Mammary cell transformation neoplastic. Medical search. Frequent questions

This process is called "the Warburg effect" and offers an attractive pharmacological target to preferentially eliminate malignant cells. (bvsalud.org)
We also show that EphA2 overexpression is sufficient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammary epithelial cells. (aacrjournals.org)
Interestingly, stimulation of EphA2 reverses the malignant growth and invasiveness of EphA2-transformed cells. (aacrjournals.org)
When malignant cells metastasize to distant sites in the body, morbidity and mortality increase significantly (3) . (aacrjournals.org)
At the cellular level, malignant cells have overcome restraints on cell growth and migration that result from physical linkages and signals conveyed by cell-cell contacts (5) . (aacrjournals.org)
Malignant cells often have increased interactions with surrounding ECM 3 proteins, which provide linkages and signals that promote several aspects of metastasis (6) . (aacrjournals.org)
Our aim was to establish a live cell culture to enable the understanding of the cellular processes driving the non-malignant growth of these tumors. (frontiersin.org)
Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (lookformedical.com)
Membrane-associated and cytoplasmic human chorionic gonadotropin (hCG), its subunits and its fragments were present in human cancer cells of neuroblastomas, medulloblastomas, retinoblastomas, and malignant gliomas of nude mice. (cancerprev.org)
Malignant mesothelioma is an aggressive neoplasm arising from the surface serosal cells of the pleural, peritoneal, and pericardial cavities. (biomedcentral.com)
Malignant transformation in vitro was determined by using the anchorage- independent growth assay on soft agar. (scirp.org)

A single exposure or multiple exposures of these cells to MNU was effective in inducing tumorigenic cells that produced palpable tumors as early as 6 weeks after transplantation. (eurekamag.com)
Two treatments with MNU (100 micrograms/ml) were optimal for neoplastic transformation and produced tumors in 79% of the injected fat pads. (eurekamag.com)
Histological examination indicated that the tumors were mammary carcinomas. (eurekamag.com)
However, most female Brca1Delta11/Delta11 Trp53+/- mice develop mammary tumors with loss of the remaining Trp53 allele within 6-12 months. (nih.gov)
Recent studies have identified overexpression of HER2 or epidermal growth factor receptor in some tumors and used this knowledge to develop successful approaches for therapeutic targeting of cancer cells (2) . (aacrjournals.org)
DMBA-induced mammary tumors was achived using DMBA dissolved in 1ml of vehicle (0.5 ml of DMSO plus 0.5 ml of saline) and injected by subcutaneous injection beneath the mammary gland on either side. (ivsajournals.com)
Expression of high levels of immune cells including neutrophils has been associated with detrimental outcome in several solid tumors and new strategies to decrease their presence and activity are currently under clinical development. (biomedcentral.com)
In this regard, tumor cell lines development has been an important tool to study the biological properties of many tumors. (biomedcentral.com)
This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)
This theory more logically explains neoplasms that contain multiple discrete cell types, such as pleomorphic adenomas and Warthin tumors. (medscape.com)

Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
The 'sick lobe' hypothesis [ 2 ], which proposes that entire lobes may be at increased risk of neoplastic transformation, would, if correct, be a powerful impetus towards lobe-directed diagnosis and treatment. (biomedcentral.com)

Here, we investigated the role of Hsp72 in Her2 oncogene-induced neoplastic transformation and tumorigenesis. (iucc.ac.il)
Expression of Her2 in untransformed MCF10A mammary epithelial cells caused transformation, as judged by foci formation in culture and tumorigenesis in xenografts. (iucc.ac.il)
2007. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. . (ucsf.edu)
Our current studies focus on how the tumor susceptibility gene 101 (TSG101) prevents tumorigenesis in mammary epithelial cells. (grantome.com)
Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)
Recognition of the effective involvement of the myoepithelial cells in mammary gland development and in hampering tumorigenesis has renewed the interest in investigating the biological roles of this second main mammary lineage. (biomedcentral.com)

In the woman's breast, this process of cell differentiation is directed by hormones produced in the later stages of pregnancy. (ewtn.com)
precancerous changescells and disorders in the structure of the tissue, indicating an early step towards neoplastic transformation, disturbances in the structure of cells, their maturation and differentiation and structure. (medicalwholesome.com)
The signal transducer and activator of transcription 5 (STAT5) regulates differentiation, survival, proliferation and transformation of hematopoietic cells. (nature.com)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Mammalian adult stem cells resemble the blastomeres of planktonic and benthic organisms with small eggs and may have evolved in mature organisms as an adaptation to the growth and maintenance of tissues via proliferation and the regulation of organ size via cell loss (e.g., terminal differentiation). (iospress.com)

Secondary transplantation of tumor pieces into intact mammary glands produced palpable carcinomas of the same histology within 1-8 weeks. (eurekamag.com)
Control cells cultured for the same periods of time as MNU-treated cells produced only ductal outgrowths that were morphologically similar to those found in the mammary glands of adult virgin hosts. (eurekamag.com)
citation needed] Prolactin is involved in the maturation of mammary glands and their secretion of milk in association with oxytocin, estrogen, progesterone, glucocorticoids, and others. (wikipedia.org)
Tobacco and alcohol, which are highly associated with head and neck squamous cell carcinoma, have not been shown to play a role in the development of malignancies of the salivary glands. (medscape.com)

Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)

Mammary epithelial cells, isolated from virgin BALB/c mice, were embedded within collagen gels and grown in a serum-free medium containing prolactin, progesterone, and linoleic acid. (eurekamag.com)
In young Hsp72 KO mice, expression of Her2 instead of mammary tissue hyperplasia led to suppression of duct development and blocked alveolar budding. (iucc.ac.il)
We use genetically engineered mice that carry somatic mutation for TSG101 in mammary tissue. (grantome.com)
Crypt hyperplasia in GCC-/- mice was associated with compensatory increases in cell migration and apoptosis. (jefferson.edu)
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. (ucsd.edu)
The primary cell cultures, obtained from four human pleural mesotheliomas, were expanded in vitro in a low serum proliferation-permissive medium and the expression of different markers as well as the tumorigenicity in immunodeficient mice was evaluated. (biomedcentral.com)
Vinyl chloride administered orally or by inhalation to mice, rats and hamsters produced tumours in the mammary gland, lung, Zymbal gland and skin and angiosarcomas of the liver [ref: 1]. (inchem.org)

Separately, deletion of GCC increased tumor growth by releasing a restriction on the cell cycle normally constraining epithelial cell proliferation. (jefferson.edu)
Over the past decades, luminal epithelial cell lineage has gained considerable attraction as the functionally milk-secreting units and as the most fruitful acreage for breast cancer launching. (biomedcentral.com)

Studies in animals and human tissue cultures indicate that cells in this state face exceptionally high risks of becoming cancerous. (ewtn.com)
Before a woman first conceives, her breasts consist mostly of connective tissue surrounding a branching network of ducts, with relatively few milk producing cells. (ewtn.com)
Telomere maintenance is normally controlled by telomerase activity as well as telomerase-associated factors throughout the cell cycle in tissue- and cell type-specific manners [ 1 - 3 ]. (oncotarget.com)
These effects were due to massive cell senescence in mammary tissue, which was associated with upregulation of p21 and downregulation of survivin. (iucc.ac.il)
Our long-term objective is to determine the mechanisms that regulate cellular growth and neoplastic transformation in breast tissue. (grantome.com)
We will investigate whether TSG101 has characteristics of a tumor suppressor gene or mammary tissue. (grantome.com)
Cells cultured as 3D were embedded as tissue blocks. (frontiersin.org)
The tumor is heterogeneous with meningeal tumor cells, mainly a mixture of fibroblast like cells, and neuroepithelial cells in a background of connective tissue. (frontiersin.org)
An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance. (ucsd.edu)
Equine mesenchymal stem cells from bonemarrow, adipose tissue and umbilical cord:immunophenotypic characterization anddifferentiation potential. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
However all the cell lines established so far were grown in medium containing at least 10% serum, and it has been shown that primary cell lines cultured under these conditions lose their ability to differentiate, acquire gene expression profiles that differ from that of tissue specific stem cells or the primary tumor they derive from, and in some cases are neither clonogenic nor tumorigenic. (biomedcentral.com)
Venereal transmitting tumor in cat composed from cells with a round to oval shape and the cytoplasm is poorly defined by routine stain, with dense fibrous tissue. (vetmedmosul.com)

Many mechanisms have been proposed for the inhibition of carcinogenesis by tea, including the modulation of signal transduction pathways that leads to the inhibition of cell proliferation and transformation, induction of apoptosis of preneoplastic and neoplastic cells, as well as inhibition of tumor invasion and angiogenesis. (indexindex.com)
details] A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 muT magnetic field exposure [med. (emf-portal.org)

In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)
These cell cultures may provide a valuable in vitro and in vivo model to investigate mesothelioma biology. (biomedcentral.com)
It induced mutation in Chinese hamster cells and unscheduled DNA synthesis in rat hepatocytes in vitro and induced transformation in BALB/c 3T3 cells and virus-infected Syrian hamster cells. (inchem.org)

Unexpectedly, elimination of one Trp53 allele completely rescues this embryonic lethality and restores normal mammary gland development. (nih.gov)
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, Balb/3T3 mouse embryonic fibroblast cell line, and NRK rat normal kidney cell line. (novusbio.com)
Profoundly different patterns of potency and division are exhibited by mammalian embryonic and adult stem cells. (iospress.com)
Mammalian embryonic stem cells would seem adapted to rapid proliferation, functioning in part to enclose yolk or to acquire access to maternal resources. (iospress.com)
The cellular products of embryonic stem cells routinely come under global influences and give rise to the cells of germ layers and organ rudiments. (iospress.com)
Strategies for regenerative therapies in adult mammals, therefore, might be based on stimulating growth of adult stem cells or their surrogates in specific tissues rather than on introducing embryonic stem cells into adults. (iospress.com)

This system provides a distinct means to study the mechanism of mammary neoplastic transformation at cellular and molecular levels. (eurekamag.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
This transformation is certainly thought as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm [1]. (irjs.info)
Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
Proliferation and cell viability were assayed by means of the enzymatic cleavage of the tetrazolium salt WST-1 to formazan dye by cellular mitochondrial dehydrogenases. (scirp.org)

Crypt expansion reflected hyperplasia of the proliferating compartment with reciprocal increases in rapidly cycling progenitor cells and reductions in differentiated cells of the secretory lineage, including Paneth and goblet, but not enteroendocrine, cells. (jefferson.edu)
Third eyelid adenomas in cats and dogs were composed of well-demarcated nodules containing neoplastic sebaceous cells present in glandular form and combined by hyperplasia of epidermis extended inside the neoplastic mass. (vetmedmosul.com)

In the multicellular theory, each tumor type is associated with a specific differentiated cell of origin within the salivary gland unit. (medscape.com)

Int J Biochem Cell Biol. (ucsf.edu)
Am J Respir Cell Mol Biol 64(1):89-99, 2021. (mdanderson.org)
Trends Cell Biol. (nature.com)

The identification of new mesothelioma markers may be useful for diagnosis and/or prognosis of this neoplasia as well as for isolation of mesothelioma tumor initiating cells. (biomedcentral.com)

Primary mammary mucinous cystadenocarcinoma: cytological and histological findings. (nih.gov)
Histological examination of feline mammary gland tumor composed from server infiltration of neoplastic cells, these neoplastic cells identified as lymphocytes in a fibrous stroma. (vetmedmosul.com)

Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)

Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
11 Substituted 2-(N-trifluoroacetylamino) imidazopyridines are known to arrest cell cycle at G2/M phase and induce apoptosis in SK-LU-1 human cancer cell line. (ivsajournals.com)

We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
The expression of a mutated hyperactive gain-of-function (GOF) STAT5 without O-GlcNAcylation resulted in decreased tyrosine phosphorylation, oligomerization and transactivation potential and complete loss of oncogenic transformation capacity. (nature.com)
Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)

Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
Additionally, MECs contributed effectively to maintaining the right luminal cells' polarization and further separating them from the adjacent stroma by making an integrated fence. (biomedcentral.com)
Indeed, disruption of the MECs layer was reported to facilitate the invasion of the cancer cells to the surrounding stroma. (biomedcentral.com)
Therefore, damaging the MECs layer resulted in the release of various factors (such as SDF1/CXCL12, CXCL14, MMP, and tenascin) [ 11 , 12 ] with a potential to modify the tumour microenvironment and facilitate the paracrine communication between the tumour epithelial cells and the enclosed stroma enhancing the tumour aggressiveness [ 11 , 13 ]. (biomedcentral.com)

However, dysregulation of the DDR pathway allows cells to proliferate beyond senescence limits. (oncotarget.com)
In mammalian organisms, cells that express markers of senescence have been shown to accumulate with age and at sites of certain age-related pathologies. (nature.com)

Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. (ucsd.edu)

If these cells undergo neoplastic transformation, they will give rise to a prolactinoma, a prolactin-secreting pituitary adenoma. (wikipedia.org)
Under the influence of these hormones, her breast cells undergo massive growth. (ewtn.com)
These samples were collected from animals that undergo surgical procedures to remove neoplastic growths in their body. (vetmedmosul.com)

In 48 cases of squamous cell carcinoma of the larynx the thymidine labeling index was a more important predictor of survival (p=0.015) than prognostic DNA values and tumor stage. (cancerprev.org)
The antibodies that were used are Vimentin for canine osteosarcoma, P53 for squamous cell carcinoma, Mdm2 for ovine pulmonary adenocarcinoma, and CD10 for neoplastic lymphocytes. (vetmedmosul.com)

This lesion is composed of the acentric layer of keratin produced by neoplastic keratinocytes. (vetmedmosul.com)

Both 2D monolayer and 3D neurospheres were successfully cultured and characterized for proliferative potential, intrinsic plasticity, presence of cancer stem cells and the expression of stem cell markers. (frontiersin.org)
Stem Cell Res. (sciendo.com)
Additional confusion surrounds stem-cell surrogates, cache and reserve cells having some characteristics of stem cells and not others. (iospress.com)
Two theories predominate: the bicellular stem cell theory and the multicellular theory. (medscape.com)

Squamous cell carcinomas are primarily found in skin lesions associated with the formation of pathognomic lesions known as keratin pearls. (vetmedmosul.com)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
After therapy, the incidence of pleomorphic adenomas, mucoepidermoid carcinomas, and squamous cell carcinomas is increased. (medscape.com)

Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (lookformedical.com)

Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. (mcmaster.ca)
Gastric acidity and preneoplastic/neoplastic changes of the stomach. (mcmaster.ca)

details] Effects of magnetic fields on mammary tumor development induced by 7,12-dimethylbenz(a)anthracene in rats [med. (emf-portal.org)
details] In vivo exposure of rats to a weak alternating magnetic field increases ornithine decarboxylase activity in the mammary gland by a similar extent as the carcinogen DMBA [med. (emf-portal.org)

Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial rate of metabolism and cell death, is linked to mitochondrion-rich (Hrthle cell) tumours of the thyroid. (irjs.info)

CBP was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Mouse Anti-Human/Mouse/Rat CBP Monoclonal Antibody (Catalog # MAB2676) at 8 µg/mL for 3 hours at room temperature. (novusbio.com)
Furthermore, the analysis by Maximo represents that Hrthle cells in thyroid carcinoma holds somatic or germline mutations in 57: 225C232. (irjs.info)
Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression. (ucsd.edu)
Mucinous breast carcinoma with tall columnar cells. (nih.gov)
Mucinous metaplasia of breast carcinoma with macrocystic transformation resembling ovarian mucinous cystadenocarcinoma in a case of synchronous bilateral infiltrating ductal carcinoma. (nih.gov)

However, expression of Her2 in Hsp72-depleted cells failed to induce transformation. (iucc.ac.il)

Our work was aimed to establish from fresh human pleural mesothelioma samples cell cultures maintaining tumorigenic properties. (biomedcentral.com)

This mutation is often accompanied by alterations in transformation-related protein 53 (Trp53, encoding p53), which substantially accelerates mammary tumor formation. (nih.gov)
Classically, therapies have been designed against molecular alterations that drive the transformation of normal cells into tumor ones [ 1 ]. (biomedcentral.com)

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
As an outcome of the two-part signalling and/or cell-cycle control. (who.int)

In women between 45 and 55 years of age, the most common occurrence is cystic-fibrous disease of the mammary gland characterized by numerous single small cystic lesions (dysplasia) and large cysts in the breast parenchyma, resulting from chronic hormonal disorders. (medicalwholesome.com)
The mucinous variant of columnar cell lesions. (nih.gov)
Better knowledge of breast ductal-lobar anatomy is also required for understanding normal human breast development, relationships between cancer precursor lesions, the pathways by which pre-cancerous cells may spread within a breast, and whether there is any link between lobe size or structure and the probability of a cancer arising in that lobe. (biomedcentral.com)

Experimental studies have demonstrated that mammary cancer is a hormone-dependent multistep process that can be induced by a variety of compounds and mechanisms, that is, hormones, chemicals, radiation, and viruses, in addition to or in combination with genetic factors. (eurekamag.com)

Likewise, strategies for the containment of cancer might be based on promoting normal pathways of cell loss, the basal mode for handling excess cells. (iospress.com)

Most cancer cells use anaerobic-like glycolysis to generate energy instead of oxidative phosphorylation. (bvsalud.org)
Our previous studies revealed that the levels of protein tyrosine phosphorylation regulate a balance between cell-cell and cell-ECM adhesions in epithelial cells (7) . (aacrjournals.org)
Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
Background: Tropomyosin 1 alpha chain (Tm1) is an actin-binding protein that regulates the endothelial cell response to oxidative stress following its phosphorylation at Serine 283 (S283). (scirp.org)
Conclusion: Phosphorylation of Tm1 at Ser283 contributes to its anti-tumor properties, and this effect results mainly from an increase in cell adhesion associated with a decrease in their migratory and invasive potentials. (scirp.org)
Simoneau, B., Houle, F. and Huot, J. (2012) Regulation of Endothelial Permeability and Transendothelial Migration of Cancer Cells by Tropomyosin-1 Phosphorylation. (scirp.org)

To identify tyrosine kinases that control tumor cell adhesion, we developed novel technologies to generate monoclonal antibodies against tyrosine kinases in cancer cells (8) . (aacrjournals.org)
Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)

The established mesothelioma cell cultures are able to engraft, after pseudo orthotopic intraperitoneal transplantation, in immunodeficient mouse and maintain this ability to after serial transplantation. (biomedcentral.com)

Furthermore, we demonstrate that reduction of PTEN protein to heterozygote levels in human MCF7 cells is associated with increased proliferation in response to IGF2, and does not result in desensitisation to IGF2 signalling. (ox.ac.uk)
culture conditions that force respiration in leukemia cells upregulate MHC-I transcription and protein levels at the cell surface, whereas these decrease in cells forced to perform fermentation as well as in leukemia cells lacking a functional mitochondrial respiratory chain. (bvsalud.org)
Here we report increased levels of the EphA2 (ECK) protein tyrosine kinase in clinical specimens and cell models of breast cancer. (aacrjournals.org)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)

Genes to Cells. (elsevierpure.com)

Metastatic cells have acquired the abilities to break away from the primary tumor, translocate to distant sites in the body, and colonize a foreign microenvironment (4) . (aacrjournals.org)
Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)

3 STAT5 regulated signaling controls important functions of innate and acquired immunity, hematopoiesis, and also growth and survival of many cell types in different organs responding to extracellular cytokines. (nature.com)

10 VEGF is a regulator of vascular permeability and an inducer of endothelial cell proliferation, migration, and survival. (ivsajournals.com)
Calcium channel blockers verapamil, nifedipine, diltiazem and isradipine arrested basic fibroblast growth factor induced human umbilical arterial endothelial cell proliferation. (cancerprev.org)

In this review, we provided an overview of the myoepithelial cells' histogenesis, molecular and biological markers, and physiological commitments. (biomedcentral.com)

Expression of increasing amounts of activated rasleu61 eliminated gap junctional intercelluar communication at substantially lower levels than required for neoplastic transformation. (cancerprev.org)

This goal, however, cannot be accomplished until the specific agent(s) or mechanisms that initiate the neoplastic process are identified. (eurekamag.com)
By mechanisms still barely understood by man, these basic cells are directed to become different from one another. (ewtn.com)
Cancer stem cells, instrumental in metastasis, would seem to ignore mechanisms normally functioning in the removal of excess cells. (iospress.com)

Pulmonary adenocarcinoma in sheep composed of a nodular formation containing dense collagen fiber deposition with transformation of cells lining alveoli into cuboidal or columnar cells can also be observed in other air passages. (vetmedmosul.com)

Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)

Cytogenetics and Cell Genetics, 69, 15-17. (scirp.org)
Cytogenetics and Cell Genetics, 71, 94-95. (scirp.org)
Cytogenetics and Cell Genetics, 68, 122-124. (scirp.org)
Cytogenetics and Cell Genetics, 72, 294-296. (scirp.org)

Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. (lookformedical.com)

Although estrogens have been shown to play a central role in breast cancer development, their carcinogenicity on human breast epithelial cells (HBECs) has not yet been clearly demonstrated. (eurekamag.com)
Instead of protecting the breast from cancer, abortion leaves millions of breast cells suspended in transitional states. (ewtn.com)
This period of rapid growth towards maturity is when breast cells arc most likely to be affected by certain cancer causing agents, or "carcinogens. (ewtn.com)
Because tumor-derived, cell-free DNA (cfDNA) is often released from cancer cells and circulates in the bloodstream, we hypothesized that breast cancer development is associated with changes in the amount of telomeric cfDNA that can be detected in the plasma. (oncotarget.com)
Effects of 60-Hz fields, estradiol and xenoestrogens on human breast cancer cells [med. (emf-portal.org)
An invasive breast adenocarcinoma characterized by the presence of tall columnar neoplastic cells that contain intracytoplasmic mucin. (nih.gov)
Methods: MDA MB231 breast cancer cells stably overexpressing wild type form of Tm1 or Tm1 mutants (S283A and S283E) were generated. (scirp.org)

References 2 and 3 describe the characteristics of cancer cells and the importance of mutations in cancer development. (nature.com)
Mystification may have been introduced historically with the concepts of determinate and regulative development, but, hopefully, the muddle can be resolved by tracing the evolution of stem cells in Metazoa. (iospress.com)
The embryos of larger arthropods and deuterostomes with well-provisioned eggs or viviparity, on the other hand, exhibit regulative development, while their larval "set-aside" or adult stem cells function in the growth, maintenance, and regulation of organ size coupled to constrained proliferation and cell turnover. (iospress.com)

Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)

In the 1970s, somatic cell genetic techniques were developed to allow the quantification and characterization of specific gene mutations arising in irradiated cultures of somatic cells. (nationalacademies.org)
We found that plasma telomeric cfDNA levels decreased with age in healthy individuals ( n = 42, R 2 = 0.094, P = 0.048), suggesting that cfDNA is likely derived from somatic cells in which telomere length shortens with increasing age. (oncotarget.com)

Within the scope of this trial, we investigated the effects of the natural pine bark extract pycnogenol on human fibrosarcoma cells. (spandidos-publications.com)
Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
A classic paper that describes the limited replicative lifespan of normal human cells. (nature.com)
18 Both enzymes, OGT and OGA as well as multiple O-GlcNAcylated proteins are enriched at sites of active transcription in human cells. (nature.com)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)

Using oncogene-transformed mammary epithelial cells, we showed that elevated tyrosine kinase activity weakens cell-cell contacts and promotes ECM adhesions (7) . (aacrjournals.org)
Both are linked to transformation due to deregulated kinase/phosphatase signaling or STAT5 gain-of-function (GOF) mutations. (nature.com)

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