Mechanically functional functional cartilage on scaffolds tissue engineering. Medical search. Frequent questions

These studies have demonstrated that mechanical forces are able to shape the mesenchymal stem cell (MSC) fate when appropriately applied in in vitro models of cartilage regeneration. (nature.com)
The book offers effective techniques to manipulate cells and growth factors successfully in the construction, restoration, and regeneration of tissues. (bibleandbookcenter.com)
Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. (bibleandbookcenter.com)
TE strategies typically incorporate cells, biomaterials and signals (e.g. growth factors), with the goal of developing a construct that once implanted will promote tissue regeneration. (nature.com)
One of the potential limitations associated with the use of alginate for in vivo tissue regeneration is that it is in general non-degradable by mammals, as they lack the enzymes needed to break down the polymer chains 21 . (nature.com)
She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
Three-dimensional (3D) printed hydrogel scaffolds enhanced with ceramics have shown potential applications for cartilage regeneration, but leaving biological and mechanical properties to be desired. (desktopmetal.com)
This paper presents our study on the development of chitosan /alginate scaffolds with nano hydroxyapatite (nHA) by combining 3D printing and impregnating techniques, forming a hybrid, yet novel, structure of scaffolds for potential cartilage regeneration. (desktopmetal.com)
2019) 3D printing approaches for cardiac tissue engineering and role of immune modulation in tissue regeneration. (aimspress.com)
In this review, biomaterial scaffolds and cell-based therapies for IVD regeneration are briefly discussed. (bjbms.org)
Following my presentation on "Prolotherapy Injections-A Silver Bullet in Connective Tissue and Ligament Reconstruction & Regeneration" at the 2003 AHVMA Conference, 22 veterinarians signed up to take a two day course in Chicago, co-taught by three professionals. (caninearthritisandjoint.com)

Biomaterials for meniscus and cartilage in knee surgery: state of the art. (mayo.edu)
Current research in tissue engineering is geared towards elucidating the appropriate compositional elements (biomaterials, biomolecules and cell sources) as well as methods of assembly. (biomedcentral.com)
Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications surveys a wide range of natural and synthetic compounds used in tissue, bone, muscle, cartilage, and organ replacement and discusses recent methods for processing, characterizing, and testing these biomaterials. (bibleandbookcenter.com)
Topics include biodegradable scaffolds for meniscus tissue, cortical bone grafts, gene therapy applications, skin biomaterials, and urology applications. (bibleandbookcenter.com)
Tissue engineering, which refers to a category of therapeutic or diagnostic products and processes which are based upon a combination of living cells and biomaterials, was defined as a field only a few years ago (1988). (bibleandbookcenter.com)
The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. (bibleandbookcenter.com)
For this, a promising approach is extrusion-based three-dimensional (3D) printing technique to deliver cells, biomaterials, and growth factors within a scaffold to the injured site. (desktopmetal.com)
Rottmar, M. Multi-functional biomaterials: combining materials modification strategies for engineering of cell contacting surfaces. (empa.ch)
Chen F, Liu X. Advancing biomaterials of human origin for tissue engineering. (scielo.br)
The main purpose of this technology is to combine cells, growth factors, and biomaterials to fabricate tissue-like constructs that can later be used for clinical and biomedical applications. (enriquemoralesorcajo.com)
Dr. George E. STAN , Scientific researcher rank I (since 2017), born in 1981, graduated the Faculty of Materials Science and Engineering (SIM) - Section "Medical Engineering" at University Politehnica of Bucharest (UPB) (2005), has a MSc degree in Biomaterials (UPB) (2007), and a PhD degree in Materials Engineering (UPB) (2011). (infim.ro)
S. Ng, W. J. Tan, M. M. X. Pek, M. H. Tan, M. Kurisawa, Mechanically and chemically defined hydrogel matrices for patient-derived colorectal tumor organoid culture, Biomaterials 219, 119400 (2019). (labby.jp)
Dr Lisbeth Grondahl's research interests are in the areas of Biomaterials Science and Tissue Engineering. (edu.au)

Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial. (unibas.ch)
The cells involved in tissue engineering can be autologous, allogeneic or xenogeneic. (bibleandbookcenter.com)
Bone grafting is a common procedure in orthopaedic surgery and the implantation of autologous bone grafts supplying osteoinductive growth factors, osteogenic cells, and a structural scaffold, has become the gold standard for the surgical treatment of bone defects caused by trauma, tumor, infection or congenital abnormalities. (biomedcentral.com)
Because of their capacity for ex vivo proliferation and differentiation they provide a good source of osteoprogenitor cells within custom-shaped scaffolds for implantable autologous bone tissue thus allowing the generation of a large transplantable cell population from a small biopsy [ 5 - 11 ]. (biomedcentral.com)

Regenerative Potential of Tissue-Engineered Nasal Chondrocytes in Goat Articular Cartilage Defects. (unibas.ch)

The cells can be employed alone or in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. (epo.org)
Effects of an articular cartilage lubrication with a viscosupplement in vitro and in vivo following osteochondral fractures in horses. (ucsd.edu)
Her research interests include the preparation and design of materials and scaffolds for in vitro and in vivo fundamental studies, and a further focus is the provision of useful tools to assess mechanisms that govern cell behavior in regenerative medicine. (ibecbarcelona.eu)

Engineering Small-Scale and Scaffold-Based Bone Organs via Endochondral Ossification Using Adult Progenitor Cells. (unibas.ch)
The loss from and water content modification in of the cells (cellular water loss) with age is a serious problem for several organs and it can alter the functional behavior of biomedical apparati. (articlesfactory.com)
Tissue engineering (TE) is a promising strategy for replacing, repairing or regenerating damaged tissues and organs. (nature.com)
The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. (mdpi.com)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
What drives this technology is to print human tissues and organs that can be used to replace our damaged ones. (enriquemoralesorcajo.com)
Printing tissues and organs has more applications than you can imagine at first glance. (enriquemoralesorcajo.com)
One of the promising applications of this technology is the ability to 3D print tissues and organs to replace our damaged ones. (enriquemoralesorcajo.com)
For now, relatively homogenous tissues like cartilage, skin, blood vessels, vagina, urine tubes and bladder have been bioprinted and transplanted in the lab or in clinical trials, but as the technology matures more complex organs are expected to be manufactured. (enriquemoralesorcajo.com)

The first tissue-engineered, ear-shaped appendages made from bovine chondrocytes and biocompatible scaffolds by the Vacanti group were prone to deformation when xenografted onto immune-compromised mice, highlighting the lack of long-term stability [ 6 ]. (biomedcentral.com)
Cartilage heals very poorly, owing to the lack of intrinsic regenerative capacity of the chondrocytes and its poor vascular supply. (openorthopaedicsjournal.com)

A recent publication titled "Co-electrospun PCL/Zein membranes as scaffolds for articular cartilage engineering" by the ETH team was featured in MDPI Bioengineering. (biotrib.eu)
Tissue engineering is an inherently interdisciplinary field, combining bioengineering, life sciences and clinical sciences. (bibleandbookcenter.com)
Manufacture of complex heart tissues: technological advancements and future directions[J]. AIMS Bioengineering, 2021, 8(1): 73-92. (aimspress.com)
M. Nadra, W. Niu, M. Kurisawa , D. Rousson M. SpectorPlatelet-Rich Plasma Lysate-Incorporating Gelatin Hydrogel as a Scaffold for Bone Reconstruction, Bioengineering 9, 513 (2022). (labby.jp)

These osteoconductive three dimensional constructs seeded with MSCs are highly porous, biodegradable and biomechanically stable scaffolds which do not evoke an immunogenic host cell response. (openorthopaedicsjournal.com)

Seeded scaffolds were implanted and studied in the post-mortem murine heart in situ, and in two additional C57BL/6 mice in vivo (using single-layered and double-layered scaffolds) and imaged immediately after and at 7 days post-implantation. (westminster.ac.uk)
In vitro MRI results justify the increased seeding density, increased in vitro MRI signal, and improved MRI visibility in vivo, in the double-layered compared to the single-layered scaffolds. (westminster.ac.uk)

Polymer characterization confirmed the chemical structure and composition of the synthesized scaffolds, while thermal, wettability, and mechanical properties were also investigated and compared in neat and porous counterparts. (westminster.ac.uk)
Zenobi-Wong, M. Development and thorough characterization of the processing steps of an ink for 3D printing for bone tissue engineering. (empa.ch)

The goal of meniscal surgery is to provide a mechanically stable meniscus while maximizing meniscal preservation. (hcplive.com)
The MEW scaffolds supported the development of a fibrocartilaginous tissue with compressive mechanical properties similar to that of native meniscus, while the anisotropic tensile properties of these constructs could be tuned by altering the fibre network aspect ratio. (regenhu.com)

Tissue-engineered ear cartilage scaffold based on three-dimensional (3D) bioprinting technology presents a new strategy for ear reconstruction in individuals with microtia. (desktopmetal.com)
This paper presents the development of a natural bioink from chicken eggwhite and sodium alginate for bioprinting cell-laden patches to be used in endothelialized tissue engineering applications. (desktopmetal.com)
3D bioprinting consists of adapting the 3D printing technology to print tissue-mimicking constructs. (enriquemoralesorcajo.com)
Tissue fragment bioprinting leverage the intrinsic capacity of closely spaced tissue fragments to fuse together, known as tissue fluidity. (enriquemoralesorcajo.com)
In this review, we summarize the progress of stem cell technology in 3D bioprinting of heart tissue and the latest technological breakthroughs. (aimspress.com)
In this study, inkjet bioprinting was used to deposit a cell-laden bioink into additively manufactured scaffolds of differing architectures to engineer fibrocartilage grafts with user defined collagen architectures. (regenhu.com)

The engineering of structurally organized meniscal grafts that mimic the anisotropy of the native tissue remains a significant challenge. (regenhu.com)

Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity. (nature.com)
Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)

The electrical conducting property of these hydrogels allow them to mimic the characteristic of nerve, muscle, and cardiac tissues. (wikipedia.org)
The myocardial nicheplays a critical role in directing the function and fate of cardiomyocytes;therefore, engineering a biomimetic scaffold holds excellent promise.We produced an electroconductive cardiac patch of bacterial nanocellulose(BC) with polypyrrole nanoparticles (Ppy NPs) to mimic the naturalmyocardial microenvironment. (ibecbarcelona.eu)

Tamaddon M, Samizadeh S, Wang L, Blunn G, Liu C. Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering. (scielo.br)
In this study, porous scaffold materials based on polyvinyl alcohol (PVA) and gelatin (Gel) were successfully fabricated and characterized. (mdpi.com)

Here, we show efficient exosome@biomaterial-based miRNA delivery systems for regenerative medicine and tissue engineering. (bvsalud.org)
Biomaterial stored under constant pneumatic pressure is delivered in droplets by the opening and closing of a mechanically, electrically or magnetically controlled microvalve. (enriquemoralesorcajo.com)
A study by Prof. Santosh Misra's team, spearheaded by Niranjan Chatterjee, displays the fabrication and use of advanced biomaterial systems as a non-drug therapeutic alternative for healing mechanically damaged muscles. (iitk.ac.in)
The field of tissue engineering has gradually grown to include cell engineering (including stem cell engineering), immune-engineering, extracellular matrix (ECM) engineering, development of biomaterial-based artificial ECMs and modulation/engineering of cell signalling. (iitk.ac.in)

This method aims to regenerate rather than repair skeletal tissue defects. (openorthopaedicsjournal.com)
The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. (scielo.br)

Current tissue-engineered auricular constructs implanted into immune-competent animal models have been observed to undergo inflammation, fibrosis, foreign body reaction, calcification and degradation. (biomedcentral.com)
The architecture of MEW scaffolds can be tailored to not only modulate the directionality of the collagen fibres laid down by cells, but also to tune the anisotropic tensile mechanical properties of the resulting constructs, thereby enabling the engineering of biomimetic meniscal-like tissues. (regenhu.com)
To progress cardiac tissue engineering strategies closer to the clinic, thicker constructs are required to meet the functional need following a cardiac event. (regenhu.com)
Consequently, pre-vascularization of these constructs needs to be investigated to ensure survival and optimal performance of implantable engineered heart tissue. (regenhu.com)

The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells. (epo.org)
Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. (nature.com)
Specifically, the employment of BC-Ppy compositesdrives partial H9c2 differentiation toward a cardiomyocyte-like phenotype.The scaffolds increase the expression of functional cardiac markersin H9c2 cells, indicative of a higher differentiation efficiency,which is not observed with plain BC. (ibecbarcelona.eu)

Hydrogel polymers present a versatile coating option for electrodes as they can be chemically modified to provide a soft and conductive scaffold. (frontiersin.org)

8 nm).Ppy NPs effectively augment the conductivity, surface roughness, andthickness of BC composites despite reducing scaffolds' transparency.BC-Ppy composites were flexible (up to 10 mM Ppy), maintained theirintricate 3D extracellular matrix-like mesh structure in all Ppy concentrationstested, and displayed electrical conductivities in the range of nativecardiac tissue. (ibecbarcelona.eu)
Alginate hydrogels are particularly attractive in wound healing, drug delivery, and tissue engineering applications, as these gels retain structural similarity to the extracellular matrices in tissues. (xantec.com)

Initial studies indicate an immense potential for cell based strategies to enhance current orthopaedic approaches in skeletal tissue reconstruction. (openorthopaedicsjournal.com)
Melek LN. Tissue engineering in oral and maxillofacial reconstruction. (scielo.br)

This fast-growing emerging technology has open many possibilities in the field of regenerative medicine and tissue engineering. (enriquemoralesorcajo.com)

Inspired by flexible biological tissues, researchers incorporate carbon-based, polymeric, ceramic and/or metallic nanomaterials to give these hydrogels superior characteristics like optical properties and stimulus-sensitivity which can potentially be very helpful to medical (especially drug delivery and stem cell engineering) and mechanical fields. (wikipedia.org)
Nanocomposite hydrogels incorporated with polymeric nanoparticles are tailored for drug delivery and tissue engineering. (wikipedia.org)

Fortunato, G. Nanofiber membranes as biomimetic and mechanically stable surface coatings. (empa.ch)

Mesenchymal stem cells (MSCs) are multipotent adult stem cells that can differ- entiate into a variety of connective tissue phenotypes such as osteoblasts, chondro- cytes and adipocytes (Westhrin et al. (ac.ir)
Between the follicles are numerous blood and lymph vessels in anoth- er connective tissue called stroma. (best10forexbrokers.com)
The goal is to rebuild and repair injured connective tissue into a stronger and more supportive tissue than it was previously. (caninearthritisandjoint.com)

To me the clear novelties of your procedure (as your already point out) are using hamstrings instead of commercially available scaffolds or fascia lata and being used in a population with mainly osteoarthritis rather than the traumatic cartilage/subchondral lesions. (wheelessonline.com)

Bio-functional and mechanical properties of the prosthetic materials can be then altered or, conversely, they can alter the physiological equilibrium altering the aqueous medium composition. (articlesfactory.com)

As a mucopolysaccharide and component of cartilage tissue, CDS shows good biocompatibility while being mechanically relatively rigid. (xantec.com)

Biologically and mechanically driven design of an RGD-mimetic macroporous foam for adipose tissue engineering applications. (unibas.ch)

Scaffold architecture was found to influence the spatial organization of the collagen network laid down by the jetted cells, with higher aspect ratios (1:4 and 1:16) supporting the formation of structurally anisotropic tissues. (regenhu.com)
This MEW framework was then used to generate scaffolds with spatially distinct fibre patterns, which in turn supported the development of heterogenous tissues consisting of isotropic and anisotropic collagen networks. (regenhu.com)

Alessio is investigating the Elucidation of Friction-Induced Failure Mechanisms in Fibrous Collagenous Tissues at ETH Zürich, Switzerland. (biotrib.eu)

Alginate (or alginic acid) is a biopolymer that has found numerous applications in biomedical science and engineering. (xantec.com)

Recent advances in regenerative medicine place us in a unique position to improve the quality of engineered tissue. (biomedcentral.com)
Due to recent advances in regenerative medicine and additive manufacturing we are entering into an age where we have the potential to replace 'like with like', by improving the quality of engineered tissue with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. (biomedcentral.com)
Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. (bibleandbookcenter.com)
The latest technological advances in stem cell biology and mechanical engineering provide new opportunities for cardiac tissue engineering, enabling the production of highly efficient differentiated cells and the manufacture of high-resolution complex cardiac tissues. (aimspress.com)
Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered the development of tissue engineering therapies. (bjbms.org)

Accordingly, investigations on cellular therapies have therefore moved to progenitor cell populations such as bone marrow derived mesenchymal stem cells (BMSCs), which have the ability to differentiate into cartilage cells 4 . (nature.com)
The designed exosomes (SGM-Exos, miR146a-Exos, and SGM-miR146a-Exos) were isolated from the engineered placental mesenchymal stem cells (PMSCs) transduced with SGM or/and pac-miR146a-pac protein. (bvsalud.org)
We use auricular cartilage as an exemplar to illustrate how the use of tissue-specific adult stem cells, assembly through additive manufacturing and improved understanding of postnatal tissue maturation will allow us to more accurately replicate native tissue anisotropy. (biomedcentral.com)
Amidst this, tissue engineering using stem cells has emerged as a hot topic of research and is a promising alternative to the traditional techniques of bone grafting. (openorthopaedicsjournal.com)

Nanocomposite hydrogels that are enforced with carbon-based nanomaterials are mechanically tough and electrically conducive, which make them suitable for use in biomedicine, tissue engineering, drug delivery, biosensing, etc. (wikipedia.org)

Dr Nelson's contributions to the fields of tissue mechanics and morphogenesis have been recognized by a number of awards, including a Burroughs Wellcome Fund Career Award at the Scientific Interface (2007), a Packard Fellowship (2008), a Sloan Fellowship (2010), the MIT TR35 (2010), the Allan P. Colburn Award (2011), a Dreyfus Teacher-Scholar Award (2012), and a Faculty Scholars Award from the Howard Hughes Medical Institute (2016). (royalsociety.org)

The platelets act as cross-links to modify molecular functions to enable the hydrogels to have superior elasticity and toughness that resembles closely that of biological tissue. (wikipedia.org)
However, even though these nanocomposite hydrogels demonstrate some functions of human tissue in lab environments, more research is needed to ensure their utility as tissue replacement. (wikipedia.org)
We next explored if spatially modulating the stiffness of 3D bioprinted hydrogels could be used to direct MSC fate inside printed tissues. (nature.com)

Additionally, the PCL/Zein membranes exhibited lower roughness when compared to pure PCL scaffolds. (biotrib.eu)
Overall, this research highlights the potential of co-electrospun PCL/Zein membranes as promising scaffolds for articular cartilage engineering, showcasing their improved protein adsorption properties and reduced surface roughness. (biotrib.eu)

Scaffold Composition Determines the Angiogenic Outcome of Cell-Based Vascular Endothelial Growth Factor Expression by Modulating Its Microenvironmental Distribution. (unibas.ch)
Combining biomimetic regenerative medicine strategies will allow us to improve tissue-engineered auricular cartilage with respect to biochemical composition and functionality, as well as microstructural organization and overall shape. (biomedcentral.com)

1:16) were produced using either fused deposition modelling (FDM) or melt electrowriting (MEW), resulting in scaffolds with different internal architectures and fibre diameters. (regenhu.com)

A number of traditional therapeutic approaches to repair skeletal tissue have been developed and hypothesised, but they have all presented with a variety of shortcomings. (openorthopaedicsjournal.com)

The study explores the application of Zein, a corn protein widely used in food packaging and drug encapsulation industries, in the development of tissue engineering scaffolds for articular cartilage. (biotrib.eu)
Through co-electrospinning, the team successfully reduced protein adsorption by half compared to scaffolds made solely of bovine serum albumin and equine synovial fluid. (biotrib.eu)
This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)

A limitation of current TE strategies is their relatively poor spatial control of the distribution of cells, matrix components and bioactive cues within the engineered construct 1 . (nature.com)

Statement of significance This study describes a multiple tool biofabrication strategy which enables the engineering of spatially organized fibrocartilage tissues. (regenhu.com)

Newer techniques using tissue engineering to regenerate musculoskeletal tissue by using biomimetic materials are now being studied. (openorthopaedicsjournal.com)

Following an undergraduate degree in Computer Engineering and a PhD in Biomechanical Engineering from Trinity College Dublin in Ireland, Dr Nowlan held research fellowships in Boston, USA and Barcelona, Spain. (royalsociety.org)

This body of work represents the first volume of a book series covering the field of tissue engineering. (bibleandbookcenter.com)
The definition of this area of work as the field of tissue engineering brought together scientists from multiple backgrounds who already were working toward the achievement of similar goals. (bibleandbookcenter.com)
The field of tissue engineering is heterogeneous. (bibleandbookcenter.com)
An attempt to cover the field of tissue engineering in a single volume, with the degree of detail necessary for individuals with different scientific back grounds and disciplines, would be a difficult task to accomplish, particularly when this field is just emerging and changing rapidly. (bibleandbookcenter.com)
Therefore, addressing different technologies within the field of tissue engineering, in a comprehen sive manner, is the main mission of this series of volumes. (bibleandbookcenter.com)
Since the implications of the field of 'tissue engineering' are largely in medicine the field has gradually begun to include aspects such as transplantation medicine, radiology (imaging especially non-invasive imaging of tissues), general surgery and other specialized medical disciplines that have to do with a specific disease condition (eg. (iitk.ac.in)

Learn, simplify and implement: developmental re-engineering strategies for cartilage repair. (unibas.ch)
The repair process begins with the formation of the clot, accompanied by an inflammatory process with proliferation of granulation tissue. (scielo.br)
An Analysis of the Quality of Cartilage Repair Studies - The Journal of Bone and Joint Surgery (American) . (wheelessonline.com)

Unlike the usual strategy for immobilization of biomolecules, this surface has no functional groups suitable for forming covalent bonds. (xantec.com)

Jost passed away on June 2016, but his legacy lives on through the countless researchers, engineers, and practitioners who have been influenced by his work. (biotrib.eu)
You'll join a community of outstanding researchers and skilled professionals devoted to conduct excellent interdisciplinary research at the frontiers of engineering and life sciences. (ibecbarcelona.eu)
Researchers have looked to cartilage tissue engineering to address the lack of cartilage regenerative capability related to cartilage disease/trauma. (desktopmetal.com)

She earned SB degrees in Chemical Engineering and Biology at MIT in 1998, a PhD in Biomedical Engineering from the Johns Hopkins University School of Medicine in 2003, followed by postdoctoral training in Life Sciences at Lawrence Berkeley National Laboratory until 2007. (royalsociety.org)

Anatomy62

Organisms5

Diseases10

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes35

Disciplines and Occupations12

Technology, Industry, Agriculture37

Information Science3

Regeneration11

Biomaterials13

Autologous5

Articular cartilage defects1

Vitro and in vivo3

Organs9

Chondrocytes2

Bioengineering4

Biodegradable1

VIVO2

Characterization2

Meniscus2

Bioprinting6

Grafts1

Treatment of cartilage2

Mimic2

Porous2

Biomaterial4

Defects2

Constructs4

Differentiation3

Chemically1

Extracellular2

Reconstruction2

Regenerative medicine and tissue1

Polymeric2

Nanofiber1

Connective tissue3

Lesions1

Mechanical properties1

Biocompatibility1

Biologically1

Anisotropic2

Fibrous1

Alginate1

Advances5

Stem Cells4

Electrically1

Mechanics1

Hydrogels3

Membranes2

Composition2

Architectures1

Therapeutic1

Protein3

Cues1

Spatially1

Biomimetic materials1

Biomechanical1

Field of tissue6

Repair3

Biomolecules1

Researchers3

Biomedical Engineering1