• Testicular
  • Testicular cancer is the most common form of cancer in men and particularly affects men aged between 20 and 35. (medic8.com)
  • Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and surgery, orchitis, varicocele, infections, prostatitis, testicular cancer, failure of immunosuppression and unprotected receptive anal or oral sex with men. (wikipedia.org)
  • Azoospermic men with testicular failure are advised to undergo karyotype and Y-micro-deletion testing. (wikipedia.org)
  • There are many causes for oligospermia including: Pre-testicular factors refer to conditions that impede adequate support of the testes and include situations of poor hormonal support and poor general health including: Hypogonadism due to various causes Drugs, alcohol, smoking Strenuous riding (bicycle riding, horseback riding) Medications, including androgens. (wikipedia.org)
  • spermatogenesis
  • Now abnormalities of methylation could be implied in defects of spermatogenesis and certain abnormalities of development of the male germ cells could be due to modifications abnormal epigenetics. (clinicaltrials.gov)
  • This is primarily due to excess estrogen interfering with normal ovulation in women and altering spermatogenesis in men. (wikipedia.org)
  • The degree of impairment is sufficient to impair spermatogenesis and / or the development of secondary sexual characteristics at puberty in males, but does not affect genital differentiation or development. (wikipedia.org)
  • this category of androgen insensitivity is diagnosed when the degree of androgen insensitivity in an individual with a 46,XY karyotype is great enough to impair virilization or spermatogenesis, but is not great enough to impair normal male genital development. (wikipedia.org)
  • 2017
  • A 2017 review and meta-analysis found sperm counts among Western men (i.e. men in Australia, Europe, New Zealand, and North America) declined 50-60% between 1973 and 2011, with an average decline of 1.4% per year. (wikipedia.org)
  • levels of testosterone
  • However, a 2006 placebo-controlled trial of low-dose testosterone supplementation in elderly men with low levels of testosterone found no benefit on body composition, physical performance, insulin sensitivity, or quality of life. (wikipedia.org)
  • Insemination
  • In case of treatment failure, depending on the severity of male infertility, insemination, IVF or microfertilisation (ICSI) can be tried regardless of the etiology. (gfmer.ch)
  • testosterone
  • While in adolescents it manifests with decreased serum testosterone level, decreased lean body mass and oligospermia in males. (thefreedictionary.com)
  • In women, total testosterone levels are 20-fold and free testosterone levels 40-fold lower relative to men. (wikipedia.org)
  • In addition, whereas bicalutamide monotherapy can increase testosterone levels by up to 2-fold in men, the drug does not increase testosterone levels in women. (wikipedia.org)
  • Polymorphism
  • In Drosophila melanogaster, mtDNA polymorphism mainly affects nuclear gene expression in males but not in females and those genes are predominantly male-biased. (wikipedia.org)
  • They demonstrated that mtDNA polymorphism is responsible for male aging, while there is no significant effect on female longevity. (wikipedia.org)
  • puberty
  • AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate muscle growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and AIDS. (wikipedia.org)
  • Induction of male puberty: Androgens are given to many boys distressed about extreme delay of puberty. (wikipedia.org)
  • analyses
  • Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or sui. (bioportfolio.com)
  • ejaculate
  • Hypospermia is a condition in which a man has an unusually low ejaculate (or semen) volume, less than 1.5 ml. (wikipedia.org)
  • Normal ejaculate when a man is not drained from prior sex and is suitably aroused, is around 1.5-6 ml, although this varies greatly with mood, physical condition and sexual activity. (wikipedia.org)
  • If a man is unable to ejaculate in a timely manner after prolonged sexual stimulation, in spite of his desire to do so, it is called delayed ejaculation or anorgasmia. (wikipedia.org)
  • estrogen
  • Although bicalutamide does not bind to the ERs, it can increase estrogen levels secondary to blockade of the AR when used as a monotherapy in males, and for this reason, the medication can indirectly activate the ERs to a degree and hence have some indirect estrogenic effects in men. (wikipedia.org)
  • females
  • In biology, mother's curse is an evolutionary effect that males inherit deleterious mitochondrial genome (mtDNA) mutations from their mother, while those mutations are beneficial, neutral or less deleterious to females. (wikipedia.org)
  • As mtDNA is usually maternally inherited, mtDNA mutations deleterious to males but beneficial, neutral or less deleterious to females are not subjected to be selected against, which results in a sex-biased selective sieve. (wikipedia.org)
  • Taken together, mtDNA mutations pose a greater threat on males than on females. (wikipedia.org)
  • Instead, mutations only deleterious to males could be maintained and reach a higher frequency by selection or genetic drift in females. (wikipedia.org)
  • The colony has a clearly defined hierarchy, with the breeding male dominant, followed by the breeding female, then non-reproductive males, and finally non-reproductive females. (wikipedia.org)
  • Frequency
  • Therefore, male-specific deleterious mtDNA mutations could be maintained and reach a high frequency in populations, decreasing males' fitness and population viability. (wikipedia.org)
  • Mother's curse predicts that mtDNA mutations pose a greater threat on males and male-specific detrimental mutations in mtDNA could be maintained and reach a high frequency. (wikipedia.org)
  • If mtDNA mutations deleterious to male fitness could not be selected against, they would reach a high frequency despite of the high fitness cost for males. (wikipedia.org)
  • Hence, selection can act on male-specific deleterious mutations when they are paternally inherited, decreasing their frequency. (wikipedia.org)
  • genetic
  • Although it is possible for men to father children into old age, the genetic quality of sperm, as well as its volume and motility, all typically decrease with age. (wikipedia.org)
  • In other words, older sperm are less likely to result in a successful pregnancy and, moreover, the cumulative fragmentation of sperm DNA over time increases the likelihood that a small fraction of men will pass on achondroplasia and transmit multiple genetic and chromosomal defects. (wikipedia.org)
  • mutations
  • It is estimated that 2-3% of infertile men have AR gene mutations. (wikipedia.org)
  • There are evidence showing mtDNA mutations are more likely to affect males. (wikipedia.org)
  • So there must be ways that species could decrease the effects of male-specific deleterious mtDNA mutations. (wikipedia.org)
  • Therefore, interaction between mtDNA and nuclear genes could be one of mechanisms that counteract deleterious effects of male-specific mtDNA mutations Positive assortative mating and kin selection could also relieve fitness cost of male-specific deleterious mtDNA mutations, while negative assortative mating has an opposite function. (wikipedia.org)
  • ejaculation
  • The man is asked to abstain from ejaculation for 2 to 3 days prior to this to ensure an accurate reading. (medic8.com)
  • Ejaculation is the discharge of semen (normally containing sperm) from the male reproductory tract, usually accompanied by orgasm. (wikipedia.org)
  • A usual precursor to ejaculation is the sexual arousal of the male, leading to the erection of the penis, though not every arousal nor erection leads to ejaculation. (wikipedia.org)
  • Penile sexual stimulation during masturbation or vaginal, anal, oral, or non-penetrative sexual activity may provide the necessary stimulus for a man to achieve orgasm and ejaculation. (wikipedia.org)
  • With regard to intravaginal ejaculation latency time, men typically reach orgasm 5-7 minutes after the start of penile-vaginal intercourse, taking into account their desires and those of their partners, but 10 minutes is also a common intravaginal ejaculation latency time. (wikipedia.org)
  • Play media When a man has achieved a sufficient level of stimulation, the orgasm and ejaculation begins. (wikipedia.org)
  • Alfred Kinsey measured the distance of ejaculation, in "some hundred" of men. (wikipedia.org)
  • Most men experience a refractory period immediately following an orgasm, during which time they are unable to achieve another erection, and a longer period again before they are capable of achieving another ejaculation. (wikipedia.org)
  • Androgen
  • All forms of androgen insensitivity are associated with infertility, though exceptions have been reported for both the mild and partial forms. (wikipedia.org)
  • clinical
  • The clinical phenotype associated with MAIS is a normal male habitus with mild spermatogenic defect and / or reduced secondary terminal hair. (wikipedia.org)