OrganismsDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
LectinsMannose-Binding LectinMannoseMannose-Binding LectinsCollectinsPlant LectinsComplement Pathway, Mannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesComplement C1qCarrier ProteinsGenotypePolymorphism, GeneticMolecular Sequence DataLectins, C-TypeReceptor, IGF Type 2Genetic Predisposition to DiseaseMannosephosphatesGuanosine Diphosphate MannoseCarbohydratesDolichol Monophosphate MannoseOligosaccharidesWheat Germ AgglutininsCarbohydrate SequenceGalectinsGlycoconjugatesPolysaccharidesMannosidesConcanavalin ACarbohydrate MetabolismAcetylgalactosamineGalactoseGlycoproteinsGalanthusMonosaccharidesGlycosylationPeanut AgglutininFucoseMannosyltransferasesMannose-6-Phosphate IsomeraseMannansReceptors, Cell Surface
DeficiencyMoleculeCarbohydrate-bindinPolymorphismMannan-bindinProteinsComplement systemAdaptive immunityInnate immune proteinCarbohydratesFucoseSerineEndogenousSuperfamilyImmunityPathway activationPathwaysHeterogeneityInteractionsCohortVitroBacterialImmuneEvaluationInfectionFailureInvestigateBlood cellsLackStudiesCellSurfaceLevelsAnimal
Deficiency7
  • Deficiency of the mannose-binding lectin (MBL) protein, an antigen-recognition molecule involved in systemic and mucosal innate immunity, is determined by variant alleles in MBL2 gene promoter and exon-1 regions. (elsevierpure.com)
  • Mannose-binding lectin (MBL) deficiency, defined as MBL protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. (nih.gov)
  • Mannose-binding lectin deficiency is a condition that affects the immune system. (nih.gov)
  • People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. (nih.gov)
  • People with mannose-binding lectin deficiency can develop infections of the upper respiratory tract and other body systems. (nih.gov)
  • Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than affected adults, but adults can also develop recurrent infections. (nih.gov)
  • Mannose Binding Lectin, IgG Subclass and Antibody Deficiency: Efficacy of Intravenous Immunoglobulins. (yumaregional.org)
Molecule2
  • Another important function of MBL is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes. (wikipedia.org)
  • Melinda also has a particular interest in innate immune protein and pattern recognition molecule mannose binding lectin. (edu.au)
Carbohydrate-bindin1
  • ArtinM is a D-mannose carbohydrate-binding lectin that interacts with phagocytic cell receptors inducing the production of pro-inflammatory mediators related to the antitumor immune response. (usp.br)
Polymorphism1
  • Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients. (cdc.gov)
Mannan-bindin3
  • Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway. (wikipedia.org)
  • Do not miss to order the product Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit at this promotional price until the end of December 2017. (assayspro.com)
  • After delivery, the specialists from Gentaur/Genprice recommend you to store the Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit between two and eight degrees Celsius to keep the quality and activity of the reagents included in the kit. (assayspro.com)
Proteins3
  • Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
  • Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
  • At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Complement system4
  • Binding of MBL to a micro-organism results in activation of the lectin pathway of the complement system. (wikipedia.org)
  • The complement system can be activated through three pathways: the classical pathway, the alternative pathway, and the lectin pathway. (wikipedia.org)
  • In order to activate the complement system when MBL binds to its target (for example, mannose on the surface of a bacterium), the MASP protein functions to cleave the blood protein C4 into C4a and C4b. (wikipedia.org)
  • Activation of the complement system occurs through the classical (CP), lectin (LP), or alternative (AP) pathways. (jrheum.org)
Adaptive immunity1
  • How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
Innate immune protein1
  • Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection. (escholarship.org)
Carbohydrates2
Fucose3
  • Cell detachment from pyrite results in microbial "footprints" which, based on lectin binding assays, consist of mannose, glucose and fucose containing compounds. (ufz.de)
  • it occurs when mannose-binding lectin (MBL), a serum protein, binds to mannose, fucose, or N -acetylglucosamine groups on bacterial cell walls, yeast walls, or viruses. (msdmanuals.com)
  • Investigation of the Binding Affinity of a Broad Array of l-Fucosides with Six Fucose-Specific Lectins of Bacterial and Fungal Origin , MOLECULES 24: (12) pp. 2262-2279. (doktori.hu)
Serine2
  • For example, MBL has been shown to bind to: yeasts such as Candida albicans viruses such as HIV and influenza A many bacteria, including Salmonella and Streptococci parasites like Leishmania SARS-CoV-2 MBL in the blood is complexed with (bound to) a serine protease called MASP (MBL-associated serine protease). (wikipedia.org)
  • TGF-β signaling is initiated when the ligand binds to type II serine/threonine kinase receptor (TGFBR2), which then phosphorylates and activates type I serine/threonine kinase receptor (TGFBR1) [ 13 ]. (degruyter.com)
Endogenous2
Superfamily1
  • MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. (wikipedia.org)
Immunity3
  • Mannose-binding lectin (MBL), a complement factor of innate immunity, has been hypothesized to play a role in the clearance of pathogenic autoantibodies from the circulation, in particular those autoantibodies that lack galactose sugar residues. (eur.nl)
  • BACKGROUND: Mannose-binding lectin (MBL) is a key component of innate immunity. (ed.ac.uk)
  • Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
Pathway activation1
Pathways1
  • The classical, lectin, and alternative pathways converge into a final common pathway when C3 convertase (C3 con) cleaves C3 into C3a and C3b. (msdmanuals.com)
Heterogeneity1
  • 2008). Genetic Heterogeneity of Lectin Complement Activation Pathway Defects See also LCAPD2 (613791), caused by variation in the MASP2 gene (605102) on chromosome 1p36, and LCAPD3 (613860), caused by variation in the FCN3 gene (604973) on chromosome 1p36. (nih.gov)
Interactions4
  • ATR- FTIR , molecular docking , and dynamic simulation between SARS-CoV-2 S and either lectins indicated molecular interactions with predicted binding energies of -85.4 and -72.0 Kcal/Mol, respectively. (bvsalud.org)
  • Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
  • We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
  • Studies on carbohydrate-lectin interactions. (doktori.hu)
Cohort1
  • Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis. (ox.ac.uk)
Vitro1
  • Here, we evaluated the in vitro anti- SARS-CoV-2 activity of two mannose-binding lectins isolated from the Brazilian plants Canavalia brasiliensis and Dioclea violacea (ConBR and DVL). (bvsalud.org)
Bacterial1
  • A Bacterial Mannose Binding Lectin as a Tool for the Enrichment of C- and O-Mannosylated Peptides. (mpg.de)
Immune1
  • 7 It is possible that these major histocompatibility complexes bind antigens in such a way that they increase the likelihood of T-cells mounting an immune response to self-antigens. (lww.com)
Evaluation1
  • Evaluation of Mannose Binding Lectin Gene Variants in Pediatric Influenza Virus-Related Critical Illness. (escholarship.org)
Infection2
  • Therefore, carbohydrate binding agents may represent potential candidates to abrogate virus infection . (bvsalud.org)
  • OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene are associated with small vessel vasculitis (SVV) and are a risk factor for intercurrent infection, as described previously in other autoimmune diseases. (ox.ac.uk)
Failure1
  • Is Plasma Level of Mannose Binding Lectin Associated With Reproductive Failure? (who.int)
Investigate1
  • The aim of this study was to investigate the role of ArtinM lectin in AFB1-induced hepatocarcinogenesis in rats. (usp.br)
Blood cells1
  • Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Lack1
  • The presence of mannose resulted in the complete lack of anti- SARS-CoV-2 activity by ConBR and DVL, recovering virus titers. (bvsalud.org)
Studies1
  • The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)
Cell1
  • Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
Surface1
  • The C4b fragments can then bind to the surface of the bacterium, and initiate the formation of a C3-convertase. (wikipedia.org)
Levels1
  • C-reactive protein, Immunoglobulins and mannose binding lectin (MBL) levels were measured and correlated to vaccine response. (manchester.ac.uk)
Animal1
  • Wistar rats were gavage-poisoned with 400 ?g AFB1 per kilogram of ration fed for three months, while the AFB1 + ArtinM group received three subcutaneous doses of the lectin (50 ?g per kilogram of animal weight per dose) 45, 60 and 75 days after the start of the experiment. (usp.br)