• Lung
  • The demonstration by Upham et al 1 that human alveolar macrophages selectively inhibit proliferation of T cells by secretion of unidentified effector molecules raises the question as to whether pathological processes in the lung characterised by extensive macrophage recruitment or activation can have a systemic effect on T cell development. (bmj.com)
  • As inferred by Dr Grange, these T cells are subjected to the powerful downregulatory influence of lung macrophages during their transit through lung tissue, resulting in a variety of functional changes including loss of proliferation capacity. (bmj.com)
  • 1-6 The suggestion that amplification of this process during inflammatory diseases characterised by enhanced lung macrophage recruitment/activation may result in significant effects on the overall recirculating T cell compartment is thus worthy of more detailed investigation. (bmj.com)
  • Alveolar (lung pleural cavity) macrophages are part of the reticuloendothelial system. (sciencephoto.com)
  • Peripolesis was also observed in lung alveoli, where the peripolesed macrophages were not injured, but the cell membrane did appear to be temporarily altered. (wikipedia.org)
  • cells
  • 1-1 1-3 1-5 While the precise mechanisms employed by the macrophages to modulate T cells are incompletely understood, it is clear that their overall efficiency in this regard is a reflection of their maturation/activation status. (bmj.com)
  • Taurine uptake by isolated alveolar macrophages and type II cells. (cdc.gov)
  • The possibility that alveolar macrophages and type-II cells can accumulate taurine was examined. (cdc.gov)
  • The rates of taurine influx during both phases of uptake were greater for alveolar macrophages than for type-II cells, although alveolar type-II cells had a higher taurine content than alveolar macrophages. (cdc.gov)
  • Alveolar macrophages displayed a higher proportion of leakage than type-II cells. (cdc.gov)
  • Thus the higher taurine content of alveolar type-II cells may be due both to differences in the surface area of the cells and to differences in the ratio of carrier mediated taurine uptake to leakage of taurine from the cells. (cdc.gov)
  • Alveolar macrophages release numerous secretory products and interact with other cells and molecules through the expression of several surface receptors. (wikipedia.org)