathogens that then induce the production of other mediators and adhesion molecules on endothelial cells and result in the recruitment of leukocytes. (unclineberger.org)
In this study, using 2 distinct mouse models of mucosal inflammatory disease (LPS-induced acute lung injury and ligature-induced periodontitis), we demonstrated that the antiinflammatory action of erythromycin (ERM) is mediated through upregulation of the secreted homeostatic protein developmental endothelial locus-1 (DEL-1). (jci.org)
Consistent with the anti-neutrophil recruitment action of endothelial cell-derived DEL-1, ERM inhibited neutrophil infiltration in the lungs and the periodontium in a DEL-1-dependent manner. (jci.org)
By interacting with the growth hormone secretagogue receptor and activating JAK2 in human lung microvascular endothelial cells, ERM induced DEL-1 transcription that was mediated by MAPK p38 and was CCAAT/enhancer binding protein-β dependent. (jci.org)
The generation of mediators and growth factors, which interact with the endothelial cells, constitute a crucial event for the lung injury. (fapesp.br)
Factors of lymph could affect the endothelial-leukocyte interaction, causing generation of new inflammatory mediators in the lung and modifying the functional state of pulmonary phagocytes. (fapesp.br)

In addition to the immunosuppressed status of the recipient, other factors that predispose to early bacterial pneumonias include the need for prolonged mechanical ventilatory support, blunted cough due to postoperative pain and weakness, disruption of lymphatics, and ischaemic injury to the bronchial mucosa with resultant impairment in mucociliary clearance. (ersjournals.com)

OBJECTIVE: To describe the clinical implications of an often neglected mechanism through which localized acute lung injury may be propagated and intensified. (healthpartners.com)
Acute transfusion reactions may present in complex clinical situations when the diagnosis requires distinguishing between a reaction to the transfused blood product and a coincidental complication of the illness being treated that occurs during or immediately after a blood transfusion. (medscape.com)
The clinical syndrome is associated with pathological findings including pneumonia, eosinophilic pneumonia, cryptogenic organizing pneumonia, acute fibrinous organizing pneumonia, and diffuse alveolar damage (DAD). (wikipedia.org)
To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. (ucsf.edu)
The prevention and treatment of acute chest syndrome (ACS) is a major clinical concern in sickle cell disease (SCD). (jci.org)
Dr. Shaver's clinical interest is in lung transplantation with a particular focus on the early postoperative events that predict long-term outcomes. (vumc.org)
One of the primary clinical manifestations of HS is the disruption of the vascular barrier, which leads to microvascular hyperpermeability in vital organs such as the lungs. (umaryland.edu)

Mechanical ventilation is associated with important complications, among which production or perpetuation of acute lung injury and product of distant organ injuries of the lung basically through the release of inflammatory mediators to the systemic circulation. (isciii.es)

Subsequently, he partnered with others in the division to examine mechanisms contribution the resolution of acute lung injury. (hopkinsmedicine.org)

HRS and HBO could all decrease the release of immflammatory cytokines in lung tissue, reduce accumulation of oxidative products and alleviate apoptosis of pulmoanry cells, and could produce good therapeutic effects on ALI induced by LPS. (researchsquare.com)
Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
Hence, treatment strategies for orchitis should focus on the balance of inflammatory cytokines, removal of oxidative and apoptotic injury, and regulation of the PK2/PKR1 pathway. (hindawi.com)

In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
The present study is aimed at investigating the anti-inflammatory, antioxidative, and antiapoptotic effects of methane on lipopolysaccharide- (LPS-) induced acute orchitis and its potential mechanisms. (hindawi.com)
Because polyphenol catechins could confer antioxidative, anti-inflammatory, antiviral, and antimicrobial activities, we assessed the therapeutic effects of catechins against SARS-CoV replication in Vero E6 cells, the preventive effect of catechins on CD25/CD69/CD94/CD8 + cytotoxic T lymphocytes-mediated adaptive immunity, and the protective effect on lipopolysaccharide-induced acute lung injury (ALI) in mice. (ntnu.edu.tw)

Acute transfusion reactions present as adverse signs or symptoms during or within 24 hours of a blood transfusion. (medscape.com)
The onset of red urine during or shortly after a blood transfusion may represent hemoglobinuria (indicating an acute hemolytic reaction) or hematuria (indicating bleeding in the lower urinary tract). (medscape.com)
His laboratory also studies the recipient immune mechanisms that cause Transfusion Related Acute Lung Injury (TRALI), a serious complication of transfusion. (lu.se)

Currently, Dr. Shaver's primary focus is to understand the inflammatory consequences of extracellular hemoglobin in the airspace, particularly focusing on the role of macrophage subpopulations in regulating immune responses in the lung. (vumc.org)
To understand the underlying mechanisms involved in lung pathology, we investigated the role of the lung-specific immune response. (uni-kiel.de)
His research is aimed at understanding the cellular immune mechanisms responsible for the generation of IgG antibodies that recognize platelet antigens. (lu.se)

We established ALI model C57/BL6 mice via an intraperitoneal injection of LPS and inhibited p53 expression by pifithrin-α, in order to validate the mechanism by which LHQW exerted protective role in ALI. (figshare.com)
In addition, the deficiency of vitamin C increased lung pathology caused by influenza A in mice ( 11 ). (frontiersin.org)
Optimizing anesthesia and delivery approaches for dosing into lungs of mice. (ucsf.edu)
Infusion of a low dose of hemin caused acute intravascular hemolysis and autoamplification of extracellular hemin in transgenic sickle mice, but not in sickle-trait littermates. (jci.org)
Replication of the ACS-like phenotype in nonsickle mice revealed that the mechanism of lung injury due to extracellular hemin is independent of SCD. (jci.org)
Our results reveal a mechanism that helps to explain the pathogenesis of ACS, and we provide proof of principle for therapeutic strategies to prevent and treat this condition in mice. (jci.org)
Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice. (ca.gov)
Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. (ca.gov)
Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics. (rutgers.edu)
I don't like wasting organs, so even though I'm a lung doctor and I mainly focus on the cells of host defense, when we do a harvest on these mice, that we've exposed for weeks and months to E-cigarettes, we harvest almost every part of the body. (scireq.com)
Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. (who.int)

Prone position ventilation is a widely used lung protection ventilation strategy. (springer.com)
Due to the precise mechanism of improving oxygenation function, development of pediatric prone ventilation technology has been largely focused on children with acute respiratory distress syndrome. (springer.com)
The purpose of this study is to evaluate the feasibility and effectiveness of prone position ventilation in infants who develop postoperative acute lung injury after surgery for congenital heart disease. (springer.com)
This study will investigate the feasibility and effectiveness of prone position ventilation techniques in children who develop postoperative acute lung injury after surgery for congenital heart disease. (springer.com)
Prone position ventilation refers to placement of the patient in the prone position during mechanical ventilation to facilitate lung expansion in the atelectatic area and improve the ventilation-perfusion ratio. (springer.com)
Prone position ventilation promotes lung recruitment and improves gas exchange through its effects on pleural pressure and lung compression [ 2 ]. (springer.com)
Prone position ventilation can reduce the difference between the dorsal and ventral pleural pressure, thereby improving the uniformity of lung ventilation and reducing alveolar hyperinflation and alveolar collapse. (springer.com)
A total of 1113 King County residents undergoing mechanical ventilation met the criteria for acute lung injury and were 15 years of age or older. (nih.gov)
Does mechanical ventilation "hit" the lungs? (healthpartners.com)
Does positive end-expiratory pressure improve CO(2) exchange in controlled ventilation of acute airflow obstruction [editorial]? (healthpartners.com)

TRALI has two proposed pathophysiologic mechanisms: the antibody hypothesis and the neutrophil priming hypothesis. (medscape.com)

Guidelines for the diagnosis and management of acute pancreatitis in China (2021). (signavitae.com)

Acute exposure to higher vapor concentrations may cause severe pulmonary edema and injury to the alveolar walls of the lung and death. (cdc.gov)
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients. (uni-kiel.de)
Effective antiviral therapeutics are urgently required to fight severe acute respiratory syndrome (SARS) caused by a SARS coronavirus (SARS-CoV). (ntnu.edu.tw)

Basic and translational studies address the mechanisms of host defense that focus on leukocyte recruitment, edema, and lung injury using in vivo, translational, imaging, cell biological, immunological, and molecular approaches. (unclineberger.org)
We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism. (rutgers.edu)

However, the mechanism underlying the pathogenesis of ACS remains elusive. (jci.org)

Although MSC-derived EVs (mEVs) are beneficial for acute lung injury and pulmonary fibrosis, mechanisms of mEV uptake by lung fibroblasts and their effects on myofibroblastic differentiation have not been established. (nih.gov)
We demonstrate that mEVs, but not fibroblast EVs (fEVs), suppress TGFβ1-induced myofibroblastic differentiation of normal and idiopathic pulmonary fibrosis (IPF) lung fibroblasts. (nih.gov)
The common reasons for prolonged hospitalization were mandatory isolation 28% (n = 62), hospital-acquired infections 17% (n = 37), acute respiratory distress syndrome 15% (n = 32), myopathy/neuropathy 14% (n = 31), pulmonary fibrosis requiring oxygen supplementation 14% (n = 31), and completion of COVID-19 treatment 12% (n = 25). (who.int)
Pulmonary fibrosis is a well-known consequence of acute respiratory distress syndrome and affects the life of survivors (5). (who.int)

Proportions of patients who had acute liver failure, received a liver transplant, and died were similar between those who tested positive for adenovirus compared with those who tested negative. (cdc.gov)
INTERPRETATION: Adenovirus, alone or in combination with other factors, might play a potential role in acute hepatitis among immunocompetent children identified in this investigation, but the pathophysiologic mechanism of liver injury is unclear. (cdc.gov)

If oxygenation remains insufficient, lung recruitment maneuvers and neuromuscular blockers may be used. (wikipedia.org)
The main outcome measures will be lung compliance and oxygenation index. (springer.com)
Zilucoplan (complement C5 inhibitor) has profound effects on inhibiting acute lung injury post COVID-19, and can promote lung repair mechanisms that lead to improvement in lung oxygenation parameters. (biomedcentral.com)

Initial attempts to perform lung transplantation (LTx) were marred by technical limitations that often resulted in early postoperative death. (ersjournals.com)

Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. (ca.gov)
There is increasingly greater evidence in both in vitro and i n vivo experimental models that show the reality of this lesional mechanism. (isciii.es)

3 days later, we study lung pathological, the levels of inflammatory factors, and cell apoptosis in the pulmonary tissue was detected by Tunel and cell apoptosis rate was calculated accordingly. (researchsquare.com)
By tracking T cell clones across tissues, we identified clonally expanded tissue-resident memory-like Th17 cells (Trm17 cells) in the lungs even after viral clearance. (uni-kiel.de)
In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)

This article will review the major medical complications, excluding allograft rejection, which may be encountered in the lung transplant recipient. (ersjournals.com)
While offering a vital therapeutic option for patients with advanced lung disease, LTx remains fraught with complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)
Following apparent recovery, post-COVID complications may occur, such as acute and chronic long-COVID-19 syndrome (2,3). (who.int)

Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)

Block H , Herter JM, Rossaint J , Stadtmann A, Kliche S, Lowell CA, Zarbock A . Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. (uni-muenster.de)
Zarbock A , Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. (uni-muenster.de)
Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
DNA, which are released from the contents monia AND neutrophil extracellular traps, of neutrophils as a defense mechanism to respiratory tract infection AND neutrophil trap and destroy microorganisms1. (bvsalud.org)

Were this true, modifications of ventilatory pattern and position aimed at geographic containment of the injury process could help prevent its generalization and limit disease severity. (healthpartners.com)
Experts remain perplexed about what is causing the nationwide outbreak of mysterious vaping-related lung disease that has affected hundreds and killed at least six people. (scientificamerican.com)
Pediatric acute lung injury (PALI) is a common complication of congenital heart disease that presents with refractory hypoxemia. (springer.com)
McGraw Lab - Understanding the mechanisms of fibrotic lung disease in order to bring new therapies to people who suffer from this devastating disease. (rochester.edu)
1] GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (signavitae.com)
Studies pursue the mechanisms through which tobacco smoke induces chronic obstructive pulmonary disease, both emphysema and chronic bronchitis and lung cancer, particularly the mechanisms that underlie exacerbations. (unclineberger.org)
T cells, which have been associated with disease severity and lung damage. (uni-kiel.de)
In April, 2022, following multiple reports of hepatitis of unknown aetiology and adenovirus viraemia in immunocompetent children in the USA and UK, the US Centers for Disease Control and Prevention (CDC) and jurisdictional health departments initiated national surveillance of paediatric acute hepatitis of unknown aetiology. (cdc.gov)
In 1998, the Council of State and Territorial Epidemiologists (CSTE) and CDC's National Institute for Occupational Safety and Health (NIOSH) convened a work group that identified priority occupational health conditions to be placed under surveillance, addressed cross-cutting surveillance concerns, and made recommendations regarding the role of states in a comprehensive nationwide surveillance system for work-related disease, injuries, and hazards. (cdc.gov)

Macrophage stimulation with free radical release in the early stage of lung injury due to acute toluene diisocyanate exposure. (cdc.gov)
The role of pulmonary macrophages (AM) and free radical (FR) formation in acute toluene diisocyanate exposure (TD/) inhalation injury is unknown. (cdc.gov)
We conclude that the early lung response to an acute irritant TDI exposure is stimulation of AM as demonstrated by increased CL, induction of NOS and FR formation. (cdc.gov)
Acute exposure to methyl isocyanate vapors below the odor threshold can be irritating to the eye and respiratory epithelium. (cdc.gov)
Acute exposure to higher vapor concentrations maycause severepulmonaryedema and injuryto the alveolar walls of the lung and death. (cdc.gov)
Pungent odor of methylisocyanatemaynot be adequate to warnof acute exposure. (cdc.gov)
This essay will provide a robust assessment of the mechanism of working of the chemical agents and the available treatment options in case of exposure to the agents. (ivoryresearch.com)
Infection rates among lung transplant recipients appear to be higher than those encountered in other solid organ transplant populations, likely related to the unique exposure of the lung allograft to the external environment and to the greater magnitude of immunosuppression employed 1 , 2 . (ersjournals.com)
Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
Interestingly, we found dilated alveolar spaces and alveolar ducts with damaged interalveolar septae, and impairment of lung function following WPS exposure. (who.int)

The purposes of this communication are to call attention to this seldom considered mechanism for extending lung injury that might further justify implementation of low tidal volume/high positive end-expiratory pressure ventilatory strategies for lung protection and to suggest additional therapeutic measures implied by this broadened conceptual paradigm. (healthpartners.com)

Lung injury is one of the most serious injuries that are difficult to handle and is a leading cause of death in patients with thoracic trauma [ 1 , 2 ] . (researchsquare.com)

Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis. (signavitae.com)

METHODS: Baseline data were collected from patients with first-ever acute cerebral infarction, serum Lp-PLA2 and MPO levels were measured. (bvsalud.org)

Right now when patients in the ICU become anemic, which is almost all of our critically ill patients, the standard is to give them blood transfusions, which has long been known to be accompanied by a host of issues including acute lung injury and increased risk of death,' Mangalmurti said. (news-medical.net)
Mangalmurti and fellow researchers are studying whether this is a valid option in diagnosing infection in critically ill patients and if this DNA-binding mechanism by red blood cells is a universal mechanism of anemia in parasitic infections. (news-medical.net)

CONCLUSIONS: The diffuse injury that characterizes acute respiratory distress syndrome is often considered a process that begins synchronously throughout the lung, mediated by inhaled or blood-borne noxious agents. (healthpartners.com)

Q: You are more focused on the lung and immunological responses to e-cigarettes, but what does the more general field of e-cigarette research look like? (scireq.com)

New regulatory mechanisms of TGF-beta receptor function. (ca.gov)

predominantly retained in the lungs during doi:10.1289/ehp.9685 available via http://dx.doi.org/ [Online 6 February 2007] the first week after inhalation. (cdc.gov)

Anatomy16

Organisms9

Diseases62

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes30

Disciplines and Occupations1

Information Science6

Health Care22

ARDS21

Sepsis9

Inflammation10

Diseases13

Treatment of acute lung i2

Dysfunction5

Respiratory failure3

Patients with acute2

Ventilator-induced lung injury2

Development of acute2

Innate immune5

Endothelial6

Bacterial1

Clinical8

Release of inflammatory mediators1

Resolution of acute1

Cytokines3

Lipopolysaccharide3

Transfusion3

Immune3

Mice11

Ventilation10

TRALI1

20211

Severe3

Molecular2

Pathogenesis1

Pulmonary fibrosis4

Liver2

Oxygenation3

Postoperative1

Experimental2

Tissue3

Complications3

Transplantation1

Neutrophil4

Disease9

Exposure10

Ventilatory1

Thoracic1

Systemic1

Methods1

Critically ill2

Mediated by inhaled1

Immunological1

Regulatory1

Inhalation1