• Rap 1 is a member of a group of proteins involved in the regulation of cell proliferation and differentiation. (medscape.com)
  • The signaling network in the niche establishes the baseline for self-renewal, fate determination, proliferation, and differentiation of intestinal stem cells. (wjgnet.com)
  • The self-renewal capacity, the balance of proliferation and differentiation are tightly controlled in the process of epithelial repair and regeneration. (wjgnet.com)
  • They help regulate cell growth, proliferation, differentiation and in the case of neurons, synaptic plasticity. (ucsd.edu)
  • Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. (thermofisher.com)
  • capable of influencing cell proliferation, differentiation and other functions in a wide range of cell types. (caslab.com)
  • Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection. (cdc.gov)
  • DNA replication is the primary event that regulates cellular and viral proliferation. (nih.gov)
  • Mammalian STE20-like kinase MST4 regulates multiple cellular aspects such as cell polarity and proliferation. (rcsb.org)
  • Basal p38 Mitogen-Activated Protein Kinase Regulates Unliganded Glucocorticoid Receptor Function in Airway Smooth Muscle Cells. (ndriresource.org)
  • Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
  • Loss of PTEN elevates PIP3 levels, promoting cell survival and tumorigenesis. (ucsd.edu)
  • Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension. (ndriresource.org)
  • Results and Conclusions: The adaptation process was characterized by initial cell population growth arrest, and after that extensive cell death, followed by proliferation and long-term survival of clonal cultures. (lu.se)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • 2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
  • Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
  • Unmethylated CpG dinucleotides in particular base contents that are relatively abundant in bacterial DNA are known to stimulate innate immune responses including immune cell proliferation and cytokine secretion in mammalian. (usda.gov)
  • Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
  • Here, we have screened more than 20 CpG-ODN for their ability to stimulate nitric oxide (NO), IL-1beta, and IFN-gamma production using chicken macrophage cell HD-11 and peripheral blood mononuclear cells. (usda.gov)
  • The multimodal nature of TGF beta is seen in its ability to stimulate or inhibit cell proliferation. (caslab.com)
  • They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. (bvsalud.org)
  • More specifically, her research examines the regulation of exit from mitosis, the regulation of the meiotic cell cycle, and effects of aneuploidy on normal physiology and tumorigenesis. (wikipedia.org)
  • However, research conducted by Professor Eldad Tzahor of the Weizmann Institute of Science's Biological Regulation Department, suggests that a protein called ERBB2 may hold the key to regenerating heart cells. (worldhealth.net)
  • Effects of the carcinogenic metal cadmium on the regulation of mammalian gene expression are reviewed and discussed in the light of observations on interference with cellular signal transduction pathways. (nih.gov)
  • Das D, Tapryal N, Goswami S.K., Fox P.L, and Mukhopadhyay C.K. Regulation of Ceruloplasmin in human hepatic cells by redox active copper: Identification of a novel AP-1 site in ceruloplasmin gene. (jnu.ac.in)
  • Transcriptome and chromatin immunoprecipitation analysis revealed c-Myc as a new and direct downstream target of XBP1 for regulation of NK cell proliferation. (cancerindex.org)
  • The DEmRNAs were mainly enriched in tumorigenesis‑associated GO terms (angiogenesis, positive regulation of cell proliferation, positive regulation of fibroblast apoptotic processes and regulation of neutrophil migration) and pathways (Hippo signaling pathway, cancer pathways, and Wnt signaling pathway). (spandidos-publications.com)
  • Our biochemical and cellular analysis thus demonstrates that the GID/CTLH complex prevents cell cycle exit in G1, at least in part by degrading Hbp1. (elifesciences.org)
  • Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)
  • Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signalling. (sigmaaldrich.com)
  • The mechanisms underlying the modulation of gene activity by cadmium are discussed in terms of interference with cellular signalling at the levels of cell surface receptors, cellular calcium and zinc homeostases, protein phosphorylation, and modification of transcription factors. (nih.gov)
  • This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
  • We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
  • Statistical evaluation Statistical analyses for BMS-536924 the cell proliferation assay had been performed using GraphPad Prism 5 software program (GraphPad NORTH PARK CA USA) with one- or two-way ANOVA accompanied by post hoc evaluation. (exposed-skin-care.net)
  • In the NHS, he is Director of the Charing Cross/ Imperial College Trophoblastic Disease and Malignant Ovarian Germ Cell Tumour (MOGCT) Centre and supraregional tumour marker assay service. (imperial.ac.uk)
  • Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and cell proliferation assay were used to explore the functional role of the key lncRNAs in GBM. (spandidos-publications.com)
  • Inherited forms of retinal degeneration, which afflict 1 in 3000 people worldwide, arise primarily from mutations in transcripts expressed in rod and cone photoreceptors and retinal pigment epithelial cells. (berkeley.edu)
  • Mature epithelial cells originate from the crypt and move up toward the villus tip. (wjgnet.com)
  • While the dispersion state did not affect cytotoxicity, improved dispersion of AP- and PD-MWCNTs increased TGF-β1 production in epithelial cells and fibroblast proliferation. (cdc.gov)
  • Further investigations revealed that cell proliferation dropped in line with declining levels of ERBB2 on the cardiomyocyte membranes. (worldhealth.net)
  • ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. (worldhealth.net)
  • Intriguingly, the cardiomyocyte cells responsible for heart muscle repair continued to be activated and proliferate. (jax.org)
  • Prior studies have focused on driving cardiomyocyte proliferation to improve cardiac regeneration in mice. (jax.org)
  • Her research group recently created haploid yeast cells containing extra copies of chromosomes and discovered that these aneuploid strains elicit phenotypes independent of the identity of the additional chromosome such as defects in cell cycle progression, increased energy demands, and interference with protein biosynthesis. (wikipedia.org)
  • Researchers were able to regenerate heart cells in mice by temporarily boosting levels of the protein ERBB2. (worldhealth.net)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • 1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
  • In the mammalian system the transcription of the cell cycle regulatory protein Wee1 is controlled by the circadian clock. (dagstuhl.de)
  • Nucleolar protein 2 (NOP2) is evolutionarily conserved from yeast to human, and has been found to play an important role in accelerating cell proliferation, cell-cycle progression, and tumor aggressiveness. (umass.edu)
  • Nop2 is expressed throughout preimplantation development, with highest mRNA and protein accumulation at the 8-cell and morula stages, respectively. (umass.edu)
  • It is the most common mechanism of regulating protein function and transmitting signals throughout the cell. (ucsd.edu)
  • Here, we demonstrate that the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 (IRE1α) and its substrate transcription factor X-box-binding protein 1 (XBP1) drive NK cell responses against viral infection and tumors in vivo. (cancerindex.org)
  • A multitasking plasma membrane protein coordinates cell division and energy metabolism in healthy-and perhaps also cancerous- Drosophila cells. (the-scientist.com)
  • Building on the newer pathways for pathogenesis includes the E3 ubiquitin ligase Peli1 as an important regulator of T-cell metabolism and antitumor immunity. (medscape.com)
  • The genetic and biochemical diversity of photoreceptor degnereration presents major challenges for therapy as there are many pathways to cell death. (berkeley.edu)
  • The pathways regulating the transition of mammalian cells from quiescence to proliferation are mediated by multiple miRNAs. (utexas.edu)
  • The Amon lab primarily investigates yeast (Saccharomyces cerevisiae) as a model for understanding the controls that govern cell-cycle progression and received an Early Career Award grant, a PECAS award, from he NIH for this work in 1998. (wikipedia.org)
  • ESC-CM enhanced proliferation of HCECs Expression of Ki67 was established to determine the role of 25%ESC-CM in the cell-cycle progression of HCECs. (giknet.org)
  • Proliferation and cell cycle progression of the serum-free cultures closely mimicked that of serum-dependent cells. (lu.se)
  • For this reason, the investigation and quantification of microglial cells is essential for better understanding their role in disease progression as well as for evaluating the cytocompatibility of novel therapeutic approaches for such conditions. (lu.se)
  • Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
  • We found that rapamycin inhibited cell proliferation and decreased the phosphorylation of mTOR pathway components in MG63 cells. (exposed-skin-care.net)
  • Schepers H, Wierenga AT, Eggen BJ, Vellenga E. Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway. (rug.nl)
  • IRE1α-XBP1 were essential for expansion of activated mouse and human NK cells and are situated downstream of the mammalian target of rapamycin signaling pathway. (cancerindex.org)
  • RAD001 (everolimus), a mammalian target of rapamycin (mTOR) pathway inhibitor in phase II clinical trials in oncology, exerts potent antiproliferative/antitumor activities. (aacrjournals.org)
  • The role of the mTOR pathway in estrogen-driven proliferation and effects of combining RAD001 and letrozole were examined in vitro in two breast cancer models. (aacrjournals.org)
  • The role of the mTOR pathway in estrogen response was evaluated in aromatase-expressing MCF7/Aro breast cancer cells by immunoblotting. (aacrjournals.org)
  • Treatment of MCF7/Aro cells with estradiol or androstenedione caused modulation of the mTOR pathway, a phenomenon reversed by letrozole or RAD001. (aacrjournals.org)
  • MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. (ndriresource.org)
  • In particular, for retinal gene therapy it would be highly advantageous to transduce a single cell type that spans the entire retina after an intravitreal injection of a gene delivery vehicle for the subsequent secretion of a general neuroprotective factor throughout the retina. (berkeley.edu)
  • Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol. (thermofisher.com)
  • Cyst development is generally attributed to increased proliferation of tubular epithelium, abnormalities in tubular cilia, and excessive fluid secretion. (medscape.com)
  • That's right, the hundreds of millions of cells that make up the bone and flesh of your body are products of thousands of generations of cell division that began when you were smaller than the period at the end of this sentence. (visionlearning.com)
  • TGF beta 2 is produced by many cell types and has been found at the highest concentration in porcine platelets and mammalian bone. (caslab.com)
  • abstract = "Microglial cells are brain-specific macrophages that swiftly react to disruptive events in the brain. (lu.se)
  • The axolotl studies suggest that focusing instead on the role of macrophages in early ECM structure and repair events that repress fibrotic activation may provide molecular targets that better promote mammalian cardiac regeneration. (jax.org)
  • B: Ki67-positive cells were analyzed by flow cytometry. (giknet.org)
  • ESC-CM promoted cell-cycle entrance of HCECs To detect the effect of 25%ESC-CM on the cell cycle, we examined the cell-cycle entrance of passage 2 and passage 4 HCECs from the 25%ESC-CM and CEM groups by flow cytometry. (giknet.org)
  • Here we define a 4-color flow cytometry panel using CD133, LeX, CD140a, NG2 to define a neural stem cell (NSC) as well as 4 classes of multipotential progenitors and 3 classes of bipotential progenitors, several of which have not been described previously. (karger.com)
  • Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)
  • Together with B and T cells , antibodies comprise the most important part of the adaptive immune system . (wikipedia.org)
  • In cells of the mammalian immune system, PI3K is activated by receptors for antigen, cytokines, costimulatory molecules, and so on. (frontiersin.org)
  • His research has had implications for understanding a number of important scientific questions, including the uncontrolled growth characteristic of cancer, the routing of nerve fibers and the success of disease-causing bacteria and viruses in overcoming the mammalian immune system. (ucsd.edu)
  • Dixon discovered that in Y. pestis , the enzyme functions as a lethal weapon when injected into mammalian cells, blocking the host immune response. (ucsd.edu)
  • As reported in a recent paper in npj Regenerative Medicine , however, axolotl with depleted macrophages (immune cells vital for clearing away dead cells as well as pathogens) showed a modified response to heart injury and impaired regeneration. (jax.org)
  • Hence, Peli1 is regarded as a novel regulator of mTORC1 and downstream mTORC1-mediated actions on T-cell metabolism and antitumor activity. (medscape.com)
  • Hamartin and tuberin heterodimerize and inhibit mammalian target of rapamycin (mTOR), the mammalian target of rapamycin. (medscape.com)
  • Our results show a novel role for DDX5 in cancer cell proliferation and suggest DDX5 as a therapeutic target in breast cancer treatment. (aacrjournals.org)
  • Drayer AL, Olthof SG, Vellenga E. Mammalian Target of Rapamycin Is Required for Thrombopoietin-Induced Proliferation of Megakaryocyte Progenitors. (rug.nl)
  • WNT, R-spondin, epidermal growth factor, and mammalian target of rapamycin are secreted by Paneth cells or mesenchymal cells. (wjgnet.com)
  • mTOR: Mammalian target of rapamycin. (wjgnet.com)
  • Mammalian testis is a target of thyroid hormone action and altered thyroid function which is known to affect testicular functions [ 8 , 9 ]. (hindawi.com)
  • After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
  • The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. (cancerindex.org)
  • Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
  • Open in a separate window Figure 5 Increased frequency of proliferating HCECs in conditioned medium from mouse embryonic stem cells. (giknet.org)
  • Open in a separate window Figure 6 Conditioned medium from mouse embryonic stem cells stimulated colony formation of HCECs. (giknet.org)
  • Open in a separate window Figure 7 Conditioned medium from mouse embryonic stem cells promoted cell-cycle entrance of HCECs. (giknet.org)
  • Furthermore, we show expression of MSTN by CML mesenchymal stromal cells, and that myostatin propeptide has a direct and instant effect on CML cells, independent of myostatin, by demonstrating binding of myostatin propeptide to the cell surface and increased phosphorylation of STAT5 and SMAD2/3. (haematologica.org)
  • Dixon is an internationally recognized scientist in the field of reversible phosphorylation - a biochemical process that involves the addition of phosphate to an organic compound and, in the context of cells, serves as a fundamental master control switch by which proteins and their functions can be altered after they have formed. (ucsd.edu)
  • In particular, the FANTOM (Functional Annotation of the Mammalian Genome) consortium pioneered the discovery of the noncoding RNA world by providing, through Cap Analysis of Gene Expression (CAGE-Seq), the first evidence that large portions of our genome are transcribed, producing a multitude of sense and antisense transcripts 12 . (nature.com)
  • To date, most gene therapies have targeted monogenic recessive retinal diseases and employed viral vectors to transfer a 'normal ' copy of the mutated gene to the affected cell. (berkeley.edu)
  • Additionally we examined the expression of the autophagy-related gene complex p62/SQSTM1 and LC-3 in MG63 cells exposed to various concentrations of rapamycin (ranging from 0.4 to 50 μM) for 24 h (Fig. 3A). (exposed-skin-care.net)
  • The optimal CpG motif for NO induction was also a strong stimulant for the IL-1beta gene expression in the macrophage HD-11 cells, whereas different CpG motifs have found to induce the IFN-gamma gene expression in PMNC. (usda.gov)
  • Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene. (cdc.gov)
  • Angelika Amon (January 10, 1967 - October 29, 2020) was an Austrian American molecular and cell biologist, and the Kathleen and Curtis Marble Professor in Cancer Research at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts, United States. (wikipedia.org)
  • My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
  • American Journal of Respiratory Cell and Molecular Biology 50(2): 301-315. (ndriresource.org)
  • American Journal of Respiratory Cell and Molecular Biology 50(3): 605-613. (ndriresource.org)
  • A molecular signature makes it possible to trace the details of hair cell replacement in the mammalian inner ear. (the-scientist.com)
  • Biochemical reconstitution demonstrates that the mammalian complex possesses inherent E3 ubiquitin ligase activity, using Ube2H as its cognate E2. (elifesciences.org)
  • In general, cells of mesenchymal origin appear to be stimulated by TGF beta while cells of epithelial or neuroectodermal origin are inhibited by the peptide. (caslab.com)
  • Indeed, Hbp1 accumulates in cells lacking GID/CTLH activity, and Hbp1 physically interacts and is ubiquitinated in vitro by reconstituted GID/CTLH complexes. (elifesciences.org)
  • Objective: Serum is usually added to growth media when mammalian cells are cultured in vitro to supply the cells with growth factors, hormones, nutrients and trace elements. (lu.se)
  • Professor Tzahor's team conducted a study on mice to determine ERBB2's role in hear cell regeneration. (worldhealth.net)
  • Newborn mice are able to regenerate damaged cardiomyocytes (heart muscle cells) however this ability is lost by the time they are just 7-days-old. (worldhealth.net)
  • Experiments in human cell lines, mice, Drosophila, and Caenorhabditis elegans have shown that endonuclease G (ENDOG) plays a protective role against the development of TSC. (medscape.com)
  • Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
  • A hormone thought to make murine insulin-secreting cells proliferate in mice did not perform in replication studies. (the-scientist.com)
  • Bender BS , Croghan T , Zhang L , Small PA Jr . Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. (cdc.gov)
  • Delayed clearance of Sendai virus in mice lacking class I MHC-restricted CD8+ T cells. (cdc.gov)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • She displayed an early interest in plant and animal biology as a child, keeping a notebook full of newspaper clippings, and was motivated to study biology after learning about Mendelian genetics and seeing time-lapse micrographs of the division of plant cells in middle school. (wikipedia.org)
  • State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. (rcsb.org)
  • 3. Department of Medical Microbiology, Immunology & Cell Biology, Southern Illinois University School of Medicine. (jcancer.org)
  • Dr. Mukhopadhyay did his doctoral studies in Biochemistry at the Department of Biochemistry from Calcutta University and received the postdoctoral training in the Department of Cell Biology, Cleveland Clinic Foundation, USA. (jnu.ac.in)
  • A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)
  • Stem Cells. (rug.nl)
  • Drayer AL, Boer AK, Los EL, Esselink MT, Vellenga E. Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase. (rug.nl)
  • Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells. (rug.nl)
  • Wang Z, Qu YJ, Cui M. Modulation of stem cell fate in intestinal homeostasis, injury and repair. (wjgnet.com)
  • These Lgr5+ intestinal stem cells reside at the bottom of the crypts and are wedged between Paneth cells, which protect and nurture stem cells. (wjgnet.com)
  • Above the stem cell zone is the lineage-committed progenitor cells, also known as the transit amplifying zone, divided to fuel the rapid epithelial cell turnover. (wjgnet.com)
  • The Wnt and Notch signaling exhibit high activity in the stem cell niche. (wjgnet.com)
  • Besides, Paneth cells provide essential Notch signals to stem cells by expressing Notch ligands. (wjgnet.com)
  • Both exogenous (inflammation, chemoradiotherapy, and diet) and endogenous factors (mitochondrial dysfunction, extracellular matrix, and enteric nervous system) have vital effects on stem cell fate modulation. (wjgnet.com)
  • Stem cells rely on extracellular signals produced by the niche, which dictate their ability to self-renew, expand and differentiate. (karger.com)
  • It is essential to have sensitive and reproducible methods of either quantifying or isolating these stem cells and progenitors to understand their intrinsic properties and how extrinsic signals regulate their development. (karger.com)
  • However, stem cells are difficult to distinguish from multipotential progenitors, which may look and act like them. (karger.com)
  • 2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • Трансплантація гемопоетичних стовбурових клітин Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
  • Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)
  • IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells. (biolegend.com)
  • IL-2 is a potent lymphoid cell growth factor which exerts its biological activity primarily on T cells, promoting proliferation and maturation. (biolegend.com)
  • 2001). Novel Cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells. (imperial.ac.uk)
  • Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
  • In summary, we identify myostatin propeptide as a novel positive regulator of primitive CML cells and corresponding normal hematopoietic cells. (haematologica.org)
  • The cascade continued until several weeks later, millions of cells were dividing - powering the exponential pattern of growth that eventually formed all of the organs and tissues of your body. (visionlearning.com)
  • He began a series of live observations under the microscope using dyed samples of animal tissues and found that a particular mass of material inside the nucleus of cells absorbed the dye quite well. (visionlearning.com)
  • The results demonstrate that DLEU1 and TRAF4 is highly expressed in GBM tissues and promotes proliferation of GBM cells. (spandidos-publications.com)
  • For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
  • Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)
  • The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
  • particularly the Sertoli cells, which play a major role in spermatogenesis and are the main cell type in the testis which expresses T 3 receptors [ 16 ]. (hindawi.com)
  • It's hard to imagine, but the cells present in a tiny embryo ultimately generate all of the cells that make up the body of an adult human being. (visionlearning.com)
  • The expression pattern and function of Nop2 during early mammalian embryo development, however, has not been investigated. (umass.edu)
  • Therefore, the overall goal of our work is to discover how DNA replication is regulated both in the large chromosomes of cells and in the "mini-chromosomes" of viruses and small extrachromosomal DNA molecules. (nih.gov)
  • Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
  • The objective of the present study is to investigate the modulation of antioxidant defence status in neonatal persistent hypothyroid rats before their sexual maturation and also to identify the specific testicular cell populations vulnerable to degeneration during neonatal hypothyroidism in immature rats. (hindawi.com)
  • During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
  • Failure of mammalian cells to regulate their proliferation cycle leads to cancer. (nih.gov)
  • 2) What are the requirements for DNA replication and transcription at the beginning of mammalian development? (nih.gov)
  • Current projects in our lab involve development of retinal cell specific viral vectors based upon lentivirus and adeno-associated viruses. (berkeley.edu)
  • Nop2 is required for mammalian preimplantation development. (umass.edu)
  • Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
  • This compromised testicular antioxidant status might have contributed to poor growth and development by affecting the spermatogenesis and steroidogenesis in rats before puberty as indicated by reduced germ cell number, complete absence of round spermatids, decreased seminiferous tubule diameter, and decreased testosterone level. (hindawi.com)
  • Transforming growth factor (TGF) betas are involved in many cell-to-cell interactions that occur during embryonic development. (caslab.com)
  • These mutations impaired MST4 kinase activation and function within the cell. (rcsb.org)
  • Cyanobacteria hydrolysate was assumed to be used as the nutrient and energy source for muscle cell growth. (researchgate.net)
  • Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
  • Results and Conclusions: The adaptation process was characterized by initial cell population growth. (lu.se)
  • Altogether our FACS (fluorescence-activated cell sorter) analyses reveal that the neonatal subventricular zone is far more heterogeneous than previously suspected and our studies provide new insights into the signals and mechanisms that regulate their self-renewal and proliferation. (karger.com)
  • Biological data points to additional couplings, including a link back from the cell cycle to the circadian clock. (dagstuhl.de)
  • Cell proliferation is a fundamental biological process, and the ability of human cells to transition from a quiescent to proliferative state is essential for tissue homeostasis. (utexas.edu)
  • Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotube s in mammalian tissue culture cells. (cdc.gov)
  • HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)
  • HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
  • Drugs that block DNA replication can arrest the spread of cancer cells and eliminate viral pathogens. (nih.gov)
  • In the past, our research focused on viral genomes as models for DNA replication in mammalian cell nuclei. (nih.gov)
  • We used isolated nuclei from virus infected cells supplemented with cytoplasm, and discovered that viral replicating chromosomes could continue replication in the absence of a nucleus. (nih.gov)
  • Naive, effector, and memory CD8 T cells in protection against pulmonary influenza virus infection: homing properties rather than initial frequencies are crucial. (cdc.gov)
  • Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection. (cdc.gov)
  • Most of the tumors represent hamartomas and, in many organs, resemble embryonic cells, suggesting that the defect occurs at an early stage in life. (medscape.com)
  • About 1 microM cadmium stimulates DNA synthesis and cell proliferation in various cell lines, whereas more elevated concentrations are inhibitory. (nih.gov)
  • Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)
  • Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • Focusing on novel positive regulators of primitive CML cells, the myostatin antagonist myostatin propeptide gave the largest increase in cell expansion and was chosen for further studies. (haematologica.org)
  • Results: Here we identified miR-503, miR-103, and miR-494 as negative regulators of proliferation in primary human cells. (utexas.edu)
  • Qualified for use in cell culture applications, especially serum-free cell culture. (sigmaaldrich.com)
  • How adaptation to serum free media influences cells has not been studied in detail. (lu.se)
  • Amon's research centered on how chromosomes are regulated, duplicated, and partitioned in the cell cycle. (wikipedia.org)
  • As a student under Nasmyth, Amon made significant discoveries related to the biosynthesis and breakdown of cyclins during the cell cycle. (wikipedia.org)
  • She identified two regulatory networks (FEAR and MEN) that promote the release of CDC14 which have the potential to identify the mechanisms that control the final stages of the mitotic cell cycle. (wikipedia.org)
  • First, we used immunostaining with the cell-cycle population marker Ki67. (giknet.org)
  • The cell-cycle entrance of HCECs treated with 25%ESC-CM was significantly higher than that of CEM group both in passage 2 (p=0.001) and passage 4 (p=0.000). (giknet.org)
  • 2007) present a computational model coupling the cell cycle and circadian rhythm, showing that this coupling can lead to multimodal cell cycle time distributions. (dagstuhl.de)
  • C57BL/6 mouse splenocytes were stimulated with Cell Activation cocktail (with Brefeldin A), stained with CD3 PE, fixed, permeabilized, and then stained with IL-2 (clone JES6-5H4) APC/Fire™ 750 (left) or rat IgG2b, κ APC/Fire™ 750 isotype control (right). (biolegend.com)