• Mannose receptor C-type 1 is a protein that in humans is encoded by the MRC1 gene. (wikipedia.org)
  • The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. (wikipedia.org)
  • We examined the carbohydrate-binding potential of the C-type lectin-like receptor Dectin-2 (Clecf4n). (elsevierpure.com)
  • The carbohydrate-recognition domain (CRD) of Dectin-2 exhibited cation-dependent mannose/fucose-like lectin activity, with an IC50 for mannose of approximately 20 mM compared to an IC50 of 1.5 mM for the macrophage mannose receptor when assayed by similar methodology. (elsevierpure.com)
  • We compared the lectin activity of Dectin-2 with that of two other C-type lectin receptors (mannose receptor and SIGNR1) known to bind fungal mannans. (elsevierpure.com)
  • Both mannose receptor and SIGNR1 were able to bind bacterial capsular polysaccharides derived from Streptococcus pneumoniae, but interestingly they exhibited distinct binding profiles. (elsevierpure.com)
  • These species were identified in the process of characterizing mannose 6-phosphate/insulin-like growth factor II (M-6-P/IGF-II) receptor binding to the surface of B lymphoblasts. (ox.ac.uk)
  • The mouse Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 175 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells (1). (rndsystems.com)
  • Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor. (biolegend.com)
  • Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. (nih.gov)
  • Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). (fishersci.com)
  • CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. (fishersci.com)
  • Exclusive elucidation of differentially expressed membrane glycoproteins and molecular modeling suggested that extended high- mannose glycosylation at the helical domain of transferrin receptor protein 1 promotes conformational changes that improve noncovalent interaction energies and lead to enhancement of cell migration in metastatic cholangiocarcinoma . (bvsalud.org)
  • Genetic mannose binding lectin deficiency is associated with airway microbiota diversity and reduced exacerbation frequency in COPD. (cdc.gov)
  • The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. (wikipedia.org)
  • Biosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and galactose (Gal) to generate core M1, M2 and M3 glycans. (genome.jp)
  • This study showed a simultaneous and rate-coordinated conversion of lignocellulose derived glucose, xylose, arabinose, mannose, and galactose into D-lactic acid by adaptively evolved Pediococcus acidilactici ZY271 by simultaneous saccharification and co-fermentation (SSCF) of wheat straw. (lu.se)
  • We previously demonstrated that the TprA/PhrA QS system is required for pneumococcal utilization of galactose and mannose, neuraminidase activity, and virulence. (frontiersin.org)
  • We found that TprA controls the expression of nine different operons on galactose and mannose. (frontiersin.org)
  • All the glycans in this SRM are made up of similar subunits of individual simple sugars including galactose, N-acetylglucosamine, fucose, sialic acid or mannose. (nist.gov)
  • LBP polysaccharides showed to have exceptional sources of the necessary cell sugars (glycoconjugates), rhamnose, xylose, sugar, mannose, arabinose and galactose- that are necessary for appropriate immune function and cells to interact. (slideshare.net)
  • Several of the CRDs participate in the Ca 2+ -dependent recognition of carbohydrates showing a preference for branched sugars with terminal mannose, fucose or N‑acetylglucosamine (7). (rndsystems.com)
  • When certain types of simple sugars, such as mannose, link to each other in certain ways, they form complex molecules called glycans. (nist.gov)
  • Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. (fishersci.com)
  • To determine whether immunization could induce antibodies to the V3-glycan bnAb binding site, we repetitively immunized macaques over a 4-year period with an Env expressing V3-high mannose glycans. (ku.edu)
  • Env immunizations elicited plasma antibodies that neutralized HIV-1 expressing only high-mannose glycans-a characteristic shared by early bnAb B cell lineage members. (ku.edu)
  • A structure of the antibody bound to glycan revealed that the three variable heavy-chain complementarity-determining regions formed a cavity into which glycan could insert and neutralized multiple HIV-1 isolates with high-mannose glycans. (ku.edu)
  • For example, glycans can be bound to monoclonal antibodies ( mAbs ), a type of biological drug used in efforts to target specific diseases. (nist.gov)
  • The glycans analyzed in this SRM represent a type known as "N-linked" glycans, which are linked to protein molecules. (nist.gov)
  • Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans. (bvsalud.org)
  • Here, we show that cholangiocarcinoma metastasis is characterized by down-regulation of the Golgi α- mannosidase I coding gene MAN1A1, leading to elevation of extended high- mannose glycans with terminating α-1,2- mannose residues. (bvsalud.org)
  • Type I G M2 gangliosidosis is also known as classic infantile acute TSD, B variant, pseudo-AB variant, or Hex A deficiency. (medscape.com)
  • Type AB G M2 gangliosidosis is also known as hexosaminidase activator deficiency. (medscape.com)
  • The differences in the specificity of these three mannose-specific lectins indicate that mannose recognition is mediated by distinct receptors, with unique specificity, that are expressed by discrete subpopulations of cells, and this further highlights the complex nature of carbohydrate recognition by immune cells. (elsevierpure.com)
  • Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. (embl.de)
  • Nasopharyngeal bacterial colonization and gene polymorphisms of mannose-binding lectin and toll-like receptors 2 and 4 in infants. (cdc.gov)
  • Effects of Rhinovirus Infection on Nasopharyngeal Bacterial Colonization in Infants With Wild or Variant Types of Mannose-Binding Lectin and Toll-Like Receptors 3 and 4. (cdc.gov)
  • Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis. (ox.ac.uk)
  • Composed of a pentameric repeating unit of mannose, glucose, and rhamnose, the biosynthesis of Psl is proposed to occur via a Wzx/Wzy-dependent mechanism. (rcsb.org)
  • D-mannose is a type of sugar that is related to glucose. (troohealthcare.com)
  • A mannose 6-phosphate-containing N-linked glycopeptide derived from lysosomal acid lipase is bound to MHC class II in B lymphoblastoid cell lines. (ox.ac.uk)
  • We have identified a novel class of peptides bound to MHC class II: mannose 6- phosphate (Man-6-P) containing glycopeptides from lysosomal enzymes. (ox.ac.uk)
  • Both subunit precursors acquire the mannose 6-phosphate marker for recognition by lysosomes. (medscape.com)
  • D-mannose is a monosaccharide (sugar) that naturally occurs in fruits including apples, blueberries, and cranberries. (physicianschoice.com)
  • The presence of d-mannose in cranberries is largely why people tend to drink cranberry juice in response to a UTI. (troohealthcare.com)
  • d-Mannose is a simple sugar found naturally in cranberries and pineapples, which can now be consumed from an easily dissolvable powdered form to help support a healthy urinary tract. (yourholisticdoc.com)
  • d-Mannose, the active urinary tract support ingredient of cranberries, provides concentrated support for proper urinary function. (yourholisticdoc.com)
  • d-Mannose is a simple sugar found naturally in cranberries and pineapples. (yourholisticdoc.com)
  • D-Mannose and proanthocyanadins from Pro Cran d'Or™ - a pure, concentrated whole cranberry fruit powder - help protect a healthy urinary tract. (physicianschoice.com)
  • As a food supplement, D-mannose is commonly used to help prevent certain kinds of bacteria from sticking to the walls of the urinary tract and causing infection. (troohealthcare.com)
  • Studies have shown that D-mannose may help keep E. coli -the bacteria responsible for the vast majority of UTIs-from sticking to the cells lining the urinary tract. (troohealthcare.com)
  • As it is flushed out of the body, d-mannose maintains a healthy environment for the mucosal surface of the urinary tract. (yourholisticdoc.com)
  • Its extracellular region is composed of an N-terminal cysteine-rich domain, followed by a single fibronectin type II repeat, and eight C-type lectin carbohydrate recognition domains (CRD) (3‑5). (rndsystems.com)
  • Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple α-helical coiled-coil. (lu.se)
  • Phonologically similar nonword stimuli were ordered to create tongue twister or control materials used in four tasks: reading aloud, immediate spoken recall, immediate typed recall, and serial recognition. (mpi.nl)
  • To understand the function of this protein, the apo-structure of the periplasmic domain of PslG (PslG(31-442)) and its complex with mannose were determined to 2.0 and 1.9 Å resolution, respectively. (rcsb.org)
  • An unusual type of protein glycosylation, C-mannosylation, involves attaching a single mannose sugar to the amino acid tryptophan by a carbon-carbon bond. (asbmb.org)
  • One of three types of internal repeat within the plasma protein, fibronectin. (embl.de)
  • Binds mannose and n-acetylglucosamine in a calcium-dependent manner. (lu.se)
  • Functionally, the EF specimens were abundant in probiotics related to mannose and cationic antimicrobial peptide metabolism. (nature.com)
  • The plant lectins from Hippeastrum hybrid (HHA) and Galanthus nivalis (GNA) are 50,000-D tetramers showing specificity for α-(1,3) and/or α-(1,6)-mannose oligomers. (aspetjournals.org)
  • How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
  • Thus, HIV-1 Env vaccination induced mannose-dependent antibodies with characteristics of V3-glycan bnAb precursors. (ku.edu)
  • Market Restraints of Mannose Oligosaccharide: Restraints are the negative factors which hinder the market growth and development in the near future. (cognitivemarketresearch.com)
  • These structures can undergo dynamic changes in composition and expression based on cell type, external stimuli, and genetic factors. (bvsalud.org)
  • Frequency of glycogen storage disease type II in The Netherlands: implications for diagnosis and genetic counselling. (medscape.com)
  • ProCran is a potent, pure powder made from cranberry extract - an effective accompaniment to D-Mannose in helping prevent UTIs. (physicianschoice.com)
  • D-Mannose is a simple sugar that occurs naturally in some plants. (vitaminlife.com)
  • by using multilocus sequence typing (MLST) and The patient with Tsukamurella infection was an whole-genome sequencing (WGS) ( 2 ). (cdc.gov)
  • OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene are associated with small vessel vasculitis (SVV) and are a risk factor for intercurrent infection, as described previously in other autoimmune diseases. (ox.ac.uk)
  • Although small amounts of D-Mannose are metabolized by the human body, most of it is rapidly excreted in the urine. (vitaminlife.com)
  • Because insubstantial amounts of D-Mannose are used by the body, it does not interfere with healthy blood sugar regulation. (vitaminlife.com)
  • Contains detailed information about the types and amounts of individual DS and antacids reported by each participant. (cdc.gov)
  • 21/33, 64%), but no association between type and DOI: http://dx.doi.org/10.3201/eid1805.111738 clinical disease or outcome was found. (cdc.gov)
  • This and other types of antibiotic-sparing therapeutics will be essential to prevent and treat increasingly prevalent infectious disease syndromes caused by antibiotic-resistant pathogens," explained Hultgren. (insidermonkey.com)
  • Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
  • Galehdari H, Emami M, Mohammadian G, Khodadadi A, Azmoon S, Baradaran M. Detection of a novel mutation in the GAA gene in an Iranian child with glycogen storage disease type II. (medscape.com)
  • Merk T, Wibmer T, Schumann C, Krüger S. Glycogen storage disease type II (Pompe disease)--influence of enzyme replacement therapy in adults. (medscape.com)
  • A diagnostic protocol for adult-onset glycogen storage disease type II. (medscape.com)
  • Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)
  • PslG formed a complex with two mannose monosaccharides in this groove, consistent with binding data obtained from intrinsic tryptophan fluorescence. (rcsb.org)
  • In fibronectin the type II domain is duplicated. (embl.de)
  • Type II domain is approximately forty residues long, contains four conserved cysteines involved in disulphide bonds and is part of the collagen-binding region of fibronectin. (embl.de)
  • Solution structure of the glycosylated second type 2 module of fibronectin. (embl.de)
  • The tertiary structure of the glycosylated second type 2 module (2F2) from the gelatin-binding domain of fibronectin was determined by two-dimensional nuclear magnetic resonance spectroscopy and simulated annealing. (embl.de)
  • Urika Active Support is an advanced blend of D-Mannose, selected herbals and essential vitamins and minerals that works quickly and gently to help address urinary discomfort whilst supporting healthy immune function. (troohealthcare.com)
  • The joint project will focus on the preclinical development of a class of mannosides, which are mannose-containing small molecule compounds. (insidermonkey.com)
  • Mannose Oligosaccharide market analysis helps to understand key industry segments, and their global, regional, and country-level insights. (cognitivemarketresearch.com)