• Capra is widely known for his studies of monoclonal antibodies. (wikipedia.org)
  • Capra was an early leader in using human monoclonal antibodies from patients with lymphocytic malignancies helping to drive the field towards biopharmaceutical therapeutics, which now represents one of the largest segments of the pharmaceutical, diagnostic and research-based industries. (wikipedia.org)
  • He was also involved in the development of mouse monoclonal antibodies directed against human tissues that are widely used as diagnostic reagents. (wikipedia.org)
  • He also co-authored a series of papers which utilized human plasmablasts after immunization to define the human immune response to influenza vaccine and generated human monoclonal antibodies from the blood. (wikipedia.org)
  • These studies led to a single cell FACS-sorting based technology for the generation of monoclonal antibodies. (wikipedia.org)
  • City of Hope research has been the basis for numerous breakthrough cancer medicines , as well as human synthetic insulin and monoclonal antibodies. (postdocjobs.com)
  • TdT is a nuclear enzyme expressed by immature lymphoid malignancies, but the expression pattern of this marker is not well characterized in the skin. (karger.com)
  • We study processes within lymphocytes and those outside (in the immune microenvironment) that drive the development of lymphoid malignancies including B- and T- cell acute lymphoblastic leukemia (ALL) and lymphomas. (postdocjobs.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • In the present study, we evaluated changes in B-cell and T-cell subsets as well as the extent of apoptosis and class-specific plasma cells in Peyer's Patches, isolated lymphoid follicles, and lamina propria. (biomedcentral.com)
  • Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
  • Hence, it can be used to overcome tumor immune escape and increase tumor rejection in numerous malignancies, including breast cancer. (unav.edu)
  • In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
  • By injecting the antibodies in a subcutaneous slow-release delivery formulation in the tumor area, we show that an eight-fold lower dose of antibody is as effective in inducing tumor eradication as systemic delivery. (aacrjournals.org)
  • The main target and effector cells of the CTLA-4 blockade treatment in the studied tumor models are tumor-specific endogenous CD8 + T cells that are capable of eradicating also distant tumors, whereas CD4 + T cells do not play a prominent role in the antibody-mediated tumor eradication. (aacrjournals.org)
  • Injecting CTLA-4 blocking antibody in a slow-release formulation close to the tumor is an effective way of activating the antitumor T-cell response. (aacrjournals.org)
  • Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. (biomedcentral.com)
  • Currently, the most widely-used TIL production method is to isolate infiltrating lymphocytes from tumor tissues and then culture and expand these cells in vitro. (biomedcentral.com)
  • Accordingly, we sought to characterize the immunogenic potential of radiation and cisplatin in human tumor models of HPV-associated malignancies. (bmj.com)
  • Results We showed that subpopulations surviving clinically relevant doses of radiation or cisplatin therapy were more susceptible to CTL-mediated lysis in four of four tumor models of HPV-associated malignancies, serving as a model for HPV therapeutic vaccine or T-cell receptor adoptive cell transfer. (bmj.com)
  • In vivo, cisplatin-induced immunogenic cell stress synergistically potentiated CTL-mediated tumor control in a human model of HPV-associated malignancy. (bmj.com)
  • A diagnosis of common variable immunodeficiency (CVID) is based on defective functional antibody formation, usually accompanied by decreased (not absent) serum immunoglobulin (Ig)G and IgA levels, generally (not invariably) decreased serum IgM, and exclusion of other known causes of antibody deficiency. (medscape.com)
  • IgG subclass determination is of limited value in assessing patients with clinical immunodeficiency because functional antibody deficiency may be present despite normal IgG subclass levels. (medscape.com)
  • 1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
  • The spleen has an active role in the production of immunoglobulin M (IgM) antibodies and complement, both of which can opsonize bacteria. (medscape.com)
  • Antibody deficiencies are treated with intravenous immunoglobulin substitution therapy. (lu.se)
  • Assessment of the ability to produce functional antibodies can be obtained by measuring antibody responses to natural antigens or those antigens to which the population commonly is exposed. (medscape.com)
  • This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
  • Protein conjugated pneumococcal vaccine elicit antibody responses that are T-cell dependent. (medscape.com)
  • Therefore, antibody responses should be measured to polysaccharide antigens that are not present in the protein-conjugated pneumococcal vaccine. (medscape.com)
  • Blockade of CTLA-4 by antibodies has potentiated antitumor T-cell responses in both preclinical models and clinical trials. (aacrjournals.org)
  • [ 2 , 3 ] Another study indicates that the T lymphocyte subset in congenital aplasia may be associated with presence of CD4(+) T cells that express the "naïve" phenotype, possible failure in CD8(+) cytotoxic effectors differentiation and tendency to the proinflammatory status of cells, low interleukin (IL) 10 expression, and suboptimal lymphocyte responses to mitogenic stimulation. (medscape.com)
  • Therefore, an early and generalized default in IgA production takes place during the acute of phase of HIV/SIV infection, which might impair not only the virus-specific antibody response but also IgA responses to other pathogens and vaccines as well. (biomedcentral.com)
  • These studies may inform rational combination immuno-oncology (IO) strategies to be employed in the clinic on the backbone of standard of care, and in so doing exploit the immunogenic potential of standard of care to improve durable responses in HPV-associated malignancies. (bmj.com)
  • Neutrophil-to-lymphocyte ratio (NLR), YKL-40 and calprotectin are biomarkers of inflammation and predict mortality in patients with different inflammatory diseases. (biomedcentral.com)
  • Recently, neutrophil-to-lymphocyte ratio (NLR) has attracted attention as an inflammatory biomarker. (biomedcentral.com)
  • However, treatment with CTLA-4 blocking antibodies is associated with autoimmune and inflammatory side effects. (aacrjournals.org)
  • solid course="kwd-title" Keywords: plasmacytoma, nasal area, sinusitis Launch Plasma cells are older B lymphocytes typically within high or low volume in various tissue and organs and in inflammatory foci generally. (siamtech.net)
  • A lower dose and slow release of the antibody results in thousand-fold decreased levels of antibody in the serum, reducing adverse events and the risk of autoimmunity. (aacrjournals.org)
  • This administration method is associated with very low serum levels of antibody, which decreases the risk of treatment-induced side effects. (aacrjournals.org)
  • Conclusion Standard of care radiation or cisplatin therapy induced immunogenic cell stress in preclinical models of HPV-associated malignancies, presenting an opportunity poised for exploitation by employing IO strategies in combination with standard of care. (bmj.com)
  • Successful treatment of B-cell malignancies with CD19-CAR T cells was a milestone for this approach ( 4 , 5 ). (snmjournals.org)
  • We predict that ABCs could be playing a role throughout γHV68 infection due to their long-term persistence, activation of T cells, and continuous cytokine and antibody production. (nature.com)
  • Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
  • 3) T cell deficiencies result usually in combined immunodeficiencies (CIDs), where both T cells and antibody production are defective. (lu.se)
  • Chemokine receptor 5 (CCR5) has gained attention as therapeutic target in various malignancies. (cancerindex.org)
  • Confocal microscopy revealed that HNF4a is present in both T UNC1215 UNC1215 lymphocytes and granulocytes, suggesting a previously unsuspected role for this transcription factor in regulating leukocyte function and therapeutic response in JIA. (tech-strategy.org)
  • MATERIAL AND METHODS: Renal biopsies from native kidneys performed between 1999 and 2020 were retrospectively reviewed. (bvsalud.org)
  • Methods This non-randomized, multicohort, phase II study evaluated the efficacy and safety of the anti-PD-1 antibody nivolumab 240 mg administered every 2 weeks in combination with the CDK4/6 inhibitor abemaciclib 150 mg twice daily and either fulvestrant (FUL) or letrozole (LET) as a first-line or second-line treatment for HR-positive HER2-negative metastatic breast cancer. (bmj.com)
  • T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, aggressive malignancy that rarely presents in the skin and is generally not considered as part of the differential diagnosis by dermatologists and dermatopathologists. (karger.com)
  • Pancreatic cancer is one of the most aggressive of gastrointestinal malignancies, with a 5- year survival rate of 4-5% [ 1 , 2 ]. (biomedcentral.com)
  • Leukemia, particularly aggressive refractory hematological malignancies unresponsive to upfront therapy, remains a difficult condition to treat. (biomedcentral.com)
  • We use different preclinical mouse models of cancer to investigate the local administration of CTLA-4 blocking antibody and its effect on cancer progression and the antitumor T-cell response. (aacrjournals.org)
  • Current pneumococcal vaccines use the pneumococcal capsular polysaccharides as antigens to generate serotype-specific antibodies, which facilitate serotype-specific clearance of pneumococci through opsonophagocytosis ( 4 ). (cdc.gov)
  • We find that mice without ABCs display defects in anti-viral IgG2a/c antibodies and are more susceptible to reactivation of γHV68 following virus challenges that typically do not break latency. (nature.com)
  • [ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • EBV was the first virus to be associated with human malignancy, which was discovered from a Burkitt's lymphoma cell line in 1964 ( 1 ). (spandidos-publications.com)
  • Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
  • We aimed to investigate the correlation between levels of these three biomarkers and neutrophil granulocyte and lymphocyte count in patients with moderate to very severe COPD stratified by use of systemic glucocorticoids. (biomedcentral.com)
  • The Postdoctoral Fellow who joins the team will lead a project focused on specifically targeting diseased immune subsets in systemic lupus erythematosus (SLE) and indolent lymphomas. (postdocjobs.com)
  • The spleen is also involved in the functional maturation of antibodies and is a significant reservoir for both B and T lymphocytes. (medscape.com)
  • Following determination of sensitivities to standard therapies using MTT assays, flow cytometry was used to characterize induction of immunogenic cell stress following sublethal exposure to radiation or cisplatin, and the functional consequence of this induction was determined using impedance-based real time cell analysis cytotoxicity assays employing HPV16 E7-specific cytotoxic lymphocytes (CTLs) with or without N803 (IL-15/IL-15-Rα superagonist) or exogenous death receptor ligands. (bmj.com)
  • The precise B cell subsets, mechanisms, and factors that facilitate the maintenance of latency and prevent reactivation are not fully understood. (nature.com)
  • In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
  • Alternatively antibody response to typhoid-Vi antigen can be measured following typhoid vaccine administration. (medscape.com)
  • His contributions to immunology have focused on the molecular features of antibody variable regions, including key discoveries related to the antibody combining site and its relationship to antibody idiotypy and the hypervariable regions of antibody molecules. (wikipedia.org)
  • He was among those who defined the subsets of human B lymphocytes. (wikipedia.org)
  • These studies led to a redefinition of many human B cell malignancies, which became important in the treatment of many Non-Hodgkin's Lymphomas. (wikipedia.org)
  • DOTA antibody reporter 1 (DAbR1) comprises a single-chain fragment of the antilanthanoid-DOTA antibody 2D12.5/G54C fused to the human CD4-transmembrane domain and binds irreversibly to lanthanoid ( S )-2-(4-acrylamidobenzyl)-DOTA (AABD). (snmjournals.org)
  • 1999. Response of normal human keratinocytes to sulfur mustard (HD): Cytokine release using a non-enzymatic detachment procedure. (cdc.gov)
  • In addition to accumulating more case series of EBV-associated gastric carcinoma (EBVaGC), the development of comprehensive molecular analyses has provided evidence that EBVaGC is a distinct subset both in terms of its clinicopathological and molecular features. (spandidos-publications.com)
  • Patients with antibody deficiencies are especially susceptible to encapsulated bacteria, which cause pyogenic infections. (lu.se)
  • Conversely, deficient levels of a single subclass of IgG may be found in individuals who have effective specific antibody production and are clinically normal. (medscape.com)
  • Their primary function may be the production of antibodies or immunoglobulins. (siamtech.net)
  • The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement. (wjgnet.com)
  • X-tile software (Yale School of Medicine, CT, USA) was used to stratify patients into 'high' and 'low' for each of the lymphocytes stained and their association with survival. (biomedcentral.com)
  • This patient's marrow stroma and lymphocytes showed a hypersensitivity to irradiation similar to that observed in PNP-deficient mice. (medilib.ir)
  • Furthermore, long-term (2-24 h/d up to 8 years) exposure to low-density ELF-EMF may cause a decrease in adaptive immune response, especially in Th1 subset. (ninamvseeno.org)
  • Breast cancer is the most common type of malignancy and leading cause of cancer death among women worldwide. (unav.edu)
  • When CD20 positive lymphocyte levels were high, survival improved (p = 0.029) and similar results were seen for CD20 in combination with intratumoural CD3 (p = 0.001) and stromal CD8 (p = 0.013). (biomedcentral.com)
  • Together, these results indicate that ABCs are a persistent effector subset during latent viral infection that impedes γHV68 reactivation. (nature.com)
  • IgA are produced from plasmablasts (plasma cell precursors) generated in germinal centers (GC) of Peyer's patches (PP) and mesenteric lymph nodes that constitute major inductive sites of T-dependent IgA antibodies. (biomedcentral.com)
  • The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
  • This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma. (biomedcentral.com)
  • This study evaluated the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma. (biomedcentral.com)
  • Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors synergistically increased the effectiveness of antiprogrammed cell death protein-1 (anti-PD-1)/programmed death-ligand 1 (PD-L1) antibodies in preclinical studies. (bmj.com)
  • Prevalence and Predictors of Cholesterol Screening, Awareness, and Statin Treatment Among US Adults With Familial Hypercholesterolemia or Other Forms of Severe Dyslipidemia (1999-2014). (cdc.gov)
  • The number of lymphocytes within specific tumour compartments (i.e. stromal and intratumoural) was quantified. (biomedcentral.com)
  • However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
  • The aim of this review is to summarize the PD-1 and PD-L1 biological functions and their alterative expression in hematological malignancies. (biomedcentral.com)
  • DNA-PKcs and the NHEJ pathway are also essential for V(D)J recombination during T and B cell lymphocyte development. (amegroups.org)
  • If the child's antibody level is low, administer 1 booster injection, then measure for antibodies 4 weeks later. (medscape.com)
  • The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. (biomedcentral.com)