Marrow bone diseases. Medical search. Frequent questions

In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer's disease. (biomedcentral.com)
Adenoviruses are increasingly realised to be responsible for serious morbidity and mortality following allogeneic bone marrow transplantation. (elsevierpure.com)
Bone Marrow Transplantation , 24 (1), 99-101. (elsevierpure.com)
Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogeneic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradation (TBI). (umn.edu)
BACKGROUND: Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence. (ox.ac.uk)

They might involve medicines, blood transfusions or a bone marrow transplant . (medlineplus.gov)
Create healthcare diagrams like this example called Diseases Treatable with a Bone Marrow or Cord Blood Transplant in minutes with SmartDraw. (smartdraw.com)
Five years after beating breast cancer, Roberts announced to viewers that she'd been diagnosed with MDS , or myelodysplastic syndrome, a rare blood and bone-marrow disease that required transplant surgery. (eonline.com)
Aim: To explore the frequency with which children and young people participate in social activities with peers, when they are affected by Mucopolysaccharidosis I Hurler Disease (MPS IH) post bone marrow transplant (BMT). (hud.ac.uk)
Since the 1990s, to do a bone marrow transplant, a patient had to have a sibling with a complete tissue match and take a medication that suppresses their immune system (Cyclophosphamide), as well as high dose chemotherapy. (medlineplus.gov)
Not everyone can get a bone marrow transplant. (medlineplus.gov)
We describe a case of fulminant hepatic failure due to adenovirus serotype 2 in a 39-year-old woman who received a matched sibling allogeneic bone marrow transplant for multiply relapsed Hodgkin's disease. (elsevierpure.com)
The acute or fulminant form of the disease (aGvHD) is normally observed within the first 10 to 100 days post-transplant, [9] [10] and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia. (medicalxpress.com)

The development of acute graft-versus-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P=.04) and improved disease-free survival (P=.11). (umn.edu)
Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect. (ox.ac.uk)
Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
[6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)

Our findings suggest routine use of 16S rRNA gene sequencing and increased numbers of bone marrow transplants as the major reasons. (cdc.gov)
We have seen an increase in the number of bone marrow transplants performed, but there has been no major change in myeloablative regimens. (cdc.gov)
Emily Meier, MD, Director of the Sickle Cell Disease Program , discusses bone marrow transplants at Children's National and some of the complications of sickle cell disease. (childrensnational.org)
University of California San Diego engineers have created artificial bone tissue that could eliminate the need for radiation before bone marrow transplants. (drugdeliverybusiness.com)
Sickle cell disease (SCD) specialists have performed bone marrow transplants in children since the 1990s. (medlineplus.gov)
Bone marrow transplants are not working in 100% of patients. (medlineplus.gov)
Although an effective treatment for HD has remained elusive, current studies using transplants of bone-marrow-derived mesenchymal stem cells provides considerable promise. (biomedcentral.com)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
This study is comparing long-term outcomes for patients who receive blood and bone marrow transplants and those who receive standard treatment with medicines. (nih.gov)

In this prospective multicenter cohort study 144 stage I-III colon cancer patients underwent bone marrow aspiration from both iliac crests prior to open oncologic resection. (nih.gov)
For the bone marrow aspiration, an EZIO-10 drill with 28mm bone marrow needle was used. (caringmedical.com)
In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)
Diagnosis is usually based on complete blood count and peripheral smear and, in selected cases, bone marrow aspiration. (who.int)

This battery of measurements are used in the diagnosis and treatment of certain liver, heart, and kidney diseases, acid-base imbalance in the respiratory and metabolic systems, other diseases involving lipid metabolism and various endocrine disorders as well as other metabolic or nutritional disorders. (cdc.gov)
Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)
Alkaline phosphatase measurements are used in the diagnosis and treatment of liver, bone, and parathyroid disease. (cdc.gov)
AST measurements are used in the diagnosis and treatment of certain types of liver and heart disease. (cdc.gov)
BUN measurements are used in the diagnosis of certain renal and metabolic diseases. (cdc.gov)
Calcium measurements are used in the diagnosis and treatment of parathyroid disease, bone diseases, chronic renal disease and tetany. (cdc.gov)
Creatinine measurements are useful in the diagnosis and treatment of renal diseases. (cdc.gov)
Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anemia, chronic renal disease, and hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin). (cdc.gov)
Diagnosis of anemia of renal disease is based on demonstration of renal insufficiency, normocytic anemia, and peripheral reticulocytopenia. (msdmanuals.com)

We were founded in memory of my sister Amber who passed away from Aplastic Anemia (rare bone marrow disease) after a 3.5 year battle. (lovingamber.com)
and immune-mediated diseases such as aplastic anemia, in which the bone marrow loses its ability to produce red-blood cells. (petmd.com)

Due to the limitations of such studies in human beings and animals, I propose to develop human in vitro models of healthy bone marrow, which can be induced to develop hematological and musculoskeletal diseases with high incidence, namely leukemia, multiple myeloma and bone metastasis. (europa.eu)
and multiple myeloma , disease of the bone marrow. (cancercare.org)

The Jamshidi-Swaim biopsy needle was utilized to perform 205 bone marrow biopsies, accompanied by simultaneous bone marrow aspirates, on patients with lymphoma, leukaemia, and a variety of solid tumours. (bmj.com)
We have examined the bone marrow biopsies and aspirates with respect to the adequacy of the bone marrow biopsy specimen, the number of positive biopsies in the various categories of neoplasia, and the disparity of biopsy and aspirate, finding that 28 of the 67 positive biopsies (41·8%) had negative aspirates. (bmj.com)
A biopsy determined she had an early form of the disease. (eonline.com)

Multipotent stem cells of both tissues - hematopoietic stem cells (HSCs) for blood and mesenchymal stem/stromal (MSCs) for bone - are the basis for their regenerative capacity. (europa.eu)
In this study, mesenchymal stem cells isolated from the bone-marrow of mice (BM MSCs), were labeled with Hoechst after low (3 to 8) or high (40 to 50) numbers of passages and then transplanted intrastriatally into 5-week-old R6/2 mice, which carries the N-terminal fragment of the human HD gene (145 to 155 repeats) and rapidly develops symptoms analogous to the human form of the disease. (biomedcentral.com)

Now, a collaborative team from Penn , Harvard , the Dana-Farber Cancer Institute (DFCI), and Brigham and Women's Hospital has created a programmable hydrogel-based in vitro model mimicking healthy and fibrotic human bone marrow. (upenn.edu)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. (medlineplus.gov)
Fibrosis can also occur in the bone marrow, the spongy tissue inside some bones that houses blood-producing hematopoietic stem cells (HSCs) and can lead to scarring and the disruption of normal functions. (upenn.edu)

The prognostic significance of bone marrow micro-metastases (BMM) in colon cancer patients remains unclear. (nih.gov)
We conducted a prospective cohort study with long-term follow-up to evaluate the relevance of BMM as a prognostic factor for disease free (DFS) and overall survival (OS) in stage I-III colon cancer patients. (nih.gov)
In total, 30 (21%) patients had disease recurrence and 56 (39%) patients died. (nih.gov)
Bone marrow micro-metastases occur in over one third of stage I-III colon cancer patients and are a significant, independent negative prognostic factor for DFS and OS. (nih.gov)
Chronic blood cancers known as " myeloproliferative neoplasms " (MPNs) are one example, in which patients can develop fibrotic bone marrow, or myelofibrosis, that disrupts the normal production of blood cells. (upenn.edu)
Then when we developed a half-matched protocol, half of the patients eventually rejected the cells, and the disease came back. (medlineplus.gov)
The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
the results also suggest that certain patients with intermediate-risk disease can receive less aggressive adjuvant treatment, or perhaps forego it altogether. (news-medical.net)
Avoiding chemotherapy spares patients from treatment side effects and long-term health risks, such as cardiovascular disease and development of a second cancer. (news-medical.net)
Allos Therapeutics, Inc. today announced that it has submitted a request to the European Medicines Agency (EMA) for a re-examination of the negative opinion issued in January by the EMA's Committee For Medicinal Products for Human Use (CHMP) for conditional approval of FOLOTYN (pralatrexate injection) for the treatment of patients with peripheral T-cell lymphoma (PTCL) whose disease has progressed after at least one prior systemic therapy. (news-medical.net)
These areas of the world often lack the laboratory infrastructure needed to diagnose fungal diseases, and limited availability of antifungal medications means that some patients may not have access to lifesaving treatments. (cdc.gov)
This study is incorporating "Individualized Pain Plans" into patients' electronic health records to allow for faster and more accurate treatment in the ED. To participate in this study, you must be between the ages of 18 and 45 and have sickle cell disease. (nih.gov)
Caution should be used if [NT005 trade name] is given to patients with liver disease, since albendazole is metabolised by the liver and has been associated with idiosyncratic hepatotoxicity. (who.int)
Anemia is common in patients with chronic kidney disease. (medscape.com)
Recombinant EPO improves anemia and reduces transfusion needs in patients with chronic kidney disease and is generally initiated when hemoglobin is (msdmanuals.com)

Monocytes, a type of white blood cell belonging to the group of myeloid cells, are overproduced from HSCs in neoplasms and contribute to the inflammation in the bone marrow environment, or niche. (upenn.edu)

It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. (news-medical.net)

The bone marrow aspirates were stained with the pancytokeratin antibody A45-B/B3 and analyzed for the presence of epithelial tumor cells. (nih.gov)
This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. (medscape.com)
Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to trigger this chemoattraction. (nih.gov)
Combining this system with mouse in vivo models of myelofibrosis, the researchers demonstrated that monocytes decide whether to enter a pro-inflammatory state and go on to differentiate into inflammatory dendritic cells based on specific mechanical properties of the bone marrow niche with its densely packed ECM molecules. (upenn.edu)
It turns out that myelofibrosis is a mechano-related disease that could be treated by interfering with the mechanical signaling in bone marrow cells. (upenn.edu)
We are trying to create a state where instead of completely replacing bone marrow with that of their donors, we are creating a mixture of donor and patient cells because we now know that as low as 20% donor cells is enough to reverse sickle cell disease. (medlineplus.gov)
Tissue engineers can choose from a wide range of living cells, biomaterials and proteins to repair a bone defect. (news-medical.net)
A new model showing how sickle cell blood cells operate within bone marrow is presented at a conference in Austria today. (news-medical.net)
To avoid some of these complications, use of adult, bone marrow (BM)-derived stem cells have gained considerable interest. (biomedcentral.com)
Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
Niemann-Pick disease is a group of autosomal recessive disorders caused by an accumulation of fat and cholesterol in cells of the liver, spleen, bone marrow, lungs, and, in some instances, brain. (nih.gov)
most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
Medications for the underlying cause may be necessary, in addition to various medications to stimulate the production of neutrophils (a type of white blood-cell that fights infection), and another medication to stimulate the production of red-blood cells by bone marrow. (petmd.com)
Whereas hypoxia in the individual with normal functioning kidneys leads to erythropoietin gene transcription, and hence increased RBC production, in those with anemia of chronic kidney disease, there is primary deficiency of erythropoietin production by the interstitial fibroblasts, also known as type I interstitial cells, thereby leading to anemia. (medscape.com)

The U.S. Food and Drug Administration today approved Iclusig (ponatinib) to treat adults with chronic myeloid leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), two rare blood and bone marrow diseases. (news-medical.net)
Type 2 (acute infantile neuropathic Gaucher disease) typically begins within three months of birth. (nih.gov)

This process causes many diseases in multiple organs, including lung fibrosis induced by smoking or asbestos, liver fibrosis induced by alcohol abuse, and heart fibrosis often following heart attacks. (upenn.edu)

Alzheimer's disease (AD) is characterized by the accumulation of aberrant Aβ peptide plaques and neurofibrillary tau tangles in pathology [ 1 ]. (biomedcentral.com)

Are you 15 to 40 years old and have severe sickle cell disease? (nih.gov)

However, how the fibrotic bone marrow niche itself impacts the function of monocytes and inflammation in the bone marrow was unknown. (upenn.edu)
Telomere shortening and chronic diseases could be caused by the same cell-damaging processes, such as oxidative stress and inflammation. (cdc.gov)

ALL is a rapidly progressing form of blood and bone marrow cancer that is more commonly diagnosed in children than adults. (news-medical.net)
Adults can get a milder form of this disease, called osteomalacia. (ihealthdirectory.com)

The bone marrow may show erythroid hypoplasia. (msdmanuals.com)

Other possible tests include urine analysis, immunologic tests for infections diseases like feline leukemia virus (FeLV), and a bone marrow examination. (petmd.com)

Compiled for your convenience are articles on bone marrow failure research and treatment from the world's major journals on hematology / oncology. (aamds.org)

Yes, Bone Marrow Diseases causes complications if it is not treated. (tabletwise.net)

radioactive microspheres containing Yittrium-90, can tolerate a 150 Gy single dose or 268 Gy repeated dose without risk of radiation-induced liver disease. (news-medical.net)
The cutaneous porphyrias are dermatologic diseases that may or may not involve the liver and nervous system. (medscape.com)
Over time, excessive storage of fats can cause permanent cellular and tissue damage, particularly in the brain, peripheral nervous system (the nerves from the spinal cord to the rest of the body), liver, spleen, and bone marrow. (nih.gov)
Serum elevations of ALT activity are rarely observed except in parenchymal liver disease, since ALT is a more liver-specific enzyme than aspartate aminotransferase (AST). (cdc.gov)
It is currently the most sensitive enzymatic indicator of liver disease, with normal values rarely found in the presence of hepatic disease. (cdc.gov)

It engaged a global discussion on sickle cell anemia, its perils and the advances in gene therapy that are showing great promise for this genetic disease. (acsh.org)
Did Gene Therapy Cure Sickle Cell Disease? (acsh.org)
A number of recent headlines imply that a new case study in the New England Journal of Medicine proves that gene therapy has cured sickle cell disease - a genetic disorder that causes tremendous pain, suffering and diminished life expectancy. (acsh.org)
This study tests a treatment called arginine therapy for pain episodes in children with sickle cell disease. (nih.gov)

Bone Marrow Diseases can occur in any gender. (tabletwise.net)
In comparison to cancers that occur in organs, or that spreads to bone tissue, bone cancer can be considered fairly uncommon. (ihealthdirectory.com)

GSD type I, also known as Von Gierke disease, is an autosomal recessive disorder, divided into two subtypes: type Ia and type Ib. (medscape.com)

I wanted to develop a way to have half-match donors contribute bone marrow and for the outcomes to be successful. (medlineplus.gov)

Some malignancies that have spread to involve the bone marrow, such as leukemia or advanced Hodgkin's disease, also cause lymphocytopenia. (wikipedia.org)

By tweaking the balance between elastic and viscous properties in these artificial ECMs, they could recapitulate the viscoelasticity of healthy and scarred fibrotic bone marrow, and study the effects on human monocytes placed into these artificial ECMs. (upenn.edu)
This opened up the possibility of a mechanical checkpoint that could be disrupted in myelofibrotic bone marrow and also may be at play in other fibrotic diseases. (upenn.edu)

I'm hoping our research can go beyond sickle cell disease to have a bigger impact. (medlineplus.gov)
It's an exciting time for sickle cell disease research. (medlineplus.gov)
The number one disease among newborn babies is sickle cell disease. (medlineplus.gov)
Researchers at Imperial College London, who developed the model, hope that it will eventually be used by clinicians to advance more effective treatments for sickle cell disease. (news-medical.net)
Sickle Cell Disease is an awful genetic disease that disproportionally affects black people. (acsh.org)
The goal of this study is to specify the interventions, implementation strategies and control conditions from the Sickle Cell Disease Implementation Consortium (SCDIC) using a mixed-methods approach to study site materials and conduct semi-structured qualitative interviews with site representatives (N=3 per site). (nih.gov)
Are you an adult with sickle cell disease? (nih.gov)
To participate in this study, you must be at least 18 years old, have sickle cell disease, and have not been on a chronic exchange transfusion program for at least 2 months. (nih.gov)
Are you an adult with sickle cell disease who's recently had a vaso-occlusive episode? (nih.gov)
This study investigates better ways for emergency departments (EDs) to manage vaso-occlusive episodes, or pain crises, in people with sickle cell disease. (nih.gov)
You must also have had at least one visit to a participating ED in the past 90 days due to pain from a vaso-occlusive episode and at least one visit at the study site sickle cell disease clinic within the past 12 months. (nih.gov)
To participate in this study, you or your child must have sickle cell disease and pain that requires medical attention. (nih.gov)

The Loving Amber Foundation is a nonprofit 501(c)(3) charitable organization focused on raising funds and awareness for children and families impacted by rare bone marrow diseases and blood disorders. (lovingamber.com)
Disorders in which intracellular material that cannot be metabolized is stored in lysosomes are called lysosomal storage diseases. (nih.gov)
One way to fight diseases including HIV infection and autoimmune disorders could involve changing how a naturally occurring enzyme called SAMHD1 works to influence the immune system, new research suggests. (medicalxpress.com)
Glycogen storage diseases (GSDs) are inherited disorders due to enzymatic defects that prevent breakdown of stored glycogen into glucose. (medscape.com)
Glycogen storage diseases ( GSD ) are a group of inherited autosomal recessive disorders caused by genetic mutations that lead to the inability to breakdown and metabolize glycogen into glucose. (medscape.com)

Minimal residual disease negativity rates were 64.3% in peripheral blood and 35.7% in bone marrow (intent-to-treat analysis). (nature.com)

This is probably secondary to the greater rate of chronic kidney disease in older individuals, as well as the lower estimated glomerular filtration rates (GFRs) that are associated with aging. (medscape.com)

In some families, inheritance of exceptionally short telomeres is linked to specific diseases, such as pulmonary fibrosis or bone marrow failure. (cdc.gov)

Researchers, journalists, and inquiring minds want to know more about telomeres, which seem to hold clues to human aging and age-related diseases. (cdc.gov)

The family hopes a fitting bone marrow donor will soon emerge. (hawaiinewsnow.com)

Congenital Heart Disease GEnetic NEtwork Study (CHD GENES). (nih.gov)
This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. (nih.gov)
It is a genetic bone disorder which makes the bones fragile. (ihealthdirectory.com)
Epigenetic changes actually are more common than the genetic mutations long known to put people at risk for cancer and other diseases and they are probably inherited as well, Dr. Bhalla says. (sciencedaily.com)

The hypothesis of the current proposal is that only when taking both tissues and their mutual crosstalk into account, we will be able to understand how the regenerative potential of blood and bone is impaired in disease and how it can be re-established with novel treatment strategies. (europa.eu)
No matter how lifeless bones seem to be, they also contain living tissues similar to the ones present in our muscles. (ihealthdirectory.com)

Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
Von Gierke disease (GSD type Ia and Ib) was first reported in 1929 based on the autopsy findings in 2 children who had excessive hepatic and renal glycogen accumulation. (medscape.com)

The clinical treatment of Alzheimer's disease remains a challenge since the pathogenesis is not fully understood. (biomedcentral.com)

Thousands of people all over the world are also dying from HIV/AIDS, drug-resistant strains of tuberculosis, and other communicable diseases. (who.int)
While communicable diseases like malaria, TB and cholera continue to be major public health challenges in several countries, concerns about the emergence of new pathogens have become equally worrying. (who.int)

Because it is a chronic disease people can go years without treatment, so it is important to monitor the disease for any changes. (cancercare.org)

Bone cancer is experienced as a malignant growth and it is very commonly found in younger children and adolescents. (ihealthdirectory.com)
Osteosarcoma is a type of bone tumor that is prevalent in children and the elderly, and many times it is commonly found in the knee area. (ihealthdirectory.com)

While it is well established that HSCs are influenced by the bone marrow in their natural environment including MSCs and their progeny, surprisingly little attention has been paid to the reciprocal relationship. (europa.eu)

Treatment depends on the primary condition that led to pancytopenia, as it is essential that the primary disease be diagnosed and treated first. (petmd.com)

Huntington's disease (HD) is an autosomal dominant disorder caused by an expanded CAG repeat (greater than 38) on the short arm of chromosome 4, resulting in loss and dysfunction of neurons in the neostriatum and cortex, leading to cognitive decline, motor dysfunction, and death, typically occurring 15 to 20 years after the onset of motor symptoms. (biomedcentral.com)
Huntington's disease (HD) is an autosomal dominant disorder caused by an expanded and unstable CAG trinucleotide repeat that results in a progressive degeneration of neurons, primarily in the putamen, caudate nucleus, and cerebral cortex. (biomedcentral.com)

The morbidity and mortality depend greatly on the underlying etiology of the patient's anemia as well as the stage of the disease, whether early or advanced. (medscape.com)
In fact, in individuals with advanced stages of chronic kidney disease, the etiology of anemia tends to be multifactorial (eg, decreased RBC production due to lack of erythropoietin, increased RBC destruction due to hemolysis [intravascular or extravascular], as well as increased blood loss due to multiple venipunctures for an array of indications). (medscape.com)

Anatomy40

Organisms10

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Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Psychiatry and Psychology1

Phenomena and Processes30

Disciplines and Occupations1

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Transplantation9

Transplant9

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