Malignant germ autologous cells cord blood stem cell transplantation. Medical search. Frequent questions

Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
A speciality of our clinic is allogeneic and autologous stem cell Transplantation. (uniklinikum-dresden.de)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)

Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
The mediastinum is the most common site of extragonadal germ cell tumors. (medscape.com)
Mediastinal germ cell tumors account for only 2-5% of all germinal tumors, but they constitute 50-70% of all extragonadal tumors. (medscape.com)
Mediastinal germ cell tumors account for 1-15% of adult anterior mediastinal tumors. (medscape.com)
Mature teratomas represent 60-70% of mediastinal germ cell tumors. (medscape.com)
Although 90-100% of malignant germ cell tumors are symptomatic, only 50% of teratomas produce symptoms. (medscape.com)
Nonseminomatous mediastinal germ cell tumors (NS-MGCTs) are faster growing and metastasize earlier than mediastinal seminomas. (medscape.com)
Distant metastases are seen only in malignant mediastinal germ cell tumors. (medscape.com)
Mature teratoma rupture, teratoma with malignant transformation, and hematologic malignancies may complicate mediastinal germ cell tumors (see Complications). (medscape.com)
The second most common site of extragonadal germ cell tumors (30-40%), after the mediastinum, is the retroperitoneum. (medscape.com)
Retroperitoneal germ cell tumors (RGCTs) represent 10% of all malignant primary retroperitoneal tumors. (medscape.com)
Often patients with retroperitoneal germ cell tumors present late, after their tumors have reached large dimensions. (medscape.com)
Very rare tumors of the adolescent and young adult, intracranial germ cell tumors (ICGCTs) are localized preferentially to the pineal and suprasellar regions. (medscape.com)
Although seminomas (60% of intracranial germ cell tumors) have a predilection for the suprasellar region, embryonal carcinomas, yolk-sac tumors, and choriocarcinomas mainly occur in the pineal region. (medscape.com)
Brain tumors may be congenital in children younger than 3 years of age and range from benign complex lesions to highly malignant neoplasms. (medlink.com)
They can present as large tumors occupying contiguous cerebral lobes or as primary pineal, brainstem, or spinal cord tumors. (medlink.com)
Success of conventional chemotherapeutic regiment is based on the principle that tumors with high growth fractions (such as acute myelogenous leukemia and the lymphomas, including Hodgkin's disease) are more sensitive to chemotherapy because a larger proportion of the targeted cells are undergoing cell division at any given time. (justia.com)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)

The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
Multiple myeloma (MM) is an incurable cancer in which uncontrolled plasma cell proliferation disrupts the bone marrow environment and impairs immune function. (hrb.ie)

12 Bang and colleagues reported the safety and feasibility of intravenous infusion of autologous mesenchymal stem cells (MSCs) with no reported adverse effects in five patients treated with intravenous MSCs. (bmj.com)

PD-L1 CAR haNKs reduced levels of macrophages and other myeloid cells endogenously expressing high PD-L1 in peripheral blood from patients with head and neck cancer. (elifesciences.org)
A median of 11 spot-forming cells and 10 spot-forming cells per 1 10 peripheral blood mononuclear cells in participants in the high dose and low dose groups, respectively, were observed at day 28. (regenerativemedicine.net)
On day 21, overall and trichoscopic photographs of mice were taken, behavioral tests were performed, and skin lesions and peripheral blood were collected. (alljournal.ac.cn)
Differentiation of Th1/ Th2 and Th17/ Treg cells from peripheral blood T lymphocyte subsets was detected by flow cytometry. (alljournal.ac.cn)

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. (wikipedia.org)
The iPSC technology was pioneered by Shinya Yamanaka and Kazutoshi Takahashi in Kyoto, Japan, who together showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. (wikipedia.org)
Pluripotent stem cells hold promise in the field of regenerative medicine. (wikipedia.org)
Upon introduction of reprogramming factors, cells begin to form colonies that resemble pluripotent stem cells, which can be isolated based on their morphology, conditions that select for their growth, or through expression of surface markers or reporter genes. (wikipedia.org)
Induced pluripotent stem cells were first generated by Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University, Japan, in 2006. (wikipedia.org)
Unlike the first generation of iPSCs, these second generation iPSCs produced viable chimeric mice and contributed to the mouse germline, thereby achieving the 'gold standard' for pluripotent stem cells. (wikipedia.org)
A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)
Human heart tissues grown as three-dimensional spheroids and consisting of different cardiac cell types derived from pluripotent stem cells (hiPSCs) recapitulate aspects of human physiology better than standard two-dimensional models in vitro. (bvsalud.org)
Recently, in combination with cardiomyocytes derived from human (induced) pluripotent stem cells they have started to become a preferred tool to examine newly developed drugs for potential cardiac toxicity in pre-clinical safety pharmacology. (bvsalud.org)

For umbilical cord blood harvest, the cord is clamped after delivery of the baby, and blood is drawn from the cord with a needle and collected in a sterile bag. (msdmanuals.com)

NK cells express germ-line receptors that are either stimulatory or inhibitory, and the summation of these signals determines activation status ( Caligiuri, 2008 ). (elifesciences.org)
They can be activated rapidly via germ-line encoded receptors that recognize the presence of stress ligands or absence of self-antigens on target cells ( 1 - 5 ). (frontiersin.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)

Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)

The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)

Each of those cell sources has specific advantages and disadvantages, and each has found particular clinical applications. (medscape.com)
Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke, which are reviewed. (bmj.com)
9 Clinical trials of cell therapy completed in the 2000s mostly treating small cohorts of patients with chronic stroke demonstrated adequate safety and a suggestion of efficacy with the use of cell therapy. (bmj.com)
13 These early clinical trials mostly focused on chronic subcortical strokes, but more recent trials are now investigating cell therapy for treatment of both cortical and subcortical infarcts. (bmj.com)
Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)
Many culturing strategies are based on the addition of feeder or accessory cells, which need to be removed prior to the clinical application of the final NK cell product. (frontiersin.org)
Our researcher, Barbara Willekens, PhD, will give a presentation entitled 'Intradermal and Intranodal Administration of Vitamin D3-Induced Tolerogenic Dendritic Cells Is Safe and Feasible in Two Phase I Clinical Trials' on June 2, 2023 at 3:05 PM. (h2020restore.eu)

They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation. (lookformedical.com)

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)

New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
To help venous blood return in a patient who is in shock, the nurse should elevate the patient's legs no more than 45 degrees. (rnpedia.com)
By making normal cells more resistant to chemotherapeutic agents, a patient's tolerance for cytotoxicity is improved, which, in turn, also improves the effectiveness of chemotherapy. (justia.com)

citation needed] Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. (wikipedia.org)
They hypothesized that genes important to embryonic stem cell (ESC) function might be able to induce an embryonic state in adult cells. (wikipedia.org)

In their immature state, DC reside in the peripheral tissues, such as the skin, airways and intestine, where they function as the "sentinels" of the immune system, i.e. they patrol the body to capture antigens, including self-antigens, invading pathogens and certain malignant cells. (h2020restore.eu)

One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
This cell therapy, a type of personalised medicine, is currently being lined up for an initial Phase 1 study in patients with MS. The researchers have developed what are known as 'tolerance-inducing' or tolerogenic dendritic cells (tolDC) - a special category of immune cells that function as the immune system's master switch. (h2020restore.eu)
Unfortunately, scientists have yet to be able to locate specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib). (justia.com)

These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. (wikipedia.org)

A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
White blood cells formed in the body's lymphoid tissue. (lookformedical.com)

Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
Because chemotherapy affects cell division, both normal and cancerous cells are susceptible to the cytotoxic effects of chemotherapeutic agents. (justia.com)
Another method of the invention comprises administering a cell growth inhibitor to the subject and administering to the subject a chemotherapy agent. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)

We previously generated a doxycycline-inducible H2B-mTurq2 reporter in hiPSCs to track cells and study cell division and apoptosis. (bvsalud.org)
An induced pluripotent stem cell (iPSC) line, in which a H2B-fluorescent protein fusion is temporally expressed, is a valuable tool to track cells and study cell divisions and apoptosis. (bvsalud.org)
Cell apoptosis was analyzed by flow cytometry. (degruyter.com)
Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)

A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. (lookformedical.com)

This book also has a dedicated section on Regenerative Medicine with chapters on platelet rich plasma, stem cell therapy, and intradiscal regenerative therapy. (nshealth.ca)
Stem cell therapy aims to use special regenerative cells (stem cells) to repopulate areas of damage that result from spinal cord injuries, with the hope of improving the ability to move ("motor outcomes") and to feel ("sensory outcomes") beyond the site of the injury. (regenerativemedicine.net)

In the field of stem cells, cumulative evidence has shown that mitochondrial transfer contributes to stem cell-triggered repair of damaged cells [ 9 ]. (biomedcentral.com)

Hence, we established a two-phase expansion protocol with IL-15 to induce an early NK cell expansion, followed by short exposure to IL-21 that boosted the cytotoxic activity of NK cells against RMS cells. (frontiersin.org)

Over the past half century, this technique has been used with increasing frequency to treat numerous malignant and nonmalignant diseases. (medscape.com)
The Internal Medicine Dept. I provides complete diagnostics and therapy of non-malignant and malignant diseases: a wide spectrum of cancers, blood disorders including coagulating disturbances, diseases of the gastro-intestinal and respiratory tract and infectious diseases including HIV and AIDS. (uniklinikum-dresden.de)
Where the diagnosis and treatment of malignant diseases requires interdisciplinary action, we collaborate with the Dresden University ComprehensiveCentre. (uniklinikum-dresden.de)
All patients with malignant lung diseases will be supported inderdisciplinarily by the collegues of the University CancerCenter to safeguard the post possible way of treatment. (uniklinikum-dresden.de)
Collectively, although scientists are increasingly aware of mitochondria's dynamic and transferable capabilities of mitochondria, the unclear mechanism and effectiveness of mitochondrial transfer/transplantation therapy limit its widespread application in diseases. (biomedcentral.com)
In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)

Symptoms are due to lack of sufficient oxygenation of various tissues due to reduced oxygen carrying capacity of sickled RBC and also reduced number of RBC(due to destruction of sickled RBC by immune system and reduced life span of sickled RBC's), blockages of blood vessels supplying various organs causing Infarction, stressed out immune system fighting with sickled RBC's and its complications. (atomictherapy.org)

Kondziolka and colleagues used N-Tera 2 cells derived from a lung metastasis of a human testicular germ cell tumour that when treated with retinoic acid generate postmitotic neurons that maintain a fetal neuronal phenotype indefinitely in vitro (LBS neurons). (bmj.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)

Based on these findings, the researchers proposed the bold idea of directly transplanting entire mitochondria, rather than drugs or whole cells, into lesions to explore the rescue effects of exogenous mitochondria. (biomedcentral.com)

In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
ReSToRe will test a new therapeutic approach based on patients' own cells. (h2020restore.eu)
Until recently, the treatment of cancer has been largely focused on the development of therapeutic agents or techniques that kill cancer cells. (justia.com)

However, since the generation of embryonic stem cells involves destruction (or at least manipulation) of the pre-implantation stage embryo, there has been much controversy surrounding their use. (wikipedia.org)
This study demonstrated safety and feasibility of stereotactic cell implantation, although there was no significant improvement in functional outcomes. (bmj.com)
Permanent Percutaneous Spinal Cord Stimulator Implantation: Cervical/Lumbar -- 19. (nshealth.ca)
These limitations hamper each individual study's statistical power to detect the true effects of the stem cell implantation. (regenerativemedicine.net)

A systematic survey of the scientific literature shows that stem cell therapy can have a statistically significant impact on animal models of spinal cord injury, and points the way for future studies. (regenerativemedicine.net)

dubious - discuss] In his Nobel seminar, Yamanaka cited the earlier seminal work of Harold Weintraub on the role of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs. (wikipedia.org)

Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)

Preclinical studies suggest that cell therapy may be safe and effective in improving functional outcomes. (bmj.com)

6) The total cell count and neutrophil count in the alveolar lavage fluid of rats in the LPS-low, LPS-mid, and LPS-high groups increased, while the mass concentration of TNF-α in the alveolar lavage fluid and IL-6 in the serum increased. (alljournal.ac.cn)

The most well-known type of pluripotent stem cell is the embryonic stem cell. (wikipedia.org)
Patient-matched embryonic stem cell lines can now be derived using somatic cell nuclear transfer (SCNT). (wikipedia.org)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
We then validated the model in both primary mouse- and human pluripotent (embryonic) stem cell-derived cardiomyocytes showing that field potentials measured in MEAs could be converted to action potentials that were essentially identical to those determined directly by electrophysiological patch clamp. (bvsalud.org)

Cell therapy may provide a promising new treatment for stroke reducing stroke-related disability. (bmj.com)
Further investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods, cell dosing, type of cells used, timing of delivery, infarct size and location of infarct that are likely to benefit from cell therapy. (bmj.com)
Cell therapy is one approach to enhancing recovery after stroke. (bmj.com)
A main challenge of NK cell therapy is that it requires a high amount of functional NK cells. (frontiersin.org)
That is the day to celebrate global solidarity and hope for all people living with MS. With the entire international ReSToRe team , we are committed to find a solution for this devastating disease by bringing an antigen-specific tolerance-inducing dendritic cell (tolDC) therapy to treat MS patients to the clinic. (h2020restore.eu)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
Will Stem Cell Therapy Help Cure Spinal Cord Injury? (regenerativemedicine.net)

Spinal Cord Stimulation, Cervical: Trialing -- 15. (nshealth.ca)
Spinal Cord Stimulation: Thoracic and Lumbar Trial -- 16. (nshealth.ca)
Spinal Cord Stimulation Hybrid Lead Array: Epidural and Peripheral Nerve Field Stimulation Trial -- 17. (nshealth.ca)
Spinal Cord Stimulation for Chronic Abdominal Pain -- 20. (nshealth.ca)
Spinal Cord Stimulation: Pelvic Pain -- 21. (nshealth.ca)
H2020 ReSToRe is a joint initiative by researchers and clinicians from Belgium, Spain, the Netherlands and Germany to find a cure for multiple sclerosis (MS), a condition that affects the brain and spinal cord. (h2020restore.eu)
High-profile campaigners like the late actor Christopher Reeve, himself a victim of sports-related spinal cord injury, have placed high hopes in stem cell transplantation. (regenerativemedicine.net)
Many studies have been performed that involve animal models of spinal cord injury (mostly rats and mice), but these are limited in scale by financial, practical, and ethical considerations. (regenerativemedicine.net)
In this case the authors assessed 156 published studies that examined the effects of stem cell treatment for experimental spinal injury in a total of about 6000 animals. (regenerativemedicine.net)
The authors went on to use their analysis to explore the effects of bias (whether the experimenters knew which animals were treated and which untreated), the way that the stem cells were cultured, the way that the spinal injury was generated, and the way that outcomes were measured. (regenerativemedicine.net)

It is also clear that pro-mitotic factors such as C-MYC/L-MYC or repression of cell cycle checkpoints, such as p53, are conduits to creating a compliant cellular state for iPSC reprogramming. (wikipedia.org)

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
In summary, this two-phased feeder cell-free ex vivo culturing protocol combined efficient expansion and high cytolytic functionality of NK cells for treatment of radiation-resistant RMS. (frontiersin.org)
Surgical treatment of a gastric ulcer includes severing the vagus nerve (vagotomy) to reduce the amount of gastric acid secreted by the gastric cells. (rnpedia.com)
Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)

10 11 Using a similar stereotactic approach implanting cells into the basal ganglia, Savitz and colleagues transplanted LGE cells (fetal porcine striatum-derived cells, Genvec) in five patients. (bmj.com)

Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)

In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
The level of miR-128-3p was decreased, and TGFBR2 expression was increased in serum samples of sepsis patients and LPS-induced HK2 cells. (degruyter.com)
Splenic functions are reduced considerably in SCD patients due to frequent splenic infarctions reducing its capability to remove defective cells and certain organisms from circulation, this reduces immunity of person significantly thus increasing the risk of frequent infections. (atomictherapy.org)
Parvovirus B19, which causes reduced production of RBC by infecting and destroying RBC's precursor cells, is a major concern in SCD patients as the RBC lifespan is 10-20days in SCD patient as compared to 90-120days in normal individuals. (atomictherapy.org)

Blood pressure can be measured directly by intra-arterial insertion of a catheter connected to a pressure-monitoring device. (rnpedia.com)
When mean arterial pressure falls below 60 mm Hg and systolic blood pressure falls below 80 mm Hg, vital organ perfusion is seriously compromised. (rnpedia.com)

Shinya Yamanaka was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent. (wikipedia.org)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)

In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

Due to reduced electricity of RBC their flexibility reduces which impairs their ability to flex and pass through small capillaries also they get deformed as they aren't able to maintain their patent form due to loss of elasticity resulting in deformed RBC in sickled shape and also due to the shape they get caught up with each other and causing blockages in blood vesseles resulting into Infarction in corresponding tissue. (atomictherapy.org)
The research group has already worked for several years to develop electrodes that are thin and flexible enough not to disturb the brain tissue, and with material that does not irritate the cells nearby. (regenerativemedicine.net)

The fibroblasts were engineered so that any cells reactivating the ESC-specific gene, Fbx15, could be isolated using antibiotic selection. (wikipedia.org)
We demonstrated that fully functional EHTs could be generated from physiologically relevant combinations of hiPSC-derived cardiomyocytes (70%), cardiac fibroblasts (15%) and cardiac endothelial cells (15%), using as few as 1.6 × 104 cells. (bvsalud.org)

In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)
Therefore, ex vivo NK cell expansion protocols are currently being developed. (frontiersin.org)
In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
In this context, cytokines have been shown to activate NK cells potently during ex vivo expansion ( 9 - 12 ). (frontiersin.org)

However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)

3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)

Signs and symptoms of sickle cell disease usually starts appearing from early childhood like dactylitis frequently presenting as earliest sign in many cases around age of 6mnths with dactilitis usually being the very early symptoms. (atomictherapy.org)
Symptoms may vary from chronic symptoms like retinopathy, CKD, hematopoietic ulcers to severe acute complaints like "Sickle Cell Crisis" triggered by dehydration, infections, acidosis and other obscure reasons. (atomictherapy.org)

We are pleased that we have succeeded in developing a functioning nano-electrode, getting it into place, and capturing signals from nerve cells, says Prof. Jens Schouenborg. (regenerativemedicine.net)

In MS, the immune system has derailed, setting a cascade of processes in motion that ultimately results in damage to the body's own cells and molecules. (h2020restore.eu)

Multi electrode arrays (MEAs) are increasingly used to detect external field potentials in electrically active cells. (bvsalud.org)
With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)

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