Malignant squamous cell carcinoma transitional present urothelium. Medical search. Frequent questions

In the bladder, however, it most commonly arises secondary to BCG immunotherapy (eg, in the treatment of high-grade papillary carcinoma or carcinoma in situ) or following transurethral resection of bladder tumor (TURBT). (medscape.com)
These include carcinoma in situ and high grade T1 tumours. (healthybladderclub.com)
The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
A common question is, "What stage of cancer is carcinoma in situ? (healthybladderclub.com)
Carcinoma in situ is referred to as stage 0 cancer. (healthybladderclub.com)

Cells that transform in a less dangerous fashion may still multiply and form masses or tumors. (emedicinehealth.com)
In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
In brief, frozen sections of profiled tumors were examined by hematoxylin-and-eosin, and areas rich in neoplastic cells were cut from the frozen blocks. (nature.com)
The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
The ovaries consist of different types of tissue ( epithelial , germ cells, and sex cord tissue), which may give rise to benign or malignant tumors . (amboss.com)
Bladder cancer is a disease caused by cells in the lining of the bladder turning into unhealthy and out-of-control cells that form tumors. (nazeerhospital.com)
Itis caused by cells in the lining of the bladder that form tumors. (nazeerhospital.com)
Upper tract urothelial carcinomas (UTUC) are malignant tumors of the urothelium of the ureter, renal pelvis, or calyces with similar properties to bladder carcinoma concerning etiology and pathology. (urology-textbook.com)
Well-differentiated tumors are less likely to exfoliate cells, and the distinction to inflammatory changes is unreliable, see section urine cytology . (urology-textbook.com)
The subsequent risk of CIS to progress to muscle-invasive or metastatic urothelial cancer is 40% or greater, especially if concomitant papillary tumors are present. (blogspot.com)

In the United States, urothelial carcinomas account for more than 90% of all bladder cancers. (emedicinehealth.com)
These cancers may also be called TCCs or urothelial carcinomas. (nazeerhospital.com)

The so-called transitional cells are normal cells that form the innermost lining of the bladder wall, the urothelium. (emedicinehealth.com)
Most bladder cancers start in the innermost lining of the bladder, which is called the urothelium or transitional epithelium. (healthybladderclub.com)

There has been a shift in human medicine and, later, in veterinary medicine from the use of transitional epithelium to urothelium to describe the specialized stretchy epithelial tissue that lines the renal pelvis, ureters, bladder, and proximal and mid-urethra. (gribblesvets.co.nz)
Urothelial is more descriptive of location, but this could be confusing, as urothelium is not present throughout the entire urinary tract (e.g. the renal tubules are composed of cuboidal to columnar epithelium, and the distal urethral lining is composed of squamous epithelium). (gribblesvets.co.nz)
Transitional epithelium is specific to the structure and function of the epithelium and is descriptive, as this epithelium can have quite a variable appearance in health (i.e. transitional). (gribblesvets.co.nz)
Another pro in the "transitional epithelium" column is that this term has been in common use for many decades, and it is probably the term most veterinarians use. (gribblesvets.co.nz)
Regardless of what you decide to call the epithelium, carcinomas arising from the transitional epithelium or urothelium can be challenging to diagnose by non- or minimally invasively means in some cases. (gribblesvets.co.nz)
Based on this feature and the degree of atypia in the epithelium, urothelial carcinoma was the presumptive diagnosis. (gribblesvets.co.nz)

Retrograde pyelography: ureteral stricture due to upper tract urothelial carcinoma. (urology-textbook.com)
Upper tract urothelial carcinoma is urothelial carcinoma in 95%, but squamous cell carcinoma or adenocarcinoma is rarely possible. (urology-textbook.com)
Renal ultrasound imaging: hypoechoic mass (x) in the renal sinus as a sign of upper tract urothelial carcinoma. (urology-textbook.com)
Flexible ureteroscopy: papillary upper tract urothelial carcinoma of a renal calyx. (urology-textbook.com)
The purpose of this study is to clarify the prognostic value of the PD-L1/PD-1/CD8 axis, and to develop and validate a comprehensive scoring system based on multiple immune variables to predict cancer survival of upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU). (bvsalud.org)

The differential diagnosis includes glandular differentiation of transitional cell carcinoma and direct extension or metastatic spread of adenocarcinoma arising primarily from the colon, prostate, appendix or endometrium. (biomedcentral.com)
AGUS stands for atypical glandular cells of undetermined significance. (com.ng)
A benign tumor that arises from glandular epithelial cells. (amboss.com)

The resulting cancers are named after the cell types. (emedicinehealth.com)
These cancers are comprised of cells that typically form as a result of bladder inflammation or irritation that has taken place for many months or years. (emedicinehealth.com)
These cancers form from cells that make up glands. (emedicinehealth.com)
Thus, individuals with transitional cell cancers of the bladder are at risk for transitional cell cancers of the kidneys/ureter (upper urinary tract). (emedicinehealth.com)
Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
Cancers that start in the cells that line your bladder are called transitional cell carcinomas. (nazeerhospital.com)
14. Which of the following lymphatic cancers is associated with multinucleated Reed-Sternberg cells and EBV? (mockdocs.org)
In many cancers, CIS is considered a "pre-malignant" lesion. (blogspot.com)

While eosinophilic inclusions can be found in the cytoplasm of other types of neoplastic epithelial cells, the appearance of this particular vacuole can aid in confirmation of urothelial cell origin in some cases. (gribblesvets.co.nz)
There is a cell with a large round eosinophilic vacuole (Melamed-Wolinska body) displacing the nucleus at the bottom left of the dense cluster of epithelial cells. (gribblesvets.co.nz)
Figures 3 (above) and 4 (below): Representative high-power fields containing malignant epithelial cells with frequent atypical features. (gribblesvets.co.nz)
Epithelial cells have a specific microscopic structure with different lateral , apical, and basal membrane domains. (amboss.com)

Only transitional cells normally line the rest of the urinary tract. (emedicinehealth.com)
Urothelial carcinoma (UC) is one the most common malignancies derived from the urothelium of the lower urinary tract. (medsci.org)
2-4% of patients with bladder carcinoma experience a recurrence in the upper urinary tract. (urology-textbook.com)
The microscopic examination of exfoliated urothelial cells in voided urine or an upper urinary tract irrigation sample can reliably identify high-grade tumor cells. (urology-textbook.com)
Cystoscopy is done at the initial diagnosis of UTUC and during follow-up to rule out urothelial carcinoma of the lower urinary tract. (urology-textbook.com)

LSIL stands for low-grade squamous intraepithelial lesion. (com.ng)
Serous Tubal Intraepithelial Carcinoma is now recognized to be the precursor lesion of most so-called ovarian high-grade serous carcinomas. (healthybladderclub.com)

Here we present a case of 68-year-old woman with primary clear cell carcinoma of the bladder, who underwent repeat TUR-BT and tumor recurrence. (biomedcentral.com)
In the present report, a case of clear cell carcinoma of the bladder with repeat recurrence is presented. (biomedcentral.com)
Because cytology alone is not highly sensitive for detection of low grade urothelial carcinoma and recurrence of the disease, several adjunct markers and urine based tests for urothelial carcinoma have been developed, which can help in the final diagnosis. (medsci.org)

However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
It proved to be a valid biomarker especially in detecting squamous intraepithelial lesions in cervical liquid-based samples and in discerning these lesions from their mimickers, as well as in ovarian, endometrial, vulvar, primary and metastatic melanomas, breast, pancreatic and renal cell carcinomas. (medsci.org)

Papillary urothelial neoplasm of low malignant potential (PUNLMP). (urology-textbook.com)

A benign mass composed of mature cells that are native to the tissue of origin but have abnormal tissue organization (e.g. (amboss.com)
A cancerous tumor is also known as a malignant tumor and can grow and spread to other body parts, while a benign tumor can grow but will not spread. (nazeerhospital.com)

ProEx C biomarker, urothelial carcinoma, urine cytology samples. (medsci.org)
Urethro-cystoscopy, which is best for detecting low-grade urothelial carcinoma (LGUC), and urine cytology as supplement, often the test that recognizes high-grade urothelial carcinoma (HGUC) are the current approaches for the initial detection and follow-up of UCs. (medsci.org)
You may have noticed the terms "urothelial cell" or "urothelium" being used in urinalysis, cytology, or histology reports over the last several years. (gribblesvets.co.nz)
The case that follows is an excellent example of a diagnostic transitional cell/urothelial cell carcinoma (TCC / UCC) cytology with a somewhat unusual presentation on physical exam. (gribblesvets.co.nz)

18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)

Metastasis means that cells spread through the tissue fluid's circulation called the lymphatic system or through the bloodstream where they can then stop off in other tissues or organs where they may grow as metastases or metastatic deposits and can become destructive in these new locations. (emedicinehealth.com)
If a bladder cancer cell metastasizes -- that is, spreads to the lungs through the bloodstream it is still called and is treated as metastatic bladder cancer, not as lung cancer . (emedicinehealth.com)

Transitional cell carcinoma, also called urothelial carcinoma, is the most common type of bladder cancer. (emedicinehealth.com)
Urothelial carcinoma (transitional cell carcinoma): This is by far the most common type of bladder cancer in the United States. (emedicinehealth.com)

Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)

As an extremely rare variant of adenocarcinoma, clear cell type affects women more often than men. (biomedcentral.com)
The pathological diagnosis was clear cell adenocarcinoma of the bladder. (biomedcentral.com)
Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma. (biomedcentral.com)
The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. (biomedcentral.com)
Bladder washings and biopsies revealed copious amounts of mucin with associated malignant nests and single cells also consistent with mucinous adenocarcinoma. (biomedcentral.com)

however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
The expression status of programmed cell death-ligand 1/programmed cell death 1 (PD-L1/PD-1) and the infiltration of CD8+ T cells in tumor tissues are considered to be related to immunotherapy efficacy and patient prognosis. (bvsalud.org)
Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)

However, these symptoms are nonspecific and may also be associated with infection of the lower genitourinary tract (urethra, vagina) or with noninfectious conditions such as bladder carcinoma, urethral diverticulum, and calculi. (medscape.com)
Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)

ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1. (cancerindex.org)
Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)

Papillary morphology with early invasion into deeper layers compared to bladder carcinoma [fig. UTUC of the renal pelvis ]. (urology-textbook.com)

ASCUS (say "ask-us") stands for atypical squamous cells of undetermined significance. (com.ng)

The muscular layer of the bladder was invaded by tumor cells. (biomedcentral.com)

Rupture of a mucinous cystadenoma or cystadenocarcinoma leading to the spread of tumor cells throughout the peritoneum . (amboss.com)

Cancer occurs when normal cells undergo a degenerative, dangerous, or what is called a malignant change or transformation causing them to grow abnormally and multiply without normal controls. (emedicinehealth.com)
In transitional cell carcinoma, these normal lining cells undergo changes that lead to the uncontrolled cell growth characteristic of cancer. (emedicinehealth.com)

In rare cases, however, transformation into a malignant variant has been observed. (symptoma.com)

A mass of cancerous cells is called a malignant tumor or cancer . (emedicinehealth.com)
Cancer cells can also metastasize . (emedicinehealth.com)
Of the different types of cells that form the bladder, the cells lining the inside of the bladder wall are the most likely to develop cancer. (emedicinehealth.com)
Bladder cancer may develop related to changes in DNA (the material in cells that makes up genes and controls how cells work). (emedicinehealth.com)
In CIS the cancer cells look very abnormal and are likely to grow quickly. (healthybladderclub.com)
Developing effective systemic therapy for bladder cancer continues to present a challenge to oncology physicians and researchers. (iospress.com)
An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
and promoted the proliferation and invasiveness of breast cancer cells both in vivo and in vitro. (cancerindex.org)
Mechanistically, co-immunoprecipitation and immunofluorescence assays both demonstrated that ZNF326 interacted with deleted in breast cancer-1 (DBC1) in breast cancer cells. (cancerindex.org)
Transitional cell carcinoma is the most common type of this cancer, making up about 90% of the cases. (nazeerhospital.com)
Some kinds of this parasite illness increase a person's risk of developing squamous cell cancer. (nazeerhospital.com)
In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

The incidence of UTUC is rising due to the effective treatment of bladder carcinoma with better survival rates (length time bias). (urology-textbook.com)

G-MDSC are also referred to as polymorphonuclear (PMN)-MDSC, which differ from conventional neutrophils via expression of lectin-type oxidized LDL receptor 1 (LOX-1), which inhibits T cell proliferation [ 7, 8 ]. (iospress.com)
Additionally, DBC1 knockdown eliminated the up-regulation of MMP7, EMT-related proteins, and cell cycle-related proteins as well as the enhanced proliferation and invasiveness induced by ZNF326. (cancerindex.org)

A Pap smear allows your doctor to look at cells from your cervix to see if there are any problems. (com.ng)
The squamous cells of your cervix were slightly abnormal on your Pap smear. (com.ng)
AGUS can occur with infections or with a change in the cells on the surface of your cervix or in the canal of your cervix. (com.ng)
This is a common condition of the cells of the cervix and often occurs when the HPV wart virus is present. (com.ng)
These changes in the cervix can be present even if you and your sexual partner are monogamous and have never had visible warts. (com.ng)
This change in the cells of the cervix often occurs from cervical cap or diaphragm use or from infection. (com.ng)

These cells were slightly abnormal on your Pap smear. (com.ng)

Immunohistochemical evaluation revealed that neoplastic cells were positive for carcinoembryonic antigen, cytokeratin-7, cytokeratin-20 and were negative for prostate specific antigen and prostatic acid phosphatase. (biomedcentral.com)

The kidney's internal collecting system, the ureters (narrow tubes that carry urine from the kidneys to the bladder), the bladder, and the urethra are lined with these cells. (emedicinehealth.com)

Microscopically, most of the tumor cells were arranged in tubular glands, microcysts or fine papillae, partly in diffuse sheets or solid nests (Figure 2 ). (biomedcentral.com)
Most tumor cells were in cuboidal or columnar shape and hobnail cells were seen containing abundant clear cytoplasm (Figure 4 ). (biomedcentral.com)

Arise from sex cord cells (e.g. (amboss.com)

Thousands of copies of the circular mtDNA are present in most cell types that are packaged by TFAM into higher-order structures called nucleoids1. (regenerativemedicine.net)

Mucinous cells cause gelatinous ascites and intraabdominal adhesions. (amboss.com)

The gold standard for the detection of urothelial carcinoma is represented by urethro-cystoscopy and biopsy. (medsci.org)

Any of three different cell types can become cancerous. (emedicinehealth.com)

High-grade urothelial carcinoma. (urology-textbook.com)

The cancerous cells are capable of spreading to other areas of the body through the process of metastasis . (emedicinehealth.com)
M1: Distant metastasis present. (urology-textbook.com)

Clinically, patients with IPB present with symptoms similar to those of transitional cell carcinoma of the bladder, exhibiting intermittent and painless macroscopic hematuria accompanied by symptoms of urothelial irritation in some cases. (symptoma.com)

HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)

As a rule, the width of an inflammatory halo (i.e., the space between the nucleus and cytoplasm) is less than the diameter of an intermediate cell nucleus and the outline or the boundary of this halo is often vague or poorly defined, These are also known as the pseudokoilocytes, The halos of koilocytes are much larger, more sharply defined and their nuclei are big and dark. (com.ng)
Vacuolar degeneration of cytoplasm, pale degenerating swollen nuclei with indistinct chromatin and loss of the sharp details of the nuclear envelope are additional features, The cells appear frayed, ragged, or moth-eaten eventually leading to cytolysis. (com.ng)
Enlargement , polymorphism , polychromasia , increased cell count and/or enlarged nucleoli are all signs of increased activity of nuclei . (amboss.com)

In general, type 2 papillary renal cell carcinoma has a poorer prognosis than type 1. (healthybladderclub.com)

Vacuolar degeneration is particularly common in metaplastic cells. (com.ng)

Anatomy22

Organisms6

Diseases101

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology1

Phenomena and Processes34

Disciplines and Occupations1

Information Science5

Health Care18

Situ5

Tumors10

Urothelial carcinomas2

Lining of the bladder2

Epithelium6

Upper tract urothelial carcinoma5

Glandular3

Cancers8

Epithelial4

Urinary5

Lesion2

Recurrence3

Pancreatic2

Neoplasm1

Benign2

Cytology4

Ovarian1

Metastatic2

Type of bladder cancer2

Adenocarcinomas1

Adenocarcinoma5

Tissues5

Vagina2

Phenotype2

Renal Pelvis1

Atypical1

Layer of the bladder1

Spread1

Undergo2

Transformation1

Cancer12

UTUC1

Proliferation2

Cervix6

Abnormal1

Neoplastic1

Urine1

Tumor cells2

Arise1

Circular1

Mucinous1

Biopsy1

Types1

High-grade1

Metastasis2

Hematuria1

Gene expression1

Nuclei3

Prognosis1

Common1