Markers found adult stem cells. Medical search. Frequent questions

The study also showed that the adult OCRs are distinct from mesenchymal stem cells (MSCs), which play a role in bone generation during development and adulthood. (sciencedaily.com)
Oct. 8, 2021 Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. (sciencedaily.com)
Jan. 29, 2020 Scientists used molecular motors to manipulate the protein matrix on which bone marrow-derived mesenchymal stem cells are grown. (sciencedaily.com)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
Promotes osteogenic, adipogenic, and chondrogenic differentiation of human mesenchymal cells (Jaiswal et al. (stemcell.com)
Promotes osteogenic, adipogenic, and chondrogenic differentiation of mouse mesenchymal cells (Tropel et al. (stemcell.com)
Karnoub's lab investigates the roles that mesenchymal stem cells (MSCs) play in the development and metastasis of breast cancer. (newswise.com)
Mesenchymal stem cells (MSC) have been isolated from several adult human tissues. (ntu.edu.sg)
In addition, these cells are enriched for β1-integrin, are cytokeratin negative, and show minimal expression of surface markers that typically are found on bone marrow-derived mesenchymal stem cells. (tau.ac.il)
HLSCs do not express hematopoietic stem cell markers, whereas they express several mesenchymal markers and display multiple differentiating abilities ( 22 ). (spandidos-publications.com)
Co-culture of human bone marrow mesenchymal stem cells (HBMSCs) and macrophages showed immunomodulatory effects via regulation of cytokine regulation. (drcremers.com)
Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. (livingroom.health)
On the other hand, other types of stem cells, such as mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells can also serve as a source for neural stem cell production, that hold a great promise for regeneration AZ505 ditrifluoroacetate of the brain. (rawveronica.com)
These stem cells presented embryonic stem cell markers (Oct-4 and Nanog), an ectomesenchymal stem cell marker (Nestin), and mesenchymal stem cell markers (Stro-1 and CD146). (elsevierpure.com)
Mesenchymal stem cells -Cells from the immature embryonic connective tissue. (cellmedicine.com)
A number of celltypes come from mesenchymal stem cells, includingchondrocytes, which produce cartilage. (cellmedicine.com)

We tested three compounds: cannabidiol, cannabigerol, and cannabichromene (CBC), and found that CBC has a positive effect on the viability of mouse NSPCs during differentiation in vitro. (nih.gov)
Next, we measured ATP levels as an equilibrium marker of adenosine and found higher ATP levels during differentiation of NSPCs in the presence of CBC. (nih.gov)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
Promotes differentiation of mature hepatocytes from mouse and human embryonic stem (ES) cells (Cai et al. (stemcell.com)
Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al. (stemcell.com)
Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al. (stemcell.com)
Life depends on constant replenishment of human body cells with new cells created by differentiation of adult stem cells. (anti-agingfirewalls.com)
As Type D cells die from trauma or apoptosis they are replaced by new cells resulting from differentiation of Type B and Type C cells. (anti-agingfirewalls.com)
C ) Feature plots showing the expression pattern of classic SPG markers (stemness and differentiation). (elifesciences.org)
Through fluorescence-activated cell sorting, microarray analysis, in vitro differentiation assays, mixed lymphocyte reaction, and a model of ischemic kidney injury, this study sought to identify and characterize multipotent organ stem/progenitor cells in the adult kidney. (tau.ac.il)
Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
NPC markers are also useful in establishing and monitoring in vitro NPC culture differentiation. (sanbio.nl)
As yet, the mechanisms involved in regulating the proliferation and differentiation of these stem cells remain unknown. (johnshopkins.edu)
The differentiation of the stem cells was regulated positively by DHH, lithium- induced signaling, and activin, and negatively by TGF-β, PDGFBB, and FGF2. (johnshopkins.edu)
Chemical messages, or morphogens, control processes in gasrointestinal stem cells such as cell division, cell differentiation and specialisation. (ox.ac.uk)
All of these complex processes of cell division, cell differentiation and specialisation are controlled by gradients of chemical messages called morphogens. (ox.ac.uk)
The presence of 'stem cell-like' cells has previously been postulated based on sphere-forming capacity and differentiation in vitro 1 and evidence for the presence of label-retaining cells in the distal fallopian tube 2 . (nature.com)
Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
Until now, gene manifestation analyses performed in the V/SVZ-RMS-OB neurogenic program relied either on microdissection of cells4 or on cell sorting predicated on manifestation of a restricted group of membrane markers5,6 define particular differentiation stages. (bios-mep.info)
Even though the stem cell compartments from the lateral and dorsal lineages are bodily separated, these areas harbor progenitors at different differentiation phases (neural stem cells [NSCs], transit amplifying progenitors and migrating neuroblasts). (bios-mep.info)
More than the next times and hours, fairly homogeneous and timed cohorts of cells go through the various differentiation phases in the V/SVZ as well as the RMS to finally integrate as. (bios-mep.info)
Multipotency To be characterised as a neural stem cell in the CNS, a cell must contain a differentiation potential to give rise to neurons, astrocytes and oligodendrocytes[41,46]. (rawveronica.com)
In addition to the effects from environment, cell intrinsic programs also influence cell differentiation capacity. (rawveronica.com)
In differentiation media, DDPSCs and DPDLSCs were able to change into cells that produce lipid vacuoles or cells that induce extracellular mineral aggregation, expressing genes correlated with adipogenesis (PPARγ2 and LPL) or osteogenesis (ALP and BSP), respectively. (elsevierpure.com)
Differentiation -The process whereby an unspecialized early embryonic cell acquires the features of a specialized cell such as a heart, liver, or muscle cell. (cellmedicine.com)
Directed differentiation -Manipulating stem cell culture conditions to induce differentiation into a particular cell type. (cellmedicine.com)
Embryonic stem cell line -Embryonic stem cells, which have been cultured under in vitro conditions that allow proliferation without differentiation for months to years. (cellmedicine.com)
Optimal differentiation was verified by qPCR and immunofluorescent (IF) staining of cell-type specific markers. (cdc.gov)
Results: qPCR analysis of the differentiation time-course shows a steady increase in markers of terminally differentiated cells, such as club (SCGB1A1), goblet (MUC5AC) and ciliated cells (FoxJ1). (cdc.gov)
The basal cell (stem/progenitor cell) marker (KRT5) shows an initial increase in expression, but did not vary much during differentiation. (cdc.gov)
Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

Destruction of a human embryo is required in order to research new embryonic cell lines. (wikipedia.org)
The researchers also performed fusion experiments using pelvic bone cells as the somatic cells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. (news-medical.net)

Many less controversial sources of acquiring stem cells include using cells from the umbilical cord, breast milk, and bone marrow, which are not pluripotent. (wikipedia.org)
Further work by Alexander Maximow and Leroy Stevens introduced the concept that stem cells are pluripotent. (wikipedia.org)
The discovery of adult stem cells led scientists to develop an interest in the role of embryonic stem cells, and in separate studies in 1981 Gail Martin and Martin Evans derived pluripotent stem cells from the embryos of mice for the first time. (wikipedia.org)
Since pluripotent stem cells have the ability to differentiate into any type of cell, they are used in the development of medical treatments for a wide range of conditions. (wikipedia.org)
According to a simplified model of this theory a newly-conceived human embryo consists of pluripotent stem cells (Type A), ones that can potentially divide into any body cells. (anti-agingfirewalls.com)
Immunofluorescent staining of PAX6 ( 12323-1-AP , 1:250 dilution) with 4% PFA fixed control human-induced pluripotent stem cell (hiPSC)-derived NPCs. (sanbio.nl)
NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
Planarians, in contrast, have large numbers of piRNAs in adult pluripotent stem cells, which go on to differentiate and develop into various tissue types. (bionity.com)
The term stem cell is generally used to describe cells that are totipotent , pluripotent , or multipotent . (citizendium.org)
Pluripotent cells may differentiate to cells of most types, and multipotent cells are capable only of differentiating to certain types within a group of cells that perform similar functions. (citizendium.org)
The use of the pluripotent and/or self-renewing qualities of stem cells is believed to have therapeutic benefits for the regeneration of tissue in humans. (citizendium.org)
Feeder layer -Cells used in co-culture to maintain pluripotent stem cells. (cellmedicine.com)
Human embryonic stem cell -A type of pluripotent stem cell derived from the inner cell mass of the blastocyst. (cellmedicine.com)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
No evidence of tumour formation was observed in the transplanted animals, a major concern when utilising a pluripotent cell source. (lu.se)

Lgr6 marks multipotent skin stem cells (29). (hubrecht.eu)
By culturing these multipotent cells with proteins and minerals, Dr. Xu has already gotten the hair follicle stem cells to differentiate into skin, nerve, muscle, bone, cartilage, and fat tissue. (loe.org)
These multipotent stem cells contain certain proteins - called markers - that have previously been found only in embryonic stem cells. (loe.org)
A multipotent population of skin stem cells express Lgr6. (prinsesmaximacentrum.nl)
With growth, these proliferate and, in a remarkably articulated manner, progressively differentiate into multipotent stem cells (Type B), progenitor cells (Type C), mature body somatic cells (Type E), and many eventually become senescent cells (Type E). (anti-agingfirewalls.com)
Tissue engineering and cell therapy approaches aim to take advantage of the repopulating ability and plasticity of multipotent stem cells to regenerate lost or diseased tissue. (tau.ac.il)
This is the first report of the presence of multipotent stem cells in the functional dental pulp and periodontal ligament tissue of deciduous teeth, which can be isolated using an explants culture method. (elsevierpure.com)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

Their propensity to differentiate into cell types of connective tissue, such as osteocytes, chondrocytes, and adipocytes, suggests that MSC may function as a reserve of progenitor cells that repair and maintain healthy adult tissues. (ntu.edu.sg)
The above list is in order of increasing cell-type specificity and decreasing cell-type potency to differentiate into other cell types. (anti-agingfirewalls.com)
Starting at conception and throughout life, all cells on this list except the senescent ones will selectively reproduce and possibly differentiate into cells of types further down in the list. (anti-agingfirewalls.com)
At maturity there are relatively very few Type A cells and a mix of Type B, C and D cells, Type B and C cells typically live in protected stem cell niches where they reproduce and, as-needed differentiate to become the normal working body Type D cells. (anti-agingfirewalls.com)
At an advanced age, the pools of Type B and Type C cells become depleted in part because of replicative senescence and the cells remaining in the pools lose their ability to differentiate as necessary to replace Type D cells. (anti-agingfirewalls.com)
Cells in those pools replicate and differentiate throughout life. (anti-agingfirewalls.com)
In response to muscle damage the muscle adult stem cells are activated and differentiate into myoblasts that regenerate the damaged tissue. (research-in-field.com)
Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)
If the cells can be coaxed into migrating to the right places and stimulated to proliferate and differentiate, they might eventually be used to repair a damaged CNS. (rupress.org)
Totipotent cells have the capacity to differentiate to all cell types, including somatic cells, germ cells, and certain cells that exist outside the embryo and are important to fetal development that are termed extraembryonic cells. (citizendium.org)
As neuroblasts divide and differentiate, they express transcription factors which ultimately direct the daughter cells on what kind of neuron to be. (nih.gov)
In order to generating a satisfactory number of neural stem cells, it is assumed that cell proliferation should be prevalent in the early developmental timing, and that more cells differentiate into a specific cell type during the latter phases. (rawveronica.com)
Neural stem cells in the SVZ can differentiate into olfactory neurons, while neural stem cells of SGZ differentiate into granular neurons of the dentate gyrus. (rawveronica.com)
However, when transplanting SVZ neural stem cells into dentate gyrus, they differentiate into calbindin-positive granular cells, while transplanting SGZ neural stem cells into the olfactory bulb, tyrosine- and calretinin hydroxylase-positive cells were observed. (rawveronica.com)
Adult stem cell -An undifferentiated cell found in a differentiated tissue that can renew itself and (with certain limitations) differentiate to yield all the specialized cell types of the tissue from which it originated. (cellmedicine.com)
Cell-based therapies -treatment in which stem cells are induced to differentiate into the specific cell type required to repair damaged or depleted adult cell populations or tissues. (cellmedicine.com)
On the same day, the cells in the apical chamber were exposed to air (airlift) to create the ALI and allowed to differentiate for 28 days. (cdc.gov)

This population of small cells includes a CD45-negative fraction that lacks hematopoietic stem cell and lineage markers and resides in the renal interstitial space. (tau.ac.il)
Hematopoietic stem cell -A stem cell from which all red and white blood cells develop. (cellmedicine.com)
Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)

In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). (hubrecht.eu)
These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (32, 47, 53). (hubrecht.eu)
Further studies of these markers might reveal adult stem cell populations in additional tissues. (prinsesmaximacentrum.nl)
By combining those two observations, Wnt drives cancer but Wnt drives healthy stem cells as well, we came up with a novel marker, LGR5, which is now widely used as a stem cell marker and LGR5 helped us to find the colon stem cell but also stem cells of many other tissues. (ecancer.org)
MSCs are adult progenitor cells that function as the body's early responders, poised to take action to help repair damaged tissues, jumping from their niches in the bone, for example, into the blood, migrating to areas of inflammation, and orchestrating the body's reactions during wound healing. (newswise.com)
Alternatively, NPCs can be isolated from fresh nervous tissues using cell sorting with NPC markers (PMID: 11121071). (sanbio.nl)
For example, cardiac tissues express a population of lineage negative, side population cells that can regenerate myocardium. (stemcellpatents.com)
Perhaps what is less known is that all adult tissues have stem cells as well. (ox.ac.uk)
The characteristic features of these stem cells, which are if you like the 'engine room' of the tissue, is that they can divide to renew themselves and also form all of the specialised tissues that can make up the entire organ. (ox.ac.uk)
Her research group is particularly interested in developing biomaterials and cell-based therapeutics to improve regeneration of various musculoskeletal tissues including bone, cartilage, tendon, blood vessels etc. (stanford.edu)
Many studies have found adult stem cells in human teeth or correlated tissues. (elsevierpure.com)
We observed cell outgrowth from these tissues in 'explants culture', and named these cells as deciduous dental pulp stem cells (DDPSCs) and deciduous periodontal ligament stem cells (DPDLSCs), respectively. (elsevierpure.com)
These tissues can be obtained easily during routine dental procedures, and could therefore represent a good source of adult stem cells for use in regenerative medicine. (elsevierpure.com)
Astrocyte -One of the large neuroglia cells of neural tissues. (cellmedicine.com)
In neonates, this area is a dense neural sheet, but, in children and adults, the respiratory and olfactory tissues interdigitate. (medscape.com)

For that reason, many researchers believe stem cells offer promise for creating populations of specialized cells that can be used to rejuvenate organs, such as the pancreas or heart, that are damaged by disease or trauma. (news-medical.net)
Colon cancer research has led to the identification of 2 related receptors, leucine-rich repeat-containing, G-protein-coupled receptors (Lgr)5 and Lgr6, that are expressed by small populations of cells in a variety of adult organs. (prinsesmaximacentrum.nl)
[ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
People always thought about a uniform stem cell population in each organ, but now we are saying there are multiple stem cell populations in a given organ, so if you're going to do therapy, you have to recognize this complexity," adds Capecchi, co-chair and distinguished professor of human genetics at the University of Utah and an investigator with the Howard Hughes Medical Institute. (utah.edu)
For example, US patent 6,946,293 teaches that the combination of EGF, a cAMP activating agent, and a steroid, may be useful in expanding such stem cell populations. (stemcellpatents.com)
The finding that neuronal heterogeneity depends upon their site of source led to the idea how the stem cell market represents a mobile mosaic where populations of stem cells in described dorsoventral and anteroposterior positions are predetermined to create particular neurons for the OB.2 This, subsequently, means that molecular determinants, for instance, expressed TFs differentially, underlie early destiny standards and neuronal function and connectivity eventually. (bios-mep.info)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Amongst the intestinal Wnt target genes (13), we found the Gpr49/Lgr5 gene to be unique in that it marks small cycling cells at crypt bottoms. (hubrecht.eu)
Two other Wnt target genes, RNF43 and ZNRF3, encode stem cell-specific E3 ligases that downregulate Wnt receptors in a negative feedback loop (35). (hubrecht.eu)
Furthermore, Eggan noted that genetic analyses of the fused cells revealed that the somatic cell genes characteristic of adult cells had all been switched off, while those characteristic of embryonic cells had been switched on. (news-medical.net)
With the exception of a few genes one way or the other -- which is perhaps because these cells are now tetraploid -- the hybrid cells are indistinguishable from human embryonic stem cells," he said. (news-medical.net)
The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
To explore whether they could be used to repair diseased muscles, the satellite cells were labelled with a glowing green protein and injected into the muscles of mice carrying a mutation in their dystrophin genes, giving them the rodent equivalent of muscular dystropy. (thenakedscientists.com)
TM-MSC express genes found on adult TM tissue, suggesting that TM-MSC are progenitor cells that serve to maintain a healthy TM. (ntu.edu.sg)
Capecchi won the Nobel - with Sir Martin Evans and Oliver Smithies - for developing gene targeting, a method of using embryonic stem cells to "knock out" genes in mice, then observing what goes wrong to determine any gene's normal function. (utah.edu)
Expression of top 10 differentially expressed genes (DEGs) of Cluster1 in Figure 1B and classic spermatogonial stem cell (SSC) and SPG markers in adult human germ cells. (elifesciences.org)
This enables the latter to recognise and degrade jumping genes (transposons). (bionity.com)
Importantly, jumping genes have the habit of constantly changing their position within the genome, thereby triggering mutations. (bionity.com)
Moreover, the Bayreuth researchers have discovered another function for SMEDWI-3: some piRNAs that SMEDWI-3 binds to do not subsequently target jumping genes but instead recognize mRNAs. (bionity.com)
Microarray analysis reveals that inhibition of Notch signalling causes downregulation of stem cell-associated genes in parallel with decreased proliferation and increased numbers of ciliated cells and that organoids also respond to oestradiol and progesterone treatment in a physiological manner. (nature.com)
Furthermore, Notch is responsible for the regulation of known stem cell factor genes. (nature.com)
Researchers know that neural stem cells called neuroblasts divide multiple times to sequentially produce neurons of specialized function, but the mechanisms of this process, and how the timing varies for different genes and neuron types, is still not fully understood. (nih.gov)
Since Drosophila midgut has recently emerged as an ideal model for the study of the molecular mechanisms underlying somatic stem cell maintenance, it provides an useful system to evaluate the effects caused by loss of function of genes involved in this process. (unina.it)
Mesodermal lineage induction of PLA cells and clones resulted in the expression of multiple lineage-specific genes and proteins. (livingroom.health)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. (sciencedaily.com)
The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. (sciencedaily.com)
An early study in mice showed that expression of Ube3a is nearly exclusively maternal in neurons within the CA3 region of the hippocampus and in cerebellar Purkinje cells, with moderate maternal bias in the cerebral cortex 6 . (nature.com)
We previously observed persistent expression of UBE3A in the suprachiasmatic nucleus (SCN) of the hypothalamus, the master circadian regulatory region in the mammalian brain, of AS model mice 15 , thus identifying a novel site for relaxation of maternal expression bias of Ube3a in the adult brain. (nature.com)
HACK: In their search for regenerative cell therapies that might some day cure Parkinson's, Alzheimer's, and other diseases, scientists have studied adult stem cells found in the hair follicles of mice. (loe.org)
we've done it for mice with liver diseases where we treat the mice with liver stem cells or liver mini-organs, that's one thing, so regenerative medicine. (ecancer.org)
Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 cells subcutaneously injected into athymic nude mice. (jcancer.org)
The volume and weight of tumors were significantly higher in mice transplanted with DU145 and stromal cells from PZ. (jcancer.org)
Working with mice and writing in the journal Cell, Harvard researcher Amy Wagers and here colleagues used chemical markers to identify a sub-population of adult muscle cells called satellite cells, some of which behave like muscle stem cells. (thenakedscientists.com)
Amongst the mice, when their muscles were examined four weeks after the injections, the team found that the stem cells had turned into new muscle and replaced up to 94% of the original muscle fibres. (thenakedscientists.com)
In the June 8 online issue of the journal Nature Genetics , Capecchi and geneticist Eugenio Sangiorgi report that when they used a gene named Bmi1 to mark the presence of adult stem cells in the intestines of mice, they were surprised to find the specific cells mostly in the upper third of the mouse intestine. (utah.edu)
D ) Immunostaining for ZBTB16 (red), FOXC2 (green), and DAPI (blue) in testicular paraffin sections from wild-type adult C57 mice. (elifesciences.org)
F ) Immunostainings for MKI67 (red), FOXC2 (green), and DAPI (blue) in adult mice testis and the proportion of MKI67 + cells in FOXC2 + population (n=10). (elifesciences.org)
Validation and characterization of the magnetic-activated cell sorting (MACS)-sorted THY1 + undifferentiated spermatogonia (uSPG) from wild-type adult C57 mice. (elifesciences.org)
B ) Immunostainings for LIN28A (red), DAPI (blue), and newly found markers (green) in testicular paraffin sections from adult mice. (elifesciences.org)
For RNA-seq, Soleus muscle tissue were harvested from 2?month older mice, and RNA was isolated as described above (cells protocol, Proteinase K added). (research-in-field.com)
Finally, when injected directly into the renal parenchyma, shortly after ischemic/reperfusion injury, renal Sca-1 + Lin - cells, derived from ROSA26 reporter mice, adopt a tubular phenotype and potentially could contribute to kidney repair. (tau.ac.il)
In previous work, the researchers identified cells that express CNP in transgenic mice using a CNP-GFP marker. (rupress.org)
The investigators report in the journal Nature that purified human stem cells can be used to improve long-term vision in mice. (drcremers.com)
The researchers transplanted purified limbal stem cells from adult humans into mice with corneal blindness and checked to see if the corneas had regrown 5 weeks later, as well as 13 months later. (drcremers.com)
They found that the mouse corneas looked normal, with the same thickness and protein expression as corneas in healthy mice. (drcremers.com)
After sixteen weeks, the injured mice who received human stem cell injections experienced a significant improvement in the motor functions that had been impaired by their injuries. (citizendium.org)
Furthermore, the use of diphtheria toxin -- which is far more toxic to human cells than mouse cells -- to destroy the human neurons in the mice reversed the observed improvements in motor function. (citizendium.org)
Cross-species transplantation was possible without the rejection of the human embryonic stem cells by the mice's immune systems because the mice were genetically modified to suppress certain immune responses that would have interfered with transplantation. (citizendium.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)

Similar structures are found in many cell types in diverse organisms, such as dendritic protrusions of neurons, root hairs and pollen tubes. (a-star.edu.sg)
Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
identify and characterize a new population of neural stem cells (NSCs) that can generate neurons in the postnatal mouse brain. (rupress.org)
have cultured the CNP-GFP + /NG2 + cells, and found that the cells quickly turn into a variety of neural cell types, including astrocytes, oligodendrocytes, and electrically active neurons. (rupress.org)
In the hippocampus, one place where neurons are born through adulthood, the CNP-GFP + /NG2 + cells turn into neurons. (rupress.org)
In contrast to previously identified GFAP + NSCs, which are thought to give rise to excitatory neurons, CNP-GFP + /NG2 + cells give rise to inhibitory neurons. (rupress.org)
So there may be several types of stem cells in the brain, generating distinct subsets of adult-born neurons. (rupress.org)
This result suggests that the observed increase in motor function was indeed produced by neurons derived from the human embryonic stem cells. (citizendium.org)
Nervous systems diversify from a small pool of neural stem cells to the great diversity of neurons we see in adult brains of higher ordered animals," said Ray. (nih.gov)
We focus on the involvement of epigenetic marks and emphasize why the identification of master transcription factors, that instruct the fate of postnatally generated neurons, can help in deciphering the mechanisms driving fate transition from embryonic to adult neuron production. (bios-mep.info)
Finally, adult-born neurons display a wide spectral range of morphologies, projection patterns, and focuses on.1 Lineage research demonstrated Apremilast small molecule kinase inhibitor how the diversity of OB interneurons Apremilast small molecule kinase inhibitor is closely linked with their spatial origin in the stem cell compartment. (bios-mep.info)
This indicates that there is a high possibility for producing two undifferentiated daughter cells at early stages of development (symmetric division), and later cell division prefers the production of differentiated neurons and glial cells (asymmetric division). (rawveronica.com)
In addition to the olfactory neurons, the epithelium is composed of supporting cells, Bowman glands and ducts unique to the olfactory epithelium, and basal cells that allow for the regeneration of the epithelium, including the olfactory sensory neurons. (medscape.com)
CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. (lu.se)
This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
In paper №2, I describe how mesDA neurons transplanted in the adult SN of a PD mouse model, extended axons across millimetres into the striatum, functionally reforming the nigrostriatal pathway. (lu.se)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
The front wings (usually called anterior or ventral horns) contain motor nerve cells (neurons), which transmit information from the brain or spinal cord to muscles, stimulating movement. (msdmanuals.com)

The researchers also suspect that OCR cells may play a role in soft tissue cancers. (sciencedaily.com)
The Organoid group, previously Clevers group, studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. (hubrecht.eu)
These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and many other tissue stem cell types. (hubrecht.eu)
Yet further treatments using stem cells could potentially be developed due to their ability to repair extensive tissue damage. (wikipedia.org)
Adult stem cells are generally limited to differentiating into different cell types of their tissue of origin. (wikipedia.org)
Prof Clevers talks to e cancertv at WIN 2014 about using single stem cells to grow tissue for cancer research and potentially cancer treatment. (ecancer.org)
If you take a stem cell from the stomach you'll grow a stomach organoid and the cells are quite dumb, they will make the tissue where they come from but they will never make anything else. (ecancer.org)
Now, in cancer it is the epithelium that is actually the malignant tissue and a tumeroid would be an organoid not grown from a normal stem cell but grown from a cell that comes out of a tumour. (ecancer.org)
Also when they are normal tissue people would have predicted that they would probably have to become cancer cells to grow for long times outside the body, that's not what we find. (ecancer.org)
There are a lot of ethics involved that are very complicated because we sequence patients and their tumours, people know how to solve that, but we also grow patients' tissue and their tumours and we don't want to recreate a problem that has existed with healer cells where the original patient never had consented that T-cells were used and they were spread around the world. (ecancer.org)
Less well understood is if there are progenitor cells within the TM that contribute to maintenance of this tissue. (ntu.edu.sg)
These have included cell culture and the bedside processing of fat tissue. (patientsforstemcells.org)
June 8, 2008 - A single organ may contain more than one type of adult stem cell - a discovery that complicates prospects for using the versatile cells to replace damaged tissue as a treatment for disease, according to a new study from the laboratory of geneticist Mario Capecchi, the University of Utah's Nobel Laureate. (utah.edu)
A subset of NSCs is present in the developed nervous system and acts as a reservoir of cells for cell replacement and nervous tissue regeneration (PMID: 20110496). (sanbio.nl)
Numerous tissue have been described to have endogenous, tissue resident, stem cells. (stemcellpatents.com)
The side population phenotype has been useful for detect other types of tissue stem cells as well, for example epidermal stem cells and even cancer stem cells . (stemcellpatents.com)
These cells are really the driving force of every organ and they are therefore vital in the growth, daily function and repair of every adult tissue. (ox.ac.uk)
Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
The investigation of stage-specific cell-cell communications among astrocyte lineage cells and with other cell types in the tissue generated valuable insight into signaling pathway networks in SCI. (nih.gov)
Glioma-associated oncogene 1 expressing (Gli1+) cells are a major source of activated fibroblasts in multiple organs, but the links between injury, inflammation, and Gli1+ cell expansion and tissue fibrosis remain incompletely understood. (bvsalud.org)
The term stem cell is also used in reference to any adult cells that are capable of assisting in the restoration of adult tissue via self-renewal. (citizendium.org)
Such tissue renewal may be accomplished via the use of adult stem cells, or embryonic stem cells, which may be derived from a human embryo in the blastocyst stage. (citizendium.org)
We believe these cells, called neural progenitor cells, are present in the optic nerve tissue at birth and remain for decades, helping to nourish the nerve fibers that form the optic nerve," said study leader Steven Bernstein, MD, Ph.D., Professor and Vice Chair of the Department of Ophthalmology and Visual Sciences at the University of Maryland School of Medicine. (debuglies.com)
To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches. (livingroom.health)
Bone marrow stromal cells -A stem cell found in bone marrow that generates bone, cartilage, fat, and fibrous connective tissue. (cellmedicine.com)
Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)

Paternal UBE3A-positive cells in the SCN show partial colocalization with the neuropeptide arginine vasopressin (AVP) and clock proteins (PER2 and BMAL1), supporting that paternal UBE3A expression in the SCN is often of neuronal origin. (nature.com)
Our analyses revealed the molecular signature, location and morphologies of potential residential neural progenitors or neural stem cells in the adult spinal cord before and after injury, and the intermediate cells enriched in neuronal markers that could potentially transition into other subpopulations. (nih.gov)
The researchers were able to confirm the presence of these stem cells by using antibodies and genetically modified animals that identified the specific protein markers on neuronal stem cells. (debuglies.com)
In addition to mesodermal capacity, PLA cells and clones differentiated into putative neurogenic cells, exhibiting a neuronal-like morphology and expressing several proteins consistent with the neuronal phenotype. (livingroom.health)
Shane Grealish: Cell Replacement Therapy for Parkinson's Disease: The Importance of Neuronal Subtype, Cell Source and Connectivity for Functional Recovery. (lu.se)
The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)

Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)

With the advent of improved immunohistochemical profiling, the tumor was reclassified as Merkel cell carcinoma because shared epithelial and neuroendocrine markers, along with ultrastructural features suggestive of neural crest origin, were observed in both the constituent tumor cell and the physiologic Merkel cell of the skin. (medscape.com)
Within skin, Merkel cells have also been shown to cluster in the basal layers of the interfollicular epidermis in specialized epithelial structures called touch domes, where they are juxtaposed with epidermal keratinocytes. (medscape.com)
Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)
Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
Here are more studies pointing to the possibility that autologous adult stem cell can heal damaged corneal epithelial cells. (drcremers.com)
The conditioned media (CM) from macrophages, HBMSCs, and HBMSCs + macrophages were treated to human corneal epithelial cells , which showed significant reduction in IL-1α and IL-1β expression levels in HBMSCs + macrophages group. (drcremers.com)
Previously published work on limbal epithelial cell grafts showed that when more than three percent of transplanted cells were stem cells, transplants were successful-less than three percent and the transplants were not, "said HSCI Affiliated Faculty member Natasha Frank. (drcremers.com)
We show that single epithelial stem cells in vitro can give rise to differentiated organoids containing ciliated and secretory cells. (nature.com)
Here we demonstrate the existence of adult stem cells in the human fallopian tube epithelium, which gives rise to a monolayer of differentiated epithelial cells in a complex 3D organoid in vitro . (nature.com)
Ki-67-positive cells were distributed along the epithelial folds, without restriction to a particular region with occasional clustering ( Fig. 1a , asterisk). (nature.com)
Figure 1: Single fallopian epithelial cells give rise to organoids that can be maintained long term. (nature.com)
Thus, the aim of this study was to investigate if aerosolized nZnO exposure leads to changes in the cellular composition of the airway epithelium, using air-liquid interface (ALI)-differentiated primary human bronchial epithelial cells. (cdc.gov)
Methods: Normal human bronchial epithelial cells (NHBEpC) (at ≥ 90% viability) were seeded on 12-well porous 0.4 µm- cell culture inserts in basal cell culture medium. (cdc.gov)

Adult stem cells have been seen as an alternative to embryonic stem cells, which are able to become any kind of cell in the body - not just in a given organ - and are obtained from test-tube fertilization of eggs left over by couples attempting to have babies. (utah.edu)
Such cells provide a potential alternative to embryonic stem cells. (citizendium.org)

The cells also represent the cells-of-origin of adenomas in the gut (25) and within adenomas Lgr5 stem cells act as adenoma stem cells (36). (hubrecht.eu)
Lgr5 crypt stem cells behave in unanticipated ways: Against common belief, they divide constantly and in a symmetric fashion. (hubrecht.eu)
Lgr5 resides in Wnt receptor complexes and mediates signaling of the Wnt-agonistic R-spondins (31), explaining the unique dependence of Lgr5 stem cells on secreted R-spondins in vivo and in vitro. (hubrecht.eu)
Long-term clonal culturing of organoids from Lgr5 stem cells. (hubrecht.eu)
Based on these combined insights, we have established Lgr5/R-spondin-based culture systems that allow the outgrowth of single mouse or human Lgr5 stem cells into ever-expanding organoids. (hubrecht.eu)
Genetic mouse models have allowed the visualization, isolation, and genetic marking of Lgr5 +ve and Lgr6 +ve cells and provided evidence that they are stem cells. (prinsesmaximacentrum.nl)
The Lgr5 +ve cells were found to occupy locations not commonly associated with stem cells in the stomach, small intestine, colon, and hair follicles. (prinsesmaximacentrum.nl)
Single Lgr5 +ve stem cells from the small intestine and the stomach can be cultured into long-lived organoids. (prinsesmaximacentrum.nl)
Identification of the ligands for Lgr5 and 6 will help elucidate stem cell functions and modes of intracellular signaling. (prinsesmaximacentrum.nl)
We then realised that LGR5 is a receptor for a very potent growth factor called R-spondin and we designed cultures where we can take, we think, any type of stem cell from an adult mouse or human, culture it in a small cocktail of growth factors, the most important being R-spondin, and then have these single stem cells grow out for as long as we want. (ecancer.org)
Dutch researchers recently found a "marker" named Lgr5 to label intestinal stem cells. (utah.edu)

However, some evidence suggests that adult stem cell plasticity may exist, increasing the number of cell types a given adult stem cell can become. (wikipedia.org)
That is called plasticity and makes us believe that some of the cells that give rise to some sorts of tumours can actually be non-stem cells, or daughter cells. (ox.ac.uk)
My line of research I believe is important because stem cell plasticity occurs if the leopard can change its spots. (ox.ac.uk)
It is noted that neural stem cell plasticity is progressively Mouse monoclonal to His tag 6X restricted as development advances, for example early neural stem cells look like specified a wide range of phenotypes, from anterior to posterior parts of the brain, while late neural stem cells is only restricted to its source[47]. (rawveronica.com)

Paternal UBE3A also partially colocalizes with a marker of neural progenitors, SOX2, implying that relaxed or incomplete imprinting of paternal Ube3a reflects an overall immature molecular phenotype. (nature.com)
What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)
The horizontal transfer of extracellular RNAs carried by EVs has been shown to be able to reprogram hematopoietic progenitors ( 11 ) and to activate endothelial cells ( 12 ). (spandidos-publications.com)
This study has significantly expanded the knowledge of the heterogeneity and cell state transition of glial progenitors in adult spinal cord before and after injury. (nih.gov)
For instance, interneurons produced by progenitors from the Rabbit polyclonal to DCP2 dorsal area of the V/SVZ will mainly integrate in the superficial levels from the OB and express subtype markers such as for example calretinin (CR), tyrosine hydroxylase, or the transcription elements (TFs) TBR1/2. (bios-mep.info)

As further evidence that these cells are MSC, they were differentiated in vitro into adipocytes, osteocytes, and chondrocytes. (ntu.edu.sg)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
In vitro, they are plastic adherent and slowly proliferating and result in inhibition of alloreactive CD8 + T cells, indicative of an immuneprivileged behavior. (tau.ac.il)
We developed a unique in vitro system of cultured seminiferous tubules to assess the ability of factors from the seminiferous tubules to regulate the proliferation of the tubule-associated stem cells, and their subsequent entry into the Leydig cell lineage. (johnshopkins.edu)
Thus, the aim of this study was to investigate the effect of the interaction of these cells on in vitro DES model. (drcremers.com)
Cell culture -Growth of cells in vitro on an artificial medium for experimental research. (cellmedicine.com)

Molecular markers are used to characterize and track adult stem cells. (prinsesmaximacentrum.nl)
The aim of the present study was to characterize stem cells isolated from the functional dental pulp and periodontal ligament of deciduous teeth. (elsevierpure.com)

The stem cell controversy is the consideration of the ethics of research involving the development and use of human embryos. (wikipedia.org)
Not all stem cell research involves human embryos. (wikipedia.org)
In 1995 adult stem cell research with human use was patented (US PTO with effect from 1995). (wikipedia.org)
In 1998, James Thomson and Jeffrey Jones derived the first human embryonic stem cells, with even greater potential for drug discovery and therapeutic transplantation. (wikipedia.org)
However, the use of the technique on human embryos led to more widespread controversy as criticism of the technique now began from the wider public who debated the moral ethics of questions concerning research involving human embryonic cells. (wikipedia.org)
In early 2009, the FDA approved the first human clinical trials using embryonic stem cells. (wikipedia.org)
Much of the debate surrounding human embryonic stem cells, therefore, concern ethical and legal quandaries around the destruction of an embryo. (wikipedia.org)
Scientists have isolated adult stem cells in human hair follicles. (loe.org)
Now, for the first time, Pathologist Dr. George Xu, at the University of Pennsylvania, has isolated a new adult stem cell in the human hair follicle. (loe.org)
Although stem cells from human hair follicles are much harder to come by, and less versatile than embryonic stem cells, they're less controversial in today's political and religious debates over the ethics of stem cell research. (loe.org)
Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al. (stemcell.com)
Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. (news-medical.net)
The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells. (news-medical.net)
This approach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used to produce human stem cells. (news-medical.net)
The scientists knew that if their studies were successful, it would provide the research community with a new option for producing reprogrammed cells using embryonic stem cells, which are more plentiful and easier to obtain than unfertilized human eggs. (news-medical.net)
In the studies published in Science, the researchers combined human fibroblast cells with human embryonic stem cells in the presence of a detergent-like substance that caused the two cell types to fuse. (news-medical.net)
One of the key findings from the study was that the fusion cells have the characteristics of human embryonic stem cells. (news-medical.net)
So, while this does not obviate the need for human oocytes, it demonstrates that this general approach of cell fusion is an interesting one that should be further explored. (news-medical.net)
Many human body cell types have a remarkable rate of turnover. (anti-agingfirewalls.com)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
Sangiorgi, a postdoctoral fellow in human genetics, adds: "There are probably different stem cells in the small intestine doing different things. (utah.edu)
Embryonic stem cells have been controversial because abortion foes consider them to be human beings rather than a small batch of cells. (utah.edu)
Identification of the FOXC2 + spermatogonial stem cells (SSCs) in adult mouse and human testis. (elifesciences.org)
H ) t-SNE plot of germ cells in adult human testis (GSE112013), colored by germ cell type. (elifesciences.org)
Feature plot showing the expression patterns of FOXC2 and MKI67 in human germ cells. (elifesciences.org)
I ) The developmental trajectory of the human germ cells, colored by germ cell type, FOXC2 expression cells (red), or MKI67 expression cells (red). (elifesciences.org)
C ) Feature plots showing the expression pattern of classic SSCs and SPG markers in adult human germ cells. (elifesciences.org)
Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas. (stemcellpatents.com)
The aim of the present study was to evaluate whether Alix is involved in the packaging of miRNAs within EVs released by human liver stem‑like cells (HLSCs). (spandidos-publications.com)
EVs were instrumental in transferring selected miRNAs from HLSCs to human endothelial cells absent in the latter cells. (spandidos-publications.com)
Vesicles derived from adult human liver stem-like cells (HLSCs) have also been shown to contain ribonucleoproteins and different RNA species involved in hepatic regeneration ( 20 ). (spandidos-publications.com)
Stem cells within the limbus of the human eye can now be purified with the help of an antibody. (drcremers.com)
The team then developed an antibody that could tag limbal stem cells in a general sample of human limbal cells, making it possible to purify only the cells responsible for successful limbal cell transplants. (drcremers.com)
Here we report on the establishment of long-term, stable 3D organoid cultures from human fallopian tubes, indicative of the presence of adult stem cells. (nature.com)
A) shows human embryonic stem cells. (citizendium.org)
The use of embryonic stem cells has been a source of considerable controversy due to its sacrifice of human embryos in the blastocyst stage, which some people view as the destruction of human life . (citizendium.org)
Human embryos fertilized in the ordinary manner and harvested in the blastocyst stage have been used as an extensive source of stem cells for research purposes, and have been shown to possess therapeutic value in laboratory animals. (citizendium.org)
Properly controlled, adequately sized studies have yet to demonstrate that human embryonic stem cells have medical value in humans. (citizendium.org)
The most infamous study of embryonic stem cells asserted that cloned human embryos had been created via somatic cell nuclear transfer, and stem cells had been generated from these embryos. (citizendium.org)
Ethical objections to the use of human embryonic stem cells revolve around the destruction of human embryos in the blastocyst stage to obtain the stem cells. (citizendium.org)
However, supporters of embryonic stem cell research frequently contend that even the comparison to abortion is inappropriate, since while a several month old fetus might have sufficient neurological development to be conscious in some meaningful sense, a human embryo in the blastocyst stage has so little development that one can safely conclude that it cannot exist as a conscious being. (citizendium.org)
Loss of function mutations of human DKC1 gene cause Dyskeratosis Congenita X-linked (X-DC), a multisystemic syndrome accompanied by telomerase defects, premature aging, increased cancer susceptibility and stem cell dysfunction. (unina.it)
Via step-wise reprogramming, adult cells can be transformed to stem cells, which again have the ability to develop into other specialised human cell types. (royalsociety.org)
The adult human airway epithelium is comprised of four major cell types, basal, club, goblet, and ciliated cells. (cdc.gov)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)
DHH functioned as a commitment factor, inducing the transition of stem cells to the progenitor stage and thus into the Leydig cell lineage. (johnshopkins.edu)
however, how diverse constituents of astrocyte lineage cells are regulated in adult spinal cord after injury and contribute to regeneration remains elusive. (nih.gov)
We performed single-cell RNA-sequencing (scRNA-seq) of astrocyte lineage cells from sub-chronic spinal cord injury (SCI) models, identified and compared with the subpopulations in the acute stage data. (nih.gov)
The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
This requirement strongly limits the number of solutions or entiation and lineage-specification, programmed cell death, and ``states'' for the system. (lu.se)
2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

C. albicans hyphal growth starts with the formation of a thin cell surface protrusion called germ tube. (a-star.edu.sg)
piRNAs have this stabilising effect in humans, too, but they only occur in our germ cells. (bionity.com)
Embryonic germ cells -Cells found in a specific part of the embryo/fetus called the gonadal ridge that normally develop into mature gametes. (cellmedicine.com)

SCNT involves transferring the nuclei of adult cells, called somatic cells, into oocytes in which scientists have removed the nuclei. (news-medical.net)
Scientists have shown that satellite cells, a form of muscle stem cell, can be used to repair muscles affected by muscular dystrophy. (thenakedscientists.com)
As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
The scientists found that the pancreatic ductal cells, which are believed to have stem cell-like properties, express not only the CD133 epitope, but also full-length prominin-1 as detected by RNA message and reactivity towards the anti-prominin-1 polysera. (stemcellpatents.com)
This way, scientists are now closer to understand how the stem cells of planarians maintain the flexibility necessary to regenerate body parts without destroying themselves at the same time. (bionity.com)

In the absence of Wnt signaling, we found that Tcf factors associate with proteins of the Groucho family of transcriptional repressors to repress target gene transcription (9). (hubrecht.eu)
We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). (hubrecht.eu)
The Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological gene program in selfrenewing crypts (13, 14). (hubrecht.eu)
The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls intestinal stem cell state (26). (hubrecht.eu)
We've even shown that you can take stem cells from a patient with cystic fibrosis, a little kid, grow them as a mini-gut, in the mini-gut repair the gene defect exactly. (ecancer.org)
So there are three bases missing in this particular patient, put the three DNA bases back in the right gene and then grow a mini-gut out of that stem cell and the promise is that we would ultimately be able to give these cells back to a patient. (ecancer.org)
Currently described online in Cell Stem Cell , the new findings demonstrate that, when silenced, the FOXP2 transcription factor, otherwise known as the speech gene, endows breast cancer cells with a number of malignant traits and properties that enable them to survive - and thrive. (newswise.com)
As a result, when the stem cells merge with the syncitium, they bring with them a healthy copy of the dystrophin gene, which enables the rest of the muscle to function much better. (thenakedscientists.com)
Stem cell gene expression evolves with age. (anti-agingfirewalls.com)
Although in principle stem cells can replicate indefinitely, in fact they age as the organism ages, continuing to change their gene expression. (anti-agingfirewalls.com)
Sangiorgi and Capecchi used a similar method but a different "marker" - a gene name Bmi1 - which is "expressed" or activated in adult stem cells in the intestinal lining. (utah.edu)
Labeling stem cells containing the Bmi1 gene involved tamoxifen, a drug used to treat and prevent breast cancer. (utah.edu)
Tamoxifen was used to activate an enzyme in cells that contain the Bmi1 gene so that the cells appeared blue when viewed under a microscope. (utah.edu)
We decided to hijack this gene to identify and label adult stem cells in the mouse intestine," Sangiorgi says. (utah.edu)
These mistakes accumulate over time and cancer occurs when one of these mistakes occurs in a gene that controls cell division. (ox.ac.uk)
Researchers then removed these non-coding DNA regions, called enhancers, using the gene-editing technique CRISPR to see how the brain of the flies were affected, and found that flies with deleted enhancers showed a complete absence of expression of the sloppy-paired TTF in medulla neuroblasts. (nih.gov)
I thus used the GAL4/UAS system to silence in vivo Nop60b/mfl, the Drosophila ortholog of DKC1, and investigate in detail the effects triggered by gene silencing on the formation of larval Adult Midgut Precursor (AMPs) cells. (unina.it)
Finally, PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression. (livingroom.health)

In APC-deficient colon carcinoma cells, we demonstrated that ß-catenin accumulates and is constitutively complexed with the TCF family member TCF4, providing a molecular explanation for the initiation of colon cancer (5). (hubrecht.eu)
Dr. Yue Wang's laboratory investigates the molecular mechanisms that control the growth transition, particularly how cells establish and maintain the highly polarized hyphal morphogenesis. (a-star.edu.sg)
Despite expanding knowledge of the role of MSCs to breast malignancy, the underlying molecular responses of breast cancer cells to MSC influences has not been fully delineated. (newswise.com)
NPCs are distinct from differentiated cells of the nervous system at the molecular level. (sanbio.nl)
The brain has come alive with the sightings of stem cells, but the molecular handles on those cells are few. (rupress.org)
Self-renewal is considered as a pivotal identity of neural stem cells because it is indispensable for the cells to preserve themselves, therefore at least one of the progeny retains similar molecular characteristics to the mother stem cells. (rawveronica.com)

The expression of NSPC and astrocyte markers nestin and Glial fibrillary acidic protein (GFAP), respectively, was up- and down-regulated, respectively. (nih.gov)
The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. (sciencedaily.com)
Hgc1 is a G1 cyclin-related protein and directly interacts with the master cell-cycle regulatory kinase Cdc28. (a-star.edu.sg)
Barker, N & Clevers, H 2010, ' Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells ', Gastroenterology , vol. 138, nr. 5, blz. (prinsesmaximacentrum.nl)
The biological marker the researchers found is the ABCB5 protein, which is located on the surface of limbal stem cells. (drcremers.com)
I also studied the role of a protein commonly found in the skin that is thought to play a role in the progression of certain peripheral neuropathies. (umaine.edu)
The presence of all four major cell types at protein level was confirmed by IF staining of the fully differentiated airway epithelium. (cdc.gov)

It is noted that cell self-renewal is tightly connected to this growth factor responsive potential. (rawveronica.com)
It is important to note that while a process of self-renewal occurs, neural stem cells may undergo changes in their abilities to produce different progeny during development[45]. (rawveronica.com)
Long-term self-renewal -The ability of stem cells to renew themselves by dividing into the same non-specialized cell type over long periods (many months to years) depending on the specific type of stem cell. (cellmedicine.com)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

Moreover, in adults, Merkel cells undergo slow turnover and are replaced by cells originating from epidermal stem cells, not through the proliferation of differentiated Merkel cells. (medscape.com)
The proliferation of the stem Leydig cells was stimulated by paracrine factors including Desert hedgehog (DHH), basic fibroblast growth factor (FGF2), platelet-derived growth factor (PDGF), and activin. (johnshopkins.edu)
Several pathways that interconnect to control cell proliferation have been well documented. (rawveronica.com)
Early neural stem cells entirely respond to fibroblast growth factor2 (FGF2 or bFGF), and the loss of FGF ligands or FGF receptors results in a significant diminution of neural stem cell proliferation[43]. (rawveronica.com)
On the other hand, the late emerging neural stem cells demand either FGF2 or epidermal growth factor for their proliferation[44]. (rawveronica.com)

A great example of an adult stem cell is the one that is found in the gastrointestinal tract because the gut is lined with a single sheet of epithelium that is replaced every 4-5 days to help protect it from the toxins in our food so the intestinal stem cell is working extremely hard. (ox.ac.uk)
Because the intestinal stem cell seems to be the only cell that hangs around long enough to accumulate these genetic mutations (everything else is shed in 4-5 days), we have therefore long believed that the intestinal stem cell is the origin of colorectal cancer and that is a very important cell to study. (ox.ac.uk)

We found they could be induced to mature into nerve cells, hair follicles, muscle cells and gut endoderm cells. (news-medical.net)

IF we could find a way to rejuvenate adult stem cells in their niches, then the stem cell supply chain could possibly be transformed from being a once-through-in-life process to a continuing closed-loop process. (anti-agingfirewalls.com)
I found that mfl silencing totally disrupts the formation of larval imaginal islands, the typical stem niches in which AMPs are organized. (unina.it)

These data define a unique phenotype for adult kidney-derived cells, which have potential as stem cells and may contribute to the regeneration of injured kidneys. (tau.ac.il)

Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. (sciencedaily.com)
The discovery by researchers at Columbia University Medical Center (CUMC) is reported today in the online issue of the journal Cell . (sciencedaily.com)
Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair. (sciencedaily.com)
Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. (sciencedaily.com)
In theory, researchers can induce embryonic stem cells to mature into a variety of specialized cells. (news-medical.net)
Stem cells also provide a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. (news-medical.net)
Eggan, Melton and their colleagues decided to pursue their alternative route after other researchers had shown that genetic reprogramming can occur when mouse somatic cells are fused to mouse embryonic stem cells. (news-medical.net)
The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. (news-medical.net)
The researchers were also able to further confirmed that fusion occurred by studying the chromosomal makeup of the fused cells. (news-medical.net)
Medical researchers hope to transplant adult stem cells to treat various diseases. (utah.edu)
But researchers have had trouble identifying the stem cells so they can be studied. (utah.edu)
Use of the CNP and NG2 markers will allow researchers to explore the full repertoire of these stem cells and to test ways to manipulate their behavior. (rupress.org)
A Boston-based scientific collaborative, led by Harvard Stem Cell Institute (HSCI) researchers, has discovered a way to collect the best cell type for regenerating a damaged cornea -the clear membrane that covers the pupil and directs light into the back of the eye. (drcremers.com)
Researchers have recently described new lines of stem cells derived from amniotic fluid [9] . (citizendium.org)
Because they are expressed in a particular way depending on when they split, these transcription factors, called temporal transcription factors, act as a marker that tells researchers what stage the neuroblast is at, and allows them to piece together the order of events in this neurogenesis cascade. (nih.gov)
Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. (debuglies.com)
What the researchers discovered is that the lamina progenitor cells may be responsible for insulating the fibers immediately after they leave the eye, supporting the connections between nerve cells on the pathway to the brain. (debuglies.com)

Limbal stem cell transplants from an uninjured eye or deceased organ donor have had promising results, but outcomes have been inconsistent. (drcremers.com)

And so, we received funding to conduct an investigator-initiated, randomized, double blind, placebo-controlled trial from the National Institutes of Health, and the results of this study were recently published in the Journal of Gerontology in January 2023.This trial primarily evaluated the impact of GlyNAC supplementation in older adults on glutathione synthesis and concentrations, oxidative stress and mitochondrial function. (reachmd.com)
GlyNAC supplementation in older adults for 16 weeks significantly improved these defects and reversed mitochondrial dysfunction. (reachmd.com)
In addition to mitochondrial dysfunction, GlyNAC supplementation in older adults also improved multiple additional aging hallmarks affecting nutrient sensing, altered intercellular communications, genomic damage, stem cell fatigue, and cellular senescence. (reachmd.com)

4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
To find any effective treatment in biology you need to understand the underpinning biology of the disease. (ox.ac.uk)
Find articles on 57,945 keywords in life science, biotech, pharma, biology and related science disciplines in the encyclopedia. (bionity.com)
Alokananda Ray, a postdoctoral researcher in the Li lab (left) with Xin Li, an assistant professor of cell and developmental biology. (nih.gov)
n a new paper published in eLife , Alokananda Ray, a Ph.D candidate during the time of the study and now graduated, and Xin Li (GNDP), an assistant professor of cell and developmental biology at the University of Illinois Urbana-Champaign, shed light on the process in the optic medulla of Drosophila melanogaster , the fruit fly. (nih.gov)

But NG2 + cells are also present in parts of the CNS that contain NSCs, and are the major cell type that continues to divide in the adult CNS. (rupress.org)
2005). Finally, negative revealed that SSEA4 is detectable in the early neuroepi- selection strategies have been also developed as an alter- thelium, and its expression decreases as development native method to enrich for NSCs from both adult proceeds. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

Adult NPCs are particularly enriched in the subventricular zone, in the dentate gyrus, and potentially also in the hypothalamus. (sanbio.nl)

If you make a fracture in the mouse, these cells will come alive again, generate both bone and cartilage in the mouse--and repair the fracture. (sciencedaily.com)
Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body's ability to repair bone injury--a process that declines significantly in old age," says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. (sciencedaily.com)
Previously, Dr. Wang found an analogous stem cell in the intestinal tract and observed that it was also abundant in the bone. (sciencedaily.com)
These cells are particularly active during development, but they also increase in number in adulthood after bone injury," says Gerard Karsenty, MD, PhD, the Paul A. Marks Professor of Genetics and Development, chair of the Department of Genetics & Development, and a member of the research team. (sciencedaily.com)
The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. (sciencedaily.com)
Curiously exempt from the draft guidance is centrifugation, despite numerous 510K cleared devices in existence that use this technique to isolate platelets from blood or concentrate the stem cells in bone marrow. (patientsforstemcells.org)

The replacement of neural stem cells, either endogenous or stem cell-derived neural stem cells, into impaired brain is highly expected as a possible therapeutic mean for neurodegenerative diseases. (rawveronica.com)

Also important is that they only make the epithelium, they do not make the blood vessels or the immune cells, just the epithelium. (ecancer.org)
It is lined by simple columnar epithelium containing secretory and ciliated cells, which produce tubular fluid and facilitate transport of gametes, respectively. (nature.com)
Since these cells reside at the bottom of the pseudostratified airway epithelium, it's possible that they were not directly impacted by nZnO exposure, at the doses/time points used. (cdc.gov)

And they can duplicate themselves without the help of other cells, meaning that a single stem cell can be extracted from a hair follicle, cultured in a lab, and produce a colony of cells. (loe.org)
Organoids are the small versions of organs that we grow from these stem cells, so colon organoids, we call them mini-guts, grow from a single stem cell taken from a colon. (ecancer.org)

Aliotta et al ( 15 ) demonstrated that lung-derived vesicles carried RNA to marrow cells and altered the phenotype of these cells both genetically and functionally. (spandidos-publications.com)
The senescent phenotype can spread from cell to cell through paracrine and juxtacrine signalling, but the dynamics of this process are not well understood. (bvsalud.org)
The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis in a paracrine manner through the senescence-associated secretory phenotype (SASP). (bvsalud.org)
Any change in the numbers of these cell types is termed as 'airway remodeling', which is a disease-related phenotype in several lung diseases. (cdc.gov)

Only cells from an embryo at the morula stage or earlier are truly totipotent, meaning that they are able to form all cell types including placental cells. (wikipedia.org)
Political leaders debate how to regulate and fund research studies that involve the techniques used to remove the embryo cells. (wikipedia.org)
And, since these cell types are derived from three different parts of the embryo, this really demonstrated the ability of these cells to give rise to a variety of different cell types. (news-medical.net)
At conception, the embryo is all Type A cells. (anti-agingfirewalls.com)
This is the product of the fertilised egg and is the stem cell that gives rise to all of the cells in the developing embryo. (ox.ac.uk)
Blastocyst -A preimplantation embryo of about 150 cells. (cellmedicine.com)
Embryonic stem cells -Primitive (undifferentiated) cells from the embryo that have the potential to become a wide variety of specialized cell types. (cellmedicine.com)
These cells give rise to the embryonic disk of the later embryo and, ultimately, the fetus. (cellmedicine.com)

Many Type D cells senesce and become Type E cells which make the corresponding organs shrivel and be susceptible to cancers and other disease processes. (anti-agingfirewalls.com)
If more than one kind of adult stem cell is required to generate the intestinal lining, "it wouldn't be surprising to see it is true for other organs as well," Capecchi says. (utah.edu)

The state of the body in terms of makeup of cell types continues to change through life and the process goes inexplicably from start (conception) leading to end (death). (anti-agingfirewalls.com)
That indicates at least one or two other types of adult stem cells must exist to maintain and repair the middle and lower thirds of the mouse's guts. (utah.edu)
The significance of these facts has remained unclear, as the function of NG2 in cell types other than oligodendrocytes had never been investigated. (rupress.org)
When examined in their natural context, CNP-GFP + /NG2 + cells are highly proliferative and give rise to a variety of cell types in different parts of the brain. (rupress.org)
Using a new p16-FDR mouse line, we show that macrophages and endothelial cells are the predominant senescent cell types in murine KRAS-driven lung tumors. (bvsalud.org)
Yet, when these brains form during embryonic development, there is initially only a small pool of cell types to work with. (nih.gov)
In the adult and perinatal forebrain, regionalized neural stem cells lining the ventricular walls produce different types of olfactory bulb interneurons. (bios-mep.info)

Promotes transdifferentiation of hepatocytes from mouse pancreatic cells (Shen et al. (stemcell.com)
However, we have found that the recent epigenetic clocks developed for mouse reduced-representation bisulphite sequencing (RRBS) data have significantly poor performance when applied to external datasets. (bvsalud.org)
Cells usually consist of mouse embryonic fibroblasts. (cellmedicine.com)
My current project is focused on the effects of neurogenic stimuli on a novel population of adult neural stem cells in the mouse brain, as well as characterizing these cells. (umaine.edu)
Townsend Lab Rotation During my rotation, I uncovered and traced the migration of adult neural stem cells in the adult mouse brain with a novel and unique stem cell marker being studied by the Townsend lab. (umaine.edu)

The stem cells in the lamina niche bathes these neuron extensions with growth factors, as well as aiding in the formation of the insulating sheath. (debuglies.com)

Also see Merkel Cell Tumors of the Head and Neck and Merkel Cell Carcinoma and Rare Appendageal Tumors . (medscape.com)
The volume and weight of tumors was measured and analyzing the ability of purified DU145 cells isolated from the tumors to migrate and proliferate. (jcancer.org)
The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
Previous work by Karnoub revealed that MSCs respond to breast tumors akin to the way they react to a wound or infection and that these cells participate in the formation of the breast tumor stroma, the supporting network of cells and their secretions that exist in the microenvironment of cancer cells. (newswise.com)
Cancer stem cells are thought to be the most virulent cells that lie within the core of most tumors, and are believed to be responsible for the resurgence of tumors following chemotherapy treatment. (newswise.com)
[ 1 ] the term medulloblastoma described a series of tumors found in the cerebellum of children. (medscape.com)
First used by Bailey and Cushing in 1925[1] , the term medulloblastoma described a series of tumors found in the cerebella of children. (medscape.com)
Treatment of recurrent primitive neuroectodermal tumors (PNET) in children and adolescents with high-dose chemotherapy (HDC) and stem cell support: results of the HITREZ 97 multicentre trial. (medscape.com)

This study aimed at elucidating the effect of major non-THC phytocannabinoids on the fate of adult neural stem progenitor cells (NSPCs), which are an essential component of brain function in health as well as in pathology. (nih.gov)
This implies that the fate of adult neural stem cells could be affected by environmental AZ505 ditrifluoroacetate cues[49]. (rawveronica.com)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Its stem cells contain the proteins SMEDWI-2 and SMEDWI-3. (bionity.com)
Through single cell transcriptomics, we identify a population of tumor-associated macrophages that express a unique array of pro-tumorigenic SASP factors and surface proteins and are also present in normal aged lungs. (bvsalud.org)

This skin cancer has been called by several other names, including primary small-cell carcinoma of the skin, APUDoma, primary undifferentiated carcinoma of the skin, and the Toker tumor. (medscape.com)
The model will be useful for understanding the mechanisms by which the prostatic stem cell niche controls the tumorigeneis of prostatic cancer stem cells. (jcancer.org)
this condition may be due to the existence of the cancer stem cells (CSCs) that are resistant to the hormone therapy. (jcancer.org)
Newswise - BOSTON - It is an intricate network of activity that enables breast cancer cells to move from the primary breast tumor and set up new growths in other parts of the body, a process known as metastasis. (newswise.com)
We think that by direct actions on the cancer cells and by manipulating other cells in the microenvironment, MSCsend up providing cancer cells with better abilities to survive and a safe haven in which to thrive," says Karnoub. (newswise.com)
The induction by MSCs of one such miRNA, miR199a, facilitated the acquisition of malignant properties by the cancer cells, including cancer stem cell and metastatic traits. (newswise.com)
After we found that miRNA-199a instigated in the cancer cells by MSCs was indeed promoting these cancer stem cells phenotypes and was facilitating cancer metastasis, we probed the mechanistic details of miR-199a's actions, " explains Karnoub. (newswise.com)
We were curious and wanted to find out the business of FOXP2 in breast cancer," he adds. (newswise.com)
Surprisingly, we found that its suppression in the tumor cells was sufficient to expand cancer stem cell traits and caused the cancer cells to metastasize much more vigorously. (newswise.com)
We are one step closer to understanding how cells in the tumor microenvironment, such as MSCs, promote the malignancy of neighboring cancer cells," says Karnoub. (newswise.com)
Cancer occurs when cell division becomes out of control and one of the key features of a cancer cell is that it no longer responds to morphogens that tell it to stop dividing. (ox.ac.uk)
Q: What's the link between gastrointestinal stem cells and cancer? (ox.ac.uk)
Because all tumours contain stem cells it is very critical that we use our therapy to kill all of those stem cells as otherwise the cancer is going to come back. (ox.ac.uk)
This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
Although senescent cells are important in ageing, wound healing and cancer, it is unclear how the spread of senescence is contained in senescent lesions. (bvsalud.org)
Genetic or senolytic ablation of senescent cells, or macrophage depletion, result in a significant decrease in tumor burden and increased survival in KRAS-driven lung cancer models. (bvsalud.org)
Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells. (medlineplus.gov)

They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)

[ 7 , 8 ] Sunshine et al offer that perhaps there are multiple cell-line precursors of Merkel cell carcinoma. (medscape.com)
Taken together, these data indicate that skeletal muscle precursors [the satellite cells] act as renewable, transplantable stem cells for adult skeletal muscle," says Wagers. (thenakedscientists.com)

Based on a previous report, we studied the potential involvement of the adenosine A1 receptor in the effect of CBC on these cells and found that the selective adenosine A1 receptor antagonist, DPCPX, counteracted both ERK1/2 phosphorylation and up-regulation of nestin by CBC, indicating that also adenosine is involved in these effects of CBC, but possibly not in CBC inhibitory effect on GFAP expression. (nih.gov)

Anatomy57

Organisms11

Diseases8

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes52

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Mesenchymal16

Differentiation33

Embryonic cell2

Pluripotent15

Multipotent8

Differentiate17

Hematopoietic stem3

Tissues15

Populations8

Genes18

Mice26

Neurons18

Tissue27

Neuronal6

Regenerative medicine1

Epithelial13

Alternative to embryonic stem2

Lgr511

Plasticity4

Progenitors5

Vitro6

Characterize2

Human46

Lineage8

Germ3

Scientists6

Gene18

Molecular6

Protein7

Self-renewal4

Proliferation5

Intestinal stem cell2

Hair follicles1

Niches2

Regeneration1

Researchers17

Transplants1

Supplementation in older adults3

Biology5

NSCs3

Dentate gyrus1

Bone6

Therapeutic1

Epithelium3

Single stem cell2

Phenotype4

Embryo8

Organs2

Types7

Mouse5

Neuron1

Tumors8

Fate3

Proteins2

Cancer17

Fibroblasts1

Precursors2

Nestin1