Marrow adipocytes. Medical search. Frequent questions

It is well-described that leptin receptor (LepR) + perivascular stromal cells provide a major source of bone-forming osteoblasts in adult and aged bone marrow. (nature.com)
These Fgfr3 + stem/stromal cells with OCT identities are abundant in the young bone marrow and depleted in the old bone marrow, denoting their transitional nature. (nature.com)
Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
The bone marrow niche includes cells belonging to the stroma, which includes mesenchymal stromal cells , adipocytes (fat cells), nerve cells, connective tissue cells, and cells involved in bone formation and remodeling. (medicalnewstoday.com)
Mesenchymal stromal cells can divide and differentiate into a number of cell types, including bone, cartilage, and adipocytes. (medicalnewstoday.com)
In contrast, there was an increase in the number of mesenchymal stromal cells in the central marrow of aged mice. (medicalnewstoday.com)
Organotins are potent activators of PPARγ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells. (ceenta.com)
Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
Progenitor cell (stem cell) lines in the bone marrow produce new blood cells and stromal cells. (medscape.com)

Pluripotent MSCs from the subchondral bone marrow are subsequently mobilized, migrate into the defect filled with the clot, and differentiate into chondrocytes and osteoblasts. (hindawi.com)
Here we show that bone marrow endosteal SSCs are defined by fibroblast growth factor receptor 3 ( Fgfr3 ) and osteoblast-chondrocyte transitional (OCT) identities with some characteristics of bone osteoblasts and chondrocytes. (nature.com)
MSCs have the ability to differentiate into adipocytes and chondrocytes forming fat tissue and cartilage as well as into bone cells - called osteocytes. (nature.com)
These cells are multipotent, meaning they have the ability to differentiate into several different specialised cell types, such as cartilage cells (chondrocytes), bone cells (osteoblasts) and fat cells (adipocytes). (rvc.ac.uk)
Besides, they were able to differentiate into osteoblasts, chondrocytes and adipocytes. (scielo.br)

Here, we studied the effect of several major green tea polyphenols on adipocyte differentiation in human bone marrow mesenchymal stem cells (hBM-MSCs) and compared it to the effect of representative antidiabetic drugs. (nih.gov)
Catechin was the most potent of the eight green tea polyphenols evaluated in promoting adipocyte differentiation in hBM-MSCs, and this effect was dose-dependent. (nih.gov)
Catechin increased the mRNA levels of various adipogenic markers, such as adiponectin, peroxisome proliferator-activated receptor gamma (PPARgamma), FABP4, and LPL, as measured during adipocyte differentiation in hBM-MSCs. (nih.gov)
Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. (hindawi.com)
The purpose of this review is to bridge the gap in our understanding between the basic science knowledge on MSCs and BMA and the clinical and technical aspects of marrow stimulation-based cartilage repair by examining available data on the role and mechanisms of MSCs and BMA in osteochondral repair. (hindawi.com)
They were first isolated from the bone marrow, and the potency of MSCs is currently being employed in the techniques of marrow stimulation for symptomatic small chondral defects. (hindawi.com)
In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
Moreover, the bone marrow clot provides a three-dimensional (3D) environment which supports the chondrogenesis of MSCs. (hindawi.com)
MSCs have a lower ability to differentiate into osteoblasts but a higher ability to differentiate into adipocytes, which could be linked to myeloid malignancies ( Woods and Guezguez, 2021 ). (techscience.com)
MSCs were first found in bone marrow, but have since been detected in many different tissues, including adipose tissue (fat) and umbilical cord blood. (rvc.ac.uk)
This kit is suitable for the differentiation of MSCs derived from human bone marrow (BM), adipose tissue, umbilical cord, or pluripotent stem cells (PSCs) that have been previously culture-expanded in serum- and animal component-free medium (e.g. (stemcell.com)
Adipogenic differentiation of human bone marrow-derived MSCs using MesenCult™ Adipogenic Differentiation Medium (Human) or a competitor medium. (stemcell.com)
Bone marrow mesenchymal stem cells (MSCs) give rise to osteoblasts and adipocytes, with an inverse relationship between the 2. (aetox.com)
However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)

Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)

Hematopoietic cells (also known as blood cells) reside in the bone marrow along with BMAds. (wikipedia.org)
The earliest pathologic characteristics of osteonecrosis are necrosis of hematopoietic cells and adipocytes followed by interstitial marrow edema. (medscape.com)
In the present study, the researchers performed several analysis in the hindlimb, forelimb, and pelvic bones from young and old mice to examine the impact of aging on the interaction between the bone marrow niche and hematopoietic cells. (medicalnewstoday.com)

When blood-forming hematopoietic stem cells that reside in the bone marrow age, the production of blood cells is altered, and the body's ability to regenerate lost cells is impaired. (medicalnewstoday.com)

The balance between osteoblasts and adipocytes is influenced by a reciprocal relationship. (ironmagazine.com)

Mesenchymal stem cells gene signature in high-risk myeloma bone marrow linked to suppression of distinct IGFBP2-expressing small adipocytes. (uams.edu)
The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. (nature.com)
Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
The aim of this study was to compare the osteogenic potential of mesenchymal stem cells obtained from bone marrow (BM-MSC) with those extracted from adipose tissue (AT-MSC) of adult dogs. (scielo.br)
The bone marrow is the main site for hematopoiesis , the process of new blood cells forming via the hematopoietic stem cells (HSC) dividing and differentiating. (medicalnewstoday.com)
Besides housing hematopoietic stem cells and their progeny, the endosteum and the central marrow also contain distinct cell populations that express molecules or secrete proteins, such as cytokines that regulate the formation, development, and function of HSCs and progenitor cells. (medicalnewstoday.com)
The expression of Prx1 has been used as a marker to define the skeletal stem cells (SSCs) populations found within the bone marrow and periosteum that contribute to bone regeneration. (researchgate.net)
These stem cells, extracted from bone marrow, can develop into fat cells but also into bone cells in the body. (ironmagazine.com)
Our results suggest that RK enhances the differentiation of C3H10T1/2 stem cells into osteoblasts, and it may promote bone formation by an action unrelated to adipocyte differentiation. (ironmagazine.com)
To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Adipose tissue residing progenitors (adipocyte lineage progenitors and adipose derived stem cells (ADSC). (mainehealth.org)
Bone marrow consists of stem cells, which are large, "primitive," undifferentiated cells supported by fibrous tissue called stroma. (medscape.com)
There are 2 main types of stem cells and, therefore, the bone marrow consists of 2 types of cellular tissue. (medscape.com)
These stem cells divide to eventually give rise to red blood cells, platelets, and most white blood cells in the red marrow. (medscape.com)
The bone marrow stroma contains mesenchymal stem cells. (medscape.com)

Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
FTO gene was universally expressed in human and mice tissues, including adipocytes. (diabetesjournals.org)
When the oxygen content of body tissues is low, if there is loss of blood or anemia, or if the number of red blood cells decreases, the kidneys produce and release erythropoietin, a hormone that stimulates the bone marrow to produce more red blood cells. (medscape.com)

HSC renewal occurs in the marrow stem cell niche, a microenvironment that contains cells and secreted factors that promote appropriate renewal and differentiation of HSC. (wikipedia.org)
Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4 + T cells. (frontiersin.org)
In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. (frontiersin.org)
This review describes how adipocytes participate in adaptive immunity from the perspective of T cells and B cells, and discusses their role in the pathogenesis of various diseases. (frontiersin.org)
Adipocytes are the main constituent cells of adipose tissue. (frontiersin.org)
Recently, an increasing number of studies have shown that adipocytes have immunological functions capable of recruiting and activating immune cells. (frontiersin.org)
Several studies have shown that adipocytes highly express CD1d, which presents lipid antigens to invariant natural killer T (iNKT) cells and stimulates the activation of iNKT cells ( 5 - 7 ). (frontiersin.org)
Moreover, like other nucleated cells, adipocytes express MHC class I molecules. (frontiersin.org)
However, there is no clear evidence that adipocytes interact directly with CD8 + T cells through antigen:MHCI complex. (frontiersin.org)
Adipocytes can directly activate CD4 + T cells through antigen:MHCII complex in a contact-dependent manner. (frontiersin.org)
Next, we summarize various cytokines produced by adipocytes that regulate the survival, activation and differentiation of B cells. (frontiersin.org)
PBM-treated hypertrophic cells (1064 nm and 17.6 J/cm2 every day for 7 days following addition of PA) decreased the lipid levels in hypertrophic adipocytes, restored the GLUT4 protein expression and enhanced glucose transport. (google.com)
A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
The term "transitional" emphasizes the unique feature of these cells that are particularly abundant in the young bone marrow. (nature.com)
Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
The number of cells per field, the AP activity, the collagen and mineralized matrix synthesis were higher in AT-MSC en differentiation, in relation to BM-MSC under the same conditions in all evaluated times. (scielo.br)
A recent study in mice shows that aging is linked to the inflammation of cells in the bone marrow. (medicalnewstoday.com)
All these cells, along with blood vessels and the extracellular matrix, form the bone marrow niche . (medicalnewstoday.com)
The endothelial cells that form the lining of these blood vessels are also a major part of the bone marrow niche. (medicalnewstoday.com)
The study found that bone marrow niche cells that support the functioning of HSCs played a key role in blood aging. (medicalnewstoday.com)
Scientists first noticed that our bone marrow contains fat-storing cells, called adipocytes, over a century ago. (ukri.org)
A study has shown that Adipocytes can absorb and metabolise the chemotherapeutic agent daunorubicin, reducing its ability to kill cancer cells. (europeanpharmaceuticalreview.com)
They measured the presence of daunorubicin through flow cytometry and liquid chromatography/mass spectrometry, and examined fat cells in bone marrow from children with leukemia. (europeanpharmaceuticalreview.com)
The presence of adipocytes significantly reduced the accumulation of daunorubicin in the ALL cells. (europeanpharmaceuticalreview.com)
The leukemia cells treated with daunorubicin survived and proliferated better in samples that contained adipocytes. (europeanpharmaceuticalreview.com)
This is important for leukemia and a lot of other cancers that grow in the bone marrow or around fat cells, since that means that fat cells might remove chemotherapy from the environment and allow the cancer cells to survive. (europeanpharmaceuticalreview.com)
Fat cells, also known as adipocytes, are the cells in the body that compose adipose tissue which store energy as fat. (searchandrestore.com)
Fat cells are scientifically known as adipocytes. (searchandrestore.com)
Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
Objective: This study evaluated the osteogenic induction of human bone marrow cells by human recombinant bone morphogenetic protein-4 (rhBMP-4) and proteins released by Saos-2 (human osteosarcoma cell line). (bvsalud.org)
Study design: Osteoinduction in the presence or absence of Saos-2 and/or rhBMP-4 was evaluated in cultured human bone marrow cells. (bvsalud.org)
Results: Bone marrow cells were adherent since the first day of culture and were positive for osteonectin. (bvsalud.org)
Osteoblasts were obtained from human bone marrow cells even in the absence of growth factors and showed a typical morphology. (bvsalud.org)
Cells derived from bone marrow can undergo osteoinduction in vitro in the absence of osteoinductive factors such as bone morphogenetic proteins. (bvsalud.org)
Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
However, the yellow marrow can revert to red if there is increased demand for red blood cells, such as in instances of blood loss. (medscape.com)
Normally, only mature cells are released from the marrow into the bloodstream. (medscape.com)
Bone marrow thus contains blood cells at varying stages of development. (medscape.com)
Illustration of the pelvis to show the site of bone marrow and blood cells derived from bone marrow. (medscape.com)
Similarly, the bone marrow produces and releases more white blood cells in response to infections, and it produces and releases more platelets in response to bleeding. (medscape.com)
As age progresses, more of the red bone marrow turns into yellow bone marrow and the production of new blood cells becomes more difficult. (medscape.com)

The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. (hindawi.com)

The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. (karger.com)
The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)
The adipocytes absorbed the chemotherapeutic agent, removing it from the leukemia microenvironment. (europeanpharmaceuticalreview.com)

Bone marrow adipocytes (BMAds) originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. (wikipedia.org)

Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation. (google.com)
[ 8 ] Interruption of the vascular supply and resultant necrosis of marrow, medullary bone, and cortex are theorized to be caused by the mechanisms listed below. (medscape.com)

A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. (hindawi.com)
If bone marrow fills a cartilage defect either as a result of marrow stimulation for chondral defects or the course of the spontaneous repair of osteochondral defects, a bone marrow clot forms within the cartilage defect. (hindawi.com)
Such enhanced techniques of marrow stimulation have been shown to improve articular cartilage repair in both animal models and patients. (hindawi.com)

Here we show region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. (wustl.edu)
A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)

MAT content was assessed by osmium tetroxide staining and adipocyte marker expression. (frontiersin.org)

For this purpose, we developed a fibrous scaffold resembling the bone/bone marrow extracellular matrix (ECM) based on protein without addition of synthetic polymers. (nature.com)

Thus, it is thought that BMAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis. (wikipedia.org)
BMAT is thought to result from preferential MSC differentiation into an adipocyte, rather than osteoblast lineage in osteoporosis based on the inverse relationship between bone and BMAT in bone-fragile osteoporotic states. (wikipedia.org)
The origins and basis for these fat deposits are largely unknown, but there is a possibility that the altered mechanical and biological environments lead to dysregulation of MSC/MPC and progression to preferential differentiation towards the adipocyte lineage. (scirp.org)

Simultaneously, adipocytes secrete various cytokines including leptin, resistin, TNF-α and IL-6 to regulate the differentiation and function of T and B lymphocytes. (frontiersin.org)

Adipocytes can regulate adaptive immunity, which is involved with various metabolic diseases. (frontiersin.org)
Since there have been many reports on the regulation of metabolic diseases through adaptive immunity ( 9 - 11 ), we focus on how adipocytes regulate adaptive immunity in this review. (frontiersin.org)
The development of modalities to promote local/systemic bone formation by inhibiting bone marrow adipose tissue is important in the treatment of fractures or metabolic bone diseases such as osteoporosis. (ironmagazine.com)
Her current research in focused on the role of lipolysis of bone marrow adipocytes and its metabolic impact on bone health. (vanderbilt.edu)

Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. (wikipedia.org)
BMAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
Having fat in our bones might strike you as unusual, but it is not: in humans and other mammals, this bone marrow adipose tissue (BMAT) develops steadily after birth and accumulates rapidly during puberty. (ukri.org)
Indeed, by the time we reach adulthood BMAT can comprise up to 70% of bone marrow volume, representing almost 10% of our total fat stores. (ukri.org)
Finally, BMAT might enhance the growth of tumours within the bone, such as those that have spread from breast or prostate cancers, as well as leukaemia and other cancers that begin in the bone marrow. (ukri.org)
Bone marrow adipose tissue (BMAT) accounts for up to 70% of total bone marrow volume and 10% of total fat mass in healthy humans. (ukri.org)

The bone marrow is the soft, spongy tissue found at the center of most bones in the body. (medicalnewstoday.com)
Bone marrow is the soft, spongy, gelatinous tissue found in the hollow spaces in the interior of bones. (medscape.com)

Both types of bone marrow are highly vascular, being enriched with numerous blood vessels and capillaries. (medscape.com)

Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. (haematologica.org)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
Bone marrow fibrosis (BMF) is characterized by the increased deposition of reticulin fibers and in some cases collagen fibers. (haematologica.org)
European consensus on the grading of bone marrow fibrosis. (haematologica.org)
Conditions associated with bone marrow fibrosis. (haematologica.org)

In an adult, roughly half of the bone marrow is still red. (medscape.com)

The current results indicated that PBMT inhibited FFA generation and release in insulin-resistant adipocytes and reduced plasma FFA levels in diabetic db/db mice and HFD-fed mice. (google.com)
Expression of FTO was tested in adipocytes from db / db mice and mouse macrophages. (diabetesjournals.org)
In an ancillary study of adipocytes from db / db mice, FTO expression was ∼50% lower than in those from wild-type mice. (diabetesjournals.org)
In addition, the expression of FTO gene was reduced in adipocytes from db / db mice. (diabetesjournals.org)
A high fat diet increases bone marrow adipose tissue (MAT) but does not alter trabecular or cortical bone mass in C57BL/6J mice. (mainehealth.org)

In conclusion, our data suggest that (-)-catechin promotes adipocyte differentiation and increased sensitivity to insulin in part by direct activation of PPARgamma, which could be at the basis of the observed pharmacological benefits of green tea intake in reducing the risk of type 2 diabetes. (nih.gov)
Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. (frontiersin.org)
Photobiomodulation therapy decreases free fatty acid generation and release in adipocytes to ameliorate insulin resistance in type 2 diabetes. (google.com)

Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)
They cocultured human acute lymphoblastic leukemia (ALL) cell lines with adipocytes and treated them with daunorubicin. (europeanpharmaceuticalreview.com)

We define proximal regulatedâ €™ MAT (rMAT) as single adipocytes interspersed with active haematopoiesis, whereas distal constitutiveâ €™ MAT (cMAT) has low haematopoiesis, contains larger adipocytes, develops earlier and remains preserved upon systemic challenges. (wustl.edu)

However, RK did not affect the inhibition of early-stage adipocyte differentiation. (ironmagazine.com)

Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. (wustl.edu)

Anatomy12

Organisms1

Diseases4

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes5

Stromal cells11

Chondrocytes5

MSCs21

Derived from human bone marrow1

Hematopoietic cells3

Reside in the bone ma1

Osteoblasts and adipocytes1

Stem cells16

Tissues3

Cells42

Bone marrow aspirate1

Microenvironment5

Progenitors1

Necrosis2

Cartilage3

Lipid2

Osmium tetroxide1

Extracellular matrix1

Lineage3

Lymphocytes1

Metabolic4

BMAT6

Spongy2

Blood vessels1

Fibrosis10

Adult1

Mice5

Insulin3

Human2

Proximal1

Inhibition1

Accumulates1