• Vivo
  • They isolated bone marrow stromal/stem cell (BMSC)-derived EVs through gradient ultracentrifugation and ultrafiltration, and tested the influence of the EVs on osteogenesis both in vivo and in vitro . (exosome-rna.com)
  • acute
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be exposed in the joint. (wikipedia.org)
  • morphogenetic protein
  • Infatti, la sovraespressione di Nanog è in grado di ridurre la dipendenza dai segnali mediati dall'attivazione dei recettori del BMP ( Bone Morphogenetic Protein ) e LIF ( Leukemia Inhibitor Factor ), permettendo l'espansione delle cellule ES in assenza di tali fattori solubili nel medium di coltura. (springer.com)
  • regenerate
  • In reptiles, chelonians, crocodilians and snakes are unable to regenerate lost parts, but many (not all) kinds of lizards, geckos and iguanas possess regeneration capacity in a high degree. (wikipedia.org)
  • Regeneration among arthropods is restricted by molting such that hemimetabolous insects are capable of regeneration only until their final molt whereas most crustaceans can regenerate throughout their lifetimes. (wikipedia.org)
  • tissues
  • These processes are necessary for proper formation of important tissues including bone, heart and muscle. (wikipedia.org)
  • Regeneration in humans is the regrowth of lost tissues or organs in response to injury. (wikipedia.org)
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (wikipedia.org)
  • Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (wikipedia.org)
  • In 2009, the regeneration of hollow organs and tissues with a long diffusion distance, was a little more challenging. (wikipedia.org)
  • vertebrate
  • salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
  • whereas
  • Eight of 20 group A patients (40%) achieved the primary endpoint of mature bone regeneration, whereas all 20 group B patients (100%) achieved the primary endpoint. (quintpub.com)
  • functional
  • BOOST-2 will investigate whether intracoronary BMC-transfer will have an effect on Left Ventricular (LV) functional and structural regeneration and have an impact on clinical endpoints as compared to a placebo cell infusion (erythrocytes only). (isrctn.com)
  • cell
  • This study thus indicates that RANKL may be clinically useful to improve T‐cell function recovery after BMT by controlling multiple facets of thymic regeneration. (cloudfront.net)
  • In this study, researchers from the Shanghai Jiao Tong University explore the role of bone marrow stromal cell-derived EVs in the regulation of osteoblast activity and bone regeneration. (exosome-rna.com)
  • The researchers anticipate that our assay using bone marrow stromal cell-derived EVs will become a valuable tool for promoting bone regeneration. (exosome-rna.com)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • clinical
  • The latest issue of our series MARROW, which presents original research, reviews, perspectives, and commentaries on topics in basic, translational, and clinical and biology and medicine. (nyas.org)
  • defects
  • Furthermore, the researchers constructed an EVs delivery system to stimulate bone formation in Sprague Dawley (SD) rats with calvarial defects. (exosome-rna.com)
  • cellular
  • Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. (wikipedia.org)
  • Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. (wikipedia.org)