• granulocyte macrop
  • Mutation in gene which coats for Protein B or C or GM-CSF (granulocyte macrophage colony stimulating factor). (mediconotebook.com)
  • Although the cause of PAP is not entirely understood, a major breakthrough in the understanding of the cause of the disease came by the chance observation that mice bred for experimental study to lack a hematologic growth factor known as granulocyte-macrophage colony stimulating factor (GM-CSF) developed a pulmonary syndrome of abnormal surfactant accumulation resembling human PAP. (wikipedia.org)
  • This gene product is also known as granulocyte macrophage colony-stimulating factor receptor. (wikipedia.org)
  • Pulmonary Alveolar Pr
  • Pulmonary alveolar proteinosis was first described by Rosen et al. (annals.org)
  • Pulmonary Alveolar Proteinosis: An Inquiry on Its Pathogenesis. (annals.org)
  • Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which an abnormal accumulation of pulmonary surfactant occurs within the alveoli (microscopic air sacs in the lung), interfering with the lungs' ability to exchange oxygen from the air, and carbon dioxide from the blood. (wikipedia.org)
  • Abnormalities in CSF2 receptor alpha have been shown to cause hereditary pulmonary alveolar proteinosis. (wikipedia.org)
  • The first advance in the treatment of pulmonary alveolar proteinosis came in November 1960, when Dr. Jose Ramirez-Rivera at the Veterans' Administration Hospital in Baltimore applied repeated "segmental flooding" as a means of physically removing the accumulated alveolar material. (wikipedia.org)