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GlycolipidsCarbohydratesAntigensCarbohydrate MetabolismDietary CarbohydratesAntigens, NeoplasmCarbohydrate SequenceMolecular Sequence DataAntigens, BacterialAntigens, SurfaceGlycosphingolipidsAmino Acid SequenceChromatography, Thin LayerAntigens, ViralCarbohydrate ConformationT-LymphocytesCell Line, TumorEpitopesAntibodies, MonoclonalCell LineGlobosidesRecognition (Psychology)Receptors, Antigen, T-CellH-2 AntigensTumor Markers, BiologicalMice, Inbred BALB CGangliosidesHistocompatibility Antigens Class IAntigens, Tumor-Associated, CarbohydrateProtein BindingSulfoglycosphingolipidsBase SequenceLymphocyte ActivationAntigen PresentationHLA AntigensTumor Necrosis Factor-alphaHistocompatibility Antigens Class IIAntigens, CDCytotoxicity, ImmunologicMice, Inbred C57BLGlycoproteinsTumor BurdenAntigens, CD1Clone CellsNeoplasmsNeoplasms, ExperimentalLectinsHLA-A2 AntigenEpitopes, T-LymphocyteCells, CulturedMutationPeptidesOligosaccharidesKiller Cells, NaturalHLA-DR AntigensAntigens, Polyomavirus TransformingFlow CytometryAntigens, CD15Antigens, ProtozoanBinding SitesTumor Cells, CulturedT-Lymphocytes, CytotoxicForssman AntigenCerebrosidesPeptide FragmentsBlood Group AntigensHybridomasCarcinoembryonic AntigenRNA, MessengerMajor Histocompatibility ComplexRecombinant ProteinsTransfectionCross ReactionsTime FactorsLigandsModels, MolecularNeoplasm ProteinsCell AdhesionHistocompatibility AntigensSignal TransductionAntigens, FungalCell DivisionPolysaccharidesAntigens, Viral, TumorCD8-Positive T-LymphocytesMembrane ProteinsTumor Suppressor Protein p53HLA-A AntigensEnzyme-Linked Immunosorbent AssayB-LymphocytesAntigens, HelminthWilms TumorGenes, Tumor SuppressorKineticsGalactoseAdenocarcinomaLewis Blood-Group SystemCell MembraneMice, TransgenicRecombinant Fusion Proteins
GlycoproteinProliferationMetastasisIntracellularProteinsProgressionInteractionsSubstancesEndothelial cellsLymphocyteLigandPolysaccharidesInhibitTherapiesAberrantInduceInnate and adaptivePathologicalImmunologyAccumulationChainsRenalTissueLipidsReceptorsInteractionHumansBiologicalDendriticSubsetsMammalianAdhesionSystemicBindCalciumMediateBacteriaImmune systemRoleGeneticsPresentationMolecularBiologyMechanismAutoimmuneCancerSurfaceAminoParticlesActivityPathogenicPresentSpecificFoundLungDevelopmentMake
Glycoprotein2
  • The oligosaccharide chains of glycoprotein and glycolipid are often terminated by sialic acids, which play intensely important role in regulating physiologically and pathologically interactions with ligands [ 9 ]. (biomedcentral.com)
  • Glycoprotein or glycolipid. (musicastorrent.com)
Proliferation5
  • In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
  • Western blotting, Co-immunoprecipitation (CO-IP), electrophoretic mobility shift assay and Cell Counting Kit-8 (CCK8) were performed to confirm the effect of X-ray irradiation on A549 cell proliferation and its mechanism. (bvsalud.org)
  • RESULTS: The expressions of fucosyltransferase IV and Lewis Y were decreased after X-ray irradiation, thus inhibiting the proliferation of A549 lung cancer cells. (bvsalud.org)
  • Activity is correlated with cellular proliferation, which suggests Runx2 phosphorylation may also be related to Runx2-mediated cellular proliferation and cell. (musicastorrent.com)
  • Mediated by the molecular processes of gene regulation and involves the cellular processes of cell proliferation, morphogenesis and cell differentiation. (musicastorrent.com)
Metastasis3
  • The role of CS-GAGs in metastasis was tested using the 4T1 murine mammary cell line (10 mice per group). (biomedcentral.com)
  • Although most patients with localized tumors can be cured with surgical therapies, 20-30 % of the patients without any evidence of metastasis will develop relapse and/or metastatic RCC in the future [ 3 ]. (biomedcentral.com)
  • There can, however, be few similarities between the two, as the bone marrow is a common site of metastasis of solid tumors too [6]. (fortunejournals.com)
Intracellular3
  • Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release, cell adhesion/migration and apoptosis. (biomedcentral.com)
  • No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
  • Finally, we demonstrated that defective BTLA function can be corrected by restoring intracellular trafficking and by normalizing the lipid metabolism in lupus CD4+ T cells. (cnrs.fr)
Proteins4
  • It binds to adhesion proteins such as integrins and blocks further binding to other cells or the extracellular matrix. (wikipedia.org)
  • They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells. (lookformedical.com)
  • These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell. (lookformedical.com)
  • Apfel R, Lottspeich F, Hoppe J, Behl C, Durr G, Bogdahn U. Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. (2medicalcare.com)
Progression1
  • In accordance, attempts have been made to establish a link between the immune system and the tumor microenvironment, to comprehend tumor progression and achieve effective therapeutic approaches. (fortunejournals.com)
Interactions4
  • Tumor-associated glycans play a significant role in promoting aggressive and metastatic behavior of malignant cells [ 1 - 5 ], participating in cell-cell and cell-extracellular matrix interactions that promote tumor cell adhesion and migration. (biomedcentral.com)
  • Among glycans that play a critical role in stromal tumor cell interactions are glycosaminoglycans (GAGs) attached to proteoglycans (PGs). (biomedcentral.com)
  • These interactions can play a role in cellular adhesion and other cellular recognition events. (musicastorrent.com)
  • Intramolecular carbohydrate-protein interactions. (musicastorrent.com)
Substances1
  • This "depot" was formed by associating the antigen with substances able to persist at the injection site, such as aluminum salts or emulsions. (mdpi.com)
Endothelial cells3
  • In previous studies we found that CS/DS-GAGs are expressed on the cell surface of murine and human breast cancer cell lines with high metastatic capacity and that they play a major role in P-selectin binding and P-selectin-mediated adhesion of cancer cells to platelets and endothelial cells [ 24 ]. (biomedcentral.com)
  • The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (lookformedical.com)
  • Bayas A, Hummel V, Kallmann BA, Karch C, Toyka KV, Rieckmann P. Human cerebral endothelial cells are a potential source for bioactive BDNF. (2medicalcare.com)
Lymphocyte1
  • Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function-associated antigen-1. (2medicalcare.com)
Ligand3
  • The concave side forms a groove in which the carbohydrate ligand can bind, and which is long enough to hold about a linear tetrasaccharide. (wikipedia.org)
  • The strength of ligand binding is determined by a number of factors: The multivalency of both of ligand and the galectin, the length of the carbohydrate and the mode of presentation of ligand to carbohydrate recognition domain. (wikipedia.org)
  • CSPG4 serves as a P-selectin ligand through its CS chain and participates in P-selectin binding to the highly metastatic breast cancer cells. (biomedcentral.com)
Polysaccharides3
Inhibit2
  • The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
  • Furthermore, we found an impaired capacity of BTLA to inhibit T cell activation in SLE due to a poor BTLA recruitment to the immunological synapse following T cell stimulation. (cnrs.fr)
Therapies1
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
Aberrant1
  • Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. (biomedcentral.com)
Induce1
  • They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. (lookformedical.com)
Innate and adaptive1
  • Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. (intestinal-microbiota.de)
Pathological2
  • even tumors with the comparable stage or the same pathological type could show a wide variation in biological behavior and clinical outcomes. (biomedcentral.com)
  • The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
Immunology2
  • When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (lookformedical.com)
  • author = {Matthieu Sawaf and Hélène Dumortier and Fanny Monneaux}, doi = {10.1155/2016/5767106}, issn = {2314-7156}, year = {2016}, date = {2016-01-01}, journal = {Journal of Immunology Research}, volume = {2016}, pages = {5767106}, abstract = {Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. (cnrs.fr)
Accumulation1
  • The storage of iron or copper can prevent their harmful accumulation in cells. (biomedcentral.com)
Chains2
  • Change in the structure of glycan chains is one of the most shared features of the malignant transformation [ 8 ]. (biomedcentral.com)
  • The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). (lookformedical.com)
Renal2
  • However, little is known about prognostic significance of ST3GAL-1 in clear cell renal cell carcinoma (ccRCC). (biomedcentral.com)
  • Renal cell carcinoma (RCC) is the most common solid lesion within kidney and accounts for 2-3 % of all cancers in adults [ 1 ]. (biomedcentral.com)
Tissue4
  • In addition, CSPG4 and CHST11 were over-expressed in tumor-containing clinical tissue specimens compared with normal tissues. (biomedcentral.com)
  • Saliva binding assays showed that only GII.4 interacted with nonsecretor saliva via the Lewis a (Lea) antigen Surprisingly, the three genotypes interacted with nonsecretor enterocytes via the Lea antigen on duodenal tissue blocks, which were more relevant for HuNoV/HBGA studies. (bvsalud.org)
  • The Lea antigen also played a pivotal role in the recognition of GII.4 and GII.17 particles by inflammatory colon tissue from a nonsecretor Crohn's disease patient. (bvsalud.org)
  • In addition to mechanisms of microbe-host interaction, the role of cell stress related to unfolded protein responses (UPR) of the endoplasmic reticulum (ER) and mitochondria is characterized in the context of inflammatory and tumorigenic processes using novel tissue-specific mouse models. (intestinal-microbiota.de)
Lipids1
  • 6) Lysosomes are the pools of metabolites in cells, including amino acids, sugars, lipids and nucleotides. (biomedcentral.com)
Receptors3
  • In innate immunity, immune cells are activated by their pattern recognition receptors (PRRs), which bind to pattern molecules of invading pathogens. (fortunejournals.com)
  • Their response involves antigen capture, enhancing their MHC-II presentation receptors and production of chemokines and/or cytokines at the site of inflammation [9]. (fortunejournals.com)
  • Coinhibitory receptors play an important role in the prevention of autoimmune diseases, such as systemic lupus erythematosus (SLE), by limiting T cell activation. (cnrs.fr)
Interaction1
  • VLP binding was observed for the three HuNoV genotypes in 10 of the 13 individuals, and competition experiments demonstrated that VLP recognition was driven by an interaction with the Lea antigen. (bvsalud.org)
Humans1
  • The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE , infecting B-cells in humans. (lookformedical.com)
Biological1
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
Dendritic1
Subsets1
  • We investigated BTLA expression on various T cell subsets, and we did not observe significant variations of BTLA expression between lupus patients and healthy controls. (cnrs.fr)
Mammalian1
  • The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. (lookformedical.com)
Adhesion1
  • When concentrations of galectin-3 are high it forms large complexes that assist in adhesion by bridging between cells or cells and the extracellular matrix. (wikipedia.org)
Systemic1
  • Follicular Helper Ŧ Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? (cnrs.fr)
Bind1
  • They cannot bind to other sugars such as mannose because this sugar will not fit inside the carbohydrate recognition domain without steric hindrance. (wikipedia.org)
Calcium1
Mediate1
  • 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
Bacteria1
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
Immune system1
  • The TLRs and CLRs of the immune cells work in coordination with the immune system. (fortunejournals.com)
Role3
  • This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
  • Overall, our data clearly showed that Lea has a pivotal role in the recognition of HuNoV in nonsecretors. (bvsalud.org)
  • H. pylori cytotoxin associated antigen A (CagA) plays a crucial role in the development of gastric cancer. (bvsalud.org)
Genetics1
Presentation1
  • Quantitative real-time PCR (qRT-PCR) and flow cytometry assays were used to detect the expression of genes involved in the sulfation and presentation of chondroitin in several human breast cancer cell lines. (biomedcentral.com)
Molecular1
  • The identification of Pathogen-Associated Molecular Patterns (PAMPs) has greatly advanced our understanding of how adjuvants work beyond the simple concept of extended antigen release and has accelerated the development of novel adjuvants. (mdpi.com)
Biology1
Mechanism2
  • Objective: To identify the mechanism of down-regulation of Lewis Y antigen caused by X-ray irradiation. (bvsalud.org)
  • The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. (mdpi.com)
Autoimmune1
  • B cell responses to the PNS protein P0 in experimental autoimmune neuritis. (2medicalcare.com)
Cancer5
  • We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. (biomedcentral.com)
  • Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
  • The CHST11 gene was highly expressed in aggressive breast cancer cells but significantly less so in less aggressive breast cancer cell lines. (biomedcentral.com)
  • The carrier proteoglycan CSPG4 was highly expressed on the aggressive breast cancer cell lines and contributed to the P-selectin binding and CS-A expression. (biomedcentral.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
Surface3
  • Enzymatic removal of tumor-cell surface CS-GAGs significantly inhibited lung colonization of the 4T1 murine mammary cell line ( P = 0.0002). (biomedcentral.com)
  • Cell surface P-selectin binding depends on CHST11 gene expression. (biomedcentral.com)
  • Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. (lookformedical.com)
Amino1
  • The galectin carbohydrate recognition domain (CRD) is constructed from beta-sheet of about 135 amino acids. (wikipedia.org)
Particles1
Activity1
  • It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)
Pathogenic1
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Present2
  • HuNoV infection affects mainly secretor individuals where ABO(H) and Lewis histo-blood group antigens (HBGAs) are present in the small intestine. (bvsalud.org)
  • The complexity of the human bone marrow, with context to haematological malignancies, is more difficult to elucidate with the present strategies compared to the niche of solid tumors. (fortunejournals.com)
Specific1
  • Competition experiments using histo-blood group antigen (HBGA)-specific monoclonal antibodies (MAbs) demonstrate that GII.4 VLPs recognized the Lewis a (Lea) antigen. (bvsalud.org)
Found2
Lung1
  • Removal of CS-GAGs greatly reduces metastatic lung colonization by 4T1 cells. (biomedcentral.com)
Development1
  • Collectively, our results evidence that the BTLA signaling pathway is altered in SLE T cells and highlight the potential of targeting this pathway for the development of new therapeutic strategies in lupus. (cnrs.fr)
Make1