• testicular
  • Risk factors for the formation of antisperm antibodies in men include the breakdown of the blood‑testis barrier, trauma and surgery, orchitis, varicocele, infections, prostatitis, testicular cancer, failure of immunosuppression and unprotected receptive anal or oral sex with men. (wikipedia.org)
  • Age (see also: Paternal age effect) Genetic defects on the Y chromosome Y chromosome microdeletions Abnormal set of chromosomes Klinefelter syndrome Centriole Neoplasm, e.g. seminoma Idiopathic failure Cryptorchidism Trauma Hydrocele Mumps Malaria Testicular cancer Defects in USP26 in some cases Acrosomal defects affecting egg penetration Idiopathic oligospermia - unexplained sperm deficiencies account for 30% of male infertility. (wikipedia.org)
  • Azoospermic men with testicular failure are advised to undergo karyotype and Y-micro-deletion testing. (wikipedia.org)
  • There are many causes for oligospermia including: Pre-testicular factors refer to conditions that impede adequate support of the testes and include situations of poor hormonal support and poor general health including: Hypogonadism due to various causes Drugs, alcohol, smoking Strenuous riding (bicycle riding, horseback riding) Medications, including androgens. (wikipedia.org)
  • spermatogenesis
  • Now abnormalities of methylation could be implied in defects of spermatogenesis and certain abnormalities of development of the male germ cells could be due to modifications abnormal epigenetics. (clinicaltrials.gov)
  • This is primarily due to excess estrogen interfering with normal ovulation in women and altering spermatogenesis in men. (wikipedia.org)
  • The degree of impairment is sufficient to impair spermatogenesis and / or the development of secondary sexual characteristics at puberty in males, but does not affect genital differentiation or development. (wikipedia.org)
  • this category of androgen insensitivity is diagnosed when the degree of androgen insensitivity in an individual with a 46,XY karyotype is great enough to impair virilization or spermatogenesis, but is not great enough to impair normal male genital development. (wikipedia.org)
  • obstruction
  • In a number of situations direct medical or surgical intervention can improve the sperm concentration, examples are use of FSH in men with pituitary hypogonadism, antibiotics in case of infections, or operative corrections of a hydrocele, varicocele, or vas deferens obstruction. (wikipedia.org)
  • Ejaculatory duct obstruction is the underlying cause for 1-5% of male infertility. (wikipedia.org)
  • Ejaculatory duct obstruction may result in a complete lack of semen (aspermia) or a very low-volume semen (oligospermia) which may contain only the secretion of accessory prostate glands downstream to the orifice of the ejaculatory ducts. (wikipedia.org)
  • Low-volume, runny/fluid semen (oligospermia) or no semen at all (dry ejaculation/aspermia) are a logical consequence of an obstruction downstream of the seminal vesicles which contribute most to the volume of the semen. (wikipedia.org)
  • Since ejaculatory duct obstruction is a relatively rare cause of infertility, this possibility may be unfamiliar to some physicians, even some urologists. (wikipedia.org)
  • levels of testosterone
  • However, a 2006 placebo-controlled trial of low-dose testosterone supplementation in elderly men with low levels of testosterone found no benefit on body composition, physical performance, insulin sensitivity, or quality of life. (wikipedia.org)
  • Insemination
  • In case of treatment failure, depending on the severity of male infertility, insemination, IVF or microfertilisation (ICSI) can be tried regardless of the etiology. (gfmer.ch)
  • testosterone
  • While in adolescents it manifests with decreased serum testosterone level, decreased lean body mass and oligospermia in males. (thefreedictionary.com)
  • In women, total testosterone levels are 20-fold and free testosterone levels 40-fold lower relative to men. (wikipedia.org)
  • In addition, whereas bicalutamide monotherapy can increase testosterone levels by up to 2-fold in men, the drug does not increase testosterone levels in women. (wikipedia.org)
  • motility
  • Swami Ramdev (http://www.swamiramdevshop.com/product/infertility/) Natural Ways Increase sperm motility. (scriptovore.com)
  • Males are more susceptible to mtDNA defects, not only because of lack of selection for mtDNA on males but also due to sperm's higher energy requirements for motility. (wikipedia.org)
  • Vasography may be indicated if there is severe oligospermia (few sperm) with a normal testis biopsy, high levels of sperm-bound antibodies, or low semen volume and poor sperm motility. (wikipedia.org)
  • Although it is possible for men to father children into old age, the genetic quality of sperm, as well as its volume and motility, all typically decrease with age. (wikipedia.org)
  • In men with a normal level of sperm production (normozoospermia), the percentage of sperm DNA fragmentation is positively correlated with age, and inversely correlated with progressive sperm motility. (wikipedia.org)
  • While advanced age can be a possible factor in sperm motility and health, the sperm of men below 20 years of age has likewise been linked to an increase in birth defects such as neural tube defects, hypospadias, cystic kidney, and Down syndrome. (wikipedia.org)
  • puberty
  • AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate muscle growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and AIDS. (wikipedia.org)
  • Induction of male puberty: Androgens are given to many boys distressed about extreme delay of puberty. (wikipedia.org)
  • analyses
  • Double-blind placebo-controlled randomized trial of daily escitalopram for 6 weeks in healthy men with normal semen analyses and no psychiatric history of depression, bipolar, mania or sui. (bioportfolio.com)
  • ejaculate
  • Normal ejaculate when a man is not drained from prior sex and is suitably aroused, is around 1.5-6 ml, although this varies greatly with mood, physical condition and sexual activity. (wikipedia.org)
  • If a man is unable to ejaculate in a timely manner after prolonged sexual stimulation, in spite of his desire to do so, it is called delayed ejaculation or anorgasmia. (wikipedia.org)
  • estrogen
  • Although bicalutamide does not bind to the ERs, it can increase estrogen levels secondary to blockade of the AR when used as a monotherapy in males, and for this reason, the medication can indirectly activate the ERs to a degree and hence have some indirect estrogenic effects in men. (wikipedia.org)
  • females
  • In biology, mother's curse is an evolutionary effect that males inherit deleterious mitochondrial genome (mtDNA) mutations from their mother, while those mutations are beneficial, neutral or less deleterious to females. (wikipedia.org)
  • As mtDNA is usually maternally inherited, mtDNA mutations deleterious to males but beneficial, neutral or less deleterious to females are not subjected to be selected against, which results in a sex-biased selective sieve. (wikipedia.org)
  • Taken together, mtDNA mutations pose a greater threat on males than on females. (wikipedia.org)
  • Instead, mutations only deleterious to males could be maintained and reach a higher frequency by selection or genetic drift in females. (wikipedia.org)
  • Frequency
  • Therefore, male-specific deleterious mtDNA mutations could be maintained and reach a high frequency in populations, decreasing males' fitness and population viability. (wikipedia.org)
  • Mother's curse predicts that mtDNA mutations pose a greater threat on males and male-specific detrimental mutations in mtDNA could be maintained and reach a high frequency. (wikipedia.org)
  • If mtDNA mutations deleterious to male fitness could not be selected against, they would reach a high frequency despite of the high fitness cost for males. (wikipedia.org)
  • Hence, selection can act on male-specific deleterious mutations when they are paternally inherited, decreasing their frequency. (wikipedia.org)
  • Sperm Counts
  • How to increase Sperm Counts advised by Baba Ramdev (http://www.herbalwale.com/male-sperm-problems/) Buy Swami Ramdev Products, Swami Ramdev Ji Herbal Medicine, natural cures and Baba Ramdev Medicine. (scriptovore.com)
  • Reference ranges for sperm counts are defined in fertile (not infertile) men. (wellinghomeopathy.com)
  • Many men conceive without trouble having low sperm counts. (wellinghomeopathy.com)
  • In 2% of men, low sperm counts may be due to hormonal imbalance from prolactinoma. (wellinghomeopathy.com)
  • The consistent use of hot tubs or baths, recreational drugs such as alcohol, cocaine, marijuana or tobacco, and fevers from flu's or other infections can all lower sperm counts in otherwise healthy men. (wellinghomeopathy.com)
  • A 2017 review and meta-analysis found sperm counts among Western men (i.e. men in Australia, Europe, New Zealand, and North America) declined 50-60% between 1973 and 2011, with an average decline of 1.4% per year. (wikipedia.org)
  • genetic
  • Genetic factors: in some cases the genetic factor is also a great contributor towards male infertility. (fertilityexpert.co.uk)
  • In other words, older sperm are less likely to result in a successful pregnancy and, moreover, the cumulative fragmentation of sperm DNA over time increases the likelihood that a small fraction of men will pass on achondroplasia and transmit multiple genetic and chromosomal defects. (wikipedia.org)
  • mutations
  • There are evidence showing mtDNA mutations are more likely to affect males. (wikipedia.org)
  • So there must be ways that species could decrease the effects of male-specific deleterious mtDNA mutations. (wikipedia.org)
  • Therefore, interaction between mtDNA and nuclear genes could be one of mechanisms that counteract deleterious effects of male-specific mtDNA mutations Positive assortative mating and kin selection could also relieve fitness cost of male-specific deleterious mtDNA mutations, while negative assortative mating has an opposite function. (wikipedia.org)
  • It is estimated that 2-3% of infertile men have AR gene mutations. (wikipedia.org)
  • concentration
  • Men with mild oligospermia (semen concentration of 15 million to 20 million sperm/ml) were studied for an association of sperm DNA damage with life style factors. (wikipedia.org)
  • Since the seminal vesicles contain a viscous, alkaline fluid rich in fructose, a chemical analysis of the semen of affected men will result in a low concentration of fructose and a low pH. (wikipedia.org)
  • Androgen
  • All forms of androgen insensitivity are associated with infertility, though exceptions have been reported for both the mild and partial forms. (wikipedia.org)
  • significantly
  • For example, the percentage of sperm with highly damaged DNA, comet extent, DNA break number, and other comet measures has been found to be significantly higher in men aged 36-57 years than in those aged 20-35 years. (wikipedia.org)