• expression
  • OGX-011 is a 2′-methoxyethyl modified phosphorothioate antisense oligonucleotide that is complementary to clusterin mRNA and has been reported to inhibit clusterin expression and enhance drug efficacy in xenograft models. (oup.com)
  • The primary objective of this clinical study was to determine a biologically effective dose of OGX-011 that would inhibit clusterin expression in human cancer. (oup.com)
  • Prostate cancer tissue, lymph nodes, and serial samples of peripheral blood mononuclear cells were assessed for clusterin expression using quantitative real-time polymerase chain reaction and immunohistochemistry. (oup.com)
  • OGX-011 is well tolerated and reduces clusterin expression in primary prostate tumors. (oup.com)
  • The authors examined the pattern of clusterin mRNA expression in the developing rat embryo and found it not to correlate with regions undergoing developmental cell death. (mussenhealth.us)
  • cell
  • Clusterin is a cytoprotective chaperone protein that promotes cell survival and confers broad-spectrum treatment resistance. (oup.com)
  • A direct role for clusterin in programmed cell death in the rat CNS was subsequently disclosed in a study by Garden and coworkers32 using in situ hybridization. (mussenhealth.us)
  • The fact that nearly every neuron in the adult forebrain was positive for clusterin mRNA made it unlikely that clusterin correlated with programmed cell death in the majority of cells expressing it. (mussenhealth.us)