• The genotype frequency was highest for AA (0.707), followed by AT (0.277) and TT (0.016). (wayne.edu)
  • The level of fat oxidation at rest and aerobic exercise of the male subjects with Trp/Arg of the 3-AR gene was significantly lower than that of the Trp/Trp genotype. (hindawi.com)
  • Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
  • Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
  • Bone loss (mean follow-up, 2.0 years) did not differ by ApoE genotype for women and men. (ox.ac.uk)
  • CST3 B/B was significantly linked with ARMD as shown by Kaplan-Meier analysis, with mean disease free survival time in pooled men and women for genotype A/A or A/B of 85 years and B/B 76 years. (bmj.com)
  • Although clinical expression of hemochromatosis is presumed to be less frequent and less severe in women than in men, because of the iron loss associated with menses and pregnancy, women with the hemochromatosis genotype can have full phenotypic expression of the disease. (medscape.com)
  • The -491A/T polymorphism of the promoter region of the APOE gene was also examined. (wayne.edu)
  • The purpose of our study was to investigate whether the Trp64Arg polymorphism in 3-AR gene and the −3826A/G polymorphism in the UCP1 gene were associated with the reduction in energy expenditure and fat oxidation both in resting and aerobic exercise in Japanese. (hindawi.com)
  • It was revealed that the Trp64Arg polymorphism in 3-AR gene is associated with reduction of fat oxidation both in resting and aerobic exercise in healthy, young Japanese males. (hindawi.com)
  • 3-Adrenergic receptor ( 3-AR) and uncoupling protein 1 (UCP1) are involved in energy expenditure of the adipocytes, and the polymorphism of these genes has been reported to be associated with the prevalence of obesity and type 2 diabetes. (hindawi.com)
  • From recent studies in humans, it is thought that the 3826A/G polymorphism in the UCP-1 gene is associated with vulnerability to weight gain and higher BMI [ 9 ]. (hindawi.com)
  • Ser9Gly polymorphism of the DRD3 gene is associated with worse premorbid social functioning and an earlier age of onset in female but not male schizophrenic patients. (ox.ac.uk)
  • UnlabelledTo study the association between the ApoE gene polymorphism and osteoporosis, we performed an association study in 5,857 subjects from the Rotterdam Study. (ox.ac.uk)
  • We did not observe an association between the ApoE polymorphism and osteoporosis in this study, which is thus far the largest study on ApoE and osteoporosis.IntroductionThe E*4 allele of the E*2, E*3, E*4 protein isoform polymorphism in the gene encoding apolipoprotein E (ApoE) has previously been associated with an increased fracture risk. (ox.ac.uk)
  • METHODS: : The entire CDKN2A coding region and exon 2 of the CDK4 gene of an affected member of each of 52 families from southern Sweden with at least two cases of melanoma in first- or second-degree relatives were screened for mutations by use of polymerase chain reaction-single-strand conformation polymorphism analysis. (lu.se)
  • AIM OF THE STUDY: To evaluate the polymorphism and prevalence of loss of heterozygosity (LOH) of APC tumor suppressor gene in mataplasia, dysplasia and adenocarcinoma. (who.int)
  • MATERIAL AND METHODS: In esophageal mucosal samples of 79 patients with: GERD (n=33), BE (n=27), BE+dysplasia (n=8) and ADC (n=11) we have studied LOH of APC tumor suppressor gene using PCR-restriction fragment length polymorphism (RFLP). (who.int)
  • Charles Darwin conjectured that the male beard, as well as the hairlessness of humans compared to nearly all other mammals, were results of sexual selection. (wikipedia.org)
  • Well-preserved remains like those of the "Ice Man" found in Austria help provide this important insight into past humans. (naturalnews.com)
  • We used molecular techniques to investigate the presence of genes conferring resistance to sulfonamides (often used to treat diarrheal illness in human settings in this region) and tetracycline (used in the past-though much less so now) in fecal specimens from humans, domestic animals, chimpanzees, and baboons in and around GNP. (cdc.gov)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • The allele frequencies of ACE gene polymorphisms in control and NAION. (molvis.org)
  • Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. (geneticsmr.com)
  • In this study, we investigated the role of the Leu53Leu, Arg213Gly, and Ala40Thr polymorphisms in extracellular superoxide dismutase (EC-SOD) gene in the development of T2DM in a Chinese population. (geneticsmr.com)
  • Association between -174G/C and -572G/C interleukin 6 gene polymorphisms and severe radiographic damage to the hands of Mexican patients with rheumatoid arthritis: a preliminary report. (geneticsmr.com)
  • Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). (geneticsmr.com)
  • ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study. (ox.ac.uk)
  • The aim of this study was to determine distribution of the angiotensin I converting enzyme (ACE) gene polymorphisms and their influence on RAS susceptibility in Czech population. (muni.cz)
  • Five ACE gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 = ACE I/D) were determined by TaqMan technique. (muni.cz)
  • Analysis of HFE gene polymorphisms may help detect early disease. (medscape.com)
  • I explore problems such as how frequency-dependent processes within and between species maintains diversity, whether genetic polymorphisms or species in ecological communities. (lu.se)
  • Disease-promoting alleles dropped in frequency while protective alleles climbed steadily. (naturalnews.com)
  • This study examines the distribution of apolipoprotein E (APOE) alleles in a population of healthy male and female Norwegians (n = 798) below the age of 40. (wayne.edu)
  • The purpose of our study was to investigate whether the energy expenditure and the fat oxidation during aerobic exercise were affected by the presence of mutant alleles in these genes. (hindawi.com)
  • The controls were from Germany, Switzerland, Italy, and the United States to cover regional or ethnic differences in frequency of CST3 alleles. (bmj.com)
  • A 133 bp fragment, spanning exon 11 of the APC gene was amplified, and Rsal digestion of the PCR product defined the alleles as either homozygous 133 bp (Rsa(-/-)) or 87 and 46 bp (Rsa(+/+)) fragments, and heterozygous (Rsa(+/-)) exhibiting the three fragments. (who.int)
  • By contrast, experts in population screening have not been supportive of screening for HH, largely because severe clinical disease is widely believed to be relatively uncommon among people with HFE genotypes associated with HH despite the high frequency of these alleles. (cdc.gov)
  • Mutations in the CYBA , CYBB , NCF1 , NCF2 , or NCF4 gene can cause chronic granulomatous disease. (medlineplus.gov)
  • Mutations in the CYBA , CYBB , NCF1 , NCF2 , and NCF4 genes result in the production of proteins with little or no function or the production of no protein at all. (medlineplus.gov)
  • Resistance to fluoroquinolones has emerged in S. pneumoniae and is caused by mutations within short DNA sequences of gyrA and parC genes that encode the type II topoisomerase subunits known as quinolone-resistance determining regions (QRDRs) ( 1 ). (cdc.gov)
  • Although the genomic profiles of African American men with prostate cancer differ from those of European American men, new data show that the frequency of actionable mutations for which targeted therapies exist occurs at a comparable rate in both populations. (onclive.com)
  • Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. (nih.gov)
  • Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
  • [ 6 ] However, the gene mutations responsible for the different forms of CMT1 are clearly myelin genes. (medscape.com)
  • The incidence of consanguineous matings in Japan, with remarks on the estimation of comparative gene frequencies and the expected rate of appearance of induced recessive mutations. (wikidata.org)
  • BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, and in the cyclin-dependent kinase 4 (CDK4) gene confer susceptibility to cutaneous malignant melanoma. (lu.se)
  • We analyzed families with two or more cases of melanoma for germline mutations in CDKN2A and CDK4 to elucidate the contribution of these gene defects to familial malignant melanoma and to the occurrence of other cancer types. (lu.se)
  • The disease is usually inherited in an autosomal recessive manner and is caused by mutations in the HFE gene. (medscape.com)
  • The 2 missense mutations (C282Y and H63D) of the HFE gene are responsible for most cases of HH in patients of European descent. (medscape.com)
  • The frequency of the C282Y and H63D mutations is 5.4% and 13.5%, respectively. (medscape.com)
  • Hereditary hemochromatosis (HH) attributable to mutations in the HFE gene is the most common autosomal recessive disorder among adults of northern European origin. (cdc.gov)
  • For example, older estimates of the cumulative incidence to age 70 of colorectal cancer among male carriers of MLH1 / MSH2 mutations in the range 65-82% have been supplanted by unbiased estimates of 41-48% based on representative samples. (cdc.gov)
  • Inherited factor XIII deficiency is usually due to mutations in the gene encoding the catalytic A subunit, located on chromosome 6. (medscape.com)
  • Genotypes of the genes involved in energy expenditure also affect efficiency of the aerobic exercise, but it remains unclear whether the strength and the length of the aerobic exercise should be modified by the genotypes of each patient with diabetes. (hindawi.com)
  • At baseline, mean BMD of the lumbar spine and femoral neck did not differ between the ApoE genotypes of men and women. (ox.ac.uk)
  • This gene encodes one of the connexin proteins. (nih.gov)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • The allele frequencies in the -491 site of the promoter region were 0.845 for the A allele and 0.155 for the T allele. (wayne.edu)
  • Allele frequencies A and B were similar between patients and controls and among controls from all locations. (bmj.com)
  • Data from SNP array and whole exome sequencing revealed that individuals with autism had a higher burden of rare exonic copy-number variants altering autism associated genes (deletions ( p = 0.0352) or duplications ( p = 0.0352)), higher inbreeding status ( p = 0.023) and a higher load of rare homozygous deleterious variants ( p = 0.011) compared to controls. (nature.com)
  • It also revealed three genes involved in synaptic plasticity, RIMS4 , KALRN , and PLA2G4A , carrying de novo deleterious variants in individuals with autism without intellectual disability. (nature.com)
  • In summary, our analysis provides a better understanding of the genetic architecture of autism in isolated populations by highlighting the role of both common and rare gene variants and pointing at new autism-risk genes. (nature.com)
  • Compound hemizygous variants in SERPINA7 gene cause thyroxine-binding globulin deficiency. (illumina.com)
  • Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. (sergas.gal)
  • Additionally, it can knock out genes, facilitating efforts to elucidate gene functions through the analysis of mutant phenotypes. (mdpi.com)
  • In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
  • 1993) give 3.8200 g for females and 4,000 g for males. (ivis.org)
  • Thus, similar behavior sequences could impress both females and males. (behavior.net)
  • He reasoned that since the bodies of females are more nearly hairless, the loss of fur was due to sexual selection of females at a remote prehistoric time when males had overwhelming selective power, and that it nonetheless affected males due to genetic correlation between the sexes. (wikipedia.org)
  • Five each of young C57BL/6J males and females, and B6.CAST-+Ahl males were exposed to a 4-kHz octave band of noise at 108 dB SPL for 4 h. (cdc.gov)
  • The congenic B6.CAST-+Ahl male mice had significantly less TTS immediately post-exposure than C57BL/6J males or females but not less PTS or hair-cell losses at 20 days post-exposure. (cdc.gov)
  • Symptoms of HH occur more frequently in males than in females, with a male-to-female ratio of 3:1. (medscape.com)
  • In relatives of patients with hemochromatosis who are homozygous for the C282Y mutation, expression of iron overload phenotype was noted in 85% males and 69% females. (medscape.com)
  • The authors calculated that routine genetic screening of such males at age 30 and females at age 45 could identify 40% of all homozygotes in Australia, compared with the detection of roughly 3% of homozygotes using current testing strategies. (cdc.gov)
  • Fragile X syndrome is the most common inherited cause of intellectual disability, with males being more commonly affected than females. (msdmanuals.com)
  • Females with the disorder are typically less impaired than males. (msdmanuals.com)
  • SUMMARY A direct correlation between HIV infection and mutation in the chemokine receptor ( CCR5 ) gene has been established. (who.int)
  • We report the frequency of the CCR5 -delta 32 mutation in a random sample of 209 healthy, HIV-1 seronegative Lebanese aged 19-68. (who.int)
  • The frequency in the Lebanese population is consistent with that in the origin of the mutation in northern Europe. (who.int)
  • HIV-1 is influenced by a mutation in the 1 infection with a typical delay of 2-4 years chemokine receptor ( CCR5 ) gene [ 3,4 ]. (who.int)
  • DNA was eluted in In this study we report the frequency of 100 µL molecular biology grade water and the CCR5 -delta 32 mutation in the Lebanese stored at -20 °C. DNA concentrations population. (who.int)
  • Radiation dose rate and mutation frequency. (wikidata.org)
  • This affected the custom scripts for calculating mutation frequencies. (lu.se)
  • This was solved by matching ID+GENE from the VCF to ID+GENE in the sample mutation table. (lu.se)
  • 2 Findings from the study have identified novel variations in the African American population and underscored genomic alterations in known therapeutic targets that present at similar frequencies in the racial groups, 1 according to Franklin W. Huang, MD, PhD, a corresponding author of the RESPOND study and an assistant professor in the Department of Medicine at the University of California, San Francisco. (onclive.com)
  • African American men are often underrepresented in clinical trials and genomics research, so 1 key takeaway is that in this study, we found that African American men have similar frequencies of genomic alterations in genes and pathways that are being targeted by currently approved drugs, so they could benefit from these therapies if we ensure access to them," Huang told OncLive . (onclive.com)
  • These results indicate that, at one month of age, mice carrying two copies of the Ahl gene have an increased susceptibility to TTS from a low-frequency noise before they have any indication of age-related hearing or hair-cell loss. (cdc.gov)
  • The Ahl gene appears to play a role in susceptibility to NIHL but, other genes as well as systemic and local factors must also be involved. (cdc.gov)
  • Study participants are 18,963 middle-aged women and men who are New York State fishing license holders and who reside in 16 New York counties that border Lakes Ontario and Erie. (cdc.gov)
  • Novel focal deletion peaks were observed in African American patients on chromosome 1q23.1 centered on ETV3 , which was not detected in European American men. (onclive.com)
  • Sex chromosome evolution is thought to involve suppression of recombination around the sex determination genes. (usda.gov)
  • We report a papaya primitive Y chromosome with a small male-specific region, the MSY, that is about 10% of the chromosome showing severe suppression of recombination and degeneration of DNA sequences. (usda.gov)
  • The symptoms of Fragile X syndrome are caused by an abnormality of the FMR1 gene on the X chromosome. (msdmanuals.com)
  • The frequencies of the T allele were 3.33% and 2.22% in IPF and ILD patients, respectively, and these values were significantly higher than those of healthy controls (P = 0.001, OR = 4.332 for IPF, and P = 0.002, OR = 2.855 for ILD). (nih.gov)
  • Previous genetic studies indicated that individuals from Scotland, Norway, Sweden, Ireland, Iceland, and British Isles have significantly contributed to the current gene pool of the Faroese population. (nature.com)
  • In contrast, some alterations, such as PTEN deletions (13.1% vs 22.2%) and TMPRSS2-ERG (13.8% vs 32.9%) rearrangements, were significantly lower in African American versus European American men. (onclive.com)
  • The APOE frequencies found in this study differ significantly from those obtained in earlier Norwegian APOE phenotypings. (wayne.edu)
  • The frequency of heterozygous cases in control group was significantly higher than in patients group (p = 0.018), whereas Rsa (-/-) were the most frequent in patients group (p = 0.008). (who.int)
  • Some of F2 plants had entirely new traits but he was unable to give possible explanation for observed data but which was brilliantly done by Mendel Julius Sachs writes "[H]e gives us the impression of a modern man of science more than any other botanist of the 18th century, with the exception of Koelreuter. (wikipedia.org)
  • Men and women share many behavioral traits and a preference for greater height may be one of them. (behavior.net)
  • Montagu emphasized that gene-frequency analysis of traits would tell us more about the evolution of human populations, arguing that the omelet conception of racial mixing was totally artificial and did nothing to explain the origins and consequences of the differences between populations. (harvardsquarelibrary.org)
  • Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
  • High frequencies of sequence duplications and transposable element insertions contributed to the degeneration of the MSY resulting in low gene density. (usda.gov)
  • In this context, we have recently reported a complete sequence analysis of a male from the Western part of The contemporary Indian population is an admixture of several waves of human migration from various directions, which is believed to have been segregated into various communities over the past 2000 y or so[ 2 ]. (ijpsonline.com)
  • Unlike the Nazis in Germany and many white Americans who adhered to a racial hierarchy, and that some races were inherently inferior (Jews and Blacks) to others and deserved to be "enslaved," Dobzhansky joined evolution and genetics by defining evolution as a "change in the frequency of an allele within a gene pool. (wn.com)
  • The proteins produced from the affected genes are parts (subunits) of an enzyme complex called NADPH oxidase, which plays an essential role in the immune system. (medlineplus.gov)
  • Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males. (nih.gov)
  • Interactions between DNA repair genes and low-frequency electromagnetic fields in childhood acute leukemia - Exploring the public health impact of electromagnetic radiation - Israel: School cancer cluster, 3 children with cancer in the same classroom - Head Teachers Safeguard the health and development of children in schools - What's wrong with smart meters? (buergerwelle.de)
  • This RFA, Environment/Infection/Gene Interactions in Autoimmune Diseases, is related to one or more of the priority areas. (nih.gov)
  • A widely accepted theory is that human growth, development and disease occurrence depends upon a complicated interaction between inherited genes and interactions with the environment. (cdc.gov)
  • It has been shown that these mice begin losing high-frequency hearing at two months. (cdc.gov)
  • and a high frequency of congenital heart defects. (medscape.com)
  • Equal contribution of male and female to the progeny 3. (wikipedia.org)
  • This process could underly many male sexual displays, at least to the extent that such are driven by female mating preferences. (behavior.net)
  • 14 were male, and 2 were female. (cdc.gov)
  • Isn't he assuming that prospective parents would fail to notice the huge reproductive advantage enjoyed by men in this hypothetical female-dominated world - not only as sexual partners for women (as you pointed out), but also for progenitors of children who will not have to bear the burdens of childbirth, breastfeeding and so on? (philosophyetc.net)
  • I would agree with Duckrabbit that childbearing isn't an advantage, though it means that an all-female society will be technologically feasible before an all-male one is. (philosophyetc.net)
  • Group selection departs from the more familiar model of individual selection that sees the evolutionary prize going to the individual, male or female, who has more surviving offspring, regardless of health and life-span, much less altruism. (prospect.org)
  • the male-to-female ratio is 1:1. (medscape.com)
  • Male bonnet monkeys (Macaca radiata) were subjected to the variable foraging demand (VFD) early stress paradigm as infants, MRI scans were completed an average of 4 years later, and behavioral assessments of anxiety and ex-vivo corpus callosum (CC) measurements were made when animals were fully matured. (nih.gov)
  • One wrinkle, though: what happens to gene frequencies of behavioral genes? (philosophyetc.net)
  • Our analysis supports the role of several genes/loci associated with autism (e.g. (nature.com)
  • However, this structural defect does not appear when modern cytogenetic techniques are used, and this is the reason why Fragile X syndrome is now considered a single-gene disorder and not a chromosomal abnormality. (msdmanuals.com)
  • In this view, the true competition to reproduce is at the level of the gene, and an organism is only a gene's way of making a copy of itself. (prospect.org)
  • All 16 levofloxacin-resistant isolates contained at least 2 amino acid alterations in the QRDRs of the gyrA, parC , and parE genes. (cdc.gov)
  • Cefoxitin (30g) was used as surrogate to determine phenotypic methicillin resistance in staphylococcus isolates, and the methicillin resistance ( mec A) gene was detected by conventional PCR assay. (who.int)
  • Four of the 9 (44.4%) CoNS isolates were cefoxitin resistant and all the 4 (100%) carried mec A gene. (who.int)
  • Both isolates had active-on-imipenem metallo-beta-lactamase emase genes. (cdc.gov)
  • CRPA isolates for carbapenemase genes and implementation of occupied room X while receiving mechanical ventilation for sink hygiene interventions, was critical in the identification of 4 weeks. (cdc.gov)
  • To investigate the gene frequency of the T235 allele and its relationship with hypertension in two Japanese populations. (lww.com)
  • The number of genes associated with autism is increasing, but few studies have been performed on epidemiological cohorts and in isolated populations. (nature.com)
  • Most annotations are related to variant frequencies in different populations. (lu.se)
  • The implication of the finding that almost 1 in 10 male C282Y homozygotes is likely to develop severe liver disease in the absence of presymptomatic detection is that widespread detection could avert considerable numbers of premature deaths in populations of predominantly European ancestry. (cdc.gov)
  • Rapid Genotyping of Cytomegalovirus in Dried Blood Spots by Multiplex Real-Time PCR Assays Targeting the Envelope Glycoprotein gB and gH Genes 2012. (cdc.gov)
  • The explanation for this has to do with chemical changes in inherited genes that occur because of the substances to which we are exposed in the womb. (cdc.gov)
  • 3) However, sexual selection is usually described as the product of genetic models, particularly 'linkage disequilibrium ' (8) in which a 'gene for' a trait is located near a presumed 'gene for an attraction to' that same trait. (behavior.net)
  • However, sensory mechanisms could reduce or eliminate the role of a 'gene for an attraction to' whatever trait is under consideration. (behavior.net)
  • The gene frequencies for thalassaemia trait and major were 0.256 and 0.0139 respectively. (who.int)
  • The research protocol saemia trait in all cases where the HbA2 mately 5% of the world's population was approved by the medical research gene was raised. (who.int)
  • The DNA of the Ice Man shows that if he had managed to escape the arrow to his back that killed him more than 5,000 years ago, he could have eventually died of a heart attack given his propensity for cardiovascular disease . (naturalnews.com)
  • In the recent paper, Grosse and coauthors reviewed the epidemiologic evidence from population-based studies on the clinical penetrance of HFE C282Y homozygosity in males in terms of the cumulative risk of severe liver disease. (cdc.gov)
  • The lifetime incidence of severe liver disease alone appears to be approximately 9% (95% confidence interval: 2.6-15.3%) of male HFE C282Y homozygotes of European ancestry based on data from prospective cohort studies. (cdc.gov)
  • because of the lack of systematic liver biopsies, studies potentially under ascertain the frequency of occurrence of severe liver disease. (cdc.gov)
  • This is not surprising given the strong evidence for interaction between myelin and axon gene expression in development and after experimental nerve lesions. (medscape.com)
  • Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
  • Genes with higher network connectivity are under stronger stabilizing selection, suggesting that stabilizing selection on expression plays an important role in promoting network robustness. (nature.com)
  • 7. Regulation of gene expression - Lac operon, Lambda operates. (teachersbadi.in)
  • After 3 weeks, we compared body weight, food intake, plasma levels of lipids and glucose, and the expression patterns of the clock genes and the genes involved in lipid metabolism in the liver and WAT. (researchgate.net)
  • LL eliminated the circadian rhythms of the expression of the clock genes as well as most of the genes involved in lipid metabolism in both liver and WAT. (researchgate.net)
  • More notably, LL markedly decreased not only the amplitude but also the average levels of the expression of the genes in the liver, but not in the WAT, suggesting that transcription in the liver is sensitive to constant light exposure. (researchgate.net)
  • Objective Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. (researchgate.net)
  • Diet composition can also affect clock gene expression. (researchgate.net)
  • Here, we assessed the combined effect of diet composition and feeding time on (1) body composition, (2) energy balance, and (3) circadian expression of hepatic clock and metabolic genes. (researchgate.net)
  • RESULTS: Among 79 patients, there were 16 heterozygous (20%) for APC gene. (who.int)
  • A small amount of gene flow per generation into a population/geographical region can drastically change its original gene frequencies in only a few thousand years as noted by Cavalli Sforza (1991). (allempires.com)
  • Despite the fact that Neolithic expansion had the same effect in Northern Africa as in Europe, the Straits of Gibraltar acted as a barrier between the two continents, limiting gene flow between North-western Africa and Western Europe through the Iberian Peninsula (Comas et al. (allempires.com)
  • ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma. (nih.gov)
  • Research has found that radio-frequency electromagnetic waves, also known as electromagnetic radiation, affect several parts of our brains. (bioelectricshield.com)
  • Approximately 80-90% of HH cases are due to homozygosity for the C282Y allele in the HFE gene. (cdc.gov)
  • On the estimation of the frequency of genetic carriers. (wikidata.org)
  • The gene frequency of different hae- thalassaemia, the percentage of carriers Centre. (who.int)
  • Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas. (nih.gov)
  • CONCLUSIONS: APC gene inactivation concerns minority of patients with esophageal adenocarcinoma, however, its detection indicates higher risk of progression to ADC. (who.int)
  • The ongoing National Cancer Institute-sponsored RESPOND study is the largest research effort seeking to identify determinants of the disproportionate incidence of prostate cancer and mortality rate among African American men. (onclive.com)
  • Education and alcohol use: A study of gene-environment interaction in young adulthood. (databasefootball.com)
  • Exudative age related macular degeneration (ARMD) is linked with the CST3 gene, a study in Germany has found. (bmj.com)
  • A study were briefed about the objectives the Hardy-Weinberg equilibrium p 2 + majority of the haemoglobinopathies are of the study and informed consent was 2 pq + q 2 = 1, where p is the frequency not clinically apparent but some produce obtained from each individual. (who.int)
  • Blood will be collected to study the function of the genes that control sex hormone levels in each person. (cdc.gov)
  • A stratified analysis showed that this variant in MUC5B associated with the risk for ILD mainly in older male Chinese subjects. (nih.gov)
  • Frequency-effect analysis and quantity-effect analysis also did not show that a reduction of meat or fish consumption (flexitarian dietary pattern), either small or large, changed the risk of axonal polyneuropathy. (bvsalud.org)
  • We recruited 405 patients with interstitial lung diseases (ILD), including 165 IPF patients and 2043 healthy controls, for genotyping the MUC5B gene in the Chinese population. (nih.gov)
  • [ 4 ] In the world population, the frequency of EVC syndrome is 1 per 60,000 to 1 per 200,000 newborns. (medscape.com)
  • If a gene affects altruism in such a way that the altruism is more likely to be directed at close relatives, the gene can spread in the population despite the cost imposed on the altruist. (prospect.org)
  • of the A allele in the population and q is serious life-threatening diseases and con- the frequency of the a allele in the popu- stitute a significant health care burden. (who.int)
  • A newly published cost-effectiveness model of population screening strategies for HH on which Lyle Gurrin collaborated has supported the argument that routine genotyping at age 30 in Australian males of northern European ancestry would be highly cost-effective . (cdc.gov)
  • Effect of the angiotensinogen gene Met235$Thr variant on blo. (lww.com)
  • Yet another variant of Darwinian theory reduces evolution to what the biologist Richard Dawkins famously called "the selfish gene. (prospect.org)
  • Either way, there could be enhanced reproductive success and resulting changes in gene frequencies. (behavior.net)
  • So recent decades produced a lot of ways of explaining the evolution of limits on selfishness, and with one exception they all involve some benefit to the individual, or at least to the genes, from restraining raw selfishness. (prospect.org)
  • In other words, far from holding that natural selection operates mainly on genes blindly replicating themselves or on individuals struggling for life and, more important, reproduction, Wilson is one of a growing number of distinguished scientists who believe that competition among superorganisms-functionally organized groups-is key to understanding evolution. (prospect.org)
  • A subanalysis of 3454 patients with localized and metastatic tumors found several alterations that were more frequent in African American versus European American men. (onclive.com)
  • [ 4 ] Moirand et al found that while men had a higher incidence of serious complications of hereditary hemochromatosis, primarily diabetes mellitus and cirrhosis, women complained more often of fatigue and skin hyperpigmentation. (medscape.com)
  • IARC scientists coordinated several studies on the adverse health effect of exposure to styrene, man-made vitreous fibres, organic mercury compounds and substances affecting workers in the paper, wood, leather and asphalt industry and in biological research laboratories. (who.int)
  • The overall goal is to explore whether the genes that control the function of sex hormones are changed by exposure to two chemicals in the womb, PCB and DDT. (cdc.gov)
  • It will also allow us to find out if genes affecting the function of sex hormones are altered and if so, whether this is related to exposure to PCBs or DDT. (cdc.gov)
  • Across all 4 data sets, 15 genes were mutated in 2 or more patients. (onclive.com)