• adaptor
  • This interaction was enhanced in the presence of the TBK1 adaptor proteins, NAP1 (NF-?B activating kinase-associated protein-1), SINTBAD (similar to NAP1 TBK1 adaptor) or TANK (TRAF family member-associated NF-?B activator). (jove.com)
  • Another DD-containing adaptor protein named TRADD, along with other proteins, binds to activated TNF1R, forming what is known as complex I. This results in activation of the NFκB pathway, which promotes cell survival. (wikipedia.org)
  • expression
  • To gain insight into this mechanism of protection, we analyzed the expression profiles of NF90ctv-positive cells as compared with parental cells transduced with the empty vector. (jove.com)
  • In this study, we demonstrate that interferon (IFN)-γ alone or in synergy with lipopolysaccharide (LPS) or interleukin 1α induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E 2 (PGE 2 ) release. (rupress.org)
  • infection
  • Here, we describe two methods to monitor RIG-I and PKR stimulation upon infection with an established interferon inducer, the Rift Valley fever virus mutant clone 13 (Cl 13). (jove.com)
  • Upon infection, there is a strong accumulation of RIG-I and PKR oligomeric complexes, whereas these proteins remained as monomers in mock infected samples. (jove.com)
  • poorly understood
  • In this review, we critically discuss the current evidence that identifies direct links between epigenetic modifications and ICD hallmarks, and put forward an otherwise poorly understood role for epigenetic drugs as ICD inducers. (frontiersin.org)
  • sequence
  • In contrast, IRF-2 is constitutively expressed and acts mostly as a repressor by competing with IRF-1 for the same cis-element (the ISRE has also been called IRF-1/IRF-2 binding sequence motif, or IRF-E), and possibly by repressing activators positioned nearby in the promoter ( 6 )( 7 )( 8 ). (rupress.org)
  • novel
  • In this study, we identified TRIM11 (tripartite motif containing 11) as a novel negative regulator of IFN? (jove.com)
  • This novel ankyrin-dependent assembly pathway suggests a mechanism whereby hereditary disorders of ankyrin may be manifested as diseases of membrane protein ER retention or mislocalization. (genes2cognition.org)
  • cells
  • In this report, we present a protocol to label the LRRK1 and LRRK2 proteins in cells with 32 P orthophosphate, thereby providing a means to measure the overall phosphorylation levels of these 2 proteins in cells. (jove.com)
  • In brief, affinity tagged LRRK proteins are expressed in HEK293T cells which are exposed to medium containing 32 P-orthophosphate. (jove.com)
  • complex
  • Leucine rich repeat kinases 1 and 2 (LRRK1 and LRRK2) are paralogs which share a similar domain organization, including a serine-threonine kinase domain, a Ras of complex proteins domain (ROC), a C-terminal of ROC domain (COR), and leucine-rich and ankyrin-like repeats at the N-terminus. (jove.com)
  • however, the mechanism by which this occurs is slightly more complex. (wikipedia.org)
  • major
  • One of the major non-speific humoral deffense mechanisms of the body for combating and clearing the infectious agents is complement system [ 14 , 15 , 16 ]. (intechopen.com)
  • alone
  • The fusion proteins and vectors encoding such fusions, alone or in combination, can be used in methods for modulating the IL-17 and IL-23 signaling pathways and for treating or preventing diseases mediated by interleukin-17 and interleukin-23, such as immune-related and inflammatory diseases. (patentsencyclopedia.com)
  • components
  • Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning "self-devouring" and κύτος kýtos, meaning "hollow") is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components. (wikipedia.org)
  • role
  • Therefore, Treg mechanisms, such as those induced and maintained by gut mucosal tolerance for the microbiota, can play a role by targeting the more conserved HSP peptide sequences in the inflamed tissues. (frontiersin.org)
  • domain
  • The zymogen contains a unique 10- amino acid insert between the pro and catalytic domain that includes a recognition motif for furin, the Golgi-associated pro protein convertase, which processes stromelysin-3 to its enzymatically active form during traversal through the constitutive secretory pathway. (rupress.org)
  • 6,7 Nevertheless, studies of molecular recognition at the transmembrane domain of proteins still lags behind those of water-soluble regions. (jove.com)