• Previously, it was demonstrated that these aptamers can selectively deliver anticancer ligands," Dr. Cruz said, such as acridine orange derivatives, and showed improved selectivity towards cancer cell lines. (utexas.edu)
  • A major difficulty in developing anticancer drugs is cross-resistance, a phenomenon whereby a cell that is resistant to one drug is also resistant to another drug in the same class. (warwick.ac.uk)
  • carboline Derivatives as Anticancer and Cancer-chemopreventive Agents. (umassmed.edu)
  • DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. (warwick.ac.uk)
  • Introduction of the Functional Amino Group at the meso Position of Cy3 and Cy5 Dyes: Synthesis, Stability, Spectra and Photolysis of 4-Amino-1-diazo-2-butanone Derivatives. (mpg.de)
  • Negatively charged red-emitting acridine dyes for facile reductive amination, separation and fluorescent detection of glycans. (mpg.de)
  • These transformations tolerated a broad range of the nucleophilic reagents thus allowing the synthesis of a wide variety of hetero- and carbocyclic compounds including the derivatives of pyridine, pyrimidine, pyrazole, pyran, dioxane, and isoxazole as well as their heterofused derivatives. (researchgate.net)
  • Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. (umassmed.edu)
  • Rapid quantification of seven major neonicotinoids and neonicotinoid-like compounds and their key metabolites in human urine. (mpg.de)
  • 5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis. (shengsci.com)
  • Inhibitory effect of a callophycin A derivative on iNOS expression via inhibition of Akt in lipopolysaccharide-stimulated RAW 264.7 cells. (umassmed.edu)
  • When Chinese hamster ovary cells expressing the human SP receptor were photolabeled with this compound and analyzed with the use of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography, several radioactive bands were observed, including a major band centered at molecular mass 80 kDa, the expected value for the SP receptor expressed in Chinese hamster ovary cells. (shengsci.com)
  • In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. (researchgate.net)
  • An azido derivative of [3H2](2S, 3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl) methyl)-1-azabicyclo[2.2.2]octon-3-amine (CP-96,345), a potent nonpeptide antagonist of the substance P (SP) (neurokinin-1) receptor, was synthesized and shown to have an affinity for the human SP receptor similar to that of the parent compound, CP-96,345. (shengsci.com)
  • The most active compound, having a meta-fluorocinnamoyl group linked to the acridine core, was 20- and 120-fold more potent, respectively, against the hepatic and gametocyte stages of Plasmodium infection than the reference drug, primaquine. (ibecbarcelona.eu)
  • Finally, in paper IV, we demonstrated how it by TRAST imaging, taking advantage of the photo-induced dark states of a mitochondrial localization fluorophore (n-Nonyl Acridine Orange, NAO), is possible to give this localization probe environmental sensing properties as well. (albanova.se)
  • Examples had been supervised at 366.69 150.1 for SMI#9 (B) or 381.3 150.1 for SMI#9 released from GNP (C). Acridine orange/ethidium bromide staining Breasts cancer tumor cells (10 103) had been seeded on cover slips and treated with automobile, free SMI#9, sMI#9-GNP or blank-GNP for 24-48 h. (icem2012.org)
  • Cover slips had been rinsed with PBS, stained with ethidium bromide/acridine orange (each 25 g/ml), and Spinosin imaged with an Olympus BX40 fluorescence microscope immediately. (icem2012.org)
  • That could cause the major- faculty of pharmacy services in northern ireland in the monograph pharmaceutical with formally separated processes, due to red flags infection, and the short-tenir use in the. (themauimiracle.org)
  • Recently, Dr. Cruz and Dr. Ellington were interviewed by a representative from the UT Austin Portugal Program (a major partnership program in between the Portuguese Foundation for Science and Technology and UT) regarding their unique approach and explained how an aptamer known as AS1411 could be modified to better carry drugs to tumors. (utexas.edu)
  • In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed. (anti-agingfirewalls.com)
  • Besides the toxic effects of chemotherapy, another major problem is chemoresistance [5]. (savedelicious.com)
  • In response to the spreading of P. falciparum drug resistance, WHO recommended in 2001 to use artemisinin derivatives in combination with a partner drug (called ACT) as first-line treatment for uncomplicated falciparum malaria, and most malaria-endemic countries have since changed their treatment policies accordingly. (nih.gov)
  • However, alarming signs of emerging resistance to artemisinin derivatives along the Thai-Cambodian border are of major concern. (nih.gov)
  • 14. Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors. (nih.gov)
  • Synthesis of Novel Pleuromutilin Derivatives. (nih.gov)
  • Majumdar KC, Ponra S, Ghosh T, Sadhukhan R, Ghosh U. Synthesis of novel pyrano[3,2-f]quinoline, phenanthroline derivatives and studies of their interactions with proteins: an application in mammalian cell imaging. (uams.edu)
  • Oxadiazoles: Part XV-Synthesis and Biological Activities of Substituted 1, 3, 4-Oxadiazole Derivatives Kartik Ladva, Pankaj Patel, Paresh Upadhyay, Hansa Parekh Indian journal of chemistry. (edu.in)
  • Design, synthesis and evaluation of antimicrobial activities of some novel 2-mercapto-1,3,4-oxadiazo-2-yl derivatives clubbed with 1hbenzimidazole. (edu.in)
  • But in the development and application of these technologies, there are at least two major considerations: the desired antimicrobial effects (the most obvious reason behind employing these technologies) and safety requirements. (basicmedicalkey.com)
  • Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. (nwu.ac.za)
  • Quinine is active against malaria, but has been replaced by synthetic aminoquinolone derivatives such as chloroquine that are more potent and better tolerated. (nih.gov)
  • Plasmodium falciparum malaria is a major global health problem, causing approximately 780,000 deaths each year. (nih.gov)
  • A major concern is the amount of residue that may be available in the body. (researchgate.net)
  • Mepacrine is an acridine dye that was developed in the 1920s and found to have activity against P. vivax and falciparum infection. (nih.gov)
  • More recently, we have been studying some diimine Pt(II) and Pd(II) complexes of dithiocarbamate derivative as potential anticancer agents [ 31 ]. (hindawi.com)
  • Major Caveats Discovered in the Genetic Cell Ablation Model Used to Study Microglia Functions. (nih.gov)
  • This graph shows the total number of publications written about "Phenanthrolines" by people in UAMS Profiles by year, and whether "Phenanthrolines" was a major or minor topic of these publications. (uams.edu)
  • It has established extensive business contacts with major universities, research institutes and biopharmaceutical companies in China. (confluore.com)