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  • renal
  • Maternal nutritional status and/or environment can affect renal development by inducing limited nephron endowment at birth, which results in diseases such as hypertension and coronary heart disease in mammals. (unt.edu)
  • Concurrently, the ureteric bud induces the nephrogenic mesenchyme to condense around the bud and undergo MET to form the renal epithelium, which ultimately forms the nephron. (wikipedia.org)
  • epithelium
  • The cell types that Osr1 expressing cells will differentiate into are determined by the timing of loss of expression - cells that will become part of the vasculature or ureteric epithelium lose expression of Osr1 early (E8.5), and those that become nephrons lose expression later (E11.5). (wikipedia.org)
  • segments
  • In the absence of HNF1β early nephron precursors gave rise to deformed S-shaped bodies characterized by the absence of the typical bulge of epithelial cells at the bend between the mid and lower segments. (biologists.org)
  • For this purpose we studied the effects of aldosterone and dexamethasone on Na−K-ATPase specific activity in microdissected nephron segments from adrenalectomized rabbits. (springer.com)
  • In other nephron segments, adrenalectomy reduced Na−K-ATPase activity and specific 3 H ouabain binding concomitantly, and therefore left this enzyme's specific activity unaltered. (springer.com)
  • Doucet A, Katz AI, Morel F (1979) Determination of Na−K-ATPase activity in single segments of the mammalian nephron. (springer.com)
  • mesenchyme
  • In normal kidney development, activation of the Pax2-Eya1-Hox11 complex and subsequent activation of Six2 and Gdnf expression allows for branching of the ureteric bud and maintenance of the nephron-forming cap mesenchyme. (wikipedia.org)
  • regeneration
  • Our new method can be used to complement nephrotoxicity-induced models of AKI and gain a high-resolution understanding of the cell and molecular alterations that are associated with epithelial regeneration in the kidney nephron. (jove.com)
  • mechanisms
  • Following epithelial cell destruction, nephrons have a limited ability to regenerate, though the mechanisms and limitations that guide this phenomenon remain poorly understood. (jove.com)
  • transport
  • Because cAMP appears to be the key second messenger leading to the increase in salt and water transport in the CCD, the alpha -2-mediated reduction in cellular cAMP has been viewed as the functional evidence for the alpha -2-induced inhibition of transport in this nephron segment. (aspetjournals.org)
  • expression
  • BMP-7 expression is attenuated when the nephron is placed under inflammatory or ischemic stress, leading to EMT, which can result in fibrosis of the kidney. (wikipedia.org)
  • water
  • The thick ascending limb of the loop of Henle is the only part of the nephron lacking in aquaporin-a common transporter protein for water channels. (wikipedia.org)
  • process
  • Birds are likely to be effective models for this process because, like mammals, they have high pressure cardiovascular systems, mammalian-type nephrons and are homeothermic. (unt.edu)
  • distal convol
  • Because NCC is located at the apical membrane of the distal convoluted tubule of the nephron, it faces the lumen of the tubule and is in contact with the tubular fluid. (wikipedia.org)
  • mice
  • Since previous research by Christiane Nüsslein-Volhard and Eric Wieschaus (which won them the Nobel Prize in Physiology or Medicine in 1995) had already established the function of Wg as a segment polarity gene involved in the formation of the body axis during embryonic development, researchers determined that the mammalian int1 discovered in mice is also involved in embryonic development. (wikipedia.org)
  • cells
  • Figure 1: Mammalian cells can be distinguished according to their morphology. (leica-microsystems.com)
  • We find these cells share many characteristics with their mammalian developmental counterparts, and also with NB cells. (biologists.org)
  • Polydendrocytes (also known as NG2 cells, NG2 glia, or oligodendrocyte progenitor cells) are process-bearing glial cells (neuroglia) in the mammalian central nervous system (CNS) that are identified by the expression of the NG2 chondroitin sulfate proteoglycan (CSPG4) and the alpha receptor for platelet-derived growth factor (PDGFRA). (wikipedia.org)
  • They are distinct from other cell populations such as neurons, astrocytes, oligodendrocytes, microglia, and neural stem cells and are recognized as the fourth major glial cell type in the mammalian CNS. (wikipedia.org)
  • salt
  • In those animals with a loop of nephron, salt (Nace) and urea are concentrated in the extra cellular fluid around the loop, allowing water to move by osmosis out of the loop and into the peritubular capillaries. (biologyboom.com)
  • form
  • TSC1 and TSC2 form a tumor suppressor complex that regulates mammalian target of rapamycin (mTOR) signaling complex by directly controlling the activity of the small GTPase Rheb via the GTPase activating protein (GAP) domain of TSC2. (wikipedia.org)
  • high
  • However, it has been shown that Lgr2, the fly orthologue of mammalian LGR5, binds with "high affinity and specificity" with bursicon, an insect heterodimeric, neurohormone that belongs in the same class as FSH, LH and TSH, which in turn are homologous to mammalian bone morphogenetic factors (BMPs) such as gremlin and cerberus. (wikipedia.org)
  • major
  • It had been known since the early 1900s that astrocytes, oligodendrocytes, and microglia make up the major glial cell populations in the mammalian CNS. (wikipedia.org)