• We found sufficient evidence related to hepatocellular carcinoma to allow us to make a favorable decision. (cms.gov)
  • Attached is a request for a technology assessment that we need in order to develop a Medicare national coverage determination for liver transplantation for malignancies other than hepatocellular carcinoma. (cms.gov)
  • The absence of NFAT2 and Egr2 in carcinoma tissues reminded us that NFAT2 may be a promising therapeutic target for hepatocellular carcinoma treatment. (researchsquare.com)
  • Hepatocellular carcinoma (HCC) has become the leading cause of deaths that are caused by all cancers worldwide [1] and the incidence and mortality of HCC are increasing at a faster pace than other cancers, which trend will continue through at least 2030 in United States [2]. (researchsquare.com)
  • N6-methyladenosine (m 6 A) modification is an emerging layer of epigenetic regulation which is widely implicated in the tumorigenicity of hepatocellular carcinoma (HCC), offering a novel perspective for investigating molecular pathogenesis of this disease. (biomedcentral.com)
  • Hepatocellular carcinoma (HCC) is one of the most prevailing malignancies with poor long-term prognosis and high mortality [ 1 ]. (biomedcentral.com)
  • Additionally, hepatocellular carcinoma incidence was increased in male mice. (cdc.gov)
  • Quinoline administered by intraperitoneal injection in CD-1 mice induced lymphoma in females and hepatocellular carcinoma in males. (cdc.gov)
  • Hepatic cholesterol accumulation and hypercholesterolemia are implicated in hepatocellular carcinoma (HCC). (nature.com)
  • In particular, obesity is an independent risk factor for the development of hepatocellular carcinoma (HCC). (elsevier.es)
  • FAP expression is associated with a poor prognosis in a variety of tumors, such as colon ( 5 ), pancreatic ( 6 ), ovarian ( 7 ), and hepatocellular carcinoma ( 8 ). (snmjournals.org)
  • The ultrasonogram shows a hyperechoic mass representing hepatocellular carcinoma. (medscape.com)
  • piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination. (physiciansweekly.com)
  • Malignancy, e.g. renal cell carcinoma. (wikipedia.org)
  • Aside from SCC, this peptide ligand of EGFr offers potential applications in focusing on treatments of individuals with EGFr-positive malignancies, such as non-small cell lung malignancy, esophageal, gastric, prostate, colorectal, bladder, pancreatic, ovarian and renal malignancies. (cancer-pictures.org)
  • Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. (scirp.org)
  • We expose the case of a patient with clear cell type renal cell carcinoma, with a previously known bone metastasis of renal origin and symptomatic goiter containing a nodule that was found to be a metastasic lesion. (scirp.org)
  • Renal cell carcinomas (RCCs) cause for 80 to 85 percent of all primary renal neoplasm. (scirp.org)
  • Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. (scirp.org)
  • We expose the case of a patient with clear cell type renal cell carcinoma, thyroid metastasis with a previously known bone metastasis of renal origin and large goiter with compressive symptoms. (scirp.org)
  • Sternal biopsy was compatible with metastases from clear cell renal carcinoma ( Figure 1 ). (scirp.org)
  • The anatomopathological analysis of the surgical specimen described micrometastasis by clear cell renal carcinoma. (scirp.org)
  • Pazopanib is a multi-kinase inhibitor active against vascular endothelial growth factor receptors-1, -2 and -3 that is used in the therapy of advanced renal cell carcinoma and soft tissue sarcomas. (nih.gov)
  • Clinical trials of pazopanib in malignant diseases in humans have shown activity against renal cell carcinoma and soft tissue sarcoma and promising effects in ovarian and thyroid cancer. (nih.gov)
  • Melanoma and renal cell carcinoma have a well-documented tendency to develop metastases to the brain. (urotoday.com)
  • For this reason, we conducted a review of modern literature analyzing the efficacy of SRS in the management of patients with melanoma and renal cell carcinoma brain metastases. (urotoday.com)
  • Value of oesophagoscopy and bronchoscopy in diagnosis of synchronous malignancies in patients with head and neck squamous cell carcinomas: a 10-year single center experience in Chinese population. (authorea.com)
  • Objectives Routine screening of patients with head and neck squamous cell carcinomas (HNSCCs) for synchronous malignancies using oesophagoscopy and bronchoscopy had been controversial. (authorea.com)
  • Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
  • Nuclear factor of activated T cells 2 (NFAT2) has been reported to regulate the development and malignancy of few tumors. (researchsquare.com)
  • Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • Conclusion: DNA aneuploidy may be a key indicator for tumors activity and malignancy in SGTs, while the SPF has a minor role in the evaluation of SGTs activity. (researchgate.net)
  • Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)
  • However, our search of the literature did not produce a significant volume of literature, or literature of sufficiently sound methodology, to permit our staff to make a determination regarding liver transplantation for other malignant diagnoses, such as metastatic disease, bile duct carcinoma and epithelioid hemangioendothelioma. (cms.gov)
  • Berstein L, Gurney JG: Carcinomas and other malignant epithelial neoplasms. (oncolink.org)
  • Wide excision of the primary tumour bed following histological confirmation of melanoma, appendageal carcinoma, malignant connective tissue or merkel cell carcinoma of the skin may be claimed using item 31371, 31372, 31373, 31374, 31375 or 31376, depending on the location of the malignancy and the size of the excision diameter. (health.gov.au)
  • Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
  • Our findings enrich the landscape of m 6 A-modulated tumor malignancy, and provide new insights into potential biomarkers and therapeutic targets of HCC treatment. (biomedcentral.com)
  • A complete of just one 1.6 million new cases of cutaneous malignancy with 12,190 fatalities from pores and skin cancer had been reported with the American Tumor Society in 20121. (cancer-pictures.org)
  • Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor−node−metastasis prognosis classification. (nature.com)
  • There was no significant correlation of ploidy status or SPF with the tumor grades of mucoepidermoid carcinomas. (researchgate.net)
  • To our knowledge, few published reports have frequently diagnosed malignancies in the United States [1] with combined histological confirmation of NMSC, tumor registry an estimated 900,000 to 1,200,000 new cases diagnosed each year. (cdc.gov)
  • The incidence of synchronous malignancies along the aerodigestive tract and the yield of oesophagoscopy and bronchoscopy were studied. (authorea.com)
  • Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. (hindawi.com)
  • It is associated with huge economic and health costs due to its clinical consequences, which includes increased incidence of type 2 diabetes, cardiovascular diseases, and development of different malignancies. (elsevier.es)
  • We had the opportunity to elucidate the risk of SCC incidence and 80% in BCC incidence were documented multiple malignancies using a large population-based series of among both males and females over 14 years [4]. (cdc.gov)
  • Therefore, besides the regulation of immune cells, NFAT2 also exerts modulatory effect of proliferation, invasion, metastasis and malignancy in breast cancer, lung cancer, melanoma and leukemia [13-15]. (researchsquare.com)
  • The initial excision of a suspected melanoma may be claimed using item 31377, 31378, 31379, 31380, 31381, 31382 or 31383, depending on the location of the malignancy and the size of the excision diameter. (health.gov.au)
  • The non melanoma skin cancers (NMSC) are the most frequently diagnosed malignancies in the United States [1] with an estimated 900,000 to 1,200,000 new cases diagnosed each year. (cdc.gov)
  • Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
  • Actinic keratosis and basal cell carcinoma are easily excised and have a very good prognosis, while cSCC has a poor prognosis, especially if it invades the lymph nodes and adjacent vital structures. (medscape.com)
  • of those, approximately 80% were basal cell carcinoma (BCC) and 20% were cSCC. (medscape.com)
  • A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
  • Skin malignancies include squamous and basal cell carcinomas and Bowen disease. (medscape.com)
  • Among 3584 participants, risk of a subsequent cancer (other than NMSC) was higher after basal cell carcinoma (BCC) (adjusted HR 1.40 [95% CI 1.15, 1.71]) than squamous cell carcinoma (SCC) (adjusted HR 1.18 [95% CI 0.95, 1.46]) compared to controls (adjusted for age, sex and current cigarette smoking). (cdc.gov)
  • The two major types of NMSC, basal cell (BCC) and squamous cell carcinoma (SCC), have a relatively small impact on mortality but their public health impact is considerable. (cdc.gov)
  • Patients receiving neoadjuvant chemotherapy plus radical nephroureterectomy for upper tract urothelial carcinoma appear more likely to experience nodal downstaging. (cancernetwork.com)
  • Development and validation of a prognostic nomogram for overall and disease-specific survival in patients with sarcomatoid urothelial carcinoma. (urotoday.com)
  • Sarcomatoid urothelial carcinoma (SUC) is a rare and aggressive variant of bladder cancer with limited data guiding prognosis. (urotoday.com)
  • Background: Increased risk of a second primary malignancy (SPM) before or after diagnosis of anal squamous cell carcinoma (ASCC) has been reported in a previous single-institution study. (elsevierpure.com)
  • Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. (hindawi.com)
  • Increased risk of second primary malignancy (SPM) in PTC has been reported in several cancer registry and epidemiologic studies [ 3 - 10 ]. (hindawi.com)
  • Result Of the 702 patients included in the study, the overall rate of synchronous malignancies was 8.3% (58/702), with the rate of synchronous esophageal and lung malignancies being 5.8% (41/702) and 0.85% (6/702) respectively. (authorea.com)
  • 14 out of the 41 esophageal malignancies were only detectable with esophagoscopy. (authorea.com)
  • Conclusion Oesophagoscopy is essential for detecting synchronous esophageal malignancies in patients with HNSCC especially in male patients, smokers, drinkers and primary hypopharyngeal cancer patients. (authorea.com)
  • Only one of the synchronous lung malignancies was detectable by bronchoscopy. (authorea.com)
  • Bronchoscopy had a low yield for synchronous lung malignancies and can be potentially replaced by imaging techniques. (authorea.com)
  • Chronic inorganic arsenic poisoning is also associated with a number of chronic medical conditions (hypertension, diabetes mellitus, and peripheral vascular disease) as well as lung, bladder, and hepatic malignancies. (medscape.com)
  • Anaplastic thyroid carcinoma (ATC) is a lethal malignancy characterized by poor response to conventional therapies. (lu.se)
  • Skin malignancy or cutaneous carcinoma, is a pre-eminent global open public health problem without symptoms of plateauing in its occurrence. (cancer-pictures.org)
  • Launch Skin cancers or cutaneous carcinoma can be a significant global public medical condition that poses huge economic burden towards the society. (cancer-pictures.org)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
  • or a cutaneous metastasis from an internal malignancy. (health.gov.au)
  • Primary urethral cancer is an extremely rare and aggressive malignancy. (bjmo.be)
  • The aim of this study is therefore to find out the rate of synchronous malignancies in patients with primary HNSCCs, the risk factors for its occurrence and the effectiveness of oesophagoscopy and bronchoscopy in a single center with Chinese population. (authorea.com)
  • Risk factors for synchronous malignancies include male gender, smokers, drinkers and primary hypopharyngeal cancer. (authorea.com)
  • In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. (wjgnet.com)
  • They usually originate as carcinomas of the lungs, breasts, prostate, kidneys, or thyroid or are sarcomas or hematologic malignancies, such as multiple myeloma or lymphoma. (msdmanuals.com)
  • Additional PET /CT can be useful in patients with questionable MRI findings of malignancy . (bvsalud.org)
  • Conclusions: Our findings support increased surveillance and screening for second malignancies in patients with these diagnoses, as patients with ASCC are often either survivors of a prior cancer diagnosis or are at increased risk of developing later malignancies. (elsevierpure.com)
  • Fine needle biopsy showed colloid material, with no malignancy findings. (scirp.org)
  • The classic combination of these laboratory findings is observed only in severe and uncomplicated iron deficiency anemia that presents in patients without infection or malignancy who are not receiving blood transfusions or iron therapy. (medscape.com)
  • Uterine serous carcinoma: increased familial risk for lynch-associated malignancies. (rush.edu)
  • Tamoxifen-related uterine malignancies: carcinomas or sarcomas? (bmj.com)
  • All markers were also elevated in some colon cancers, cervical cancers, uterine cancers and other peritoneal malignancies. (bmj.com)
  • Mohammed N Islam, Chehal H, Islam S, Housley-Smith M, Bhattacharyya I. Merkel cell carcinoma of the buccal mucosa and lower lip. (creighton.edu)
  • Medicare conducted an analysis of the scientific evidence related to liver transplantation for patients with malignancies. (cms.gov)
  • Patients with ASCC had an increased rate of previous malignancy (SIR = 1.23), especially Kaposi sarcoma or vulvar cancer. (elsevierpure.com)
  • To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). (hindawi.com)
  • Title: Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. (thyroidmanager.org)
  • In patients with multiple nodules malignancy is not always present in the predominant nodule. (thyroidmanager.org)
  • He uses a multidisciplinary approach in managing all malignancies to optimize patient outcomes and supports patients and their families in their respective goals of care. (medstarhealth.org)
  • Notably, among patients with ERBB2 alterations, 50% had amplifications and 2 patients had breast carcinoma. (cancernetwork.com)
  • A Cox proportional hazard model was used to estimate risk of subsequent malignancies in NMSC patients versus controls and to assess the potential confounding effects of multiple risk factors on this risk. (cdc.gov)
  • Indications for pancreatoduodenectomy in patients undergoing lymphadenectomy for advanced gallbladder carcinoma. (cancercentrum.se)
  • We present the case of a 62-year-old male with squamous cell carcinoma of the posterior urethra treated at our institution followed by an in-depth discussion on presentation, diagnosis and treatment of this rare cancer. (bjmo.be)
  • Recent studies using ultrasonographic-guided FNA cytology report a 7-14 % prevalence of thyroid cancer and suggest that neither nodule size nor number of nodules influences the likelihood of malignancy. (thyroidmanager.org)
  • Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
  • Other studies in oral cancer [23,24] reported that there is no relationship between the histopathological grade of oral epithelial dysplasia or oral squamous cell carcinoma and the ploidy status. (researchgate.net)
  • In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA) on predictive molecular profiling and histologic diagnosis in a cohort of advanced malignancies. (researchgate.net)
  • Examination of consecutive slides actually revealed small assemblies of carcinoma cells that required a final diagnosis as non-invasive carcinoma in pleomorphic adenoma. (researchgate.net)
  • PET/CT and 3-T whole-body MRI in the detection of malignancy in treated oropharyngeal and hypopharyngeal carcinoma. (bvsalud.org)
  • We performed a prospective comparison of the diagnostic capability of integrated fluorodeoxyglucose (FDG) positron emission tomography ( PET )/computed tomography (CT) ( PET /CT), 3-T whole-body magnetic resonance imaging (WB-MRI) and their combination in detecting malignancy in treated oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC). (bvsalud.org)
  • Although intraductal papillomas (IDPs) are benign, they are occasionally involved by a monomorphic, atypical cellular proliferation, morphologically identical to ductal carcinoma in situ (DCIS) or atypical ductal hyperplasia (ADH). (medscape.com)
  • Although these changes are histologically benign, it is not known whether they are precursors of malignancy. (rxlist.com)
  • and benign simulants such as lichen planus-like keratosis and a malignancy. (aad.org)
  • Moreover, clinical parameters were also important determinants of malignancy. (thyroidmanager.org)
  • Is thyroid malignancy more frequent in solitary nodules? (thyroidmanager.org)
  • The objectives of this study were to determine the prevalence, distribution, and frequency of malignancy in solitary and multiple thyroid nodules. (thyroidmanager.org)
  • In a patient with one or more thyroid nodules larger than 10 mm in diameter, the likelihood of malignancy per patient is independent of the number of nodules in the gland, whereas the probability of malignancy decreases as the number of nodules increases. (thyroidmanager.org)
  • The present study evaluated one or more thyroid nodules (>10 mm) evaluated by US-FNA cytology, and reported that the risk of malignancy was similar in a given patient whether single or multiple nodules are present. (thyroidmanager.org)
  • Squamous cell carcinoma (SCC) is among the most common epidermis GSK256066 cancers which makes up about around 20% of non-melanocytic epidermis malignancies2. (cancer-pictures.org)
  • There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. (researchgate.net)
  • Systematic preoperative radiochemotherapy and total mesorectal excision are the standard of care for locally advanced rectal carcinoma. (medscape.com)
  • CT scan for low rectal carcinoma preoperative staging. (medscape.com)
  • Hepatic resection in 485 R0 pT2 and pT3 cases of advanced carcinoma of the gallbladder: results of a Japanese Society of Biliary Surgery survey--a multicenter study. (cancercentrum.se)
  • They may also present mammographically as calcifications concerning for malignancy. (medscape.com)
  • Sonographic features associated with malignancy include nodule composition, calcifications, and vascularity examined by color Doppler. (thyroidmanager.org)
  • Therefore, it is quite essential to further explicate the biological mechanisms of HCC malignancy aiming to develop more effective therapeutic strategies. (biomedcentral.com)
  • In all cases of undiagnosed persistent or recurring abnormal vaginal bleeding, adequate diagnostic measures should be undertaken to rule out malignancy. (rxlist.com)
  • A human colon carcinoma cell line, designated GEO, is marginally responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells, which are highly responsive to TGFβ. (nebraska.edu)
  • Components and Strategies Cell culture Human being squamous carcinoma cell collection (A431) and human being colorectal cell collection (HT29) had been from the American Type Tradition Collection (ATCC), while regular human being dermal fibroblast cell GSK256066 collection (NHDF) was from LONZA (Tuas, Singapore). (cancer-pictures.org)
  • patient age, however, did not correlate with the likelihood of malignancy. (thyroidmanager.org)
  • Abnormal DNA content has been related to aggressive behavior in Mucoepidermoid Carcinomas (MEC), Adenoid Cystic Carcinomas (AdCC), Acinic Cell Carcinomas (ACC) and oncocytomas (Onc) [8]. (researchgate.net)