Lectin deficiencyPattern recognition molecule mannose-bindinLectinsCalled mannose-bindinDeficiencyFucoseCation-independentPolymorphismSerine proteasesReceptorGlucoseResiduesProteinsInnate immune proteinReceptorsEndogenousPhosphateMannan-bindinPeptidesLigandsImmunityImmuneOligosaccharidesInteractionsGlycansInfectionPrimarilyCohortProcessesMechanismSelectiveEnablesActivityMolecularDiseaseDescriptionDomainComplexSitesLevelSurface
Lectin deficiency3
- Mannose-binding lectin deficiency is a condition that affects the immune system. (nih.gov)
- People with mannose-binding lectin deficiency can develop infections of the upper respiratory tract and other body systems. (nih.gov)
- Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than affected adults, but adults can also develop recurrent infections. (nih.gov)
Pattern recognition molecule mannose-bindin1
- Melinda also has a particular interest in innate immune protein and pattern recognition molecule mannose binding lectin. (edu.au)
Lectins4
- Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2. (bvsalud.org)
- Here, we evaluated the in vitro anti- SARS-CoV-2 activity of two mannose-binding lectins isolated from the Brazilian plants Canavalia brasiliensis and Dioclea violacea (ConBR and DVL). (bvsalud.org)
- ATR- FTIR , molecular docking , and dynamic simulation between SARS-CoV-2 S and either lectins indicated molecular interactions with predicted binding energies of -85.4 and -72.0 Kcal/Mol, respectively. (bvsalud.org)
- At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Called mannose-bindin1
- People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. (nih.gov)
Deficiency2
- Deficiency of the mannose-binding lectin (MBL) protein, an antigen-recognition molecule involved in systemic and mucosal innate immunity, is determined by variant alleles in MBL2 gene promoter and exon-1 regions. (elsevierpure.com)
- Mannose-binding lectin (MBL) deficiency, defined as MBL protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. (nih.gov)
Fucose3
- Cell detachment from pyrite results in microbial "footprints" which, based on lectin binding assays, consist of mannose, glucose and fucose containing compounds. (ufz.de)
- it occurs when mannose-binding lectin (MBL), a serum protein, binds to mannose, fucose, or N -acetylglucosamine groups on bacterial cell walls, yeast walls, or viruses. (msdmanuals.com)
- The biochemical activity of GDP-D-mannose-4,6 dehydratase (GMD) that converts mannose to fucose is decreased in patients with LAD type 2. (medscape.com)
Cation-independent3
- Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9. (ox.ac.uk)
- The cation-independent mannose 6-phosphate (M6P)/Insulin-like growth factor-2 receptor (CI-MPR/IGF2R) is an ∼300 kDa transmembrane protein responsible for trafficking M6P-tagged lysosomal hydrolases and internalizing IGF2. (ox.ac.uk)
- Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. (nih.gov)
Polymorphism1
- Mannose-Binding Lectin 2 Gene Polymorphism in PANDAS Patients. (cdc.gov)
Serine proteases2
- Mannose-binding protein-associated serine protease are serine proteases involved in the complement system. (wikipedia.org)
- They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). (bvsalud.org)
Receptor6
- These species were identified in the process of characterizing mannose 6-phosphate/insulin-like growth factor II (M-6-P/IGF-II) receptor binding to the surface of B lymphoblasts. (ox.ac.uk)
- Peptides eluted from the Man-6-P/IGF-II receptor-binding fraction of immunoaffinity-purified MHC class II from the Swei cell line contained a sequence derived from the propiece of lysosomal acid lipase. (ox.ac.uk)
- Remarkably the D7-11 structure matches an IGF2-bound state of the receptor, suggesting this may be an intrinsically stable conformation at neutral pH. (ox.ac.uk)
- The aim of this study was to assess the correlation between polymorphisms in the genes coding for mannose-binding lectin (MBL) and interleukin-1 receptor antagonist (IL1-Ra) and RVCC in women from São Paulo, Brazil. (usp.br)
- TGF-β signaling is initiated when the ligand binds to type II serine/threonine kinase receptor (TGFBR2), which then phosphorylates and activates type I serine/threonine kinase receptor (TGFBR1) [ 13 ]. (degruyter.com)
- M phi binding and phagocytosis of unopsonized P. aeruginosa appeared to occur by a mechanism independent of complement receptor 3 and mannose receptors. (jci.org)
Glucose1
Residues3
- Mannose-binding lectin (MBL), a complement factor of innate immunity, has been hypothesized to play a role in the clearance of pathogenic autoantibodies from the circulation, in particular those autoantibodies that lack galactose sugar residues. (eur.nl)
- PNGase F cleaves between the innermost GlcNAc and asparagine residues of high mannose, hybrid and complex oligosaccharides from N -linked glycoproteins (5), as shown in Figure 2. (neb.com)
- The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. (yeastgenome.org)
Proteins2
- Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
- Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
Innate immune protein1
- Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection. (escholarship.org)
Receptors1
- Based on the expression of CD206 mannose receptors on disease-associated macrophages, BIND and Macrophage plan to conduct joint research to develop a CD206 targeted Accurin nanoparticle that is capable of concentrating various therapeutic payloads to the tumor microenvironment. (businesswire.com)
Endogenous1
- Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. (researchgate.net)
Phosphate2
- A mannose 6-phosphate-containing N-linked glycopeptide derived from lysosomal acid lipase is bound to MHC class II in B lymphoblastoid cell lines. (ox.ac.uk)
- We have identified a novel class of peptides bound to MHC class II: mannose 6- phosphate (Man-6-P) containing glycopeptides from lysosomal enzymes. (ox.ac.uk)
Mannan-bindin2
- Do not miss to order the product Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit at this promotional price until the end of December 2017. (assayspro.com)
- After delivery, the specialists from Gentaur/Genprice recommend you to store the Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit between two and eight degrees Celsius to keep the quality and activity of the reagents included in the kit. (assayspro.com)
Peptides2
- Binding of peptides to MHC class II Ag generates ligands for TCR of Th lymphocytes. (ox.ac.uk)
- This study defines a novel approach for isolating rare glycan-modified peptides from MHC class II and demonstrates that very large secondary modifications are tolerated in peptides bound to MHC class II. (ox.ac.uk)
Ligands1
- This collaboration represents a potentially significant advance in the evolution of our platform as we develop Accurins with novel targeting ligands," said Andrew Hirsch, president and chief executive officer of BIND Therapeutics. (businesswire.com)
Immunity1
- BACKGROUND: Mannose-binding lectin (MBL) is a key component of innate immunity. (ed.ac.uk)
Immune1
- 7 It is possible that these major histocompatibility complexes bind antigens in such a way that they increase the likelihood of T-cells mounting an immune response to self-antigens. (lww.com)
Oligosaccharides1
- These oligosaccharides were found to be primarily associated with the bound peptide. (ox.ac.uk)
Interactions2
- In particular, intertwined FimA-FimA and FimH-mannose interactions lead to a 5 to 25-fold decrease of the fimbrial unwinding for pulling rates larger than 10 μm/s and for pH values outside the range 5 to 7. (pasteur.fr)
- The results reported in this work suggest that "catch bond effect" was negligible over the range of pulling rates tested, and both FimA-FimA and FimH-mannose interactions under given pH and external shear force conditions modify the ability of the bacteria to efficiently colonize host surfaces. (pasteur.fr)
Glycans1
- Structures are shown for sialylated glycans present in the array in nonfucosylated (glycans 1-9) and fucosylated (glycans 11-19) forms and binding by hemagglutinins is shown in Figures 2 and 7 . (cdc.gov)
Infection2
- Therefore, carbohydrate binding agents may represent potential candidates to abrogate virus infection . (bvsalud.org)
- OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene are associated with small vessel vasculitis (SVV) and are a risk factor for intercurrent infection, as described previously in other autoimmune diseases. (ox.ac.uk)
Primarily1
- Other commonly used endoglycosidases such as Endoglycosidase H ( NEB #P0702 ) are not suitable for general deglycosylation of N -linked sugars, because it only deglycosylates glycoproteins containing primarily high mannose N -linked structures, as well as leaving one N -acetylglucosamine residue attached to the asparagine. (neb.com)
Cohort1
- Mannose-binding lectin gene polymorphisms in a cohort study of ANCA-associated small vessel vasculitis. (ox.ac.uk)
Processes1
- Furthermore, the mode of the intermolecular interaction may demonstrate the existence of D-mannose-specific binding sites in several cell recognition processes. (scirp.org)
Mechanism1
- 6) The mechanism proposed is through the mannose-binding lectin. (saratoga.com)
Selective1
- CAMBRIDGE, Mass. & DUBLIN, Ohio--( BUSINESS WIRE )--BIND Therapeutics, Inc. (NASDAQ: BIND), a clinical-stage nanomedicine company developing targeted and programmable therapeutics called Accurins™, and Macrophage Therapeutics, a subsidiary of Navidea Biopharmaceuticals, Inc. (NYSE: NAVB) today announced they have entered into a research collaboration to engineer Accurins with the Manocept™ targeting platform that enables selective, efficient binding to CD206 positive disease-associated macrophages. (businesswire.com)
Enables1
- Enables insulin-like growth factor binding activity and mannose binding activity. (nih.gov)
Activity1
- The presence of mannose resulted in the complete lack of anti- SARS-CoV-2 activity by ConBR and DVL, recovering virus titers. (bvsalud.org)
Molecular2
- Dynamic modulation of fimbrial extension and FimH-mannose binding force on live bacteria under pH changes: a molecular atomic force microscopy analysis. (pasteur.fr)
- The enhancement of the FimH-mannose binding force at neutral pH, as evidenced from molecular AFM analyses, strongly correlates with an optimum in yeast agglutination detected at pH 5 to 7. (pasteur.fr)
Disease1
- An Accurin nanoparticle that binds to CD206 positive macrophages could be a valuable asset in the armament against multiple cancers and disease states. (businesswire.com)
Description1
- We have focused on solving the first structures of human D7-10 within two multi-domain constructs, D9-10 and D7-11, and provide the first high-resolution description of the high-affinity M6P-binding D9. (ox.ac.uk)
Domain1
- The extracellular region of the CI-MPR has 15 homologous domains, including M6P-binding domains (D) 3, 5, 9, and 15 and IGF2-binding domain 11. (ox.ac.uk)
Complex1
- PslG formed a complex with two mannose monosaccharides in this groove, consistent with binding data obtained from intrinsic tryptophan fluorescence. (rcsb.org)
Sites1
- The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. (degruyter.com)
Level1
- Is Plasma Level of Mannose Binding Lectin Associated With Reproductive Failure? (who.int)
Surface1
- We evidenced that both fimbrial extension and fimbrial binding force to mannosylated-surface are modulated with changing the externally applied shear force and the solution pH. (pasteur.fr)