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  • solid-state NMR spectr
  • PhysOrg.com) -- A new study using solid-state NMR spectroscopy to analyze intact bone paves the way for atomic-level explorations of how disease and aging affect bone. (phys.org)
  • Today such sources are available as turn-key instruments, making DNP a valuable and indispensable method especially in the field of structure determination by high-resolution solid-state NMR spectroscopy DNP was first realized using the concept of the Overhauser effect, which is the perturbation of nuclear spin level populations observed in metals and free radicals when electron spin transitions are saturated by the microwave irradiation. (wikipedia.org)
  • transfer spectroscopy
  • His recent work has focused on developing new NMR methods (such as paramagnetic relaxation enhancement, dark state exchange saturation transfer spectroscopy and lifetime line broadening) to characterize the structure and dynamics of sparsely-populated states of macromolecules, which are important in macromolecular interactions but invisible to conventional structural and biophysical techniques. (wikipedia.org)
  • COSY
  • The first and most popular two-dimension NMR experiment is the homonuclear correlation spectroscopy (COSY) sequence, which is used to identify spins which are coupled to each other. (wikipedia.org)
  • typically
  • These properties are fundamentally the same as those used in the more familiar magnetic resonance imaging (MRI) , but the molecular applications use a somewhat different approach, appropriate to the change of scale from millimeters (of interest to radiologists) to nanometers (bonded atoms are typically a fraction of a nanometer apart), a factor of a million. (wikipedia.org)
  • Also, for some metastatic lesions and for high-grade gliomas, typically, there are resonances corresponding to lactate or lipids ( 26 , 27 ). (aacrjournals.org)
  • Hyperpolarized noble gases are typically used in magnetic resonance imaging (MRI) of the lungs. (wikipedia.org)
  • MRSI
  • Tumor-bearing mice are anesthetized by breathing isoflurane in a magnetic resonance (MR) scanner dedicated to small animal MR. Here we describe the overall setup and steps for measuring 1 H and 31 P MRS and 1 H MRSI of orthotopic breast tumor models in mice with surface coils. (springer.com)
  • Danishad KK, Sharma U, Sah RG, Seenu V, Parshad R, Jagannathan NR (2010) Assessment of therapeutic response of locally advanced breast cancer (LABC) patients undergoing neoadjuvant chemotherapy (NACT) monitored using sequential magnetic resonance spectroscopic imaging (MRSI). (springer.com)
  • biomolecular
  • He is known for his foundational work in three-dimensional protein and nucleic acid structure determination by biomolecular NMR spectroscopy, for advancing experimental approaches to the study of large macromolecules and their complexes by NMR, and for developing NMR-based methods to study rare conformational states in protein-nucleic acid and protein-protein recognition. (wikipedia.org)
  • experiment
  • We present a proof-of-principle experiment in which we search for PNC in the 13 C resonances of small molecules, and use the 1 H resonances, which are insensitive to PNC, as an internal reference. (osti.gov)
  • In the echo experiment, two short, intense pulses of radiofrequency magnetic field are applied to the spin ensemble at the nuclear resonance condition and are separated by a time interval of τ. (wikipedia.org)
  • In the Hahn-Maxwell experiment, the decay was modulated by two frequencies: one frequency corresponded with the difference in chemical shift between the two non-equivalent spins and a second frequency, J, that was smaller and independent of magnetic field strength (J/2π = 0.7 Hz). (wikipedia.org)
  • atoms
  • This type of spectroscopy determines the physical and chemical properties of atoms or the molecules in which they are contained. (wikipedia.org)
  • These experiments are often used to assign specific resonance signals to specific atoms in an isotopically-enriched protein. (wikipedia.org)
  • sequential
  • Many of these experiments have since become the standard set of experiments used for sequential assignment of NMR resonances in the determination of protein structure by NMR. (wikipedia.org)
  • The sequential walking methodology is not possible for non-double helical nucleic acid structures, nor for the Z-DNA form, making assignment of resonances more difficult. (wikipedia.org)
  • early 1950s
  • The Purcell group at Harvard University and the Bloch group at Stanford University independently developed NMR spectroscopy in the late 1940s and early 1950s. (wikipedia.org)
  • The first DNP experiments were performed in the early 1950s at low magnetic fields but until recently the technique was of limited applicability for high-frequency, high-field NMR spectroscopy, because of the lack of microwave (or terahertz) sources operating at the appropriate frequency. (wikipedia.org)
  • spectrum
  • Single Voxel Spectroscopy (SVS): has a minimum spatial resolution of approximately 1 cm3, and has the cleanest spectrum free from unwanted artefacts due to the small acquired volume. (wikipedia.org)
  • Owing to rapid spin relaxation, the electron-nuclear coupling is not observed in the NMR spectrum, so the affected nuclear resonance appears at the average of the two coupled energy states, weighted according to their spin populations. (wikipedia.org)
  • There is a tradition in diamond spectroscopy to label a defect-induced spectrum by a numbered acronym (e.g. (wikipedia.org)
  • chemical
  • We set a constraint on molecular PNC in 13 C chemical shifts at a level of 10 -5 ppm, and provide a discussion of important considerations in the search for molecular PNC using NMR spectroscopy. (osti.gov)
  • It relies on the phenomenon of nuclear magnetic resonance and can provide detailed information about the structure, dynamics, reaction state, and chemical environment of molecules. (wikipedia.org)
  • frequency
  • The intramolecular magnetic field around an atom in a molecule changes the resonance frequency, thus giving access to details of the electronic structure of a molecule and its individual functional groups. (wikipedia.org)
  • The resonant frequency, energy of the absorption, and the intensity of the signal are proportional to the strength of the magnetic field. (wikipedia.org)
  • The selection rules of NMR spectroscopy dictate that ΔI = 1, which means that a given photon (in the radio frequency range) can affect ("flip") only one of the two nuclear spins. (wikipedia.org)
  • spins
  • Note that the alignment of electron spins at a given magnetic field and temperature is described by the Boltzmann distribution under the thermal equilibrium. (wikipedia.org)
  • functional
  • In single-voxel fMRS the selection of the volume of interest (VOI) is often done by running a functional magnetic resonance imaging (fMRI) study prior to fMRS to localize the brain region activated by the task. (wikipedia.org)
  • Shimming
  • These steps include: Shimming the magnetic field: this step is taken to correct for the inhomogeneity of the magnetic field by tuning different pulses in the x, y, and z directions. (wikipedia.org)
  • large
  • Modern NMR spectrometers have a very strong, large and expensive liquid helium-cooled superconducting magnet, because resolution directly depends on magnetic field strength. (wikipedia.org)
  • analysis
  • Reyes-Valerio's contributions were possible due to his combined background of history and chemistry, through a thorough revision of primary texts (Sahagun, Hernandez, Jimenez, and others), microscopic analysis of the mural paintings and fourier transform infrared spectroscopy. (wikipedia.org)
  • properties
  • Although this sp3 center disrupts the continuous overlap of p-orbitals, traditionally thought to be a requirement for aromaticity, considerable thermodynamic stability and many of the spectroscopic, magnetic, and chemical properties associated with aromatic compounds are still observed for such compounds. (wikipedia.org)
  • The number of electrons influences the magnetic properties of an atom. (wikipedia.org)