• Richter's transformation (RT), also known as Richter's syndrome, is the conversion of chronic lymphocytic leukemia (CLL) or its variant, small lymphocytic lymphoma (SLL), into a new and more aggressively malignant disease. (wikipedia.org)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
  • Immunologic classification of leukemia and lymphoma. (bdbiosciences.com)
  • When these unique processes go wrong, the defective lymphocytes give rise to lymphoid cancers, lymphoma, myeloma and lymphocytic leukemia. (bccancerfoundation.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • Ibrutinib has been granted Breakthrough Therapy Designation as a monotherapy in the treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma with deletion of the short arm of chromosome 17 (del17p). (jnj.com)
  • The effectiveness and safety of ibrutinib alone or in combination with other treatments is being studied in several B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Waldenström's macroglobulinemia and multiple myeloma. (jnj.com)
  • A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. (lookformedical.com)
  • Richter's Transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma or Hodgkin lymphoma (both are B-cell origin) are well described in literature. (najms.com)
  • Michelis FV, Kourti G, Skertsou M. Richter transformation of chronic lymphocytic leukemia into composite diffuse large B-cell and Hodgkin lymphoma. (najms.com)
  • Transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma to interdigitating dendritic cell sarcoma: Evidence for transdifferentiation of the lymphoma clone. (najms.com)
  • Shao H, Xi L, Raffeld M, Feldman AL, Ketterling RP, Knudson R. Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: A study of seven cases. (najms.com)
  • IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. (najms.com)
  • Leukemia & Lymphoma , 21 (5-6), pp. 497-500. (ntu.ac.uk)
  • Venetoclax is active in other lymphoid malignancies including several B cell non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, with the highest intrinsic sensitivity observed in mantle cell lymphoma and Waldenstrom macroglobulinemia. (biomedcentral.com)
  • We study processes within lymphocytes and those outside (in the immune microenvironment) that drive the development of lymphoid malignancies including B- and T- cell acute lymphoblastic leukemia (ALL) and lymphomas. (postdocjobs.com)
  • It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. (biogenex.com)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • Baer MR, Krantz SB, Cousar JB, Glick AD, Collins RD. Malignant histiocytoses developing in patients with b-cell lymphomas. (najms.com)
  • Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. (thermofisher.com)
  • This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. (fgf-erk.com)
  • Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
  • The most common malignant neoplasms of childhood are the leukemias, central nervous system tumors, and the lymphomas 2 . (bvsalud.org)
  • CLL is the circulation of malignant B lymphocytes with or without the infiltration of these cells into lymphatic or other tissues while SLL is the infiltration of these malignant B lymphocytes into lymphatic and/or other tissues with little or no circulation of these cells in the blood. (wikipedia.org)
  • These symptoms are often accompanied by the development of extra-nodal disease, i.e. swelling or tumors due to the infiltration of malignant B lymphocytes into the gastrointestinal tract, bone, skin, central nervous system, spleen, liver, urinary bladder, thyroid gland, and/or pulmonary pleurae. (wikipedia.org)
  • Occasionally, the paraneoplastic syndromes of immune mediated hemolytic anemia or thrombocytopenia will be present secondary to protein production by malignant lymphocytes. (vin.com)
  • We apply this to develop therapies that specifically target malignant lymphocytes. (postdocjobs.com)
  • In lymphoid cancer the cells which turn malignant are lymphocytes, the white blood cells of which our immune system is composed. (bccancerfoundation.com)
  • We have described previously unknown errors in the genetic code of lymphocytes that transform normal lymphocytes into malignant ones. (bccancerfoundation.com)
  • Chronic Lymphocytic Leukemia (CLL) is a slow-growing cancer of the white blood cells (lymphocytes), most commonly B-cells. (jnj.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. (thermofisher.com)
  • Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of phenotypically mature malignant B lymphocytes. (merckmanuals.com)
  • The white blood cells (leukocytes) are further divided into phagocytes or myeloid (neutrophils, eosinophils, basophils, monocytes) and immunocytes or lymphoid (lymphocytes). (medscape.com)
  • TdT is a nuclear enzyme expressed by immature lymphoid malignancies, but the expression pattern of this marker is not well characterized in the skin. (karger.com)
  • Lymphoid malignancies are cancers of immune cells that have been transformed to grow out of control. (rochester.edu)
  • We propose to utilize these xenograft models to study the critical microenvironment cells and factors required for growth and survival of lymphoid malignancies. (rochester.edu)
  • Our long-term goal is to apply these studies toward the identification of unique cell subpopulations and factors in the local tumor microenvironment of lymphoid malignancies that will aid in the diagnosis and treatment of these cancers. (rochester.edu)
  • Additionally, we aim to advance a laboratory model of the local tumor microenvironment that will accelerate testing of therapeutic drug candidates to promote rapid clinical benefit for patients with lymphoid malignancies. (rochester.edu)
  • Acute myeloid leukemia (AML), which accounts for 15-20% of all leukemias in childhood, belongs to a heterogeneous group of hematopoietic malignancies of monoclonal origin, which result from the malignant transformation of a stem cell. (bvsalud.org)
  • These malignancies are further characterized by the maturity and differentiation of the individual cell types and are divided into acute leukemias such as acute myeloid leukemia and acute lymphoblastic leukemia and chronic leukemias such as chronic myeloid leukemia and chronic lymphocytic leukemia. (medscape.com)
  • As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
  • Chronic leukemia showed higher treatment duration. (sld.cu)
  • There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
  • Chronic lymphocytic leukemia was retained in 3 patients (3.5%) and Castleman disease in 1 patient. (scirp.org)
  • Engraftment of human chronic lymphocytic leukemia cells (hCD20+, brown) in an immune deficient mouse spleen showing typical follicle-like structures (arrows, Hemotoxylin and Eosin stain, H&E). (rochester.edu)
  • Chronic leukemias have more mature cells than do acute leukemias. (msdmanuals.com)
  • Usually the cause is apparent, but apparent benign neutrophilia can be mimicked by chronic neutrophilic leukemia or chronic myeloid leukemia. (msdmanuals.com)
  • Hallek M, Cheson BD, Catovsky D. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. (najms.com)
  • Lortholary P, Boiron M, Ripault P. chronic lymphoid leukemia secondarily associated with a malignant reticulopathy: Richter's syndrome. (najms.com)
  • Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. (najms.com)
  • Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome. (thermofisher.com)
  • The only currently approved BH3-mimetic, the selective BCL2 inhibitor venetoclax, is highly efficacious in chronic lymphocytic leukemia and has rapidly advanced to an approved standard of care in frontline and relapsed disease in combination with anti-CD20 monoclonal antibodies. (biomedcentral.com)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • It is a clonal genetic heterogeneous disease generally thought to arise from the malignant transformation and expansion of a single lymphoid progenitor at various stages of development ( 3 - 5 ). (frontiersin.org)
  • ALL is a malignant clonal proliferation of lymphoid progenitor cells, most commonly of the B-cell lineage (B-ALL). (biomedcentral.com)
  • Acute lymphoblastic leukemia (ALL) results from malignant transformation of lymphoid progenitor cells, and is a blood cancer found predominantly in the pediatric population. (simplyblood.org)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant. (fgf-erk.com)
  • The current approach to classifying leukemia is based on the 2016 World Health Organization (WHO) system ( classification for hematopoietic neoplasms ). (msdmanuals.com)
  • These are the malignant proliferations of abnormal clones of white blood cells within the bone marrow that are broadly categorized into lymphoid and myeloid neoplasms depending on the type of white cell proliferation. (medscape.com)
  • Greaves MF, Hariri G, Newman RA, Sutherland DR, Ritter MA, Ritz J. Selective expression of the common acute lymphoblastic leukemia (gp100) antigen on immature lymphoid cells and their malignant counterparts. (bdbiosciences.com)
  • Among the leukemias, the most prevalent type is acute lymphoblastic leukemia (ALL), which is characterized by accumulation of immature lymphoid cells in the bone marrow 2,3 and accounts for roughly 80% of all cases of leukemia in childhood. (bvsalud.org)
  • Liposarcomas are malignant tumors of the lipocytes ( fat cells ) and are not commonly found in pet birds. (ivis.org)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • CLL/SLL is the most common adult leukemia in Western countries, accounting for 1.2% of the new cancers diagnosed each year in the United States. (wikipedia.org)
  • Building on the insight we had gained in the 1980s and 1990s into why lymphoid cancers develop and how they respond to treatment, we turned our attention to the basic molecular biology of these diseases. (bccancerfoundation.com)
  • Lymphoid cancers are unique among human cancers in several aspects. (bccancerfoundation.com)
  • My research group concentrates on understanding the underlying genetic instructions that cause lymphoid cancers. (bccancerfoundation.com)
  • Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
  • Multiple myeloma (MM) is a malignant plasma cell (PC) disorder accounting for approximately 10% of all hematological cancers. (oncotarget.com)
  • In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. (biogenex.com)
  • A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
  • They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder. (lookformedical.com)
  • Later came to be used to describe all forms of lymphoid neoplastic proliferations that arise as discrete tissue masses. (fdocuments.net)
  • Acute leukopenia, with almost total absence of granular leukocytes, leukoblastic groups and lymphoid tissue in the bone marrow, was reported in the case of a 36-year-old chemist who had worked with radium for 14 years (Reitter and Martland 1926). (cdc.gov)
  • Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
  • Acute lymphoblastic leukemia (ALL) is a malignant expansion of lymphoblasts in the bone marrow, blood, and extramedullary tissues [ 1 ]. (karger.com)
  • Decreased WBC count, leukopenia, is seen when supply is depleted by infection or treatment such as chemotherapy or radiation therapy, or when a hematopoietic stem cell abnormality does not allow normal growth/maturation within the bone marrow, such as myelodysplastic syndrome or leukemia. (medscape.com)
  • Anti-CD20 can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, and B cell localization in tissues. (biogenex.com)
  • It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. (biogenex.com)
  • Through these multiple actions, BTK helps to direct malignant B-cells to lymphoid tissues, thus allowing access to a microenvironment necessary for survival. (jnj.com)
  • After more than four decades of intensive research, the cellular origins of acute lymphocytic leukemia (ALL) have been well defined, and several distinct genetic mechanisms that lead to malignant transformation of these cells have been identified ( 1 - 4 ). (aacrjournals.org)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
  • 50 × 10 9 /L) not caused by malignant transformation of a hematopoietic stem cell. (msdmanuals.com)
  • After myeloma, macroglobulinemia is the 2nd most common malignant disorder associated with a monoclonal gammopathy. (merckmanuals.com)
  • The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
  • Very severe infiltration may cause myelophthisis (crowding out of normal marrow elements by malignant cells) and may be manifested as peripheral cytopenias and lymphoid leukemia. (vin.com)
  • The HaeMa laboratory in Mannheim covers a broad range of hematological diagnostics for detecting diseases and disorders affecting the blood cells - from reactive changes to leukemias. (jenoptik.com)
  • To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
  • show that this approach can detect characteristic changes that affect blood cells as a result of malaria, spherocytosis, bacterial and viral infections, and leukemia. (elifesciences.org)
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • RUNX1-positive leukemia cells in preclinical models. (lu.se)
  • Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. (digibookee.com)
  • Recently, isolated human lymphoid malignant cells have been successfully grown outside of the patient after transplant into immune deficient mice (a "xenograft", or cross-species transplant). (rochester.edu)
  • Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms related to cytopenias. (msdmanuals.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. (biomedcentral.com)
  • This seminal observation instigated the ensuing decades of research that characterized the complex mechanisms of intrinsic cell death and lay the foundations for the development of therapeutics capable of restoring apoptosis in malignant cells. (biomedcentral.com)
  • Perhaps most importantly, pharmacological inhibition of CDC42 induced cell death in ETV6-RUNX1+ leukemia cells and this was associated with suppression of STAT3-regulated survival programs. (simplyblood.org)
  • ALL may be distinguished from other malignant lymphoid disorders by the immunophenotype of the cells, which is similar to B- or T-precursor cells. (medscape.com)
  • Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (merckmanuals.com)
  • Cyclophosphamide is a antineoplastic , immunosuppressive agent that is FDA approved for the treatment of malignant diseases , minimal change nephrotic syndrome in pediatric patients. (wikidoc.org)
  • Cytogenetics advances of B-ALL have led to the discovery of numerous additional genetic changes, including mutations involving key cellular pathways in lymphoid development, tumor suppression, and cell cycle regulation. (biomedcentral.com)
  • Elevated WBC, leukocytosis, is seen in response to infection, stress, inflammatory disorders (referred to as reactive leukocytosis), or abnormal production as in leukemia. (medscape.com)
  • T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, aggressive malignancy that rarely presents in the skin and is generally not considered as part of the differential diagnosis by dermatologists and dermatopathologists. (karger.com)
  • In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent childhood hematological malignancy, as well as the leading cause of childhood cancer-related mortality. (biomedcentral.com)
  • Studies on malignant melanoma have largely focused on Caucasian populations due to higher incidence in lighter-skinned individuals. (biomedcentral.com)
  • Lymphocytic infiltrates in the skin, both malignant and benign, can have overlapping clinical and histological features, presenting a diagnostic challenge. (karger.com)
  • The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
  • Malignant histiocytosis (clinical): (single agent) 40 to 50 mg/kg IV in divided doses over 2 to 5 days OR 10 to 15 mg/kg IV every 7 to 10 days OR 3 to 5 mg/kg IV twice weekly. (wikidoc.org)
  • Malignant histiocytosis (clinical): (single agent) oral cyclophosphamide is usually administered at dosages in the range of 1 to 5 mg/kg/day for both initial and maintenance dosing. (wikidoc.org)
  • A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. (lookformedical.com)
  • Immunological classification of acute myeloblastic leukemias: relevance to patient outcome. (bdbiosciences.com)
  • Lymph nodes are lymphoid organs in which the immune response develops. (scirp.org)
  • We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)
  • See the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
  • It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. (lookformedical.com)
  • Leukemic cell infiltration of the skin (i.e., leukemia cutis) typically occurs after the diagnosis of leukemia and may precede the appearance of leukemic blasts in the peripheral blood [ 2 ]. (karger.com)
  • In Experimental Hematology ("Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes", November 2020), Jacobs et al. (simplyblood.org)
  • TdT may assist dermatopathologists in discriminating malignant infiltrates of T-ALL from other conditions. (karger.com)
  • May be normal, or may reveal anemia, cytopenias or a lymphoid leukemia. (vin.com)
  • Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis? (frontiersin.org)
  • Treatment and prophylaxis of hypermenorrhea with leuprorelin in premenopausal women affected by acute leukemia at diagnosis. (ntu.ac.uk)
  • It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
  • Hypercalcemia is a paraneoplastic syndrome that occurs secondary to malignant cell production of a parathyroid hormone-related peptide (PTH-rp). (vin.com)
  • High-throughput sequencing (HTS) of the immunoglobulin heavy chain ( IgH ) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (frontiersin.org)
  • B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common pediatric neoplasm ( 1 , 2 ). (frontiersin.org)
  • Generalized reticular cell sarcoma of lymph nodes associated with lymphatic leukemia. (najms.com)
  • Diagnostic workup of a patient with pre-B-cell acute lymphoblastic leukemia. (medscape.com)
  • Acute Lymphocytic Leukemia Drug Pipeline Analysis and Therapeutic Assessment, H2 2016 - Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia Pipeline Review, H2 2016, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape. (powershow.com)
  • Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Acute Lymphocytic Leukemia Pipeline Review, H2 2016, provides an overview of the Acute Lymphocytic Leukemia (Oncology) pipeline landscape. (powershow.com)