AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
UrticariaMast CellsUrticaria PigmentosaAngioedemaHistamine ReleaseCell DegranulationHistamine H1 Antagonists, Non-SedatingHistamine H1 AntagonistsSkin TestsImmunoglobulin EAnaphylaxisReceptors, IgETryptasesMastocytosisDrug HypersensitivityAnti-Allergic AgentsChymasesp-Methoxy-N-methylphenethylamineHistamine AntagonistsChronic DiseaseFood HypersensitivityHistamineHypersensitivityBasophilsCetirizineLoratadineCromolyn SodiumProto-Oncogene Proteins c-kitMastocytosis, SystemicPruritusAnisakiasis
PigmentosaMastocytosisAnaphylaxisHivesDegranulationAngioedemaAtopic DermatitisCutaneousPruritusCold urticariaDiseasesIdiopathicAllergyPatientsMediatorsSystemicChronic inducible urticariaBone marrowCause urticariaTryptaseAutoimmuneBasophils and mast cellsReceptors on mast cellsBasophilAcute urticariaCholinergic urticariaDisordersLesionsAntihistamineAsthmaVibratoryRelease of histamineInflammatoryRole of mast cellsSkinDermisMonoclonalDiseaseD816VAllergic reactionsActinic keratosisDifferentiationManifestationsAntibodyPruriticImmunologicImmune systemImmunoglobulin
Pigmentosa15
Mastocytosis10
  • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. (medigraphic.com)
  • KIT mutation in mast cells and other bone marrow haemotopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. (medigraphic.com)
  • The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of "mast cell activation syndrome" (MCAS) grown significantly. (degruyter.com)
  • To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with focal bone marrow involvement, particularly low grade malignant B cell lymphoma of lymphoplasmacytic immunocytoma subtype, which frequently exhibits increased mast cell (MC) numbers. (bmj.com)
  • Mastocytosis (mast cell disease) is a relatively uncommon haematological tumour of bone marrow origin. (bmj.com)
  • Lead study coordinator responsible for education, regulatory affairs, and management of protocols for pediatric mastocytosis and for evaluation of the prevalence and significance of clonal mast cell disease in patients with idiopathic or allergen-specific anaphylaxis. (nih.gov)
  • If your child has chronic hives (urticaria), mast cell diseases (such as mastocytosis) or atopic dermatitis (eczema) AND if discontinuing the medication will cause significant worsening of symptoms or discomfort for your child, then you do not have to discontinue antihistamines prior to your appointment. (luriechildrens.org)
  • Patients with cutaneous mastocytosis experienced more mast cell-mediated symptoms than did those with indolent mastocytosis. (medscape.com)
  • Three distinct diagnostic outcomes including systemic mastocytosis, monoclonal mast cell activation syndrome and non-clonal HVA were revealed. (biomedcentral.com)
  • Mastocytosis is a rare disorder characterized by functional secretion or abnormal proliferation of tissue mast cells. (medscape.com)
Anaphylaxis9
  • Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense against pathogens, and vascular permeability in brain tumors. (wikipedia.org)
  • Acute IgE-mediated urticaria is the most benign form of anaphylaxis . (medscape.com)
  • Therefore, the clinician must rule out these more severe syndromes of anaphylaxis in patients presenting with urticaria. (medscape.com)
  • Most medications used in treating urticaria and anaphylaxis are also used in the management of many types of angioedema. (medscape.com)
  • He has served as the principal investigator and co-investigator for basic and translational studies examining the role of IgE receptor expression and activation in allergic airways disease, anaphylaxis, and chronic urticaria. (hopkinsmedicine.org)
  • The MCBS program emphasizes basic research that may be translated into the clinic and from the clinic to the bench, where protocols include studies on the pathogenesis of anaphylaxis, physical urticarias and clonal mast cell disorders. (nih.gov)
  • Other than anaphylaxis, however, it is not clear what other manifestations of mast cell disorders post a risk for the fetus. (medscape.com)
  • Urticaria needs to be differentiated from other medical conditions where wheals, angioedema, or both can occur, e.g. anaphylaxis, autoinflammatory syndromes, urticarial vasculitis, orbradykinin-mediated angioedema including hereditary angioedema (HAE). (cyberderm.net)
  • Anaphylaxis is defined as an acute life-threatening systemic event triggered by the sudden release of mediators from basophils and mast cells after exposure to a triggering agent. (medscape.com)
Hives8
  • The red welts of hives happen when mast cells in the bloodstream release the chemical histamine, which makes tiny blood vessels under the skin leak. (kidshealth.org)
  • Cold urticaria can become dangerous in rare cases , such as when hives appear all over the body after jumping into cold water. (ecarf.org)
  • Hives develop when the body's immune cells , known as mast cells , are activated and then release messenger substances. (ecarf.org)
  • At least one mutation in the ADGRE2 gene has been identified in people with vibratory urticaria, a condition in which vibration, repetitive stretching, or friction on the skin results in allergy symptoms such as hives (urticaria), swelling (angioedema), redness (erythema), and itching (pruritus) in the affected area. (medlineplus.gov)
  • Urticaria is a group of diseases characterized by the development of wheals (hives), angioedema (see chapter 1.1.2), or both. (cyberderm.net)
  • Urticaria or hives is a hypersensitive condition described by bothersome, red, raised lesions on skin. (dermamiracle.in)
  • Mast cell degranulation is the system behind hives. (dermamiracle.in)
  • While most of the immune system Urticaria is an essential ailment, hives can likewise be a side effect of some other immune system illnesses. (dermamiracle.in)
Degranulation9
  • When activated, a mast cell can either selectively release (piecemeal degranulation) or rapidly release (anaphylactic degranulation) "mediators", or compounds that induce inflammation, from storage granules into the local microenvironment. (wikipedia.org)
  • Other membrane activation events can either prime mast cells for subsequent degranulation or act in synergy with FcεRI signal transduction. (wikipedia.org)
  • A unique, stimulus-specific set of mast cell mediators is released through degranulation following the activation of cell surface receptors on mast cells. (wikipedia.org)
  • Electron microscopy reveals mast cell and eosinophilic degranulation. (cdc.gov)
  • Being highly expressed on skin mast cells, MRGPRX2 triggers their degranulation and release of proinflammatory mediators, and it promotes multicellular signaling cascades, such as itch induction and transmission in sensory neurons. (iasp-pain.org)
  • Given the importance of mast cells in normal pregnancy, the question arises of the degree to which diseases that trigger mast cell degranulation, and diseases of mast cells themselves, influence pregnancy. (medscape.com)
  • The type I allergic immunoglobulin E (IgE) response is initiated by antigen-mediated IgE immune complexes that bind and cross-link Fc receptors on the surface of mast cells and basophils, thus causing degranulation with histamine release. (medscape.com)
  • At the point when the mast cell gets stacked it begins degranulation and it supports other mast cells just as other fiery cells to discharge moreover. (dermamiracle.in)
  • Elevated serum HISTAMINE and TRYPTASE levels and cutaneous MAST CELL degranulation are often associated with post-exertional allergic reactions which sometimes are triggered only in combination with prior consumption of a specific food such as wheat. (bvsalud.org)
Angioedema10
  • In general, patients with urticaria do not require further inpatient care unless their urticaria is severe and does not respond to antihistamine therapy or unless they progress to laryngeal angioedema and/or anaphylactic shock or have comorbidities that necessitate inpatient therapy. (medscape.com)
  • Many cases of angioedema occur in patients with urticaria. (medscape.com)
  • Urticaria also may be accompanied by angioedema, which results from mast cell and basophil activation. (merckmanuals.com)
  • Urticaria is a common, mast-cell-driven disease, characterized clinically by the development of wheals, angioedema, or both. (skintherapyletter.com)
  • Urticaria is the development of transient localised oedema in the dermis , characterised by wheals and often co-exists with angioedema. (dermnetnz.org)
  • an estimated 40% of patients with chronic urticaria (lasting over 6 weeks) have associated angioedema. (dermnetnz.org)
  • Angioedema is caused by an increase in local capillary permeability and plasma extravasation , usually mediated by mast cells , histamine , or bradykinin release. (dermnetnz.org)
  • Angioedema with urticaria tends to suggest a histaminergic form, which includes acute allergic angioedema and histaminergic idiopathic angioedema. (dermnetnz.org)
  • Urticaria may be associated with angioedema: Pronounced erythematous or skin colored swelling of the lower dermis and subcutis or mucous membranes. (cyberderm.net)
  • Acute spontaneous urticaria: Occurrence of spontaneous wheals, angioedema or bothfor less than 6 weeks. (cyberderm.net)
Atopic Dermatitis2
  • The expression of MRGPRX2 by skin mast cells and the levels of the MRGPRX2 agonists (eg, substance P, major basic protein, eosinophil peroxidase) are upregulated in the serum and/or skin of patients with inflammatory and pruritic skin diseases, such as chronic spontaneous urticaria or atopic dermatitis. (iasp-pain.org)
  • We found that omalizumab in patients with severe persistent asthma (SPA) was an effective therapy for asthma and the following co-morbid conditions: chronic urticaria (CU), bee venom allergy, latex allergy, atopic dermatitis, food allergy and Samter's syndrome. (medscimonit.com)
Cutaneous1
  • The deduced amino acid sequence between the primers was identical to that reported for neutrophil cathepsin G, indicating that the protein of cutaneous mast cells previously shown to be immunologically cross-reactive with neutrophil cathepsin G has a comparable amino acid sequence. (duke.edu)
Pruritus3
Cold urticaria4
  • ECARF spoke to Dr Markus Magerl of Allergie-Centrum-Charité in Berlin about the strange phenomenon of cold urticaria. (ecarf.org)
  • People who react in such a way to a cold stimulus within five to ten minutes probably have a specific type of urticaria , known as cold urticaria . (ecarf.org)
  • Doctors generally use a provocation test to confirm a diagnosis of cold urticaria. (ecarf.org)
  • Various medications are available for the treatment of cold urticaria. (ecarf.org)
Diseases7
  • Usually, however, the experienced clinician is able to distinguish these other diseases from urticaria because of the latter's distinctive appearance (see the images below), because it is intensely pruritic, and because it blanches completely with pressure. (medscape.com)
  • Jasper is a clinical-stage biotechnology company developing briquilimab, a monoclonal antibody targeting c-Kit (CD117) as a therapeutic for chronic mast and stem cell diseases such as chronic spontaneous urticaria and lower to intermediate risk myelodysplastic syndromes (MDS) and as a conditioning agent for stem cell transplants for rare diseases such as sickle cell disease (SCD), Fanconi anemia (FA) and severe combined immunodeficiency (SCID). (itbusinessnet.com)
  • Focus is on the studies of the genetic analysis and specific gene expression related with human mast cell diseases. (nih.gov)
  • Provides research assistance on the diagnosis and treatment of allergic diseases and clonal mast cell disorders. (nih.gov)
  • Her research interests are the identification and characterization of mast cell receptors and their contribution to pathogenesis of mast cell associated diseases. (nih.gov)
  • Physicians treating mast cell diseases in pregnancy should remember that mast cells and their mediators are clinically relevant not only in disease, but also in the uterus of the healthy patient. (medscape.com)
  • The type III immune-complex disease is associated with systemic lupus erythematosus and other autoimmune diseases that cause urticaria. (medscape.com)
Idiopathic1
  • As with asthma, chronic idiopathic urticaria may be influenced by the hormonal changes of pregnancy, [ 5 ] for either better or worse. (medscape.com)
Allergy5
  • Since the mast cells play an important role in allergies , the disease is often referred to as a 'cold allergy' . (ecarf.org)
  • Researchers suggest that once the subunits are disconnected, the beta subunit signals the mast cells to react and produce the allergy symptoms in the skin that occur in vibratory urticaria. (medlineplus.gov)
  • Urticaria occurring at the time of antibiotic use is often due to the underlying infection rather than an allergy to the antibiotic. (rch.org.au)
  • Hymenoptera venom allergy (HVA) represents a particular risk for exceptionally severe anaphylactic sting reactions in patients with clonal mast cell disorders (CMD). (biomedcentral.com)
  • We evaluated characteristics of the bone marrow mast cells by pathology, flow cytometry and detection of D816V mutation by using current WHO-criteria, which led to changes in the final diagnosis compared to the assessments done by classical allergy work-up and measurements of sBT. (biomedcentral.com)
Patients4
  • If urticaria patients don't show a "signal" in the reporting system, w e can't get our problem addressed. (researchgate.net)
  • Recruits and enrolls patients and healthy volunteer subjects for stimulation and apheresis collection of CD34+ cells in. (nih.gov)
  • Patients with chronic spontaneous urticaria (CSU) 1)Patients who were diagnosed as chronic spontaneous urticaria following the criteria of the Japanese Dermatological Association Guidelines. (go.jp)
  • At Derma miracle we provide safe & effective urticaria treatment to our patients with 100% results. (dermamiracle.in)
Mediators6
  • The Fc region of immunoglobulin E (IgE) becomes bound to mast cells and basophils, and when IgE's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators. (wikipedia.org)
  • Stress can activate your mast cells and cause them to release mediators like histamine. (hoffmancentre.com)
  • Mediators and cells classically involved in pro-coagulant and anticoagulant pathways together play a role in SPA and CU pathophysiology and omalizumab effect. (medscimonit.com)
  • The safety of higher-dose antihistamines (beyond the level of US Food and Drug Administration approval) has not been studied in pregnancy, and because mast cells mediators, including histamine, participate in uterine adaptation, there is reason for caution. (medscape.com)
  • Release of histamine and other mediators such as platelet-activating factor (PAF) and cytokines released from activated skin mast cells, result invasodilatation and plasma extravasation as well as sensory nerve activation and cell recruitmentto urticarial lesions. (cyberderm.net)
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
Systemic2
Chronic inducible urticaria1
  • Standardized provocation testing to diagnose chronic inducible urticaria are required for an accurate diagnosis. (cyberderm.net)
Bone marrow2
  • Basophils leave the bone marrow already mature, whereas the mast cell circulates in an immature form, only maturing once in a tissue site. (wikipedia.org)
  • 2 To make the diagnosis of SM, bone marrow histology must show, by definition, at least one compact or dense mast cell (MC) infiltrate. (bmj.com)
Cause urticaria1
Tryptase2
  • In the pregnant uterus, mast cell numbers increase in the myometrium and shift from both tryptase and chymase mast cells to the tryptase-only phenotype. (medscape.com)
  • The diagnosis is confirmed by means of immunohistochemical (IHC) staining with monoclonal antibodies against mast-cell markers (CD117 and tryptase). (medscape.com)
Autoimmune2
  • The mast cell-activating signals in urticaria are ill defined and likely to be heterogeneous and diverse (IgE-mediated Type I-reaction, non specific histamine liberators, activation of complement, autoimmune mediated urticaria - IgG against IgE or against high affinity IgE-receptor and IgE against autoantigens, as well as other poorly understood mechanisms). (cyberderm.net)
  • Type 1 DM is diagnosed mostly in children and young adults as the result of autoimmune destruction of β cells in the pancreas and the resulting lack of insulin. (lecturio.com)
Basophils and mast cells1
Receptors on mast cells1
  • Complement proteins can activate membrane receptors on mast cells to exert various functions as well. (wikipedia.org)
Basophil4
  • The mast cell is very similar in both appearance and function to the basophil, another type of white blood cell. (wikipedia.org)
  • Mast cells are very similar to basophil granulocytes (a class of white blood cells) in blood. (wikipedia.org)
  • Their nuclei differ in that the basophil nucleus is lobated while the mast cell nucleus is round. (wikipedia.org)
  • mast cell and basophil stimulation results in histamine release. (dermnetnz.org)
Acute urticaria5
Cholinergic urticaria1
Disorders3
  • Mast Cell-Mediated and Associated Disorders in Pregnancy: A Risky Game With an Uncertain Outcome? (medscape.com)
  • Mast cell disorders in pregnancy do not garner the same degree of attention but merit a closer look in no small way, because mast cells appear to play a critical role in pregnancy. (medscape.com)
  • Complex referral history suggestive of chronic urticaria, mast cell disorders or eosinophilic oesophagitis. (who.int)
Lesions2
  • The lesions of IgE-mediated urticaria usually last less than 24 hours and are often migratory and leave no residual skin abnormalities. (medscape.com)
  • UP is a disease characterized by skin lesions containing high numbers of mast cells. (duke.edu)
Antihistamine1
  • A large body of data has demonstrated that omalizumab, a biologic agent, is safe and effective in the treatment of H1- antihistamine refractory urticaria and should be considered as a third-line agent, with cyclosporin A reserved for fourth-line therapy. (skintherapyletter.com)
Asthma3
  • Urticaria will be discussed here because of its more direct association with occupational asthma, in terms of both clinical coexistence and mechanistic similarities. (cdc.gov)
  • As with asthma, hormonal changes of pregnancy have an unpredictable influence on the underlying mast cell condition. (medscape.com)
  • Occupational asthma days, clones of these T cells become sensitized to the allergen and resulting from respiratory sensitization can be life-threatening circulate as memory cells in the bloodstream, and some reside in (Fabbri et al. (cdc.gov)
Vibratory2
  • The ADGRE2 gene mutation that causes vibratory urticaria, written as Cys492Tyr or C492Y, replaces the protein building block (amino acid) cysteine with the amino acid tyrosine at position 492 of the protein sequence. (medlineplus.gov)
  • Vibratory Urticaria Associated with a Missense Variant in ADGRE2. (medlineplus.gov)
Release of histamine3
Inflammatory3
  • Mast cells play a key role in the inflammatory process. (wikipedia.org)
  • The spots present contain a large number of mast (inflammatory) cells. (skinsite.com)
  • This multifunctional inflammatory cell is involved in both innate and acquired immunity and plays a central role in the induction of allergic inflammation. (nih.gov)
Role of mast cells2
  • We discuss the current knowledge about sex differences in migraine and its comorbidities, and focus on the potential role of mast cells (MCs) in both. (frontiersin.org)
  • The authors discuss the role of mast cells in pregnancy in both healthy and disease states in a review article published in May. (medscape.com)
Skin11
  • Mast cells are present in most tissues characteristically surrounding blood vessels, nerves and lymphatic vessels, and are especially prominent near the boundaries between the outside world and the internal milieu, such as the skin, mucosa of the lungs, and digestive tract, as well as the mouth, conjunctiva, and nose. (wikipedia.org)
  • Mast cells are immune cells that fight infection and live within the skin. (skinsite.com)
  • When the skin condition starts after the age of five, the abnormal collections of mast cells will sometimes involve the internal organs and the disease does not always go away. (skinsite.com)
  • According to study authors, this electrical communication between skin cells may have the potential for therapeutic implications. (dermatologytimes.com)
  • Urticaria Urticaria consists of migratory, well-circumscribed, erythematous, pruritic plaques on the skin. (merckmanuals.com)
  • Mast cells, which are found in many body tissues including the skin, are important for the normal protective functions of the immune system. (medlineplus.gov)
  • vibration, friction, or stretching of the skin can disrupt the association between subunits in mast cells. (medlineplus.gov)
  • This study establishes the primary structure of human skin chymase and provides further evidence for the presence of a cathepsin G-like proteinase within human mast cells. (duke.edu)
  • These studies provide further evidence that human skin mast cells contain two different chymotrypsin-like proteinases. (duke.edu)
  • Urticaria is a skin condition that results in the appearance of itchy red welts on the skin. (dermamiracle.in)
  • In the event that you have visit scenes of Urticaria, here are a few hints recommended by Dr. Navnit Haror for Urticaria treatment in Delhi (South Delhi) at DermaMiracle skin & Hair clinic, the most favored dermatologist in Greater Kailash 1. (dermamiracle.in)
Dermis1
  • Urticaria appears as raised, well-circumscribed areas of erythema and edema, often with central pallor, that involve the dermis and epidermis and are usually very pruritic. (medscape.com)
Monoclonal1
  • In contrast, B cells from immunocytomas showed light chain restriction and monoclonal rearrangement for IgH, confirming their neoplastic nature. (bmj.com)
Disease5
  • The prognosis in chronic urticaria is more guarded and depends on the comorbid disease causing the urticaria, as well as on the response to therapy. (medscape.com)
  • Hematologic manifestations of mast cell disease: a prospective study of laboratory and morphologic features and their relation to prognosis. (medigraphic.com)
  • An integrated program investigating mast cell biology includes studies into the growth and differentiation of mast cells, mast-cell signal transduction, and the products generated by mast cells that lead to disease. (nih.gov)
  • Research efforts have contributed to the identification of mutations in mast cell disease, understanding signaling through KIT and the high affinity IgE receptor, and how alterations in the control of mast cell mediator production affect human disease. (nih.gov)
  • Urticaria is a mast cell-driven disease. (cyberderm.net)
D816V1
Allergic reactions1
  • In allergic reactions, mast cells remain inactive until an allergen binds to IgE already coated upon the cell. (wikipedia.org)
Actinic keratosis1
  • ICYMI, this week we had stories about clascoterone cream 1% for acne vulgaris management, CRH-R1 increases in psoriasis and actinic keratosis mast cells, cannabinoid use in dermatology, and more. (dermatologytimes.com)
Differentiation2
  • The first in vitro differentiation and growth of a pure population of mouse mast cells has been carried out using conditioned medium derived from concanavalin A-stimulated splenocytes. (wikipedia.org)
  • Later, it was discovered that T cell-derived interleukin 3 was the component present in the conditioned media that was required for mast cell differentiation and growth. (wikipedia.org)
Manifestations1
Antibody5
  • As a result, mast cells are coated with IgE, which is produced by plasma cells (the antibody-producing cells of the immune system). (wikipedia.org)
  • For chronic or recurrent urticaria, basic laboratory studies should include a complete blood count (CBC), erythrocyte sedimentation rate (ESR), thyroid-stimulating hormone (TSH) level, and an antinuclear antibody (ANA) test to look for possible causes of the urticaria. (medscape.com)
  • The binding makes the protein-drug complex immunogenic, stimulating antidrug antibody production, T-cell responses against the drug, or both. (merckmanuals.com)
  • Xaluritamig is a novel humanized bispecific T cell recruiting antibody cross-reactive to human and nonhuman primate STEAP1 and CD3. (drugbank.com)
  • Hypersensitivity reactions originally described by Gell and Coombs have been extended into nine different types comprising antibody- (I-III), cell-mediated (IVa-c), tissue-driven mechanisms (V-VI) and direct response to chemicals (VII). (bvsalud.org)
Pruritic3
  • Urticaria is defined as the transient appearance of elevated, erythematous pruritic wheals or serpiginous exanthem, usually surrounded by an area of erythema. (cdc.gov)
  • It occurs primarily in children and is characterized by multiple persistent small, reddish-brown, hyperpigmented, pruritic macules and papules due to an increased number of mast cells. (dermis.net)
  • One type of urticaria in pregnancy-pruritic urticaria papules and plaques of pregnancy-has not yet clearly been linked to mast cells, but antihistamines are effective in this condition. (medscape.com)
Immunologic3
  • These include irritant contact dermatitis, allergic contact dermatitis (Type IV delayed hypersensitivity), and urticaria (Type I immunologic and nonimmunoIogic). (cdc.gov)
  • These cells have both an immunologic and a nonimmunologic role in pregnancy. (medscape.com)
  • NMH is a major metabolite of histamine, which is released from storage in mast cells and basophils when these cells degranulate in response to stimulation (both immunologic and nonimmunologic). (medscape.com)
Immune system2
  • The ADGRE2 gene provides instructions for making a protein found in several types of immune system cells, including mast cells. (medlineplus.gov)
  • In the event that you've encountered any of these, you may in reality have immune system Urticaria, and this warrants further examination. (dermamiracle.in)
Immunoglobulin2