• Oxidative Stress
  • In this section we will demonstrate how moderately elevated to high levels of GGT contribute to the disease process by depleting glutathione levels leading to increased oxidative stress, causing cell damage, lipid peroxidation, DNA mutagenisis and major life-threatening diseases affecting the body's vital organs. (publishpath.com)
  • Nevertheless, other lines of evidence proposed a protective role of alpha-syn against oxidative stress (a major feature of PD), even if the exact mechanism of this protective action and the role of the pathogenetic mutations to this respect have not been elucidated yet. (jove.com)
  • Free
  • All patients scored at least 18 on the Hamilton Anxiety Scale and were free of major depressive disorder (i.e. (scielo.br)
  • L-PGA is present in the diet and is produced endogenously by enzymatic conversion of gamma-glutamyl amino acids to L-PGA and free amino acids. (wikipedia.org)
  • data
  • Many data suggest that alpha-syn aggregation is the key event that triggers alpha-syn-mediated neurotoxicity. (jove.com)
  • high
  • Metadoxine is a selective antagonist of the serotonin receptor subtype 5-HT2B and displays high affinity to the gamma-aminobutyric acid (GABA) transporter. (wikipedia.org)