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  • receptors
  • Three measles virus cell receptors have been identified so far, and the structures of the first two in complex with measles virus hemagglutinin (MV-H) have been reported. (uniprot.org)
  • Finally, a hydrophobic pocket centered in the β4-β5 groove is involved in binding to all three identified measles virus receptors, representing a potential target for antiviral drugs. (uniprot.org)
  • Successful attempts to retarget MV by inserting genes for tumour-specific ligands to antigens such as carcinoembryonic antigen (CEA), CD20, CD38, and by engineering the virus to express synthetic microRNA targeting sequences, and "blinding" the virus to the natural viral receptors are exciting measures to increase viral specificity and enhance the oncolytic effect. (mdpi.com)
  • First, the virus binds to HN glycoprotein receptors expressed on the surface of the cell. (wikipedia.org)
  • pneumonia
  • Complications with measles are relatively common, ranging from mild complications such as diarrhea to serious complications such as pneumonia (either direct viral pneumonia or secondary bacterial pneumonia), bronchitis (either direct viral bronchitis or secondary bacterial bronchitis), otitis media, acute brain inflammation (and very rarely SSPE-subacute sclerosing panencephalitis), and corneal ulceration (leading to corneal scarring). (wikipedia.org)
  • The death rate in the 1920s was around 30% for measles pneumonia. (wikipedia.org)
  • viral
  • Based on our preclinical results as well as the safety of measles derivatives in clinical trials against other tumour types, these viral strains could represent excellent candidates for clinical testing against advanced prostate cancer, including androgen resistant tumours, said Evanthia Galanis, M.D., of the Mayo Clinic, senior author of the study. (thaindian.com)
  • His research was instrumental towards understanding the intracellular mechanisms of viral and membrane protein sorting in epithelial cells and the cell-surface assembly of several RNA viruses. (wikipedia.org)
  • It functions as a processivity factor for the virus RNA-dependent RNA polymerase, and promotes viral RNA synthesis. (wikipedia.org)
  • encephalitis
  • Recently, MeV-induced encephalitis among human immunodeficiency virus (HIV)-infected children has become a great concern in high-HIV-prevalence countries. (pnas.org)
  • epithelial
  • After being appointed at the University of Texas Southwestern Medical Center at Dallas, his research focused on the (i) basis of enveloped viruses assembly, and (ii) the mechanisms of membrane protein sorting and endocytosis in polarized epithelial cells. (wikipedia.org)
  • Measles virus matrix protein specifies apical virus release and glycoprotein sorting in epithelial cells. (wikipedia.org)
  • therapeutic agents
  • Measles remains a major cause of childhood morbidity and mortality worldwide, and no licensed therapeutic agents are currently available. (pnas.org)
  • rash
  • The characteristic measles rash is classically described as a generalized red maculopapular rash that begins several days after the fever starts. (wikipedia.org)
  • The measles rash appears two to four days after the initial symptoms and lasts for up to eight days. (wikipedia.org)
  • glycoproteins
  • Syncytin-1 shares many structural elements with class I retroviral glycoproteins (such as, Murine Leukemia Virus gp, Ebolavirus gp, and HIV gp120, gp41). (wikipedia.org)
  • immune response
  • Measles is an enormous problem in developing countries, where infections often occur in very young children with immature immune systems, many of whom are also malnourished, which further impairs their immune response to the virus. (oncologynurseadvisor.com)
  • fever
  • Play media The classic signs and symptoms of measles include four-day fevers (the 4 D's) and the three C's-cough, coryza (head cold, fever, sneezing), and conjunctivitis (red eyes)-along with fever and rashes. (wikipedia.org)
  • spreads
  • An article published in the Nov. 2, 2011 issue of Nature explains why this virus spreads so rapidly. (bio-medicine.org)
  • 17, 855-871 Measles virus spreads in rat hippocampal neurons by cell-to-cell contact and in a polarized fashion. (wikipedia.org)
  • Measles is an airborne disease which spreads easily through the coughs and sneezes of those infected. (wikipedia.org)
  • carcinoembryonic antigen
  • Repeated measurements of the marker CEA (carcinoembryonic antigen, produced when the virus replicates) following MV-CEA treatment can be performed via a simple blood test, and can potentially allow for optimization of dosing as well as the tailoring of individualized treatment. (bio-medicine.org)
  • This imaging technique is an improvement over initial efforts to engineer a Measles virus to carry the soluble marker human carcinoembryonic antigen (CEA). (wikipedia.org)
  • protein
  • Hussein Naim is a Lebanese-Swiss biochemist and molecular virologist, known for his research in cell biology (membrane protein sorting and internalization) and virology (measles, SARS, HIV and Influenza). (wikipedia.org)
  • The Pneumoviridae M2-1 protein is distinctive, and no homologue has been found in any other virus families. (wikipedia.org)
  • Then, through the action of the fusion protein, the virus fuses to the host plasma membrane and the nucleocapsid is released. (wikipedia.org)
  • Enders
  • In 1949, Enders, Thomas Huckle Weller, and Frederick Chapman Robbins reported successful in vitro culture of an animal virus-poliovirus. (wikipedia.org)
  • Disappointed by polio vaccine's development and involvement in some cases of polio and death-what Enders attributed to Salk's technique-Enders began development of measles vaccine. (wikipedia.org)
  • Replication
  • Once sufficient P, N, L, and M2 proteins are available to create a capsid around the newly replicated genome, the virus undergoes replication. (wikipedia.org)
  • Pathogen
  • A subclinically infected person is thus an asymptomatic carrier of a microbe, intestinal parasite, or virus that usually is a pathogen causing illness, at least in some individuals. (wikipedia.org)
  • adults
  • Both children and adults should pay attention to measles. (go.jp)
  • Forthal DN, Aarnaes S, Blanding J, de la Maza L, Tilles JG (1992) Degree and length of viremia in adults with measles. (springer.com)
  • Complications are usually more severe in adults who catch the virus. (wikipedia.org)
  • Ebola
  • CIDRAP News) - Twelve of the 30 recent cases of a disease thought to be Ebola hemorrhagic fever in Sudan have been reclassified as measles, the World Health Organization (WHO) announced today. (umn.edu)
  • given
  • The latter view seems more likely to be correct given that molecular estimates place the evolution of measles sometime after 500 AD. (wikipedia.org)
  • early
  • A Warthin-Finkeldey cell is a type of giant multinucleate cell found in hyperplastic lymph nodes early in the course of measles and also in HIV-infected individuals, as well as in Kimura disease, and more rarely in a number of neoplastic (e.g. lymphoma) and non-neoplastic lymph node disorders. (wikipedia.org)
  • disease
  • Henderson served as Chief of the CDC virus disease surveillance programs from 1960 to 1965, working closely with the inspirational epidemiologist Dr. Alexander Langmuir. (wikipedia.org)
  • research
  • The SV40 promoter was conventionally used until research showed that vectors driven by the Rous Sarcoma Virus (RSV) promoter had much higher expression rates. (wikipedia.org)
  • During his time in Shaowu, located in the Fujian province of China, Bliss provided general care and also performed research on the rinderpest virus. (wikipedia.org)
  • causes
  • short for "Mevrou", Afrikaans equivalent of Mrs. In organizations: Michigan Emergency Volunteers, a former name of the Michigan Volunteer Defense Force Minds-Eye-View, a company which acquired the assets iPIX in 2007 In science and technology: Measles virus Mink enteritis virus, a species of parvovirus that infects mink and causes enteritis. (wikipedia.org)
  • spread
  • JC virus will be spread and establish a latent infection in lungs, kidney and lymphoid organs. (medicalrealm.net)
  • The activation of JC virus will lead to the spread of infection to the brain and lead to progressive multifocal leukoencephalopathy. (medicalrealm.net)
  • The rotavirus is shed in the feces of infected persons and is spread by the fecal oral route, so this virus can be picked up from contaminated hands, objects, food and water. (wikipedia.org)