AzithromycinErythromycinLincosamidesTaking a macrolide antibioticRulideActive pharmaceutInfectionsSemi-syntheticAnti-inflammatoryBacteria0.00Placebo for any indicationAntimicrobial activityTelithromycinAntibiotic resistanceInfants exposedProtein synthesisGastrointestinalConcurrentlyAdverseClinicallySubunitInteractAllergicEffectivenessAirwayMechanismPenicillinInfectionWidelyPregnantTreatmentBreast milkTabletsTabletDoseChronicExposurePregnancyOralGroupEffectsHumanStudyEffect
Azithromycin12
- The anti-inflammatory properties of macrolides are related to structure, with immunomodulatory effects seen with 14- (erythromycin, clarithromycin and roxithromycin) and 15- (azithromycin) but not 16-member (josamycin) macrolides 16 . (ersjournals.com)
- May interact in the environment with other macrolide antiobiotics, such as azithromycin, erythromycin and roxithromycin. (janusinfo.se)
- The effects of various macrolide antibiotics [triacetyloleandomycin (TAO), clarithromycin, azithromycin, roxithromycin, erythromycin base] and the new ketolide HMR3004 on CYP3A expression were evaluated in human and rat hepatocytes. (aspetjournals.org)
- Interacts with the tunnel-blocking modified macrolide azithromycin. (proteopedia.org)
- HAMAP-Rule:MF_01328_B] This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel. (proteopedia.org)
- Roxithromycin is a semi-synthethic macrolide antibiotic that is structurally and pharmacologically similar to erythromycin, azithromycin, or clarithromycin. (drugbank.com)
- We included trials using any of the four most commonly used macrolide antibiotics: azithromycin, clarithromycin, erythromycin, or roxithromycin. (edu.au)
- Azithromycin and erythromycin were more commonly studied than clarithromycin and roxithromycin. (edu.au)
- Among the group exposed to macrolide antibiotics, 41.9% used erythromycin, 36.2% used azithromycin, 18.2% used roxithromycin, and 3.6% used clarithromycin. (infectiousdiseaseadvisor.com)
- Roxithromycin is very similar in composition, chemical structure (semi-synthetic) and mechanism of action to erythromycin, azithromycin, or clarithromycin. (canadianepharmacy.com)
- Zithromax (azithromycin tablets and oral suspension) contains the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. (buysumamed.com)
- OBJECTIVES: To test four 16-membered macrolides (josamycin, spiramycin, midecamycin and rokitamycin) along with other compounds in the same class (erythromycin, clarithromycin, roxithromycin and azithromycin) plus clindamycin and telithromycin, against Streptococcus pyogenes and Streptococcus pneumoniae isolates with well-characterized resistance genotypes. (unicam.it)
Erythromycin11
- Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. (wikipedia.org)
- citation needed] Roxithromycin has fewer interactions than erythromycin as it has a lower affinity for cytochrome P450. (wikipedia.org)
- Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. (wikipedia.org)
- The chance finding that erythromycin treatment radically improved the clinical outcome of a patient with diffuse panbronchiolitis rekindled interest in the use of macrolides as a potential treatment in other inflammatory airway disorders, e.g. cystic fibrosis 8 . (ersjournals.com)
- In rat hepatocytes, no induction of CYP3A1 expression was observed following exposure to macrolides, even to erythromycin base and TAO (well known in vivo CYP3A1 inducers), whereas dexamethasone and phenobarbital were confirmed to induce this enzyme. (aspetjournals.org)
- To elucidate the structural basis of ribosome-antibiotic interactions, we determined the high-resolution X-ray structures of the 50S ribosomal subunit of the eubacterium Deinococcus radiodurans, complexed with the clinically relevant antibiotics chloramphenicol, clindamycin and the three macrolides erythromycin, clarithromycin and roxithromycin. (proteopedia.org)
- Most of the macrolide prescriptions were for erythromycin, but only 1.7% were for clarithromycin. (drugs.com)
- 5] Kuenzi B, Segessenmann CH, Gerber AU, Postantibiotic effect roxithromycin, erythromycin and clindamycin against selected Gram-ppositive bacteria and Haemophilus influenze, J. Antimicrob. (edu.pl)
- Macrolide antibiotics (Macs) such as erythromycin, clarithromycin (CAM) and roxithromycin (RXM) provide not only antibacterial activity, but also anti-inflammatory effects. (sch.ac.kr)
- Activities of 16-membered ring macrolides and telithromycin against different genotypes of erythromycin-susceptible and erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae. (unicam.it)
- METHODS: Four hundred and eighty-six isolates of S. pyogenes and 375 isolates of S. pneumoniae were assayed for their macrolide susceptibilities and investigated by PCR to detect their different erythromycin resistance genes. (unicam.it)
Lincosamides2
- Macrolides are prescribed for intolerance to antibiotics of the penicillin series or cephalosporins, and in the presence of allergy to macrolides, lincosamides are indicated. (abchealthonline.com)
- They have some features in common - for example they inhibit protein synthesis in bacteria (with macrolides, lincosamides, and chloramphenicol acting at a similar site), and have some similar pharmacokinetic features. (veteriankey.com)
Taking a macrolide antibiotic2
- A cohort study of infants diagnosed with infantile hypertrophic pyloric stenosis found that affected infants were 2.3 to 3 times more likely to have a mother taking a macrolide antibiotic during the 90 days after delivery. (drugs.com)
- A study comparing the breastfed infants of mothers taking amoxicillin to those taking a macrolide antibiotic found no instances of pyloric stenosis. (drugs.com)
Rulide4
- Roxithromycin 300 mg (Rulide®) was given to each volunteer. (scholarsresearchlibrary.com)
- Rulide is a macrolide antibiotic used to treat infections of of upper respiratory tract. (pharmacie-en-ligne.net)
- Rulide is a semi-synthetic macrolide antibiotic used for the treatment of mild to moderate infections of upper respiratory tract infections (acute pharyngitis, tonsillitis, sinusitis) caused by susceptible pathogens. (pharmacie-en-ligne.net)
- Hypersensitivity to Rulide or macrolide antibiotics, concomitant therapy with vasoconstrictive ergotamine type medications. (pharmacie-en-ligne.net)
Active pharmaceut1
- In a case study of the separation of an active pharmaceutical ingredient (API) (roxithromycin macrolide antibiotic (Roxi)) from genotoxic impurities (GTIs) (4-dimethylaminopyridine (DMAP) and ethyl tosylate (EtTS)), adsorptive solvent recovery by activated carbon exhibited lower energy consumption and a smaller carbon footprint than distillation (96% and 70% lower respectively) 2 . (confex.com)
Infections11
- Macrolide antibiotics are used as first-line agents in the treatment of acute bacterial infections, such as community-acquired pneumonia 1 . (ersjournals.com)
- Background: Macrolide antibiotics (macrolides) are among the most commonly prescribed antibiotics worldwide and are used for a wide range of infections. (edu.au)
- The indications for macrolide antibiotics varied greatly, with most studies using macrolides for the treatment or prevention of either acute respiratory tract infections, cardiovascular diseases, chronic respiratory diseases, gastrointestinal conditions, or urogynaecological problems. (edu.au)
- Roxithromycin is used for treating several different infections, including some STDs, upper and lower respiratory tract infections and asthma, gum infections like gingivitis, and bacterial infections associated with stomach and intestinal ulcers. (canadianepharmacy.com)
- It is used to treat respiratory tract, urinary and soft tissue infections.Roxithromycin has also been tested to possess antimalarial activity. (mosinterchem.com)
- Zithromax is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions. (buysumamed.com)
- Roxid 50mg Liquid contains Roxithromycin 50mg used to treat any type of bacterial infections such as otitis media acute pharyngitis, sinusitis, bronchitis, urethritis, impetigo, cellulitis, sexually transmitted diseases like gonorrhea, and also in typhoid fever in children. (drugcarts.com)
- Roxithromycin is a macrolide antibiotic that produces its action by inhibiting the growth of bacteria which is responsible for infections. (drugcarts.com)
- Roxid 50mg Liquid contains Roxithromycin 50mg is a macrolide antibiotic used to treat bacterial infections. (drugcarts.com)
- Roxithromycin is a semi-synthetic macrolide antibiotic and is used to treat respiratory tract, urinary, and soft tissue infections. (pharmacy-medshop.com)
- Roxithromycin is an antibiotic that belongs to a group of medicines called macrolides and is used to treat various infections caused by bacteria such as acute pharyngitis (sore throat and discomfort when swallowing) tonsillitis. (pharmacy-medshop.com)
Semi-synthetic2
- Roxithromycin is a semi-synthetic macrolide antibiotic. (wikipedia.org)
- Roxithromycin is a semi-synthetic long-acting macrolide antibiotic. (cyno.co.in)
Anti-inflammatory3
- Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C: Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. (karger.com)
- Macrolides are an antibiotic group with anti-inflammatory and immunomodulatory properties. (healthline.com)
- Macrolide antibiotics provide not only antibacterial activity but also anti-inflammatory effects. (sch.ac.kr)
Bacteria2
- citation needed] Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. (wikipedia.org)
- We analysed specific adverse events, deaths, and subsequent carriage of macrolide-resistant bacteria separately. (edu.au)
0.001
- Mean ± SE value for clearance ratio between drug clearance and creatinine clearance was 0.04 ± 0.00 which indicates reabsorption (back diffusion) of roxithromycin. (scholarsresearchlibrary.com)
Placebo for any indication2
Antimicrobial activity1
- In addition to direct antimicrobial activity, macrolides also exert immune modifying effects 2 , 3 . (ersjournals.com)
Telithromycin1
- In S. pyogenes, the activity of both 16-membered macrolides and telithromycin against the iMLS(B) strains proved to be dependent on the erm gene involved, being greater against isolates with erm(A). (unicam.it)
Antibiotic resistance1
- This also takes into account the risk of antibiotic resistance selection and environmental interaction between other macrolide antibiotics. (janusinfo.se)
Infants exposed4
- However, most of the infants exposed to a macrolide in breastmilk were exposed to roxithromycin. (drugs.com)
- Only 6 of the 55 infants exposed to a macrolide were exposed to clarithromycin. (drugs.com)
- Adverse reactions occurred in 12.7% of the infants exposed to macrolides which was similar to the rate in amoxicillin-exposed infants. (drugs.com)
- In total, 457 infants exposed to macrolide antibiotics in utero were diagnosed with a major birth defect. (infectiousdiseaseadvisor.com)
Protein synthesis1
- Roxithromycin exerts its antibacterial action by binding to the bacterial ribosome and interfering with bacterial protein synthesis. (drugbank.com)
Gastrointestinal2
- There was no clear consistent difference in gastrointestinal adverse events between different types of macrolides or route of administration. (edu.au)
- 11] Hang S, Xing J, Hong D, pH-dependent geometric isomerisation of roxithromycin in simulated gastrointestinal fluids and in rats, J. Pharm. (edu.pl)
Concurrently2
- This is shown by an increase in prothrombin time and/or international normalised ratio (INR) in patients taking roxithromycin and warfarin concurrently. (wikipedia.org)
- In one study, patients concurrently treated with the macrolide troleandomycin were able to significantly reduce their total steroid dose without a significant decrease in asthma control 5 . (ersjournals.com)
Adverse1
- However, macrolides also expose people to the risk of adverse events. (edu.au)
Clinically1
- In addition to many of the usual risks from antimicrobial therapy, macrolides also have clinically significant effects on cardiac conduction 21 and may be important promoters of antimicrobial resistance 22 . (ersjournals.com)
Subunit2
- Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. (wikipedia.org)
- Its biological activity is due to interference with peptidyltransferase activity at the 50S ribosomal subunit, which is near the site of action of macrolide antibiotics and for which there can be competition (Yunis, 1988). (veteriankey.com)
Interact4
- Roxithromycin is not known to interact with hormonal contraceptives, prednisolone, carbamazepine, ranitidine or antacids. (wikipedia.org)
- Roxithromycin appears to interact with warfarin. (wikipedia.org)
- Some medical conditions may interact with Roxithromycin. (canadianepharmacy.com)
- Ask your health care provider if Roxithromycin may interact with other medicines that you take. (canadianepharmacy.com)
Allergic1
- you are allergic to any ingredient in Roxithromycin. (canadianepharmacy.com)
Effectiveness1
- A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions. (ersjournals.com)
Airway3
- Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
- Macrolides are postulated to reduce airway inflammation via several mechanisms. (ersjournals.com)
- What is less clear is the evidence for a role of macrolides in the treatment of other chronic inflammatory airway diseases, e.g. cystic fibrosis, bronchiectasis, asthma, obliterative bronchiolitis, chronic obstructive pulmonary disease (COPD) and chronic rhinosinusitis. (ersjournals.com)
Mechanism1
- These results confirmed the interspecies variability of CYP3A regulation in hepatocytes and raised the question of its mechanism of induction by macrolides in human liver. (aspetjournals.org)
Penicillin1
- These data indicate that the risk for major birth defects in offspring was not found to be increased among pregnant women exposed to macrolide antibiotics compared with penicillin exposure or no antibiotic exposure during pregnancy. (infectiousdiseaseadvisor.com)
Infection4
- Due to the high concentration in phagocytes, roxithromycin is actively transported to the site of infection. (wikipedia.org)
- To clear up your infection completely, take Roxithromycin for the full course of treatment. (canadianepharmacy.com)
- Long-term or repeated use of Roxithromycin may cause a second infection. (canadianepharmacy.com)
- Use Roxithromycin with extreme caution in children younger 10 years who have diarrhea or an infection of the stomach or bowel. (canadianepharmacy.com)
Widely1
- Roxithromycin is a secondgeneration macrolide widely used in human clinics for different infectious diseases. (scholarsresearchlibrary.com)
Pregnant1
- You will need to discuss the benefits and risks of using Roxithromycin while you are pregnant. (canadianepharmacy.com)
Treatment2
- The role of macrolides in the treatment of diffuse panbronchiolitis is well established. (ersjournals.com)
- Be sure to use Roxithromycin for the full course of treatment. (canadianepharmacy.com)
Breast milk1
- Roxithromycin is found in breast milk. (canadianepharmacy.com)
Tablets2
- Roxithromycin is commonly available as tablets or oral suspension. (wikipedia.org)
- The behavior of dispersible tablets containing enteric-coated pellets and oral suspension, both containing roxithromycin, was investigated using dissolution tests in different media. (edu.pl)
Tablet1
- The cumulative percentage of oral dose of 300 mg tablet of roxithromycin excreted through urine during 48 hours was 12.87 ± 1.31 percent. (scholarsresearchlibrary.com)
Dose1
- If you miss a dose of Roxithromycin, take it as soon as possible. (canadianepharmacy.com)
Chronic1
- Macrolide antibiotics are effective drugs in chronic bronchiolitis and chronic rhinosinusitis with mucus hypersecretion. (karger.com)
Exposure4
- A retrospective database study in Denmark of 15 years of data found a 3.5-fold increased risk of infantile hypertrophic pyloric stenosis in the infants of mothers who took a macrolide during the first 13 days postpartum, but not with later exposure. (drugs.com)
- Exposure to macrolide antibiotics in utero was not found to increase the risk for major birth defects in offspring, according to results from a nationwide cohort study published in The British Medical Journal . (infectiousdiseaseadvisor.com)
- A total of 13,019 pregnancies had macrolide antibiotic exposure. (infectiousdiseaseadvisor.com)
- The median time from start of pregnancy to macrolide antibiotic exposure was 28 days. (infectiousdiseaseadvisor.com)
Pregnancy2
- Investigators examined the association between use of macrolide antibiotics in pregnancy and the risk of major birth defects in offspring. (infectiousdiseaseadvisor.com)
- Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study. (infectiousdiseaseadvisor.com)
Oral1
- Absorption: Roxithromycin is absorbed after oral administration. (cyno.co.in)
Group1
- Roxyzen is more useful in the case of gonorrhea as it is a group of macrolide antibiotics. (drugcarts.com)
Effects5
- The effects of the two macrolides on tumor necrosis factor-α (TNF-α) release were also examined. (karger.com)
- In addition to direct antibacterial actions, 14- and 15-member-ring macrolides have immune modulating effects that appear to be the reason for clinical benefit in diffuse panbronchiolitis. (ersjournals.com)
- 7 , in a 2-yr double-blind placebo-controlled study, showed that the combination of macrolide and methylprednisolone produced no significant clinical benefit in steroid-dependent asthma but, instead, resulted in an increase in steroid-induced side-effects, e.g. accelerated loss of bone density and increased sugar levels. (ersjournals.com)
- Roxithromycin is absorbed well into the gastro-intestinal tract, with few side effects, and actively responds to the presence of cryptosporidium, pneumocystis carinii (PCP), toxoplasma gondii, and Mycobacterium Avium (MAC). (canadianepharmacy.com)
- they may be more sensitive to the effects of Roxithromycin. (canadianepharmacy.com)
Human1
- 12] Motta M, Ribeiro W, Ifa DR, Moares ME, Moraes MO, Corrado AP, De Nucci G, Bioequivalence evaluation of two roxithromycin formulations in healthy human volunteers by high performance liquid chromatography coupled to tandem mass spectrometry, Acta Physiol. (edu.pl)
Study2
- Objective: In current study, influence of environmental situation and genetic variations on renal clearance and urinary excretion of roxithromycin was determined in local healthy adult female subjects. (scholarsresearchlibrary.com)
- Results: In present study the renal clearance of roxithromycin was 0.08 ± 0.01 ml/min/kg. (scholarsresearchlibrary.com)
Effect2
- Morikawa K, Zhang J, Nonaka M, Morikawa S: Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. (karger.com)
- Other tested macrolides had no induction effect on CYP3A expression. (aspetjournals.org)