• The causative mutation affects the protein that is involved in mediating transcriptional responses after activation of nuclear receptors (e.g. sex hormone receptors). (europa.eu)
  • A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. (wikipedia.org)
  • Although pausing has been connected to extremely rapid and synchronous activation of genes, pausing is also highly associated with constitutively expressed genes that encode signalling and transcription factors. (nature.com)
  • Pausing provides a mechanism to tune these key genes to cellular and external regulatory cues. (nature.com)
  • Distinct signals that act through diverse targeted transcription factors can regulate different steps in the transcription pathway and provide a highly modulated transcriptional response at individual genes. (nature.com)
  • The K27M and G34R mutations induced several of the same pathways suggesting key shared oncogenic mechanisms including activation of neurogenesis and NOTCH pathway genes. (nature.com)
  • AB - Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms. (imperial.ac.uk)
  • This molecular clock mechanism involves activation of core clock genes and many downstream clock-output genes by the transcriptional activators BMAL1 and CLOCK. (hhs.gov)
  • These agents affect the transcription of insulin-responsive genes through activation of nuclear hormone receptors. (buckingham.ac.uk)
  • To isolate possible mechanisms underlying these structural and functional changes, we used whole-genome RNA sequencing and found prominent dopamine-induced enrichment of genes containing the CCCTC-binding factor (CTCF) motif, suggesting involvement of chromatin restructuring in the nucleus. (jneurosci.org)
  • We further show that this plasticity depends on activation of genes sensitive to DNA-binding protein CTCF. (jneurosci.org)
  • A total of 173 genes were differentially expressed, many of which were not found in previous transcriptional studies of other flaviviruses ( 3 ). (cdc.gov)
  • While significant advances have been made in understanding the plant adaptation in stress environments, there are still challenges to translate this acquired knowledge for improved crop performance and productivity under stress environments due to complex genetics involving multitude of genes and stress tolerance mechanisms and interaction with numerous environmental factors pose. (eurekaselect.com)
  • However, the existence of specific transcriptional repressors responsible for the silencing of lineage inappropriate genes remains elusive. (eur.nl)
  • Here we addressed the molecular mechanism behind repression of non-lymphoid genes in B cells. (eur.nl)
  • Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)
  • Recent years have witnessed a sea change in our understanding of transcription regulation: whereas traditional models focused solely on the events that brought RNA polymerase II (Pol II) to a gene promoter to initiate RNA synthesis, emerging evidence points to the pausing of Pol II during early elongation as a widespread regulatory mechanism in higher eukaryotes. (nature.com)
  • Lis, J. Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation. (nature.com)
  • Taken together, the data from the present work shed a light on the transcriptional regulation of DegS-DegU two-component system in B. subtilis and implicated intracellular glutamate as a positive stimulus involved as a transducer of the information from the environment to the intracellular apparatus. (uni-marburg.de)
  • A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)
  • In an effort to examine the molecular mechanisms involved in the cellular regulation of OST, we have characterized its expression in MC3T3 osteoblasts during differentiation. (umn.edu)
  • However, the mechanism underlying the regulation of transcriptional bursting kinetics (burst size and frequency) in mammalian cells remains elusive. (janelia.org)
  • We provide a new mechanism for the regulation of heart development by PITX2 isoforms through the regulation of ANF and PLOD1 gene expression and Nkx2.5 transcriptional activity. (lu.se)
  • Activation of Btk results in a cascade of signaling events resulting in calcium mobilization and fluxes, cytoskeletal rearrangements, and transcriptional regulation involving nuclear factor-kappaB (NF-kappaB) and nuclear factor of activated T cells (NFAT). (medscape.com)
  • Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • The inhibition of Pin1 expression or its activity selectively reduced the transcriptional activities of full-length AR and AR-V7. (bcgsc.ca)
  • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. (umu.se)
  • Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmental toxicity in an AHR-dependent manner. (oregonstate.edu)
  • Previously, our research team had found that two molecules, or more specifically, co-transcriptional regulators, known as YAP and TAZ, are involved in the damage of the lung epithelial cells. (lu.se)
  • We find that early transcriptional patterning of key morphogenetic transcription factors drives the selective activation of downstream morphogenetic modules, such as GPCR signaling that activates apical-medial actomyosin activity to drive cell wedging at the future asymmetrically placed invagination point. (elifesciences.org)
  • We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)
  • Overall, our findings define common and distinct K27M and G34R oncogenic mechanisms, including potentially targetable pathways. (nature.com)
  • These results illustrate that exposure to WC-Co nanoparticle s induces angiogenic response by activating ROS, AKT, and ERK1/2 signaling pathways and the downstream molecules and elucidate the potential molecular mechanisms during this process. (cdc.gov)
  • Chromatin and Transcriptional Signatures for Nodal Signaling During Endoderm Formation in hESCs The first stages of embryonic differentiation are driven by signaling pathways hardwired to induce particular fates. (ca.gov)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • Here we have used a highly efficient procedure based on lentiviral-mediated transgenesis to carry out in vivo fine-mapping of, cis-regulatory sequences that control lineage-specific activation of Neurog3, a master regulator of pancreatic endocrine differentiation. (imperial.ac.uk)
  • Transient transfection of the OST promoter in differentiating MC3T3 results in a significant increase in transcriptional activation from day 0 to day 5 of differentiation, similar in timing and intensity to the observed upregulation of the endogenous gene. (umn.edu)
  • Culturing these preosteoblast cells in the absence of critical co-factors results in an inhibition of differentiation and leads to a delayed induction of OST transcripts as well as the attenuation of transcriptional activation. (umn.edu)
  • These results show that the murine OST gene is regulated at the transcriptional level in an osteoblast-specific, differentiation-dependent manner during the differentiation of MC3T3 osteoblasts. (umn.edu)
  • Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
  • Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
  • Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the extinction of the previous one. (eur.nl)
  • However, murine models, including knockout and transgenic mice, have been useful in understanding the mechanisms of B lymphopoiesis, B-cell differentiation, and antibody formation. (medscape.com)
  • To elucidate the Nodal transcriptional network that governs endoderm formation, we used ChIP-seq to identify genomic targets for SMAD2/3, SMAD3, SMAD4, FOXH1 and the active and repressive chromatin marks, H3K4me3 and H3K27me3, in human embryonic stem cells (hESCs) and derived endoderm. (ca.gov)
  • These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus. (cdc.gov)
  • Activator proteins consist of two main domains: a DNA-binding domain that binds to a DNA sequence specific to the activator, and an activation domain that functions to increase gene transcription by interacting with other molecules. (wikipedia.org)
  • We have elucidated the molecular mechanisms involved in the increase in IL-6 expression caused by CXCL1 incubation in SFs, which was regulated by its receptor CXCR2, c-Raf and MAPK signaling components, and activator protein-1 (AP-1) transcriptional activation. (researchsquare.com)
  • HRV-induced CXCL10 transcription depends on activation of NF-ĸB and IFN-regulatory factor-1 (IRF-1), and we now also implicate two signal transducer and activator of transcription (STAT) consensus sequences in the CXCL10 promoter in HRV-induced CXCL10 expression. (greenmedinfo.com)
  • One mechanism underlying CRPC and resistance to hormonal therapies is the expression of constitutively active splice variant(s) of androgen receptor (AR-Vs) that lack its C-terminus ligand-binding domain. (bcgsc.ca)
  • Blocking androgen receptor (AR) transcriptional activity by androgen deprivation therapy (ADT) improves the response to radiotherapy for intermediate and high risk prostate cancer. (bcgsc.ca)
  • The mechanism by which the androgen receptor (AR) distinguishes between agonist and antagonist ligands is poorly understood. (rcsb.org)
  • Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis. (medscape.com)
  • We will use analysis of patients' primary fibroblasts, induced pluripotent stem (iPS) cells and CRISPR-Cas9 edited cell lines to investigate how the mutation impacts transcriptional responses after hormonal stimulations. (europa.eu)
  • Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. (oregonstate.edu)
  • Thus, enhanced extracellular matrix or beta-glucan synthesis during biofilm growth might prevent antifungals, such as azoles and polyenes, from reaching biofilm cells, thus limiting their toxicity to these cells and the associated transcriptional responses. (who.int)
  • Taken together, our findings suggest striking overlap between putative mechanisms of K27M and G34R mutations and point to increased NOTCH signaling playing a key role in K27M-related gliomagenesis, resulting from aberrant gene derepression due to impaired H3K27me3 deposition at super-enhancers in H3.3 mutant cells. (nature.com)
  • We conducted a global transcriptional analysis of human glioblastoma cell response to infection with WNV during peak virus production to determine the crucial virus-host interactions that take place during a severe neuroinvasive attack and identify putative mechanisms involved in WNV pathogenesis. (cdc.gov)
  • In addition, CSE inhibited HRV-induced chromatin accessibility around the transcriptional start site of the CXCL10 promoter. (greenmedinfo.com)
  • To gain insight into the molecular mechanisms mediating HDAC7 repression in pre-B cells, we undertook co-immunoprecipitation and chromatin immunoprecipitation experimental approaches. (eur.nl)
  • Cardiac Toll-like receptors and inflammasome complexes may be key inducers for inflammation probably through NF- B activation and ROS overproduction. (hindawi.com)
  • HRV also induced formation of complexes at the STAT region in the CXCL10 promoter, and HRV-induced activation of STAT-1 was inhibited by CSE. (greenmedinfo.com)
  • Our group discovered the Gcn2 positive effectors Gcn1 and Gcn20 and the importance of ribosomal Gcn1/Gcn20/Gcn2 regulatory complexes in Gcn2 activation. (nih.gov)
  • The detected internal degU promoter was shown to be activated through a positive feedback mechanism from the phosphorylated DegU protein. (uni-marburg.de)
  • The cytoplasmic localisation of the DegS protein raised the following question: what are the molecular mechanisms underlying the perceiption of a certain stimuli from the environment and their transition to the sensor kinase. (uni-marburg.de)
  • In parallel to exploring the role of the DegS-DegU system at the transcriptional and at the protein level, some additional experiments were performed in order to identify possible downstream regulated targets of the system. (uni-marburg.de)
  • ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. (kegg.jp)
  • Its activation is tightly controlled by numerous other signaling proteins including protein kinase C (PKC), Sab/SH3BP, and caveolin-1. (medscape.com)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • CSE inhibited HRV-induced activation and nuclear translocation/binding of both NF-ĸB, and IRF-1to their respective recognition sequences in the CXCL10 promoter. (greenmedinfo.com)
  • Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo . (jneurosci.org)
  • Our data suggest that cardiomyocyte-specific cytokine expression, early fibroblast activation, and the shift in metabolic gene expression are hallmarks of cardiomyopathy progression. (jci.org)
  • Transcriptional bursting is the stochastic activation and inactivation of promoters, contributing to cell-to-cell heterogeneity in gene expression. (janelia.org)
  • These results uncovered the key molecular mechanisms underlying transcriptional bursting and cell-to-cell gene expression noise in mammalian cells. (janelia.org)
  • We propose potential mechanisms underlying transcriptional induction of endothelial MT isoforms. (go.jp)
  • Early accomplishments of the SNCGE in this area include discovering the novel regulatory mechanism that induces translation of GCN4 mRNA via small upstream ORFs (uORFs) in the mRNA leader by phosphorylation and inhibition of eIF2 by the kinase Gcn2, now understood to regulate expression of key transcription factors (Atf4 and Atf5) in mammals and implicated in learning and memory. (nih.gov)
  • Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. (mdpi.com)
  • Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs. (oregonstate.edu)
  • Level of PI(3,5)P2 elevates by 20X its basal level, under hyperosmotic stress, helping cells to sustain salt toxicity, the mechanism of which is incompletely understood. (upstate.edu)
  • Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro . (jneurosci.org)
  • Finally, the lack of correlation between DNA binding and transcriptional activation plus the fact that PP1 and genistein both inhibited kappaB-dependent transcription without affecting DNA binding activity demonstrate the existence of regulatory steps downstream of NF-kappaB DNA binding. (nih.gov)
  • A vital temporal integrator of environmental stimuli, metabolism, and cellular transcriptional control is the circadian system. (hhs.gov)
  • Histone H3.3 mutations are a hallmark of pediatric gliomas, but their core oncogenic mechanisms are not well-defined. (nature.com)
  • This article aims to provide an in-depth exploration of molecular hydrogen, from its basic properties to its therapeutic potential and mechanisms of action. (water-for-health.co.uk)
  • Studies are undertaken to examine the mechanism of action of several medicinal plants to evaluate their therapeutic potential compared with synthetic drugs. (buckingham.ac.uk)
  • Whole blood-based transcriptional risk score for nonobese type 2 diabetes predicts dynamic changes in glucose metabolism. (medscape.com)
  • Focusing on the ageing brain, we reveal that activation of STING triggers reactive microglial transcriptional states, neurodegeneration and cognitive decline. (nih.gov)
  • However, the underlying mechanisms involved in the induction of genomic instability, genotoxicity, mutations and consequent increased cell proliferation are still a matter of intense research. (benthamscience.com)
  • We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
  • In this study, we performed single-cell RNA sequencing to analyze the intrinsic noise and mRNA levels for elucidating the transcriptional bursting kinetics in mouse embryonic stem cells. (janelia.org)
  • Informatics analyses and functional assays revealed that transcriptional bursting kinetics was regulated by a combination of promoter- and gene body-binding proteins, including the polycomb repressive complex 2 and transcription elongation factors. (janelia.org)
  • These findings have helped to illuminate the molecular mechanism of TC recruitment and assembly of 43S PICS at an early stage of the initiation pathway. (nih.gov)
  • The mechanisms of cellular adaptation preventing water loss under hyperosmotic conditions (osmoregulation) have b. (uni-marburg.de)
  • Activation follows a spring-loaded mechanism not requiring further translation of other cellular factors in oocytes and is associated with unfolding of the inhibitory structure that blocks the tetramerization interface. (elifesciences.org)
  • At the cellular level, 24-h circadian rhythms are driven by a transcriptional-translational feedback loop system. (hhs.gov)
  • This molecular clock mechanism ensures that specific cellular and biological processes occur at the correct time of day. (hhs.gov)
  • Mechanistic studies at the cellular level showed that MDM2 can interact with STAT2 to form a transcriptional complex and thus promote RAGE transcriptional activation . (bvsalud.org)
  • This is done through various mechanisms, such as recruiting transcription machinery to the promoter and triggering RNA polymerase to continue into elongation. (wikipedia.org)
  • CTCF binding to promoter sites bidirectionally regulates gene transcription and depends on activation of poly-ADP-ribose polymerase 1 (PARP1). (jneurosci.org)
  • As noted above, a key accomplishment of the SNCGE was elucidating the unique mechanism of translational control of GCN4 mRNA. (nih.gov)
  • Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells. (janelia.org)
  • Surprisingly, PITX2A activation of the ANF and PLOD1 promoters is repressed by co- transfection of Nkx2.5 in the C3H10T1/ 2 embryonic fibroblast cell line. (lu.se)
  • However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)
  • JMJD3, a histone demethylase, is simultaneously recruited to the promoters of the endodermal gene GSC and EOMES, suggesting a conservation of mechanism at multiple promoters genome-wide. (ca.gov)
  • Proof of principle studies are being conducted on pioneer therapeutics together with more fundamental studies to identify the mechanism of action of these pioneer compounds. (buckingham.ac.uk)
  • Transcriptional and epigenetic modulation of human rhinovirus-induced CXCL10 production by cigarette smoke. (greenmedinfo.com)
  • Pre-DCM hearts were phenotypically normal yet displayed proliferation of nonmyocytes (59% relative increase vs. WT, P = 8 × 10 -4 ) and activation of proinflammatory signaling with notable cardiomyocyte-specific induction of a subset of profibrotic cytokines including TGFβ2 and TGFβ3. (jci.org)
  • Specifically, both MRE activation by MTF-1 and that of ARE in the promoter region of the MT-2A gene by Nrf2 are involved in transcriptional induction of MT-1A , whereas only MRE activation by MTF-1 or other transcriptional factor(s) is required for transcriptional induction of MT-2A in vascular endothelial cells. (go.jp)
  • Activation of Toll-like receptors (TLRs) and the inflammasome complex has recently been proposed to be central in cardiac inflammation and likely in the pathogenesis of DCM. (hindawi.com)
  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are common joint disorders that are considered to be different diseases due to their unique molecular mechanisms and pathogenesis. (researchsquare.com)
  • A better understanding of how these novel basal cells communicate with adjacent cells will help define disease mechanisms and suggest new diagnostic and therapeutic strategies for male infertility, and diseases of the lung, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). (nih.gov)
  • Thus, in order t o find good therapeutics and better treatment options, we first need to better understand the disease mechanisms at play. (lu.se)
  • Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
  • These data reveal an imprecise relationship between IKK activation, IkappaBalpha degradation, and NF-kappaB DNA binding, suggesting the existence of additional mechanisms that regulate NF-kappaB activation. (nih.gov)
  • To cite this article: Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M. Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. (cdc.gov)
  • Further work is now needed to investigate the exact molecular mechanisms behind the activation of p63. (elifesciences.org)
  • Here we investigate whether blocking the transcriptional activities of full-length AR and AR-Vs with ralaniten leads to enhanced sensitivity to radiotherapy. (bcgsc.ca)
  • p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. (kegg.jp)
  • Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. (nih.gov)
  • Investigations of the main degS-degU promoter in the presence of different charged and non-charged compound, which raised the surrounding osmolarity to an equal extent, demonstrated that the activation of the system is rather an osmotic response and not consequence of salt-specific stimulation. (uni-marburg.de)
  • In this study, we investigated angiogenic response and relative mechanisms after exposure to WC-Co nanoparticle s. (cdc.gov)
  • We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. (cdc.gov)
  • These results suggested that the resistance of C. albicans biofilms to azoles or polyenes was due not to the activation of specific mechanisms in response to exposure to these antifungals but rather to the intrinsic properties of the mature biofilms. (who.int)
  • Like parent PAHs, OPAHs exert structure-dependent mutagenic activities and activation of the aryl hydrocarbon receptor (AHR) and cytochrome p450 metabolic pathway. (oregonstate.edu)
  • Adapted from Ingenuity canonical pathway PPARα/RXRα activation. (jci.org)
  • ChIP-seq analysis broadly linked K27M to altered H3K27me3 activity including within super-enhancers, which exhibited perturbed transcriptional function. (nature.com)
  • Single-nucleus RNA-sequencing analysis of microglia and hippocampi of a cGAS gain-of-function mouse model demonstrates that engagement of cGAS in microglia is sufficient to direct ageing-associated transcriptional microglial states leading to bystander cell inflammation, neurotoxicity and impaired memory capacity. (nih.gov)
  • It inhibited the function of the MDM2/STAT2 complex and suppressed the transcriptional activation of RAGE , thereby exerting antiglycation effects. (bvsalud.org)
  • In addition we have recently started to explore the structure and molecular function of pain receptors from animals, i.e. transient receptor potential (TRP) ion channels, and their activation by temperature and various ligands. (lu.se)
  • Here, we use CXCL10 as a model antiviral gene to examine the mechanisms by which CSE inhibits epithelial antiviral immunity. (greenmedinfo.com)
  • article{8e9d1763-f7d6-4a01-9b4e-8e3bd91233f8, abstract = {{PITX2 and Nkx2.5 are two of the earliest known transcriptional markers of vertebrate heart development. (lu.se)
  • The molecular mechanisms involved in the antifungal resistance of biofilms remain poorly understood. (who.int)
  • Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)
  • Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. (oregonstate.edu)
  • We have begun to realize the complexity of the biological mechanisms that link obesity and being overweight to many forms of cancer. (benthamscience.com)
  • To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
  • In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
  • Germ cells - from which egg cells and sperm cells develop - are particularly vulnerable as they contain sensitive quality control mechanisms that kill any cell that contain damaged DNA. (elifesciences.org)
  • We identified the eIF2α phosphatases in yeast and made key contributions to elucidating the mechanism whereby phosphorylated eIF2 inhibits its GDP-GTP exchange factor, eIF2B, defining the catalytic and regulatory subcomplexes of eIF2B and their distinct roles in binding phosphorylated or nonphosphorylated eIF2. (nih.gov)
  • Echinacoside-Zinc Nanomaterial Inhibits Skin Glycation by Suppressing the Transcriptional Activation of the Receptor for Advanced Glycation End-Products. (bvsalud.org)
  • With a longstanding interest in biomedical research and a passion for better understanding one of the least regenerative organs in the body, the lung, he has spent the past four years helping to uncover some of the mechanisms that may drive a lung disease currently without a cure, idiopathic pulmonary fibrosis. (lu.se)
  • Journal Article] Molecular mechanism of strict substrate specificity of an Extradiol Dioxygenase, DesB, derived from Sphingobium sp. (nii.ac.jp)
  • Structural mechanism of plant aquaporin gating. (lu.se)
  • Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences. (imperial.ac.uk)
  • This activation appears to be specific to osteoblasts, since progression to a myoblast phenotype results in no change in reporter gene activity. (umn.edu)
  • Among the reasons the current approved drugs are not very efficient is the fact that they do not target a specific mechanism in the lung. (lu.se)