• Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. (wikipedia.org)
  • citation needed] Roxithromycin has fewer interactions than erythromycin as it has a lower affinity for cytochrome P450. (wikipedia.org)
  • Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. (wikipedia.org)
  • The chance finding that erythromycin treatment radically improved the clinical outcome of a patient with diffuse panbronchiolitis rekindled interest in the use of macrolides as a potential treatment in other inflammatory airway disorders, e.g. cystic fibrosis 8 . (ersjournals.com)
  • In rat hepatocytes, no induction of CYP3A1 expression was observed following exposure to macrolides, even to erythromycin base and TAO (well known in vivo CYP3A1 inducers), whereas dexamethasone and phenobarbital were confirmed to induce this enzyme. (aspetjournals.org)
  • To elucidate the structural basis of ribosome-antibiotic interactions, we determined the high-resolution X-ray structures of the 50S ribosomal subunit of the eubacterium Deinococcus radiodurans, complexed with the clinically relevant antibiotics chloramphenicol, clindamycin and the three macrolides erythromycin, clarithromycin and roxithromycin. (proteopedia.org)
  • Most of the macrolide prescriptions were for erythromycin, but only 1.7% were for clarithromycin. (drugs.com)
  • 5] Kuenzi B, Segessenmann CH, Gerber AU, Postantibiotic effect roxithromycin, erythromycin and clindamycin against selected Gram-ppositive bacteria and Haemophilus influenze, J. Antimicrob. (edu.pl)
  • Macrolide antibiotics (Macs) such as erythromycin, clarithromycin (CAM) and roxithromycin (RXM) provide not only antibacterial activity, but also anti-inflammatory effects. (sch.ac.kr)
  • Activities of 16-membered ring macrolides and telithromycin against different genotypes of erythromycin-susceptible and erythromycin-resistant Streptococcus pyogenes and Streptococcus pneumoniae. (unicam.it)
  • METHODS: Four hundred and eighty-six isolates of S. pyogenes and 375 isolates of S. pneumoniae were assayed for their macrolide susceptibilities and investigated by PCR to detect their different erythromycin resistance genes. (unicam.it)
  • Nws tau dhau los ua kev hloov pauv rau erythromycin ntawm macrolide hmoov tshuaj tua kab mob. (ballyabio.com)
  • Cov kab mob tua kab mob zoo ib yam li erythromycin thiab roxithromycin, tab sis cov tshuaj tua kab mob rau cov kab mob Gram-positive xws li Streptococcus, pneumococcus, thiab staphylococcus zoo dua me ntsis, thiab nws tseem muaj qee yam cuam tshuam rau cov kab mob erythromycin-resistant. (ballyabio.com)
  • Macrolides are prescribed for intolerance to antibiotics of the penicillin series or cephalosporins, and in the presence of allergy to macrolides, lincosamides are indicated. (abchealthonline.com)
  • They have some features in common - for example they inhibit protein synthesis in bacteria (with macrolides, lincosamides, and chloramphenicol acting at a similar site), and have some similar pharmacokinetic features. (veteriankey.com)
  • A cohort study of infants diagnosed with infantile hypertrophic pyloric stenosis found that affected infants were 2.3 to 3 times more likely to have a mother taking a macrolide antibiotic during the 90 days after delivery. (drugs.com)
  • A study comparing the breastfed infants of mothers taking amoxicillin to those taking a macrolide antibiotic found no instances of pyloric stenosis. (drugs.com)
  • Roxithromycin 300 mg (Rulide®) was given to each volunteer. (scholarsresearchlibrary.com)
  • Rulide is a macrolide antibiotic used to treat infections of of upper respiratory tract. (pharmacie-en-ligne.net)
  • Rulide is a semi-synthetic macrolide antibiotic used for the treatment of mild to moderate infections of upper respiratory tract infections (acute pharyngitis, tonsillitis, sinusitis) caused by susceptible pathogens. (pharmacie-en-ligne.net)
  • Hypersensitivity to Rulide or macrolide antibiotics, concomitant therapy with vasoconstrictive ergotamine type medications. (pharmacie-en-ligne.net)
  • In a case study of the separation of an active pharmaceutical ingredient (API) (roxithromycin macrolide antibiotic (Roxi)) from genotoxic impurities (GTIs) (4-dimethylaminopyridine (DMAP) and ethyl tosylate (EtTS)), adsorptive solvent recovery by activated carbon exhibited lower energy consumption and a smaller carbon footprint than distillation (96% and 70% lower respectively) 2 . (confex.com)
  • Macrolide antibiotics are used as first-line agents in the treatment of acute bacterial infections, such as community-acquired pneumonia 1 . (ersjournals.com)
  • Background: Macrolide antibiotics (macrolides) are among the most commonly prescribed antibiotics worldwide and are used for a wide range of infections. (edu.au)
  • The indications for macrolide antibiotics varied greatly, with most studies using macrolides for the treatment or prevention of either acute respiratory tract infections, cardiovascular diseases, chronic respiratory diseases, gastrointestinal conditions, or urogynaecological problems. (edu.au)
  • Roxithromycin is used for treating several different infections, including some STDs, upper and lower respiratory tract infections and asthma, gum infections like gingivitis, and bacterial infections associated with stomach and intestinal ulcers. (canadianepharmacy.com)
  • It is used to treat respiratory tract, urinary and soft tissue infections.Roxithromycin has also been tested to possess antimalarial activity. (mosinterchem.com)
  • Zithromax is a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions. (buysumamed.com)
  • Roxid 50mg Liquid contains Roxithromycin 50mg used to treat any type of bacterial infections such as otitis media acute pharyngitis, sinusitis, bronchitis, urethritis, impetigo, cellulitis, sexually transmitted diseases like gonorrhea, and also in typhoid fever in children. (drugcarts.com)
  • Roxithromycin is a macrolide antibiotic that produces its action by inhibiting the growth of bacteria which is responsible for infections. (drugcarts.com)
  • Roxid 50mg Liquid contains Roxithromycin 50mg is a macrolide antibiotic used to treat bacterial infections. (drugcarts.com)
  • Roxithromycin is a semi-synthetic macrolide antibiotic and is used to treat respiratory tract, urinary, and soft tissue infections. (pharmacy-medshop.com)
  • Roxithromycin is an antibiotic that belongs to a group of medicines called macrolides and is used to treat various infections caused by bacteria such as acute pharyngitis (sore throat and discomfort when swallowing) tonsillitis. (pharmacy-medshop.com)
  • Roxithromycin is a semi-synthetic macrolide antibiotic. (wikipedia.org)
  • Roxithromycin is a semi-synthetic long-acting macrolide antibiotic. (cyno.co.in)
  • Steel HC, Theron AJ, Cockeran R, Anderson R, Feldman C: Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. (karger.com)
  • Macrolides are an antibiotic group with anti-inflammatory and immunomodulatory properties. (healthline.com)
  • Macrolide antibiotics provide not only antibacterial activity but also anti-inflammatory effects. (sch.ac.kr)
  • citation needed] Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. (wikipedia.org)
  • We analysed specific adverse events, deaths, and subsequent carriage of macrolide-resistant bacteria separately. (edu.au)
  • Objectives: To quantify the incidences of reported adverse events in people taking macrolide antibiotics compared to placebo for any indication. (edu.au)
  • Selection criteria: We included RCTs that compared a macrolide antibiotic to placebo for any indication. (edu.au)
  • In S. pyogenes, the activity of both 16-membered macrolides and telithromycin against the iMLS(B) strains proved to be dependent on the erm gene involved, being greater against isolates with erm(A). (unicam.it)
  • This also takes into account the risk of antibiotic resistance selection and environmental interaction between other macrolide antibiotics. (janusinfo.se)
  • However, most of the infants exposed to a macrolide in breastmilk were exposed to roxithromycin. (drugs.com)
  • Only 6 of the 55 infants exposed to a macrolide were exposed to clarithromycin. (drugs.com)
  • Adverse reactions occurred in 12.7% of the infants exposed to macrolides which was similar to the rate in amoxicillin-exposed infants. (drugs.com)
  • In total, 457 infants exposed to macrolide antibiotics in utero were diagnosed with a major birth defect. (infectiousdiseaseadvisor.com)
  • Roxithromycin exerts its antibacterial action by binding to the bacterial ribosome and interfering with bacterial protein synthesis. (drugbank.com)
  • There was no clear consistent difference in gastrointestinal adverse events between different types of macrolides or route of administration. (edu.au)
  • 11] Hang S, Xing J, Hong D, pH-dependent geometric isomerisation of roxithromycin in simulated gastrointestinal fluids and in rats, J. Pharm. (edu.pl)
  • This is shown by an increase in prothrombin time and/or international normalised ratio (INR) in patients taking roxithromycin and warfarin concurrently. (wikipedia.org)
  • In one study, patients concurrently treated with the macrolide troleandomycin were able to significantly reduce their total steroid dose without a significant decrease in asthma control 5 . (ersjournals.com)
  • In addition to many of the usual risks from antimicrobial therapy, macrolides also have clinically significant effects on cardiac conduction 21 and may be important promoters of antimicrobial resistance 22 . (ersjournals.com)
  • Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. (wikipedia.org)
  • Its biological activity is due to interference with peptidyltransferase activity at the 50S ribosomal subunit, which is near the site of action of macrolide antibiotics and for which there can be competition (Yunis, 1988). (veteriankey.com)
  • Cov tshuaj no yog cov tshuaj tua kab mob macrolide, thiab nws cov txheej txheem yog txhawm rau txhawm rau ua kom muaj protein ntau los ntawm kev thaiv qhov kev sib txuas ntawm 50S subunit ntawm nucleoprotein los tsim cov tshuaj tua kab mob. (ballyabio.com)
  • A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions. (ersjournals.com)
  • Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
  • Macrolides are postulated to reduce airway inflammation via several mechanisms. (ersjournals.com)
  • What is less clear is the evidence for a role of macrolides in the treatment of other chronic inflammatory airway diseases, e.g. cystic fibrosis, bronchiectasis, asthma, obliterative bronchiolitis, chronic obstructive pulmonary disease (COPD) and chronic rhinosinusitis. (ersjournals.com)
  • These results confirmed the interspecies variability of CYP3A regulation in hepatocytes and raised the question of its mechanism of induction by macrolides in human liver. (aspetjournals.org)
  • These data indicate that the risk for major birth defects in offspring was not found to be increased among pregnant women exposed to macrolide antibiotics compared with penicillin exposure or no antibiotic exposure during pregnancy. (infectiousdiseaseadvisor.com)
  • Roxithromycin is a secondgeneration macrolide widely used in human clinics for different infectious diseases. (scholarsresearchlibrary.com)
  • Roxithromycin is commonly available as tablets or oral suspension. (wikipedia.org)
  • The behavior of dispersible tablets containing enteric-coated pellets and oral suspension, both containing roxithromycin, was investigated using dissolution tests in different media. (edu.pl)
  • Macrolide antibiotics are effective drugs in chronic bronchiolitis and chronic rhinosinusitis with mucus hypersecretion. (karger.com)
  • A retrospective database study in Denmark of 15 years of data found a 3.5-fold increased risk of infantile hypertrophic pyloric stenosis in the infants of mothers who took a macrolide during the first 13 days postpartum, but not with later exposure. (drugs.com)
  • Exposure to macrolide antibiotics in utero was not found to increase the risk for major birth defects in offspring, according to results from a nationwide cohort study published in The British Medical Journal . (infectiousdiseaseadvisor.com)
  • A total of 13,019 pregnancies had macrolide antibiotic exposure. (infectiousdiseaseadvisor.com)
  • The median time from start of pregnancy to macrolide antibiotic exposure was 28 days. (infectiousdiseaseadvisor.com)
  • Roxyzen is more useful in the case of gonorrhea as it is a group of macrolide antibiotics. (drugcarts.com)
  • The effects of the two macrolides on tumor necrosis factor-α (TNF-α) release were also examined. (karger.com)
  • In addition to direct antibacterial actions, 14- and 15-member-ring macrolides have immune modulating effects that appear to be the reason for clinical benefit in diffuse panbronchiolitis. (ersjournals.com)
  • 7 , in a 2-yr double-blind placebo-controlled study, showed that the combination of macrolide and methylprednisolone produced no significant clinical benefit in steroid-dependent asthma but, instead, resulted in an increase in steroid-induced side-effects, e.g. accelerated loss of bone density and increased sugar levels. (ersjournals.com)
  • Roxithromycin is absorbed well into the gastro-intestinal tract, with few side effects, and actively responds to the presence of cryptosporidium, pneumocystis carinii (PCP), toxoplasma gondii, and Mycobacterium Avium (MAC). (canadianepharmacy.com)
  • they may be more sensitive to the effects of Roxithromycin. (canadianepharmacy.com)
  • 12] Motta M, Ribeiro W, Ifa DR, Moares ME, Moraes MO, Corrado AP, De Nucci G, Bioequivalence evaluation of two roxithromycin formulations in healthy human volunteers by high performance liquid chromatography coupled to tandem mass spectrometry, Acta Physiol. (edu.pl)
  • Morikawa K, Zhang J, Nonaka M, Morikawa S: Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production. (karger.com)
  • Other tested macrolides had no induction effect on CYP3A expression. (aspetjournals.org)