• Vivo
  • They isolated bone marrow stromal/stem cell (BMSC)-derived EVs through gradient ultracentrifugation and ultrafiltration, and tested the influence of the EVs on osteogenesis both in vivo and in vitro . (exosome-rna.com)
  • acute
  • PLX-R18 were initially developed with Prof Raphael Gorodetsky at Hadassah Hospital for the treatment of acute radiation syndrome and enhancement of bone marrow regeneration. (wikipedia.org)
  • Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be exposed in the joint. (wikipedia.org)
  • morphogenetic protein
  • Infatti, la sovraespressione di Nanog è in grado di ridurre la dipendenza dai segnali mediati dall'attivazione dei recettori del BMP ( Bone Morphogenetic Protein ) e LIF ( Leukemia Inhibitor Factor ), permettendo l'espansione delle cellule ES in assenza di tali fattori solubili nel medium di coltura. (springer.com)
  • tissues
  • These processes are necessary for proper formation of important tissues including bone, heart and muscle. (wikipedia.org)
  • Regeneration in humans is the regrowth of lost tissues or organs in response to injury. (wikipedia.org)
  • Some tissues such as skin and large organs including the liver regrow quite readily, while others have been thought to have little or no capacity for regeneration. (wikipedia.org)
  • However ongoing research, particularly in the heart and lungs, suggests that there is hope for a variety of tissues and organs to eventually become regeneration-capable. (wikipedia.org)
  • Advances in research have enabled the induced regeneration of many more tissues and organs than previously thought possible. (wikipedia.org)
  • In 2009, the regeneration of hollow organs and tissues with a long diffusion distance, was a little more challenging. (wikipedia.org)
  • whereas
  • Eight of 20 group A patients (40%) achieved the primary endpoint of mature bone regeneration, whereas all 20 group B patients (100%) achieved the primary endpoint. (quintpub.com)
  • functional
  • BOOST-2 will investigate whether intracoronary BMC-transfer will have an effect on Left Ventricular (LV) functional and structural regeneration and have an impact on clinical endpoints as compared to a placebo cell infusion (erythrocytes only). (isrctn.com)
  • cell
  • This study thus indicates that RANKL may be clinically useful to improve T‐cell function recovery after BMT by controlling multiple facets of thymic regeneration. (cloudfront.net)
  • In this study, researchers from the Shanghai Jiao Tong University explore the role of bone marrow stromal cell-derived EVs in the regulation of osteoblast activity and bone regeneration. (exosome-rna.com)
  • The researchers anticipate that our assay using bone marrow stromal cell-derived EVs will become a valuable tool for promoting bone regeneration. (exosome-rna.com)
  • In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell treatment, again at Jerusalem's Hadassah Medical Center and again under the terms of compassionate use. (wikipedia.org)
  • clinical
  • The latest issue of our series MARROW, which presents original research, reviews, perspectives, and commentaries on topics in basic, translational, and clinical and biology and medicine. (nyas.org)
  • defects
  • Furthermore, the researchers constructed an EVs delivery system to stimulate bone formation in Sprague Dawley (SD) rats with calvarial defects. (exosome-rna.com)
  • cellular
  • Regeneration in biology, however, mainly refers to the morphogenic processes that characterize the phenotypic plasticity of traits allowing multi-cellular organisms to repair and maintain the integrity of their physiological and morphological states. (wikipedia.org)
  • Above the genetic level, regeneration is fundamentally regulated by asexual cellular processes. (wikipedia.org)
  • disease
  • Other indications include rheumatoid arthritis, avascular necrosis, traumatic arthritis, protrusio acetabuli, certain hip fractures, benign and malignant bone tumors, arthritis associated with Paget's disease, ankylosing spondylitis and juvenile rheumatoid arthritis. (wikipedia.org)